Mouse CXCR4 APC-conjugated Antibody

FAB21651A 2 Citations Datasheet / COA / SDS

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FAB21651A-100UG
FAB21651A-025UG

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Detection of CXCR4 in Mouse Thymocytes by Flow Cytometry.

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Citations (2)

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Mouse CXCR4 APC-conjugated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse CXCR4 transfectants. Does not stain irrelevant transfectants.

Source

Monoclonal Rat IgG_2B Clone # 247506

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Y3 rat myeloid cell line transfected with mouse CXCR4
Met1-Ser359
Accession # P70658

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

Allophycocyanin

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25-1 µg/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry

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Detection of CXCR4 in Mouse Thymocytes by Flow Cytometry. Mouse thymocytes were stained with (A) Rat Anti-Mouse CXCR4 APC-conjugated Monoclonal Antibody (Catalog # FAB21651A) or (B) Rat IgG_2B isotype control antibody (Catalog # IC013A) and Rat anti-Mouse CD8 alpha PE-conjugated Monoclonal Antibody (Catalog # FAB116P). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: CXCR4

CXCR4 is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and-2 viral entry into cells.

Entrez Gene IDs

7852 (Human); 12767 (Mouse); 60628 (Rat); 483900 (Canine); 493676 (Feline)

Alternate Names

CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CXCR4; CXC-R4; CXCR-4; D2S201ESDF-1 receptor; FB22; Fusin; HM89NPYRL; HSY3RR; LAP3; LCR1; LESTRCD184 antigen; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; NPY3RWHIM; NPYR; NPYY3R; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor

Product Datasheets

Product Datasheet

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Related Research Areas

Citations for Mouse CXCR4 APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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Osteoblasts protect AML cells from SDF-1-induced apoptosis.
Authors: Kremer K, Dudakovic A, McGee-Lawrence M, Philips R, Hess A, Smith B, van Wijnen A, Karp J, Kaufmann S, Westendorf J, Hedin K
J Cell Biochem, 2014;115(6):1128-37.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Application of the chemokine CXCL12 expression plasmid restores wound healing to near normal in a diabetic mouse model.
Authors: Restivo TE, Mace KA, Harken AH, Young DM
J Trauma, 2010;69(2):392-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry