Home / Amphiregulin / Mouse Amphiregulin Antibody

Mouse Amphiregulin Antibody

Catalog #: AF989
25 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF989
AF989-SP
Detection of Recombinant Human and Mouse Amphiregulin by Western Blot.
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Product Details
Citations (25)
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Mouse Amphiregulin Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse Amphiregulin in ELISAs and Western Blots. In sandwich immunoassays, less than 1% cross-reactivity with recombinant human Amphiregulin is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant mouse Amphiregulin
Ser94-Lys191
Accession # P31955
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
See below
Immunohistochemistry
5-15 µg/mL
See below

Mouse Amphiregulin Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
0.2-0.8 µg/mL 

Use in combination with:

Detection Reagent: Mouse Amphiregulin Biotinylated Antibody (Catalog # BAF989)

Standard: Recombinant Mouse Amphiregulin Protein (Catalog # 989-AR)

Neutralization
Measured by its ability to neutralize Amphiregulin-induced proliferation in the Balb/3T3 mouse embryonic fibroblast cell line. The Neutralization Dose (ND50) is typically 0.3-1.5 µg/mL in the presence of 50 ng/mL Recombinant Mouse Amphiregulin.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Recombinant Human and Mouse Amphiregulin antibody by Western Blot. View Larger

Detection of Recombinant Human and Mouse Amphiregulin by Western Blot. Western blot shows 25 ng of Recombinant Mouse Amphiregulin (Catalog # 989-AR), Recombinant Human Amphiregulin (Catalog # 262-AR), and Recombinant Mouse HB-EGF. PVDF Membrane was probed with 0.1 µg/mL of Goat Anti-Mouse Amphiregulin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF989) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for Amphiregulin at approximately 16-25 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 3.

Immunohistochemistry Amphiregulin antibody in Mouse Skin by Immunohistochemistry (IHC-Fr). View Larger

Amphiregulin in Mouse Skin. Amphiregulin was detected in immersion fixed frozen sections of mouse skin using Goat Anti-Mouse Amphiregulin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF989) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to keratinocytes. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Neutralization Cell Proliferation Induced by Amphiregulin and Neutralization by Mouse Amphiregulin Antibody. View Larger

Cell Proliferation Induced by Amphiregulin and Neutralization by Mouse Amphiregulin Antibody. Recombinant Mouse Amphiregulin (Catalog # 989-AR) stimulates proliferation in the Balb/3T3 mouse embryonic fibroblast cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse Amphiregulin (50 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Amphiregulin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF989). The ND50 is typically 0.3-1.5 µg/mL.

Immunocytochemistry/ Immunofluorescence Detection of Amphiregulin by Immunocytochemistry/ Immunofluorescence View Larger

Detection of Amphiregulin by Immunocytochemistry/ Immunofluorescence GPR174 regulates neovascularization by inhibiting AREG expression in Tregs. d Representative immunofluorescent images of AREG (red) & DAPI (blue) staining in Tregs isolated from ischemic muscle of WT & Gpr174−/Y mice 7 days after HLI. Scale bar, 10 μm. Image collected & cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/36473866), licensed under a CC-BY license. Not internally tested by R&D Systems.

Flow Cytometry Detection of Amphiregulin by Flow Cytometry View Larger

Detection of Amphiregulin by Flow Cytometry GPR174 regulates neovascularization by inhibiting AREG expression in Tregs. b Serum AREG, IL-10, & VEGF protein content in Rag1−/− mice receiving Tregs 7 days after adoptive transplantation experiments (n = 6 for PBS → Rag1−/− mice; n = 7 for wild-type Tregs→Rag1−/− mice; n = 7 for GPR174-deficient Tregs→Rag1−/− mice). Image collected & cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/36473866), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Amphiregulin by Immunocytochemistry/ Immunofluorescence View Larger

Detection of Amphiregulin by Immunocytochemistry/ Immunofluorescence GPR174 regulates neovascularization by inhibiting AREG expression in Tregs. d Representative immunofluorescent images of AREG (red) & DAPI (blue) staining in Tregs isolated from ischemic muscle of WT & Gpr174−/Y mice 7 days after HLI. Scale bar, 10 μm. Image collected & cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/36473866), licensed under a CC-BY license. Not internally tested by R&D Systems.

