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Human TNF-beta/TNFSF1 Quantikine ELISA Kit

Catalog #: DTB00
9 Citations Datasheet / COA / SDS

Discontinued Product

DTB00 has been discontinued.
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Citations (9)
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Summary Product Datasheets Preparation and Storage Background Related Research Areas

Human TNF-beta/TNFSF1 Quantikine ELISA Kit Summary

Sensitivity
7 pg/mL
Assay Range
31.2 - 2,000 pg/mL
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Product Summary

Product Datasheets

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Product Datasheet
COA

Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Lymphotoxin-alpha/TNF-beta

Lymphotoxin alpha and Lymphotoxin beta are pro-inflammatory TNF superfamily ligands that play important roles in immune system development. LT-alpha can be secreted as a homotrimer that binds and activates TNF RI, TNF RII, HVEM, and TROY. It is required for development of the spleen, lymph nodes, and Peyer’s patches. It also regulates T cell homing to the gut and IgA induction. LT-alpha can additionally form membrane-associated heterotrimers with two copies of LT-beta/TNF-beta on the surface of B, T, LTi, and ILC3 cells. This heterotrimer binds and activates the Lymphotoxin beta R on macrophages, dendritic cells, hepatocytes, intestinal epithelial cells (IEC), follicular dendritic cells (FDC), and high endothelial venules (HEV). The heterotrimer promotes the development of FDC networks and HEV in lymphoid tissue, the class switching of immature B cells for IgA production, and the production of homeostatic IL-22 by IEC.

Long Name:
Tumor Necrosis Factor beta
Entrez Gene IDs:
4049 (Human); 16992 (Mouse)
Alternate Names:
LT; LTA; LT-alpha; lymphotoxin alpha (TNF superfamily, member 1); Lymphotoxin alpha; Lymphotoxinalpha; Lymphotoxin-alpha; tnfb; TNF-beta; TNFBlymphotoxin-alpha; TNFSF1; TNFSF1B; TNFSF1TNF-beta; tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1

Citations for Human TNF-beta/TNFSF1 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

9 Citations: Showing 1 - 9
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  1. Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome.
    Authors: Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W
    Microbes Infect., 2005-02-24;7(3):427-36.
    Species: Human
    Sample Types: Serum
  2. Cytokines and adhesion molecules in multiple sclerosis patients treated with interferon-beta1b.
    Authors: Jensen J, Krakauer M, Sellebjerg F
    Cytokine, 2005-01-07;29(1):24-30.
    Species: Human
    Sample Types: Plasma
  3. Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis.
    Authors: Casazza S, Zappia E, Pistorio A, Gambini C
    Proc. Natl. Acad. Sci. U.S.A., 2004-07-19;101(30):11064-9.
    Species: Human
    Sample Types: CSF
  4. Inflammatory cytokine concentrations are elevated in seminal plasma of men with spinal cord injuries.
    Authors: Basu S, Aballa TC, Ferrell SM, Lynne CM, Brackett NL
    J. Androl., 2004-03-01;25(2):250-4.
    Species: Human
    Sample Types: Seminal Plasma
  5. Implications of serum TNF-beta and IL-13 in the treatment response of childhood nephrotic syndrome.
    Authors: Tain YL, Chen TY, Yang KD
    Cytokine, 2003-02-07;21(3):155-9.
    Species: Human
    Sample Types: Serum
  6. Natural interferon alpha/beta-producing cells link innate and adaptive immunity.
    Authors: Kadowaki N, Antonenko S, Lau JY, Liu YJ
    J. Exp. Med., 2000-07-17;192(2):219-26.
    Species: Human
    Sample Types: Cell Culture Supernates
  7. Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion.
    Authors: Raghupathy R, Makhseed M, Azizieh F, Omu A, Gupta M, Farhat R
    Hum. Reprod., 2000-03-01;15(3):713-8.
    Species: Human
    Sample Types: Cell Culture Supernates
  8. Effects of UVB radiation on cytokine generation, cell adhesion molecules, and cell activation markers in T-lymphocytes and peripheral blood HPCs.
    Authors: Lankford KV, Mosunjac M, Hillyer CD
    Transfusion, 2000-03-01;40(3):361-7.
    Species: Human
    Sample Types: Cell Culture Supernates
  9. Serum levels of interleukins, growth factors and angiogenin in patients with endometrial cancer.
    Authors: Chopra V, Dinh TV, Hannigan EV
    J. Cancer Res. Clin. Oncol., 1997-01-01;123(3):167-72.
    Species: Human
    Sample Types: Serum

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