Mouse Arylsulfatase G/ARSG Antibody

Detection of Mouse Arylsulfatase G/ARSG by Western Blot

Oligodendrocyte protein levels are rescued in TRa1+m hypothalamus by early postnatal thyroid hormone. (A-D) Comparison of the protein-expression of oligodendrocyte markers from the whole-hypothalamus homogenates in adult wild type (TR alpha 1++) and TR alpha 1+m mutant, in which TR alpha 1 signaling was reactivated either postnatally or pre- and postnatally by crossing to endogenously hyperthyroid TR beta knockout mice or additionally bred by hyperthyroid TR beta knockout dams. Raw western blots (A-C) and their quantifications (B,D) for the expression of classic oligodendrocyte markers (A,B) and some of the differentially expressed genes between TR alpha 1++ and TR alpha 1+m (C,D) on the TR beta knockout background (postnatal rescue) and additionally bred by TR beta knockout dams (pre- and postnatal rescue). *P<0.05 for TR alpha 1++ versus TR alpha 1+m mutant; #P<0.05 for additional effect of prenatal treatment (two-way ANOVA, n=3 per group, Table S1). Data are mean±s.d. AU, arbitrary unit. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/36715020), licensed under a CC-BY license. Not internally tested by R&D Systems.

Detection of Mouse Arylsulfatase G/ARSG by Western Blot

Alterations in oligodendrocytic proteins in the TRa1+m hypothalamus. (A-F) Comparison of the protein-expression of cellular and oligodendrocyte markers from whole-hypothalamus homogenates in adult wild type and TR alpha 1+m mutant, with and without T3 treatment. Raw western blots (A,C,E) and their quantifications (B,D,F) for the expression of overall hypothalamic cell markers (A,B), classic oligodendrocyte markers (C,D) and four potentially differentially expressed genes between the WT and the mutant (E,F). *P<0.05, **P<0.01, ***P<0.001 for wild type versus TR alpha 1+m mutant; #P<0.05 for T3-treatment; $P<0.05, $$P<0.01 for interaction between T3 treatment and genotype (two-way ANOVA, n=3 per group, Table S1). Data are mean±s.d. AU, arbitrary unit. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/36715020), licensed under a CC-BY license. Not internally tested by R&D Systems.

Detection of Mouse Arylsulfatase G/ARSG by Western Blot

Oligodendrocyte protein levels are rescued in TRa1+m hypothalamus by early postnatal thyroid hormone. (A-D) Comparison of the protein-expression of oligodendrocyte markers from the whole-hypothalamus homogenates in adult wild type (TR alpha 1++) and TR alpha 1+m mutant, in which TR alpha 1 signaling was reactivated either postnatally or pre- and postnatally by crossing to endogenously hyperthyroid TR beta knockout mice or additionally bred by hyperthyroid TR beta knockout dams. Raw western blots (A-C) and their quantifications (B,D) for the expression of classic oligodendrocyte markers (A,B) and some of the differentially expressed genes between TR alpha 1++ and TR alpha 1+m (C,D) on the TR beta knockout background (postnatal rescue) and additionally bred by TR beta knockout dams (pre- and postnatal rescue). *P<0.05 for TR alpha 1++ versus TR alpha 1+m mutant; #P<0.05 for additional effect of prenatal treatment (two-way ANOVA, n=3 per group, Table S1). Data are mean±s.d. AU, arbitrary unit. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/36715020), licensed under a CC-BY license. Not internally tested by R&D Systems.