Flow Cytometry Detection of Amphiregulin by Flow Cytometry View Larger

Detection of Amphiregulin by Flow Cytometry GPR174 regulates neovascularization by inhibiting AREG expression in Tregs. b Serum AREG, IL-10, & VEGF protein content in Rag1−/− mice receiving Tregs 7 days after adoptive transplantation experiments (n = 6 for PBS → Rag1−/− mice; n = 7 for wild-type Tregs→Rag1−/− mice; n = 7 for GPR174-deficient Tregs→Rag1−/− mice). Image collected & cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/36473866), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Amphiregulin by Western Blot View Larger

Detection of Amphiregulin by Western Blot MyD88 silencing and NF kappa B inhibition restrain extracellular AREG-induced macrophage pyroptosis. NLRP3, CASPASE1-p20, and GSDMD-N expression levels were detected in extracellular AREG-induced Myd88−/− and Trif−/−BMDM via Western blot (A, B). NLRP3, CASPASE1-p20, and GSDMD-N expression levels were detected in the inhibitor of NF kappa B (P65) (20 μM) pretreating extracellular AREG-induced BMDM for 2 h via Western blot (C, D). Data are presented as mean ± SEM (n ≥ 3). *P < 0.05, **P < 0.01, ***P < 0.001 vs. Control. ns, no significient; AREG, amphiregulin; BMDM, bone marrow-derived macrophages; EGFR, epidermal growth factor receptor; GSDMD, gasdermin D. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/40292295), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Amphiregulin by Western Blot View Larger

Detection of Amphiregulin by Western Blot MyD88 silencing and NF kappa B inhibition restrain extracellular AREG-induced macrophage pyroptosis. NLRP3, CASPASE1-p20, and GSDMD-N expression levels were detected in extracellular AREG-induced Myd88−/− and Trif−/−BMDM via Western blot (A, B). NLRP3, CASPASE1-p20, and GSDMD-N expression levels were detected in the inhibitor of NF kappa B (P65) (20 μM) pretreating extracellular AREG-induced BMDM for 2 h via Western blot (C, D). Data are presented as mean ± SEM (n ≥ 3). *P < 0.05, **P < 0.01, ***P < 0.001 vs. Control. ns, no significient; AREG, amphiregulin; BMDM, bone marrow-derived macrophages; EGFR, epidermal growth factor receptor; GSDMD, gasdermin D. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/40292295), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Amphiregulin by Western Blot View Larger

Detection of Amphiregulin by Western Blot EGFR inhibition and TLR4 silencing impair AREG-induced macrophage pyroptosis. BMDM was stimulated with AREG+ATP or LPS+ATP, and the expression of NLRP3, p-P65, p-I kappa B, CASPASE-1-p20, and GSDMD-N was detected via Western blot (A-C). BMDM was stimulated with AREG+ATP or LPS+ATP, and oligomerization of ASC was detected using immunofluorescence (D, E). Experimental diagram of AREG-induced macrophage pyroptosis. For the priming step, BMDM was treated with AREG for 2.5 as the first signal and the ATP as the second signal (F). NLRP3, CASPASE-1-p20, and GSDMD-N expressions were detected in the EGFR inhibitor (1 mM) pretreating AREG +ATP-induced BMDM for 4 h through Western blot (G, J). NLRP3, CASPASE-1-p20, and GSDMD-N expressions were detected in AREG +ATP-induced TLR4−/−BMDM via Western blot (H, K). The expression of IL-1b and IL-18 was detected in the supernatant of AREG +ATP-induced TLR4−/−BMDM via ELISA (I). Data are presented as mean ± SEM (n ≥ 3). *P < 0.05, **P < 0.01, ***P < 0.001 vs. Control. ns, no significant; AREG, amphiregulin; BMDM, bone marrow-derived macrophages; EGFR, epidermal growth factor receptor; GSDMD, gasdermin D; ATP, adenosine triphosphate. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/40292295), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Amphiregulin by Immunocytochemistry/ Immunofluorescence View Larger

