JWH 133 (in Tocrisolve™ 100)
Chemical Name: (6aR,10aR)-3-(1,1-dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Biological Activity
Potent CB2 selective agonist (Ki = 3.4 nM), in water-soluble emulsion (for details see TocrisolveTM 100). Approx. 200-fold selective over CB1 receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis.JWH 133 available as a solid.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Cannabinoid receptor type-2 stimulation, blockade, and deletion alters the vascular inflammatory responses to traumatic brain injury.
Amenta P, Jallo J, Tuma R, Hooper D, Elliott M
J Neuroinflammation, 2014;11(1):191. -
Pharmacology of cannabinoid receptor ligands.
Pertwee
Curr.Med.Chem., 1999;6:635 -
Cannabinoids control spasticity and tremor in a multiple sclerosis model.
Baker et al.
Nature, 2000;404:84 -
3-(1'-Dimethylbutyl)-1-deoxy-Δ8-THC and related compounds: synthesis of selective ligands for the CB2 receptor.
Huffman et al.
Bioorg.Med.Chem., 1999;7:2905
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Citation for JWH 133 (in Tocrisolve™ 100)
The citations listed below are publications that use Tocris products. Selected citations for JWH 133 (in Tocrisolve™ 100) include:
1 Citation: Showing 1 - 1
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△(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection.
Authors: Williams Et al.
Autophagy 2014;9:369
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