Detects human TNF RI in Western blots. In Western blots, does not cross-react with recombinant human TNF RII, recombinant mouse (rm) TNF RI, or rmTNF RII.
Monoclonal Mouse IgG
1 Clone # 16803
Protein A or G purified from ascites
E. coli-derived recombinant human TNF RI/TNFRSF1A Accession # NP_001056
Supplied in a saline solution containing BSA and Sodium Azide.
Please Note: Optimal dilutions should be determined by each laboratory for each application.
are available in the Technical Information section on our website.
Detection of TNF RI/TNFRSF1A in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human TNF RI/TNFRSF1A PE‑conjugated Monoclonal Antibody (Catalog # FAB225P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
Background: TNF RI/TNFRSF1A
TNF RI occurs both in membrane bound and soluble forms and functions as
a receptor for TNF-alpha and TNF-beta. In the superfamily nomenclature, it is
Tumor Necrosis Factor Receptor I
Entrez Gene IDs:
7132 (Human); 21937 (Mouse); 25625 (Rat); 102135285 (Cynomolgus Monkey)
CD120a antigen; CD120a; FPF; p55; p55-R; p60; TNF RI; TNFARMGC19588; TNF-R; TNF-R1; TNFR1TBP1; TNFR55; TNF-R55; TNFR60; TNFRI; TNF-RI; TNF-R-I; TNFR-I; TNFRSF1A; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor
Related Research Areas
R&D Systems personnel manually curate a database that contains references using R&D Systems products.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
13 Citations: Showing 1 - 10 Filter your results:
Species All Human Mouse Applications All Flow Sample Type All Whole Cells Tumour necrosis factor receptor I blockade shows that TNF-dependent and TNF-independent mechanisms synergise in TNF receptor associated periodic syndrome. Authors: Fairclough L, Stoop A, Negm O, Radford P, Tighe P, Todd I Eur J Immunol, 2015;45(10):2937-44. Species: Human Sample Type: Whole Cells Application: Flow TNFR2 and IL-12 coactivation enables slanDCs to support NK-cell function via membrane-bound TNF-alpha. Authors: Tufa D, Chatterjee D, Low H, Schmidt R, Jacobs R Eur J Immunol, 2014;44(12):3717-28. Species: Human Sample Type: Whole Cells Application: Flow TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-kappaB pathways and signals TRAF2 protein degradation in macrophages. Authors: Ruspi G, Schmidt E, McCann F, Feldmann M, Williams R, Stoop A, Dean J Cell Signal, 2014;26(4):683-90. Species: Human Sample Type: Whole Cells Application: Flow Secretory lysosome targeting and induced secretion of human soluble TNF-alpha receptor in murine hematopoietic cells in vivo as a principle for immunoregulation in inflammation and malignancy. Authors: Johansson AC, Nandakumar KS, Persson AM, Olsson I, Hansson M Exp. Hematol., 2009;37(8):969-78. Species: Mouse Sample Type: Whole Cells Application: Flow Generation of Th1 and Th2 chemokines by human eosinophils: evidence for a critical role of TNF-alpha. Authors: Liu LY, Bates ME, Jarjour NN, Busse WW, Bertics PJ, Kelly EA J. Immunol., 2007;179(7):4840-8. Species: Human Sample Type: Whole Cells Application: Flow Interaction between transmembrane TNF and TNFR1/2 mediates the activation of monocytes by contact with T cells. Authors: Rossol M, Meusch U, Pierer M, Kaltenhauser S, Hantzschel H, Hauschildt S, Wagner U J. Immunol., 2007;179(6):4239-48. Species: Human Sample Type: Whole Cells Application: Flow Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated periodic syndrome indicates misfolding consistent with abnormal function. Authors: Rebelo SL, Bainbridge SE, Amel-Kashipaz MR, Radford PM, Powell RJ, Todd I, Tighe PJ Arthritis Rheum., 2006;54(8):2674-87. Species: Human Sample Type: Whole Cells Application: Flow Neutrophils from patients with TNFRSF1A mutations display resistance to tumor necrosis factor-induced apoptosis: pathogenetic and clinical implications. Authors: D&amp;apos;Osualdo A Arthritis Rheum., 2006;54(3):998-1008. Species: Human Sample Type: Whole Cells Application: Flow Human cytomegalovirus blocks tumor necrosis factor alpha- and interleukin-1beta-mediated NF-kappaB signaling. Authors: Montag C, Wagner J, Gruska I, Hagemeier C J. Virol., 2006;80(23):11686-98. Species: Human Sample Type: Whole Cells Application: Flow Phagocytosis of codeveloping megakaryocytic progenitors by dendritic cells in culture with thrombopoietin and tumor necrosis factor-alpha and its possible role in hemophagocytic syndrome. Authors: Saito K, Hirokawa M, Inaba K, Fukaya H, Kawabata Y, Komatsuda A, Yamashita J, Sawada K Blood, 2005;107(4):1366-74. Species: Human Sample Type: Whole Cells Application: Flow Codevelopment of dendritic cells along with erythroid differentiation from human CD34(+) cells by tumor necrosis factor-alpha. Authors: Fukaya H, Xiao W, Inaba K, Suzuki Y, Hirokawa M, Kawabata Y, Komatsuda A, Endo T, Kishimoto H, Takada G, Sawada K Exp. Hematol., 2004;32(5):450-60. Species: Human Sample Type: Whole Cells Application: Flow Tumor necrosis factor-alpha inhibits generation of glycophorin A+ cells by CD34+ cells. Authors: Xiao W, Koizumi K, Nishio M, Endo T, Osawa M, Fujimoto K, Sato I, Sakai T, Koike T, Sawada K Exp. Hematol., 2002;30(11):1238-47. Species: Human Sample Type: Whole Cells Application: Flow Inhibition of programmed cell death impairs in vitro vascular-like structure formation and reduces in vivo angiogenesis. Authors: Segura I, Serrano A, De Buitrago GG, Gonzalez MA, Abad JL, Claveria C, Gomez L, Bernad A, Martinez-A C, Riese HH FASEB J., 2002;16(8):833-41. Species: Human Sample Type: Whole Cells Application: Flow
Expand to show all 13 Citations
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