Human TrkC PE-conjugated Antibody

  (1 citations)     
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Citations (1)
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  • Species Reactivity
    Human
  • Specificity
    Detects human TrkC in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human TrkB is observed.
  • Source
    Polyclonal Goat IgG
  • Purification
    Antigen Affinity-purified
  • Immunogen
    Mouse myeloma cell line NS0-derived recombinant human TrkC
    Cys32-Asp428
    Accession # Q16288
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Phycoerythrin
Product Datasheets

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Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Example
Detection of TrkC in Differentiated Human Neural Progenitor Cells by Flow Cytometry. Differentiated human neural progenitor cells were stained with Goat Anti-Human TrkC PE‑conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB373P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TrkC
The neurotrophins, including NGF, BDNF, NT-3 and NT-4/5, constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to and activating two unrelated receptor types: the p75 neurotrophin receptor (p75NTR) and the Trk family of receptor tyrosine kinases. p75NTR is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF16. Although it binds all neurotrophins with low-affinity, it complexes with the Trks to form high affinity neurotrophin receptors, and with Sortilin to form high affinity receptors for the proneurotrophins. Three Trk family proteins, TrkA, TrkB and TrkC, that exhibit different ligand specificities have been identified. TrkA binds NGF and NT‑3, TrkB binds BDNF, NT-3 and NT-4/5, and TrkC binds NT-3 and BDNF. All Trk family proteins share a conserved, complex subdomain organization consisting of two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in their extracellular region, as well as an intracellular region that contains a tyrosine kinase domain. Natural splice variants of the different Trks, lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described. At the protein sequence level, Trks are highly conserved between species with the extracellular domains of human and mouse TrkC showing 94% amino acid sequence identity. The proteins also exhibit cross-species activity. The 135-140 kDa full-length form of TrkC has been found in select embryonic tissues (dorsal root ganglia neurons; renal collecting ducts) and multiple adult cell types, including cortical neurons, astrocytes, endothelial cells, vascular smooth muscle cells, melanocytes, ovarian granulosa cells, and neural stem cells.
  • Long Name:
    Neurotrophic Tyrosine Kinase Receptor C
  • Entrez Gene IDs:
    4916 (Human); 18213 (Mouse); 29613 (Rat)
  • Alternate Names:
    EC 2.7.10; EC 2.7.10.1; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; gp145(trkC); GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT 3 receptor; NT-3 growth factor receptor; NTRK3; TrkC tyrosine kinase; TrkC; trk-C; TRKCneurotrophin 3 receptor; tyrosine kinase receptor C
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citations: Showing 1 - 1

  1. Neurotrophins regulate bone marrow stromal cell IL-6 expression through the MAPK pathway.
    Authors: Rezaee F, Rellick SL, Piedimonte G
    PLoS ONE, 2010;5(3):e9690.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow

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Isotype Controls
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Goat IgG PE-conjugated Antibody

Ctrl IC108P 8  
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Staining Reagents
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Flow Cytometry Staining Buffer (1X)

Flow FC001 7
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 5
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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