Human SLC5A8/SMCT1 APC-conjugated Antibody

FAB8398A has been discontinued. View all SLC5A8/SMCT1 products.
  
  • Species Reactivity
    Human
  • Specificity
    Detects HEK293 human embryonic kidney cell line transfected with human SLC5A8/SMCT1 by Flow Cytometry. Does not detect untransfected or irrelevant transfected HEK293 cells.
  • Source
    Monoclonal Mouse IgG1 Clone # 903502
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    NS0 mouse myeloma cell line transfected with human SLC5A8/SMCT1
    Met1-Leu610
    Accession # NP_666018
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Allophycocyanin
Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of SLC5A8/SMCT1 in MCF‑7 Human Cell Line by Flow Cytometry. MCF‑7 human breast cancer cell line was stained with Mouse Anti-Human SLC5A8/SMCT1 APC‑conjugated Monoclonal Antibody (Catalog # FAB8398A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Detection of SLC5A8/SMCT1 in HEK293 Human Cell Line Transfected with Human SLC5A8/SMCT1 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with human SLC5A8/SMCT1 and eGFP was stained with either (A) Mouse Anti-Human SLC5A8/SMCT1 APC‑conjugated Monoclonal Antibody (Catalog # FAB8398A) or (B) Mouse IgG1 Allophycocyanin Isotype Control (Catalog # IC002A). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: SLC5A8/SMCT1
SLC5A8/SMCT1 (Solute Carrier family 5, member 8) is a member of the solute carrier family of multi-pass membrane proteins. SLC5A8 has been shown to transport iodide by a passive mechanism. It also transports monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism. SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinoma (1). It may be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract.
  • References:
    1. Helm, J. et al. (2012) Pancreas 41:904.
  • Long Name:
    Solute Carrier Family 5 Iodide Transporter), Member 8
  • Entrez Gene IDs:
    160728 (Human); 216225 (Mouse); 500820 (Rat)
  • Alternate Names:
    AIT; AITSolute carrier family 5 member 8; Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; MGC125354; SLC5A8; SMCT; SMCTSMCT1; Sodium iodide-related cotransporter; sodium-coupled monocarboxylate transporter 1; solute carrier family 5 (iodide transporter), member 8
Related Research Areas

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