Rapidly and efficiently releases glutamate
(Cat. No. 0218) when photolysed (350 - 365 nm excitation). Water soluble and stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to 200 μ
M). 5.5 times more photosensitive than MNI-caged L-glutamate
(Cat. No. 1490). Laser activation of MDNI-glu evokes a rapid increase in intracellular Ca2+
concentration in astrocytes.
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All Tocris products are intended for laboratory research use only.
Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells.
Fedoryak et al.
Chem. Commun. (Camb.), 2005;7:3664
Synthetic and photochemical studies of substituted 1-acyl-7-nitroindolines.
Papageorgiou et al.
Electrical behaviour of dendritic spines as revealed by voltage imaging.
Popovic et al.