Mouse IL-1 beta/IL-1F2 DuoSet ELISA

Catalog # Availability Size / Price Qty
DY401
DY401-05
Ancillary Products Available
Mouse IL-1 beta / IL-1F2 ELISA Standard Curve
1 Image
Product Details
Procedure
Citations (227)
FAQs
Supplemental Products
Reviews (18)

Mouse IL-1 beta/IL-1F2 DuoSet ELISA Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Sample Volume Required
100 µL
Sufficient Materials
For five or fifteen 96-well plates*
Specificity
Please see the product datasheet

* Provided that the recommended microplates, buffers, diluents, substrates and solutions are used, and the assay is run as summarized in the Assay Procedure provided.

This DuoSet ELISA Development kit contains the basic components required for the development of sandwich ELISAs to measure natural and recombinant mouse IL-1 beta/IL-1F2. The suggested diluent is suitable for the analysis of most cell culture supernate samples. Diluents for complex matrices, such as serum and plasma, should be evaluated prior to use in this DuoSet.

Product Features

  • Optimized capture and detection antibody pairings with recommended concentrations save lengthy development time
  • Development protocols are provided to guide further assay optimization
  • Assay can be customized to your specific needs
  • Economical alternative to complete kits

Kit Content

  • Capture Antibody
  • Detection Antibody
  • Recombinant Standard
  • Streptavidin conjugated to horseradish-peroxidase (Streptavidin-HRP)

Other Reagents Required

DuoSet Ancillary Reagent Kit 2 (5 plates): (Catalog # DY008) containing 96 well microplates, plate sealers, substrate solution, stop solution, plate coating buffer (PBS), wash buffer, and Reagent Diluent Concentrate 2.

The components listed above may be purchased separately:

PBS: (Catalog # DY006), or 137 mM NaCl, 2.7 mM KCl, 8.1 mM Na2HPO4, 1.5 mM KH2PO4, pH 7.2 - 7.4, 0.2 µm filtered

Wash Buffer: (Catalog # WA126), or 0.05% Tween® 20 in PBS, pH 7.2-7.4

Reagent Diluent: (Catalog # DY995), or 1% BSA in PBS, pH 7.2-7.4, 0.2 µm filtered

Substrate Solution: 1:1 mixture of Color Reagent A (H2O2) and Color Reagent B (Tetramethylbenzidine) (Catalog # DY999)

Stop Solution: 2 N H2SO4 (Catalog # DY994)

Microplates: R&D Systems (Catalog # DY990)

Plate Sealers: ELISA Plate Sealers (Catalog # DY992)

 

Data Example

Mouse IL-1 beta / IL-1F2 ELISA Standard Curve

Product Datasheets

Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IL-1 beta/IL-1F2

The Interleukin 1 (IL-1) family of proteins consists of IL-1 alpha, IL-1 beta, and the IL-1 receptor antagonist (IL-1ra). IL-1 alpha and IL-1 beta bind to the same cell surface receptors and share biological functions (1). IL-1 is not produced by unstimulated cells of healthy individuals with the exception of skin keratinocytes, some epithelial cells, and certain cells of the central nervous system. However, in response to inflammatory agents, infections, or microbial endotoxins, a dramatic increase in the production of IL-1 by macrophages and various other cell types is seen. IL-1 beta plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. Inappropriate or prolonged production of IL-1 has been implicated in a variety of pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulindependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases (2-5). 

 IL-1 alpha and IL-1 beta are structurally related polypeptides that show approximately 25% homology at the amino acid (aa) level. Both are synthesized as 31 kDa precursors that are subsequently cleaved into mature proteins of approximately 17.5 kDa (6, 7). Cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response (2, 8). Neither IL-1 alpha nor IL-1 beta contains a typical hydrophobic signal peptide (9-11), but evidence suggests that these factors can be secreted by non-classical pathways (12, 13). A portion of unprocessed IL-1 alpha can be presented on the cell membrane and may retain biological activity (14). The precursor form of IL-1 beta, unlike the IL-1 alpha precursor, shows little or no biological activity in comparison to the processed form (13, 15). Both unprocessed and mature forms of IL-1 beta are exported from the cell. 
 IL-1 alpha and IL-1 beta exert their effects through immunoglobulin superfamily receptors that additionally bind IL-1ra. The 80 kDa transmembrane type I receptor (IL-1 RI) is expressed on T cells, fibroblasts, keratinocytes, endothelial cells, synovial lining cells, chondrocytes, and hepatocytes (16, 17). The 68 kDa transmembrane type II receptor (IL-1 RII) is expressed on B cells, neutrophils, and bone marrow cells (18). The two IL-1 receptor types show approximately 28% homology in their extracellular domains but differ significantly in that the type II receptor has a cytoplasmic domain of only 29 aa, whereas the type I receptor has a 213 aa cytoplasmic domain. IL-1 RII does not appear to signal in response to IL-1 and may function as a decoy receptor that attenuates IL-1 function (19). The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction (20). IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 (21, 22). Soluble forms of both IL-1 RI and IL-1 RII have been detected in human plasma, synovial fluids, and the conditioned media of several human cell lines (23, 24). In addition, IL-1 binding proteins that resemble soluble IL-1 RII are encoded by vaccinia and cowpox viruses (25).