Detection of Amphiregulin by Immunocytochemistry/ Immunofluorescence Dynamic expression of AREG in sepsis. RAW264.7 cells were stimulated with LPS (100 ng/mL or 1 μg/mL) for 1, 3, 6, 12, and 24 h. AREG mRNA and protein expressions were detected using RT-PCR and ELISA (A-C). WT C57BL/6 mice were intraperitoneally injected with LPS (20 mg/kg) and constructed with the CLP model, whereas AREG protein expression in serum was detected via ELISA (D). BMDM was stimulated with LPS (100 ng/mL or 1 μg/mL) for 12 h, and AREG protein expression was detected via Immunofluorescence (E). Data presented as mean ± SEM (n ≥ 3). *P < 0.05, **P < 0.01, ***P < 0.001 vs. Control. AREG, amphiregulin; WT, wild type; BMDM, bone marrow-derived macrophages; CLP, cecal ligation and puncture. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/40292295), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Amphiregulin by Western Blot View Larger

Detection of Amphiregulin by Western Blot EGFR inhibition and TLR4 silencing impair AREG-induced macrophage pyroptosis. BMDM was stimulated with AREG+ATP or LPS+ATP, and the expression of NLRP3, p-P65, p-I kappa B, CASPASE-1-p20, and GSDMD-N was detected via Western blot (A-C). BMDM was stimulated with AREG+ATP or LPS+ATP, and oligomerization of ASC was detected using immunofluorescence (D, E). Experimental diagram of AREG-induced macrophage pyroptosis. For the priming step, BMDM was treated with AREG for 2.5 as the first signal and the ATP as the second signal (F). NLRP3, CASPASE-1-p20, and GSDMD-N expressions were detected in the EGFR inhibitor (1 mM) pretreating AREG +ATP-induced BMDM for 4 h through Western blot (G, J). NLRP3, CASPASE-1-p20, and GSDMD-N expressions were detected in AREG +ATP-induced TLR4−/−BMDM via Western blot (H, K). The expression of IL-1b and IL-18 was detected in the supernatant of AREG +ATP-induced TLR4−/−BMDM via ELISA (I). Data are presented as mean ± SEM (n ≥ 3). *P < 0.05, **P < 0.01, ***P < 0.001 vs. Control. ns, no significant; AREG, amphiregulin; BMDM, bone marrow-derived macrophages; EGFR, epidermal growth factor receptor; GSDMD, gasdermin D; ATP, adenosine triphosphate. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/40292295), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Amphiregulin by Western Blot View Larger

Detection of Amphiregulin by Western Blot DTT-pretreated extracellular AREG restrains macrophage pyroptosis. NLRP3, CASPASE1-p20, and GSDMD-N expressions were detected in LPS-induced BMDM after DTT (1 mM) or H2O2 (100 μM) pretreating LPS for 1 h (A, B). NLRP3, Caspase1-p20, and GSDMD-N expression were detected in AREG-induced BMDM after DTT (1 mM) or H2O2 (100 μM) pretreating AREG for 1 h (C, D). Data are presented as mean ± SEM (n ≥ 3).*P < 0.05, **P < 0.01, ***P < 0.001 vs. Control. ns, no significient; AREG, amphiregulin; BMDM, bone marrow-derived macrophages; EGFR, epidermal growth factor receptor; GSDMD, gasdermin D. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/40292295), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Amphiregulin by Western Blot View Larger

Detection of Amphiregulin by Western Blot Neutralizing extracellular AREG decreases LPS-induced TLR4 expression and pyroptosis in macrophages. LPS-induced BMDM was pretreated with a neutralizing antibody of AREG. p-EGFR, TLR4, and GSDMD-N expression levels were detected via Western blot and immunofluorescence (A-C, E, F), TLR4 expression and ASC oligomerization was detected through immunofluorescence (D, G, H). Formation of pyrosomes (red arrows) was detected using electron microscopy, scale bars, 2 μm (I). Data are presented as mean ± SEM (n ≥ 3).*P < 0.05, **P < 0.01, ***P < 0.001 vs. Control. AREG, amphiregulin. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/40292295), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Amphiregulin by Western Blot View Larger

Detection of Amphiregulin by Western Blot EGFR inhibition and TLR4 silencing impair AREG-induced macrophage pyroptosis. BMDM was stimulated with AREG+ATP or LPS+ATP, and the expression of NLRP3, p-P65, p-I kappa B, CASPASE-1-p20, and GSDMD-N was detected via Western blot (A-C). BMDM was stimulated with AREG+ATP or LPS+ATP, and oligomerization of ASC was detected using immunofluorescence (D, E). Experimental diagram of AREG-induced macrophage pyroptosis. For the priming step, BMDM was treated with AREG for 2.5 as the first signal and the ATP as the second signal (F). NLRP3, CASPASE-1-p20, and GSDMD-N expressions were detected in the EGFR inhibitor (1 mM) pretreating AREG +ATP-induced BMDM for 4 h through Western blot (G, J). NLRP3, CASPASE-1-p20, and GSDMD-N expressions were detected in AREG +ATP-induced TLR4−/−BMDM via Western blot (H, K). The expression of IL-1b and IL-18 was detected in the supernatant of AREG +ATP-induced TLR4−/−BMDM via ELISA (I). Data are presented as mean ± SEM (n ≥ 3). *P < 0.05, **P < 0.01, ***P < 0.001 vs. Control. ns, no significant; AREG, amphiregulin; BMDM, bone marrow-derived macrophages; EGFR, epidermal growth factor receptor; GSDMD, gasdermin D; ATP, adenosine triphosphate. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/40292295), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Amphiregulin by Western Blot View Larger

Detection of Amphiregulin by Western Blot Neutralizing extracellular AREG decreases LPS-induced TLR4 expression and pyroptosis in macrophages. LPS-induced BMDM was pretreated with a neutralizing antibody of AREG. p-EGFR, TLR4, and GSDMD-N expression levels were detected via Western blot and immunofluorescence (A-C, E, F), TLR4 expression and ASC oligomerization was detected through immunofluorescence (D, G, H). Formation of pyrosomes (red arrows) was detected using electron microscopy, scale bars, 2 μm (I). Data are presented as mean ± SEM (n ≥ 3).*P < 0.05, **P < 0.01, ***P < 0.001 vs. Control. AREG, amphiregulin. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/40292295), licensed under a CC-BY license. Not internally tested by R&D Systems.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Amphiregulin

Amphiregulin (AR), also known as Schwannoma-derived growth factor (SDGF), is a member of the epidermal growth factor (EGF) family of growth factors which includes, AR, EGF, transforming growth factor-a (TGF-a), heparin binding EGF-like growth factor (HB-EGF), betacellulin (BTC), epiregulin, and the neuregulins-1 through -4. All EGF family members are synthesized as type I transmembrane precursors and contain one or several EGF domains in their extracellular region. The bioactive form of the proteins is released by proteolytic cleavage. The ErbB family of receptors that includes ErbB1‑B4, mediates the biological activities of the EGF family ligands. AR was originally isolated from the conditioned media of PMA-treated MCF-7 human breast carcinoma cell line. AR mRNA expression can be detected in numerous carcinoma cell lines and in the epithelial cells of various human tissues including colon, stomach, breast, ovary and kidney. AR stimulates the proliferation of keratinocytes, mammary epithelial cells, fibroblasts, astrocytes and glial cells. AR is also a growth inhibitor for certain tumor cells. The gene for AR has been mapped to human chromosome 4q13-q21 and mouse chromosome 5. Human and mouse AR cDNA encode 252 and 248 amino acid residue type I membrane proteins, respectively. The two proteins share approximately 69% sequence identity. Mouse AR also shares 81% amino acid sequence homology with rat AR. Several secreted isoforms of AR that vary in length and/or glycosylation level can be found in cell conditioned media. The 98 amino acid residue recombinant AR has better receptor binding and biological activity than the C-terminal truncated forms of the protein.

References
  1. Thompson, S.A. et al. (1996) J. Biol. Chem. 271:17927.
  2. Sonoda, H. et al. (1992) Biochem. Biophys. Res. Commun. 185:103.
  3. Normanno, N. et al. (2001) Frontiers in Bioscience 6:685.
Entrez Gene IDs
374 (Human); 11839 (Mouse)
Alternate Names
Amphiregulin; AR; AREG; AREGB; Colorectum cell-derived growth factor; CRDGF; MGC13647; schwannoma-derived growth factor; SDGF

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Citations for Mouse Amphiregulin Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

25 Citations: Showing 1 - 10
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  1. Mechanisms for Alternaria alternata Function in the Skin During Induction of Peanut Allergy in Neonatal Mice With Skin Barrier Mutations
    Authors: Lauren M. Buelow, Akihiko Hoji, Kiet Tat, Lindsay M. Schroeder-Carter, Daniela J. Carroll, Joan M. Cook-Mills
    Frontiers in Allergy
  2. Mammary tumorigenesis induced by fibroblast growth factor receptor 1 requires activation of the epidermal growth factor receptor
    Authors: Lindsey K. Bade, Jodi E. Goldberg, Hazel A. DeHut, Majken K. Hall, Kathryn L. Schwertfeger
    Journal of Cell Science
  3. Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections
    Authors: Hani Harb, Mehdi Benamar, Peggy S. Lai, Paola Contini, Jason W. Griffith, Elena Crestani et al.
    Immunity
  4. Compatibility of intravitreally applied epidermal growth factor and amphiregulin
    Authors: Mukharram M. Bikbov, Timur A. Khalimov, Marc Cerrada-Gimenez, Symantas Ragauskas, Giedrius Kalesnykas, Jost B. Jonas
    International Ophthalmology
  5. The GABAA Receptor Influences Pressure Overload-Induced Heart Failure by Modulating Macrophages in Mice
    Authors: Jin Bu, Shiyuan Huang, Jue Wang, Tong Xia, Hui Liu, Ya You et al.
    Frontiers in Immunology
  6. Tissue remodeling by an opportunistic pathogen triggers allergic inflammation
    Authors: Karen Agaronyan, Lokesh Sharma, Bharat Vaidyanathan, Keith Glenn, Shuang Yu, Charles Annicelli et al.
    Immunity
  7. Esophageal ILC2s mediate abnormal epithelial remodeling in eosinophilic esophagitis via Areg-EGFR signaling
    Authors: Lim, M;Kim, T;Kim, H;Jang, BG;Myung, JK;Kim, HY;
    Cellular and Molecular Immunology
    Species: Transgenic Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  8. Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia
    Authors: Ma, R;Prigge, AD;Ortiz Serrano, TP;Cheng, Y;Davis, JM;Lou, KF;Wood, WA;Do, HC;Ren, Z;Fulcer, MM;Lotesto, MJ;Singer, BD;Coates, BM;Ridge, KM;
    Cell reports
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo assay
  9. Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis
    Authors: Walkenhorst, M;Sonner, JK;Meurs, N;Engler, JB;Bauer, S;Winschel, I;Woo, MS;Raich, L;Winkler, I;Vieira, V;Unger, L;Salinas, G;Lantz, O;Friese, MA;Willing, A;
    Nature communications
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. An amphiregulin reporter mouse enables transcriptional and clonal expansion analysis of reparative lung Treg cells
    Authors: Loffredo, LF;Kaiser, KA;Kornberg, A;Rao, S;de Los Santos-Alexis, K;Han, A;Arpaia, N;
    bioRxiv : the preprint server for biology
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  11. GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression
    Authors: J Liu, L Pan, W Hong, S Chen, P Bai, W Luo, X Sun, F He, X Jia, J Cai, Y Chen, K Hu, Z Song, J Ge, A Sun
    Nature Communications, 2022-12-06;13(1):7519.
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  12. Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces
    Authors: AM Tsou, H Yano, CN Parkhurst, T Mahlakõiv, C Chu, W Zhang, Z He, KJ Jarick, C Zhong, GG Putzel, M Hatazaki, JRI IBD Li, IC Lorenz, D Andrew, P Balderes, CSN Klose, SA Lira, D Artis
    Nature, 2022-11-02;0(0):.
