Mouse BTN2A2/Butyrophilin 2A2 Antibody
Mouse BTN2A2/Butyrophilin 2A2 Antibody Summary
10% cross-reactivity with recombinant mouse (rm) BTN and rmBTNL2 is observed.
Accession # A4QPC6.1
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: BTN2A2/Butyrophilin 2A2
Mouse Butyrophilin 2 (BTN2; also Btn2a2) is a 65‑70 kDa member of the BTN/MOG family of proteins. It is expressed on colonic epithelium and endothelial cells, and marginally on monocytes. The counterreceptor for BTN2 is DC-SIGN and binding is predicated on the presence of BTN2 mannose residues. Mature mouse BTN2 is presumably 487 amino acids (aa) in length. It is a type I transmembrane glycoprotein that potentially contains a 206 aa extracellular domain (ECD) (aa 29‑234). The ECD contains one V-type (aa 52‑129) and one C2-type (aa 152‑234) Ig-like domain. There is one alternative splice variant. It shows a deletion of aa 372‑400 plus a 17 aa substitution for aa 422‑451. Over aa 30‑248, mouse BTN2 shares 70% and 89% aa identity with human and rat BTN2, respectively.
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