Human TDRD1 Antibody

TDRD1 (Tudor domain containing protein 1; also CT41.1) is a 120-140 kDa member of the Tudor family of proteins. It is expressed in spermatocytes and spermatids, and forms part of an RNA-silencing complex that regulates gene expression. TDRD1, through its Tudor and MYND domains, binds methylated PIWI (P-element-induced wimpy testis) protein and PIWI-interacting RNA loading factor, respectively. This serves to promote the recruitment of germline-specific small RNAs into a PIWI ribonucleoprotein complex. Human TDRD1 is 1180 aa in length. It contains one MYND-type Zn finger region (aa 170-206), and four methyl-binding Tudor domains (aa 312-1048). There are four potential splice variants with predicted molecular weights ranging between 79 kDa and 133 kDa. One contains an alternate start site at Met404, another contains an alternative start site at Met22, accompanied by deletions of aa 554-610 and 775-831, a third shows a 10 aa substitution for Ser1180, while a fourth contains deletions of aa 328-375, 554-610 and 1059-1134. Over aa 837-968, human TDRD1 shares 66% aa identity with mouse TDRD1.