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  13. Mechanisms for Alternaria alternata Function in the Skin During Induction of Peanut Allergy in Neonatal Mice With Skin Barrier Mutations
    Authors: Lauren M. Buelow, Akihiko Hoji, Kiet Tat, Lindsay M. Schroeder-Carter, Daniela J. Carroll, Joan M. Cook-Mills
    Frontiers in Allergy
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo assay
  14. Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
    Authors: H Shime, M Odanaka, M Tsuiji, T Matoba, M Imai, Y Yasumizu, R Uraki, K Minohara, M Watanabe, AJ Bonito, H Fukuyama, N Ohkura, S Sakaguchi, A Morita, S Yamazaki
    Proc. Natl. Acad. Sci. U.S.A., 2020-08-07;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC, Neutralization
  15. Deoxycholic acid activates epidermal growth factor receptor and promotes intestinal carcinogenesis by ADAM17-dependent ligand release
    Authors: W Dong, L Liu, Y Dou, M Xu, T Liu, S Wang, Y Zhang, B Deng, B Wang, H Cao
    J. Cell. Mol. Med., 2018-06-29;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
  16. Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway
    Authors: S Taverna, M Pucci, M Giallombar, MA Di Bella, M Santarpia, P Reclusa, I Gil-Bazo, C Rolfo, R Alessandro
    Sci Rep, 2017-06-09;7(1):3170.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  17. A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation
    Authors: K Fujiu, M Shibata, Y Nakayama, F Ogata, S Matsumoto, K Noshita, S Iwami, S Nakae, I Komuro, R Nagai, I Manabe
    Nat. Med., 2017-04-10;23(5):611-622.
    Species: Mouse
    Sample Types: In Vivo, Whole Tissue
    Applications: IHC, Neutralization
  18. Amphiregulin Antibody and Reduction of Axial Elongation in Experimental Myopia
    Authors: WJ Jiang, HX Song, SY Li, B Guo, JF Wu, GP Li, DD Guo, L Shi, HS Bi, JB Jonas
    EBioMedicine, 2017-02-23;0(0):.
    Species: Guinea Pig
    Sample Types: In Vivo
    Applications: Neutralization
  19. Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice
    Authors: Owen M. Siggs, Adam Grieve, Hongmei Xu, Paul Bambrough, Yonka Christova, Matthew Freeman
    Biology Open
    Species: Transgenic Mouse
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  20. ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism.
    Authors: Yang Y, Ahn Y, Chen Y, Tan X, Guo L, Gibbons D, Ungewiss C, Peng D, Liu X, Lin S, Thilaganathan N, Wistuba I, Rodriguez-Canales J, McLendon G, Creighton C, Kurie J
    J Clin Invest, 2014-04-24;124(6):2696-708.
    Species: Mouse
    Sample Types: Protein
    Applications: Western Blot
  21. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice.
    Authors: Murthy A, Defamie V, Smookler DS
    J. Clin. Invest., 2010-07-12;120(8):2731-44.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  22. Pubertal exposure to high fat diet causes mouse strain-dependent alterations in mammary gland development and estrogen responsiveness.
    Authors: Olson LK, Tan Y, Zhao Y, Aupperlee MD, Haslam SZ
    Int J Obes (Lond), 2010-03-16;34(9):1415-26.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  23. The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1.
    Authors: Mallakin A, Sugiyama T, Kai F, Taneja P, Kendig RD, Frazier DP, Maglic D, Matise LA, Willingham MC, Inoue K
    Int. J. Cancer, 2010-03-15;126(6):1403-16.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC-P, Western Blot
  24. Wounding-induced synthesis of hyaluronic acid in organotypic epidermal cultures requires the release of heparin-binding egf and activation of the EGFR.
    Authors: Monslow J, Sato N, Mack JA, Maytin EV
    J. Invest. Dermatol., 2009-02-19;129(8):2046-58.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  25. Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice
    Authors: Owen M. Siggs, Adam Grieve, Hongmei Xu, Paul Bambrough, Yonka Christova, Matthew Freeman
    Biology Open

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