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Mouse BST-2/Tetherin APC-conjugated Antibody

Catalog #: FAB8660A Datasheet / COA / SDS
Recombinant Monoclonal Antibody

Discontinued Product

FAB8660A has been discontinued.
View all BST-2/Tetherin products.
Detection of BST-2/Tetherin in Mouse Bone Marrow Cells by Flow Cytometry.
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Mouse BST-2/Tetherin APC-conjugated Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse BST-2/Tetherin in flow cytometry.
Source
Recombinant Monoclonal Rat IgG2A Clone # 44E9R
Purification
Protein A or G purified from cell culture supernatant
Immunogen
Recombinant extracellular domain of CD317
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of BST-2/Tetherin antibody in Mouse Bone Marrow Cells antibody by Flow Cytometry. View Larger

Detection of BST-2/Tetherin in Mouse Bone Marrow Cells by Flow Cytometry. Mouse bone marrow cells were stained with Rat Anti-Mouse B220/CD45R PE-conjugated Monoclonal Antibody (Catalog # FAB1217P) and either (A) Rat Anti-Mouse BST-2/Tetherin APC-conjugated Monoclonal Antibody (Catalog # FAB8660A) or (B) Rat IgG2AAllophycocyanin Isotype Control (Catalog # IC006A). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: BST-2/Tetherin

BST2, also known as Tetherin or PDCA1 and designated CD317, is a 30-35 kDa interferon-inducible protein that shows an unusual topology. The N-terminus is cytoplasmic, followed by a transmembrane segment, an extracellular loop, and a C-terminal GPI-linkage. BST2 is expressed on bone marrow stromal cells and is upregulated in breast cancer and astrocytoma. It binds to ILT7 on plasmacytoid dendritic cells and inhibits proinflammatory TLR7 and TLR9 signaling. BST2 inhibits the release of Kaposi sarcoma virus, HIV-1, and Lassa virus from infected cells, but this function is counteracted by viral proteins which directly bind and trigger the degradation of BST2. 

Long Name
Bone Marrow Stromal Cell Antigen 2
Entrez Gene IDs
684 (Human); 69550 (Mouse)
Alternate Names
bone marrow stromal antigen 2; bone marrow stromal cell antigen 2; BST2; BST-2; CD317 antigen; CD317; HM1.24 Antigen; NPC-A-7; PDCA-1; Tetherin

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Product Datasheet
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