Human Sigma-1 R Antibody Summary
Accession # Q99720
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Sigma-1 R in HeLa Human Cell Line. Sigma-1 R was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line using Rabbit Anti-Human Sigma-1 R Monoclonal Antibody (Catalog # MAB1076) at 3 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (red; Catalog # NL004) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Sigma-1 R
Sigma non-opioid intracellular receptor 1 (SIGMAR1, OPRS1 or Sigma1 receptor) is a 223 aminoacids (aa), 25KDa chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. Sigmar1 functions as a lipid transporter and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. In Human, at least 4 other isoforms have been found, ranging from 12-22 KDa.
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Cell and Tissue Staining Kits
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