Human STAT5b Alexa Fluor® 350-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: STAT5b

Signal Transduction and Activator of Transcription 5B (STAT5b) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL-22, IL-6, IFN alpha ). Upon cytokine activation, STAT5b is phosphorylated and translocates to the nucleus where it binds to the DNA consensus site TTCN₃GAA and activates transcription of specific genes. STAT5b shares 93% amino acid identity with STAT5a. STAT5b is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation, differentiation and survival.

Product Datasheets

Related Research Areas

• Apoptosis Transcription Factors and Regulators
• Cancer Stem Cell Transcription Factors
• Common gamma Chain Receptor Family
• Hematopoietic Stem Cell Markers
• IL-10 and Interferon Family Regulators
• IL-10 Family
• IL-12 Family
• Immunoglobulin-Like Domain Transcription Factors
• Interferons
• Jak and STAT Proteins
• PDGF Family
• Regulatory T Cells (Tregs)
• STAT
• Th2 Cells
• Transcription Factors in the Akt Pathway
• Transcriptional Regulators in Allergy and Asthma