Human STAT5b Alexa Fluor® 647-conjugated Antibody

Catalog # Availability Size / Price Qty
IC1584R-100UG
R&D Systems Antibodies
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Human STAT5b Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human STAT5b in Western blots.
Source
Monoclonal Mouse IgG2b Clone # 389215
Immunogen
Human STAT5b synthetic peptide
MDSQWIPHAQS
Accession # NP_036580
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Label
Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration
Sample
Intracellular Staining by Flow Cytometry
0.25-1 µg/106 cells
Jurkat human acute T cell leukemia cell line fixed with paraformaldehyde and permeabilized with methanol

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: STAT5b

Signal Transduction and Activator of Transcription 5B (STAT5b) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL-22, IL-6, IFN alpha ). Upon cytokine activation, STAT5b is phosphorylated and translocates to the nucleus where it binds to the DNA consensus site TTCN3GAA and activates transcription of specific genes. STAT5b shares 93% amino acid identity with STAT5a. STAT5b is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation, differentiation and survival.

Long Name
Signal Transducer and Activator of Transcription 5b
Entrez Gene IDs
6777 (Human); 20851 (Mouse)
Alternate Names
signal transducer and activator of transcription 5B; STAT5; STAT5b; transcription factor STAT5B

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