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EGF Family

R&D Systems offers a wide selection of tools to Epidermal Growth Factor (EGF) Family members and their EGF R/ErbB receptors. These include highly specific EGF family antibodies, proteins, ELISAs, and more.

The members of the EGF family are best known for their ability to stimulate cell growth and proliferation and are important for many developmental processes including promoting mitogenesis and differentiation of mesenchymal and epithelial cells. EGF family members have at least one common structural motif, the EGF domain, which consists of six conserved cysteine residues forming three disulfide bonds. Most are synthesized in membrane-associated pro forms before liberation by proteolytic cleavage. Family members include EGF, Neuregulins, Amphiregulin, Betacellulin, and others. The activity of EGF family members is mediated by the EGF R/ErbB receptor tyrosine kinases. When unregulated, members of this family and their receptors are known to be involved in tumor formation.