Chemical Name: (2R,6S-rel)-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl-4-morpholineacetamide
Biological ActivityPotent ATM kinase inhibitor (IC50 = 6.3 nM). Exhibits little to no nonspecific target effects against a panel of 229 protein kinases; displays similar target selectivity to KU 55933 (Cat. No. 3544). Inhibits migration and invasion of human glioma cells in vitro.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of KU 60019 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises Ins, AKT and ERK prosurvival signaling, and inhibits migration and invasion.
Golding et al.
Mol.Cancer Ther., 2009;8:2894
Citations for KU 60019
The citations listed below are publications that use Tocris products. Selected citations for KU 60019 include:
14 Citations: Showing 1 - 10
Cell type-dependent bimodal p53 activation engenders a dynamic mechanism of chemoresistance.
Authors: Yang Et al.
Sci Adv 2018;4:eaat5077
Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug.
Authors: Ryl Et al.
Cell Syst 2017;5:237
ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.
Authors: Jaiswal Et al.
EMBO J 2017;36:2161
Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways.
Authors: Deng Et al.
PLoS Pathog 2016;12:e1005399
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
Authors: Parplys Et al.
Cell Cycle 2015;43:9817
RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression.
Authors: Koo Et al.
Nucleic Acids Res 2015;290:7463
Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators.
Authors: Mehta Et al.
PLoS Pathog 2015;11:e1004763
Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation.
Authors: Wu Et al.
J Biol Chem 2014;289:34378
Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.
Authors: Barton Et al.
J Cell Biol 2014;206:877
Checkpoint kinase 2 is required for efficient immunoglobulin diversification.
Authors: Davari Et al.
Cell Cycle 2014;13:3659
Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase.
Authors: Müllers Et al.
Cell Cycle 2014;13:2733
The kinase activity of ataxia-telangiectasia mutated interferes with adenovirus E4 mutant DNA replication.
J Virol 2013;87:8687
ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
Authors: Montané and Menand
J Biol Chem 2013;64:4361
Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells.
Authors: Rass Et al.
J Biol Chem 2013;288:7086
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