Catalog Number: 5785
Alternate Names: caged MDNI glutamate, DNI glutamate, DNI-GLU
Chemical Name: (S)-α-Amino-2,3-dihydro-4-methoxy-5,7-dinitro-δ-oxo-1H-indole-1-pentanoic acid
Biological Activity
Rapidly and efficiently releases glutamate (Cat. No. 0218) when photolysed (350 - 365 nm excitation). Water soluble and stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to 200 μM). 5.5 times more photosensitive than MNI-caged L-glutamate (Cat. No. 1490). Laser activation of MDNI-glu evokes a rapid increase in intracellular Ca2+ concentration in astrocytes.
Technical Data
  • M.Wt:
    368.3
  • Formula:
    C14H16N4O8
  • Solubility:
    Soluble to 10 mM in water with gentle warming and to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    864085-92-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells.
    Fedoryak et al.
    Chem. Commun. (Camb.), 2005;7:3664
  2. Synthetic and photochemical studies of substituted 1-acyl-7-nitroindolines.
    Papageorgiou et al.
    Photochem.Photobiol.Sci., 2005;4:887
  3. Electrical behaviour of dendritic spines as revealed by voltage imaging.
    Popovic et al.
    Nat.Commun., 2015;6:8436
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