Human SLPI Antibody

Catalog #: MAB1274
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB1274
MAB1274-SP

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Product Details

Citations (2)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human SLPI Antibody Summary

Species Reactivity

Human

Specificity

Detects recombinant human SLPI in direct ELISAs and Western blots. In direct ELISAs, no cross‑reactivity with recombinant mouse SLPI is observed.

Source

Monoclonal Mouse IgG₁ Clone # 20409

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

E. coli-derived recombinant human SLPI
Accession # P03973

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human SLPI (Catalog # 1274-PI) under non-reducing conditions only

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Reconstitution Buffer Available

Reconstitution Buffer 1 (PBS)

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SLPI

SLPI is a member of the Serpin family and is primarily expressed in secretory glandular epithelial cells. It is found in various secretory fluids and functions as a potent inhibitor of many proteolytic enzymes. SLPI can modulate cell proliferation and has been shown to have anti-inflammatory, anti-viral, and anti-bacterial activities (1, 2).

References

Zhang, D. et al. (2002) J. Biol. Chem. 277:29999.
Taggart, C.C. et al. (2002) J. Biol. Chem. 277:33648.

Long Name

Secretory Leukocyte Protease Inhibitor

Entrez Gene IDs

6590 (Human); 20568 (Mouse)

Alternate Names

ALK1; ALPProtease inhibitor WAP4; antileukoproteinase; BLPISeminal proteinase inhibitor; HUSI; HUSI-I; Mucus proteinase inhibitor; secretory leukocyte peptidase inhibitor; secretory leukocyte protease inhibitor (antileukoproteinase); Secretory leukocyte protease inhibitor; SLPI; WAP four-disulfide core domain protein 4; WAP4HUSI-1; WFDC4MPI

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human SLPI Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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Endogenous secretory leukocyte protease inhibitor (SLPI) inhibits microbial-induced monocyte activation
Authors: S Nugteren, Y Simons-Oos, CL Menckeberg, DH Hulleman-v, DJ Lindenberg, JN Samsom
European Journal of Immunology, 2022;0(0):.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Capture
Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach.
Authors: Gronborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, Molina H, Jensen ON, Hruban RH, Goggins MG, Maitra A, Pandey A
Mol. Cell Proteomics, 2006;5(1):157-71.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot