Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 49M4D2

Format

BSA Free
View all IL-17RA/IL-17R Primary Antibodies »

Product Specifications

Immunogen

Within the range of amino acids 186-267 of human IL-17RA were used as the immunogen for the antibody.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for IL-17RA/IL-17R Antibody (49M4D2) - BSA Free

Western Blot: IL-17RA/IL-17R Antibody (49M4D2)BSA Free [NBP2-25258]

Western Blot: IL-17RA/IL-17R Antibody (49M4D2)BSA Free [NBP2-25258]

Western Blot: IL-17 RA/IL-17 R Antibody (49M4D2) [NBP2-25258] - Analysis of an IL-17RA recombinant protein fragment and human heart lysate using IL-17RA antibody at 0.5 and 3 ug/ml, respectively. goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Immunohistochemistry-Paraffin: IL-17RA/IL-17R Antibody (49M4D2) - BSA Free [NBP2-25258]

Immunohistochemistry-Paraffin: IL-17RA/IL-17R Antibody (49M4D2) - BSA Free [NBP2-25258]

Immunohistochemistry-Paraffin: IL-17 RA/IL-17 R Antibody (49M4D2) [NBP2-25258] - Formalin-fixed, paraffin-embedded human spleen stained with IL-17RA antibody (1 ug/ml), peroxidase-conjugate and DAB chromogen. TMA was used for this test.
IL-17RA/IL-17R Antibody (49M4D2) - BSA Free

Immunohistochemistry: IL-17RA/IL-17R Antibody (49M4D2) - BSA Free [NBP2-25258] -

IL-17RA expression in ILD lungs. (A) Representative immunohistochemical image of lung specimens from subjects with COP, sarcoidosis and IPF. Magnification ×200. (B, C) Immunohistochemical staining showed no significant difference in IL-17RA expression amongst lung specimens from patients with COP, sarcoidosis and IPF. (D, E) The correlation between IL-17RA expression and IL-17 expression in ILDs. IL-17, interleukin-17; IL-17RA, interleukin-17 receptor A; IPF, idiopathic pulmonary fibrosis; COP, cryptogenic organizing pneumonia; OD, opacity density score; **p < 0.01. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/35865549), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Applications for IL-17RA/IL-17R Antibody (49M4D2) - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:20-1:1000

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-17RA/IL-17R

IL-17RA (IL-17 receptor A), a type I transmembrane protein with a ubiquitous cell and tissue distribution has no homology with any known cytokine receptor family. This receptor is a member of the IL-17 Receptor family. IL-17RA encodes an unusually large cytoplasmic tail and was shown to activate inflammatory events typical of innate cytokines such as http://imgenex.com/search_result.php?txtSearch=TNFa>TNFa and http://imgenex.com/search_result.php?txtSearch=IL-1b>IL-1b including activation of the transcription factor http://imgenex.com/NF-kBPathway.php>NF-KappaB. IL-17RA is highly expressed on hematopoietic cells, but also at lower levels on osteoblasts, fibroblasts, endothelial cells, and epithelial cells (Chang SH, 2011) (Zhu S, 2010).>The role of the http://imgenex.com/search_result.php?txtSearch=il-17>IL-17 family during parasite infections is an emerging area of research with often contradicting results. In this regard, IL-17RA signaling has been shown to be both deleterious and protective during Toxoplasma gondii infection. Furthermore, two groups demonstrated that IL-17 plays a protective role in T. cruzi infection although the underlying mechanisms remains poorly understood. Indeed, both reports showed significant contradictions that might be related to the different experimental settings but deserves further investigation and discussion, since members of the IL-17 family, http://imgenex.com/search_result.php?txtSearch=il-17a>IL-17A, http://imgenex.com/search_result.php?txtSearch=il-17e>IL-17E and http://imgenex.com/search_result.php?txtSearch=il-17f>IL-17F, are produced during T. cruzi infection. Furthermore, it is confirmed that IL-17RA signaling is required for host resistance during the T. cruzi infection and focused at the mechanisms underlying IL-17RA-mediated protective effect. IL-17RA antibody has the potential to be a therapeutic option for many diseases (Raychaudhuri SP, 2012) (Tosello Boari J.2012).

Long Name

Interleukin 17 Receptor

Alternate Names

CD217, Cdw217, IL-17 R, IL-17 RA, IL17RA

Gene Symbol

IL17RA

UniProt

NP_055154

Additional IL-17RA/IL-17R Products

Product Documents for IL-17RA/IL-17R Antibody (49M4D2) - BSA Free

Certificate of Analysis

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Product Specific Notices for IL-17RA/IL-17R Antibody (49M4D2) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Cytokines and Receptors Research

Citations for IL-17RA/IL-17R Antibody (49M4D2) - BSA Free

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Protocols

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