Catalog Number: 1783
Chemical Name: (6aR,10aR)-3-(1,1-dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Biological Activity
Potent CB2 selective agonist (Ki = 3.4 nM), in water-soluble emulsion (for details see TocrisolveTM 100 Cat. No. 1684). Approx. 200-fold selective over CB1 receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis. JWH 133 also available as a solid (Cat. No. 1343).
Technical Data
  • M.Wt:
  • Formula:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Pharmacology of cannabinoid receptor ligands.
    Curr.Med.Chem., 1999;6:635
  2. Cannabinoids control spasticity and tremor in a multiple sclerosis model.
    Baker et al.
    Nature, 2000;404:84
  3. 3-(1'-Dimethylbutyl)-1-deoxy-Δ8-THC and related compounds: synthesis of selective ligands for the CB2 receptor.
    Huffman et al.
    Bioorg.Med.Chem., 1999;7:2905

The citations listed below are publications that use Tocris products. Selected citations for JWH 133 (in Tocrisolve™ 100) include:

Showing Results 1 - 1 of 1

  1. △(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection.
    Authors: Williams Et al.
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