Mouse CCL21/6Ckine Antibody

(30 citations)
(1 Review)
  
  • Species Reactivity
    Mouse
  • Specificity
    Detects mouse CCL21/6Ckine in direct ELISAs and Western blots. In direct ELISAs, approximately 100% cross reactivity with recombinant rat CCL21/6Ckine is observed and less than 15% cross-reactivity with recombinant human CCL21/6Ckine is observed.
  • Source
    Polyclonal Goat IgG
  • Purification
    Antigen Affinity-purified
  • Immunogen
    E. coli-derived recombinant mouse CCL21/6Ckine
    Ser24-Gly133
    Accession # P84444
  • Formulation
    Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
  • Endotoxin Level
    <0.10 EU per 1 μg of the antibody by the LAL method.
  • Label
    Unconjugated
Applications
  •  
    Recommended
    Concentration
    Sample
  • Western Blot
    0.1 µg/mL
    Recombinant Mouse CCL21/6Ckine (Catalog # 457-6C)
  • Immunohistochemistry
    5-15 µg/mL
    See below
  • CyTOF-ready
    Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
  • Intracellular Staining by Flow Cytometry
    2.5 µg/106 cells
    See below
  • Neutralization
    Measured by its ability to neutralize CCL21/6Ckine-induced chemotaxis in the BaF3 mouse pro‑B cell line transfected with human CCR7. The Neutralization Dose (ND50) is typically 0.5-2.5 µg/mL in the presence of 50 ng/mL Recombinant Mouse CCL21/6Ckine.
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples

Chemotaxis Induced by CCL21/6Ckine and Neutralization by Mouse CCL21/6Ckine Antibody. Recombinant Mouse CCL21/6Ckine (Catalog # 457‑6C) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CCR7 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Mouse CCL21/6Ckine (50 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse CCL21/6Ckine Antigen Affinity-purified Polyclonal Antibody (Catalog # AF457). The ND50 is typically 0.5‑2.5 µg/mL.

Immunohistochemistry

CCL21/6Ckine in Mouse Thymus. CCL21/6Ckine was detected in perfusion fixed frozen sections of mouse thymus using Goat Anti-Mouse CCL21/6Ckine Antigen Affinity-purified Polyclonal Antibody (Catalog # AF457) at 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to endothelial cells. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Intracellular Staining by Flow Cytometry

Detection of CCL21/6Ckine in D3 Mouse Cell Line by Flow Cytometry. D3 mouse embryonic stem cell line was stained with Goat Anti-Mouse CCL21/6Ckine Antigen Affinity-purified Polyclonal Antibody (Catalog # AF457, filled histogram) or control antibody (Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0107).  To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin.

Preparation and Storage
  • Reconstitution
    Reconstitute at 0.2 mg/mL in sterile PBS.
  • Shipping
    The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
  • Stability & Storage
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CCL21/6Ckine

6Ckine is a novel CC chemokine discovered independently by three groups from the EST database. 6Ckine, also named SLC (secondary lymphoid-tissue chemokine), CCL21 and Exodus-2, shows 21-33% identity to other CC chemokines. 6Ckine contains the four conserved cysteines characteristic of beta chemokines plus two additional cysteines in its unusually long carboxyl-terminal domain. Human 6Ckine cDNA encodes a 134 amino acid residue, highly basic, precursor protein with a 23 amino acid residue signal peptide that is cleaved to form the predicted 111 amino acid residue mature protein. Mouse 6Ckine cDNA encodes a 133 amino acid residue protein with a 23 residue signal peptide that is cleaved to generate the 110 residue mature protein. Human and mouse 6Ckine are highly conserved, exhibiting 86% amino acid sequence identity. 6Ckine is constitutively expressed at high levels in lymphoid tissues such as lymph nodes, spleen and appendix. In mouse, high levels of 6Ckine mRNA are also detected in the lung. The gene for human 6Ckine has been localized at human chromosome 9p13 rather than chromosome 17 where the genes of many human CC chemokines are clustered. The 6Ckine gene location is within a region of about 100 kb from the MIP-3 beta /ELC gene, another identified novel CC chemokine. Unlike most CC chemokines, 6Ckine is not chemotactic for monocytes. 6Ckine has also been reported to inhibit hemopoietic progenitor colony formation in a dose-dependent manner. 6Ckine acts via a class of as yet unidentified CC receptors on both T cells and B cells that are not shared by any other CC chemokines. Mature rat CCL21 shares 84% aa sequence identity with mouse CCL21.

