KU 60019

Discontinued Product

4176 has been discontinued.
View all ATM and ATR Kinase Inhibitors products.
KU 60019 | CAS No. 925701-46-8 | ATM and ATR Kinase Inhibitors
1 Image
Description: Potent ATM kinase inhibitor

Chemical Name: (2R,6S-rel)-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl-4-morpholineacetamide

Purity: ≥98%

Product Details
Citations (14)

Biological Activity

Potent ATM kinase inhibitor (IC50 = 6.3 nM). Exhibits little to no nonspecific target effects against a panel of 229 protein kinases; displays similar target selectivity to KU 55933 (Cat. No. 3544). Inhibits migration and invasion of human glioma cells in vitro.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of KU 60019 is reviewed on the chemical probes website.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for KU 60019

The citations listed below are publications that use Tocris products. Selected citations for KU 60019 include:

14 Citations: Showing 1 - 10

  1. Cell type-dependent bimodal p53 activation engenders a dynamic mechanism of chemoresistance.
    Authors: Yang Et al.
    Sci Adv  2018;4:eaat5077
  2. Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug.
    Authors: Ryl Et al.
    Cell Syst  2017;5:237
  3. ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.
    Authors: Jaiswal Et al.
    EMBO J  2017;36:2161
  4. Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways.
    Authors: Deng Et al.
    PLoS Pathog  2016;12:e1005399
  5. NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
    Authors: Parplys Et al.
    Cell Cycle  2015;43:9817
  6. RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression.
    Authors: Koo Et al.
    Nucleic Acids Res  2015;290:7463
  7. Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators.
    Authors: Mehta Et al.
    PLoS Pathog  2015;11:e1004763
  8. Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation.
    Authors: Wu Et al.
    J Biol Chem  2014;289:34378
  9. Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.
    Authors: Barton Et al.
    J Cell Biol  2014;206:877
  10. Checkpoint kinase 2 is required for efficient immunoglobulin diversification.
    Authors: Davari Et al.
    Cell Cycle  2014;13:3659


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for KU 60019

There are currently no reviews for this product. Be the first to review KU 60019 and earn rewards!

Have you used KU 60019?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.