Human SOCS-5 Antibody Summary
Met1-Lys536
Accession # O75159
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human SOCS‑5 by Western Blot. Western blot shows lysates of Jurkat human acute T cell leukemia cell line. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human SOCS-5 Monoclonal Antibody (Catalog # MAB4796) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for SOCS-5 at approximately 60 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: SOCS-5
SOCS-5 (Suppressor of cytokine signaling 5; also CIS-6) is a 55‑60 kDa member of the SOCS family of proteins. It is an SH2-domain containing cytoplasmic adaptor protein expressed by Th1 cells that is known to reduce the expression of the EGF receptor and block signaling by the IL-4 R alpha chain. Human SOCS-5 is 536 amino acids (aa) in length. It contains one SH2 domain (aa 381‑476) and a SOCS box (aa 471‑520) that mediates interaction with E3 ubiquitin ligase complexes. Full-length SOCS-5 is 94% aa identical to mouse SOCS-5.
Product Datasheets
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