  • Entrez Gene IDs:
    6366 (Human); 18829 (Mouse); 298006 (Rat)
  • Alternate Names:
    6Ckine; 6CkineSmall-inducible cytokine A21; Beta-chemokine exodus-2; CCL21; chemokine (C-C motif) ligand 21; CKb9; exodus-2; member 21; SCYA21; SCYA21MGC34555; secondary lymphoid tissue chemokine; SLC; SLCSecondary lymphoid-tissue chemokine; TCA-4
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

30 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. Increased migration of antigen presenting cells to newly-formed lymphatic vessels in transplanted kidneys by glycol-split heparin
    Authors: DT Talsma, K Katta, M Boersema, S Adepu, A Naggi, G Torri, C Stegeman, G Navis, H van Goor, JL Hillebrand, S Yazdani, J van den Bo
    PLoS ONE, 2017;12(6):e0180206.
    Species: Human
    Sample Type: Recombinant Proteins
    Application: Functional Assay
  2. Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration
    Authors: C Colin Brinkman
    Nat Commun, 2016;7(0):12021.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Functional Assay
  3. Structural and functional features of central nervous system lymphatic vessels.
    Authors: Louveau A, Smirnov I, Keyes T, Eccles J, Rouhani S, Peske J, Derecki N, Castle D, Mandell J, Lee K, Harris T, Kipnis J
    Nature, 2015;523(7560):337-41.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC Not Specified
  4. Collecting lymphatic vessel permeability facilitates adipose tissue inflammation and distribution of antigen to lymph node-homing adipose tissue dendritic cells.
    Authors: Kuan E, Ivanov S, Bridenbaugh E, Victora G, Wang W, Childs E, Platt A, Jakubzick C, Mason R, Gashev A, Nussenzweig M, Swartz M, Dustin M, Zawieja D, Randolph G
    J Immunol, 2015;194(11):5200-10.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC Not Specified
  5. Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection.
    Authors: Astrup E, Ranheim T, Damas J, Davi G, Santilli F, Jensenius M, Vitale G, Aukrust P, Olano J, Otterdal K
    BMC Infect Dis, 2014;14(0):70.
  6. The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel.
    Authors: Aspelund A, Tammela T, Antila S, Nurmi H, Leppanen V, Zarkada G, Stanczuk L, Francois M, Makinen T, Saharinen P, Immonen I, Alitalo K
    J Clin Invest, 2014;124(9):3975-86.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC Fresh
  7. Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection.
    Authors: Ibrahim M, Barnes J, Osorio E, Anstead G, Jimenez F, Osterholzer J, Travi B, Ahuja S, White A, Melby P
    Infect Immun, 2014;82(8):3098-112.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC
  8. CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.
    Authors: Geherin, Skye A, Wilson, R Paul, Jennrich, Silke, Debes, Gudrun F
    PLoS ONE, 2014;9(4):e95626.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC
  9. CLEC-2 is required for development and maintenance of lymph nodes.
    Authors: Benezech C, Nayar S, Finney B, Withers D, Lowe K, Desanti G, Marriott C, Watson S, Caamano J, Buckley C, Barone F
    Blood, 2014;123(20):3200-7.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC Frozen
  10. Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation.
    Authors: Baluk P, Adams A, Phillips K, Feng J, Hong Y, Brown M, McDonald D
    Am J Pathol, 2014;184(5):1577-92.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC
  11. Occurrence of tertiary lymphoid tissue is associated with T-cell infiltration and predicts better prognosis in early-stage colorectal cancers.
    Authors: Di Caro G, Bergomas F, Grizzi F, Doni A, Bianchi P, Malesci A, Laghi L, Allavena P, Mantovani A, Marchesi F
    Clin Cancer Res, 2014;20(8):2147-58.
    Species: Human
    Sample Type: Whole Tissue
    Application: IHC Paraffin-embedded
  12. TWEAK promotes peritoneal inflammation.
    Authors: Sanz A, Aroeira L, Bellon T, del Peso G, Jimenez-Heffernan J, Santamaria B, Sanchez-Nino M, Blanco-Colio L, Lopez-Cabrera M, Ruiz-Ortega M, Egido J, Selgas R, Ortiz A
    PLoS ONE, 2014;9(3):e90399.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC Paraffin-embedded
  13. Exposure to Ionizing Radiation Induces the Migration of Cutaneous Dendritic Cells by a CCR7-Dependent Mechanism.
    Authors: Cummings, Ryan J, Gerber, Scott A, Judge, Jennifer, Ryan, Julie L, Pentland, Alice P, Lord, Edith M
    J Immunol, 2012;189(9):4247-57.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC
  14. NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-gamma and perforin-dependent mechanisms.
    J Immunol, 2012;189(5):2099-109.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC Frozen
  15. Remodeling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli.
    Authors: Betterman K, Paquet-Fifield S, Asselin-Labat M, Visvader J, Butler L, Stacker S, Achen M, Harvey N
    Am J Pathol, 2012;181(6):2225-38.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC Frozen
  16. Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs.
    Authors: Rehm A, Mensen A, Schradi K, Gerlach K, Wittstock S, Winter S, Buchner G, Dorken B, Lipp M, Hopken UE
