KU 60019

  ( 9 citations )    
Product Datasheet
Catalog Number:4176
Chemical Name:(2R,6S-rel)-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl-4-morpholineacetamide
Product Details
Citations (9)
Reviews
Biological Activity
Potent ATM kinase inhibitor (IC50 = 6.3 nM). Exhibits little to no nonspecific target effects against a panel of 229 protein kinases; displays similar target selectivity to KU 55933 (Cat. No. 3544). Inhibits migration and invasion of human glioma cells in vitro.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of KU 60019 is reviewed on the chemical probes website.
Technical Data
  • M.Wt:
    547.67
  • Formula:
    C30H33N3O5S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    925701-46-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for KU 60019 include:

9 Citations: Showing 1 - 9
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  1. NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
    Authors: Parplys Et al.
    Cell Cycle  2015;43:9817
  2. RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression.
    Authors: Koo Et al.
    Nucleic Acids Res  2015;290:7463
  3. Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators.
    Authors: Mehta Et al.
    PLoS Pathog  2015;11:e1004763
  4. Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation.
    Authors: Wu Et al.
    J Biol Chem  2014;289:34378
  5. Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.
    Authors: Barton Et al.
    J Cell Biol  2014;206:877
  6. Checkpoint kinase 2 is required for efficient immunoglobulin diversification.
    Authors: Davari Et al.
    Cell Cycle  2014;13:3659
  7. Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase.
    Authors: Müllers Et al.
    Cell Cycle  2014;13:2733
  8. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
    Authors: Montané and Menand
    J Biol Chem  2013;64:4361
  9. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells.
    Authors: Rass Et al.
    J Biol Chem  2013;288:7086

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