Human Trypsin 1/PRSS1 Antibody
Human Trypsin 1/PRSS1 Antibody Summary
Accession # P07477
under non-reducing conditions only
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Trypsin 1/PRSS1
Human Trypsin 1, encoded by the PRSS1 gene, is also known as cationic trypsinogen (1). Constituting approximately two‑thirds of the total trypsin content in normal pancreatic juice, it is the most abundant trypsin isoform produced by the pancreas. It contains a signal peptide (residues 1‑15), a pro region (residues 16‑23), and a mature chain (residues 24‑247). Trypsin 1 is synthesized in the pancreas and secreted into the duodenum lumen, where it is activated by enterokinase. Its major physiologic function is to digest food and to activate other pro‑enzymes (2). Mutations in the PRSS1 gene can cause hereditary pancreatitis (3).
- Emi, M. et al. (1986) Gene 41:305.
- Halfon, S. et al. (2004) in Handbook of Proteolytic Enzymes (ed. Barrett, et al.) p. 1483, Academic Press, San Diego.
- Teich, N. et al. (2006) Hum. Mutat. 27:721.
Citation for Human Trypsin 1/PRSS1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Autoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression profiling and immunoassays identify pancreatic enzymes as a major target of the inflammatory process.
Authors: Lohr JM, Faissner R, Koczan D, Bewerunge P, Bassi C, Brors B, Eils R, Frulloni L, Funk A, Halangk W, Jesenofsky R, Jesnowski R, Kaderali L, Kleeff J, Kruger B, Lerch MM, Losel R, Magnani M, Neumaier M, Nittka S, Sahin-Toth M, Sanger J, Serafini S, Schnolzer M, Thierse HJ, Wandschneider S, Zamboni G, Kloppel G
Am. J. Gastroenterol., 2012;105(9):2060-71.
Sample Types: Tissue Homogenates
Applications: Western Blot
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