    Blood, 2011;118(4):1020-33.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC Frozen
  17. Comprehensive assessment of chemokine expression profiles by flow cytometry.
    Authors: Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D
    J. Clin. Invest., 2010;120(3):907-23.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Flow
  18. Ontogeny of stromal organizer cells during lymph node development.
    Authors: Benezech C, White A, Mader E, Serre K, Parnell S, Pfeffer K, Ware CF, Anderson G, Caamano JH
    J. Immunol., 2010;184(8):4521-30.
    Species: Mouse
    Sample Type: Whole Cells
    Application: ICC
  19. Induction of targeted cell migration by cutaneous administration of a DNA vector encoding a biologically active chemokine CCL21.
    Authors: Jalili A, Pashenkov M, Kriehuber E, Wagner C, Nakano H, Stingl G, Wagner SN
    J. Invest. Dermatol., 2010;130(6):1611-23.
    Species: Mouse
    Sample Type: Cell Lysates
    Application: WB
  20. Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines.
    Authors: St John AL, Abraham SN
    Nat. Med., 2009;15(11):1259-65.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  21. Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice.
    Authors: Grabner R, Lotzer K, Dopping S, Hildner M, Radke D, Beer M, Spanbroek R, Lippert B, Reardon CA, Getz GS, Fu YX, Hehlgans T, Mebius RE, van der Wall M, Kruspe D, Englert C, Lovas A, Hu D, Randolph GJ, Weih F, Habenicht AJ
    J. Exp. Med., 2009;206(1):233-48.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC Paraffin-embedded
  22. CCR7-CCL19/CCL21-regulated dendritic cells are responsible for effectiveness of sublingual vaccination.
    Authors: Song JH, Kim JI, Kwon HJ, Shim DH, Parajuli N, Cuburu N, Czerkinsky C, Kweon MN
    J. Immunol., 2009;182(11):6851-60.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  23. Macrophage mannose receptor on lymphatics controls cell trafficking.
    Authors: Marttila-Ichihara F, Turja R, Miiluniemi M, Karikoski M, Maksimow M, Niemela J, Martinez-Pomares L, Salmi M, Jalkanen S
    Blood, 2008;112(1):64-72.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC Frozen
  24. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo.
    Authors: Worbs T, Mempel TR, Bolter J, von Andrian UH, Forster R
    J. Exp. Med., 2007;204(3):489-95.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC Frozen
  25. The role of lymphoid tissue inducer cells in splenic white pulp development.
    Authors: Withers DR, Kim MY, Bekiaris V, Rossi SW, Jenkinson WE, Gaspal F, McConnell F, Caamano JH, Anderson G, Lane PJ
    Eur. J. Immunol., 2007;37(11):3240-5.
    Species: Mouse
    Sample Type: Whole Cells
    Application: ICC
  26. The chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking.
    Authors: Jin Y, Shen L, Chong EM
    Mol. Vis., 2007;13(0):626-34.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  27. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium.
    Authors: Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG
    J. Exp. Med., 2006;203(12):2763-77.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: IHC Frozen
  28. The role of CCL21 in recruitment of T-precursor cells to fetal thymi.
    Authors: Ueno T, Kuse S, Saito F, Nitta T, Kakiuchi T, Hollander GA, Takahama Y
    Blood, 2005;105(1):31-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Neut
  29. Local delivery of recombinant vaccinia virus expressing secondary lymphoid chemokine (SLC) results in a CD4 T-cell dependent antitumor response.
    Authors: Flanagan K, Glover RT, Horig H, Yang W, Kaufman HL
    Vaccine, 2004;22(21):2894-903.
    Species: Mouse
    Sample Type: Cell Lysates
    Application: WB
  30. Role of CC chemokines (macrophage inflammatory protein-1 beta, monocyte chemoattractant protein-1, RANTES) in acute lung injury in rats.
    Authors: Bless NM, Huber-Lang M, Guo RF, Warner RL, Schmal H, Czermak BJ, Shanley TP, Crouch LD, Lentsch AB, Sarma V, Mulligan MS, Friedl HP, Ward PA
    J. Immunol., 2000;164(5):2650-9.
    Species: Rat
    Sample Type: In Vivo
    Application: In vivo
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Average Rating: 5 (Based on 1 review)

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We have 1 review tested in 1 application: Immunocytochemistry/Immunofluorescence.

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Immunocytochemistry/Immunofluorescence Mouse CCL21/6Ckine Antibody AF457
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 ICC/IF Mouse Anonymous 04/07/2016
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Immunocytochemistry/Immunofluorescence Mouse CCL21/6Ckine Antibody AF457
Immunocytochemistry/Immunofluorescence: Mouse CCL21/6Ckine Antibody [AF457]

Summary

ApplicationImmunocytochemistry/Immunofluorescence
Sample TestedSmall intestine tissue
SpeciesMouse

Other Experimental Details

Other Experimental DetailsRed staining is CCL21

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