Human XCR1 PE-conjugated Antibody

Recombinant Monoclonal Antibody..
  • Species Reactivity
  • Specificity
    Detects human XCR1 in direct ELISAs.
  • Source
    Recombinant Monoclonal Rabbit IgG Clone # 1097A
  • Purification
    Protein A or G purified from cell culture supernatant
  • Immunogen
    E. coli-derived recombinant human XCR1
    Met1-Thr31, Ser89-Lys103, His168-His190, Phe251-Tyr267
    Accession # P46094
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of XCR1 in CD141+ HLA-DR+ Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with (A) Mouse Anti-Human HLA-DR Fluorescein-Conjugated MonoclonalAntibody (Catalog # FAB4869F), Mouse Anti-Human Thrombomodulin/BDCA-3 (CD141) APC-Conjugated Monoclonal Antibody (Catalog #FAB3947A) and (B) Rabbit Anti-Human XCR1 PE‑conjugated Monoclonal Antibody (Catalog # FAB8571P, filled histogram) or isotype control antibody (Catalog # IC105P, open histogram). View our protocol for Staining Membrane-associated Proteins
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: XCR1

XCR1, also known as GPR5 and Lymphotactin/SCM-1 (Single Cysteine Motif 1) Receptor, is a 38 kDa member of the G-protein coupled receptor 1 family. It binds XCL1/Lymphotactin/SCM-1 alpha and XCL2/SCM-1 beta. In addition, Human Herpes Virus 8 (HHV8) encodes two viral chemokines vCCL2/vMIP-II and vCCL3/vMIP-III that function as an antagonist and a highly selective agonist, respectively, for XCR1. XCR1 is expressed on neutrophils, CD8+ T cells, NK cells, CD4+ T cells and B cells. Human XCR1 is a 333 amino acid (aa), 7-transmembrane molecule. It contains a 32 aa N-terminus that lacks glycosylation sites and a 42 aa C-terminal cytoplasmic tail. Over the extracellular regions used for immunization, human XCR1 shares 62%, 54% and 64% aa identity with canine, mouse and porcine XCR1, respectively.

  • Long Name:
    Chemokine [C Motif] Receptor 1
  • Entrez Gene IDs:
    2829 (Human); 23832 (Mouse); 301086 (Rat)
  • Alternate Names:
    CCXCR1; CCXCR1XC chemokine receptor 1; chemokine (C motif) receptor 1; chemokine XC receptor 1; G protein-coupled receptor 5; GPR5; GPR5chemokine (C motif) XC receptor 1; G-protein coupled receptor 5; Lymphotactin receptor
Related Research Areas
Isotype Controls
Description Application Cat# Citations Images  

Normal Rabbit IgG PE-conjugated Control

Ctrl IC105P
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Rabbit IgG PE-conjugated Antibody

Ctrl IC1051P
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