Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human, Mouse

Applications

Validated:

Flow Cytometry

Cited:

Flow Cytometry

Label

Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)

Antibody Source

Polyclonal Goat IgG
View all TGF-beta RII Primary Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human TGF‑ beta  RII
Ile24-Asp159
Accession # P37173.2

Specificity

Detects human TGF-beta RII in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant mouse (rm) TGF‑ beta  RII and less than 1% cross-reactivity with recombinant human TGF-beta RIII and rmTGF-beta RI is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Human TGF‑ beta  RII APC‑conjugated Antibody

Detection of TGF-beta RII antibody in Human Blood Lymphocytes antibody by Flow Cytometry.

Detection of TGF-beta RII in Human Blood Lymphocytes by Flow Cytometry.

Human peripheral blood lymphocytes were stained with Goat Anti-Human TGF-beta RII APC-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB2411A, filled histogram) or isotype control antibody (Catalog # IC108A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Detection of Human TGF-beta RII by Flow Cytometry

Detection of Human TGF-beta RII by Flow Cytometry

Extrafacial expression of T beta RII on malignant breast cancer cell-derived EVs&its regulation by TGF-beta. f FACS analysis&quantification of the %age of T beta RII positive (T beta RII+) EVs from different breast cancer cell lines (left panel). n = 3 biological replicates per group (right panel). The %age was referred to as the %age of beads with T beta RII+ EVs. Image collected & cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/35915084), licensed under a CC-BY license. Not internally tested by R&D Systems.

Applications for Human TGF‑ beta  RII APC‑conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: Human peripheral blood lymphocytes

Reviewed Applications

Read 1 review rated 4 using FAB2411A in the following applications:

Spectra Viewer

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Flow Cytometry Panel Builder

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Advanced Features

  • Spectra Viewer - Custom analysis of spectra from multiple fluorochromes
  • Spillover Popups - Visualize the spectra of individual fluorochromes
  • Antigen Density Selector - Match fluorochrome brightness with antigen density
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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: TGF-beta RII

TGF beta RII is a membrane bound serine/threonine kinase. Upon ligand binding, TGF beta RII interacts with TGF beta RI to form the heteromeric signaling complex thattransduces TGF beta signals. A splice variant of the type II receptor, TGF beta RIIb, containing a 25 amino acid residue insertion near the Nterminus of the mature protein has also been described.

Long Name

Transforming Growth Factor beta Receptor II

Alternate Names

TGF-bRII, TGFbetaRII, TGFBR2

Entrez Gene IDs

7048 (Human); 21813 (Mouse)

Gene Symbol

TGFBR2

UniProt

P37173.2

Additional TGF-beta RII Products

Product Documents for Human TGF‑ beta  RII APC‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human TGF‑ beta  RII APC‑conjugated Antibody

For research use only

Citations for Human TGF‑ beta  RII APC‑conjugated Antibody

Customer Reviews for Human TGF‑ beta  RII APC‑conjugated Antibody (1)

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  • Human TGF-beta  RII APC-conjugated Antibody
    Name: Anonymous
    Application: Flow Cytometry
    Sample Tested: NK-92 human natural killer lymphoma cell line
    Species: Human
    Verified Customer | Posted 02/02/2023
    Intra-cellular staining
    Human TGF‑ beta  RII APC‑conjugated Antibody FAB2411A

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