Long Name:
Interleukin 1 beta
Entrez Gene IDs:
3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)
Alternate Names:
catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1b; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta

Assay Procedure

GENERAL ELISA PROTOCOL

Plate Preparation

  1. Dilute the Capture Antibody to the working concentration in PBS without carrier protein. Immediately coat a 96-well microplate with 100 μL per well of the diluted Capture Antibody. Seal the plate and incubate overnight at room temperature.
  2. Aspirate each well and wash with Wash Buffer, repeating the process two times for a total of three washes. Wash by filling each well with Wash Buffer (400 μL) using a squirt bottle, manifold dispenser, or autowasher. Complete removal of liquid at each step is essential for good performance. After the last wash, remove any remaining Wash Buffer by aspirating or by inverting the plate and blotting it against clean paper towels.
  3. Block plates by adding 300 μL of Reagent Diluent to each well. Incubate at room temperature for a minimum of 1 hour.
  4. Repeat the aspiration/wash as in step 2. The plates are now ready for sample addition.

Assay Procedure

  1. Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at room temperature.
  2. Repeat the aspiration/wash as in step 2 of Plate Preparation.
  3. Add 100 μL of the Detection Antibody, diluted in Reagent Diluent, to each well. Cover with a new adhesive strip and incubate 2 hours at room temperature.
  4. Repeat the aspiration/wash as in step 2 of Plate Preparation.
  5. Add 100 μL of the working dilution of Streptavidin-HRP to each well. Cover the plate and incubate for 20 minutes at room temperature. Avoid placing the plate in direct light.
  6. Repeat the aspiration/wash as in step 2.
  7. Add 100 μL of Substrate Solution to each well. Incubate for 20 minutes at room temperature. Avoid placing the plate in direct light.
  8. Add 50 μL of Stop Solution to each well. Gently tap the plate to ensure thorough mixing.
  9. Determine the optical density of each well immediately, using a microplate reader set to 450 nm. If wavelength correction is available, set to 540 nm or 570 nm. If wavelength correction is not available, subtract readings at 540 nm or 570 nm from the readings at 450 nm. This subtraction will correct for optical imperfections in the plate. Readings made directly at 450 nm without correction may be higher and less accurate.

Citations for Mouse IL-1 beta/IL-1F2 DuoSet ELISA

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

227 Citations: Showing 1 - 10
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  1. Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury
    Authors: C Espinosa-G, F Atif, S Yousuf, I Sayeed, GN Neigh, DG Stein
    Int J Mol Sci, 2020;21(11):.
    Species: Mouse
    Sample Types: Cell Supernatants
  2. Maternal high fat diet consumption reduces liver alpha7 nicotinic cholinergic receptor expression and impairs insulin signalling in the offspring
    Authors: SO Costa, CM Souza, PG Lanza, JO Sartori, LM Ignacio-So, T Candreva, HG Rodrigues, AS Torsoni, M Milanski, MA Torsoni
    Sci Rep, 2020;10(1):48.
    Species: Mouse
    Sample Types: Tissue Homogenates
  3. Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions
    Authors: HJ Jung, JH Kang, S Pak, K Lee, JK Seong, SH Oh
    Int J Mol Sci, 2020;21(2):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  4. I&kappaB? controls NLRP3 inflammasome activation via upregulation of the Nlrp3 gene
    Authors: J Kim, H Ahn, S Yu, JH Ahn, HJ Ko, MN Kweon, EJ Hong, BS An, E Lee, GS Lee
    Cytokine, 2020;127(0):154983.
    Species: Mouse
    Sample Types: Serum
  5. Honokiol-Mediated Mitophagy Ameliorates Postoperative Cognitive Impairment Induced by Surgery/Sevoflurane via Inhibiting the Activation of NLRP3 Inflammasome in the Hippocampus
    Authors: JS Ye, L Chen, YY Lu, SQ Lei, M Peng, ZY Xia
    Oxid Med Cell Longev, 2019;2019(0):8639618.
    Species: Mouse
    Sample Types: Tissue Secretion
  6. Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism
    Authors: JL Fachi, JS Felipe, LP Pral, BK da Silva, RO Corrêa, MCP de Andrade, DM da Fonseca, PJ Basso, NOS Câmara, ÉL de Sales E, F Dos Santos, SES Guima, AM Thomas, JC Setubal, YT Magalhães, FL Forti, T Candreva, HG Rodrigues, MB de Jesus, SR Consonni, ADS Farias, P Varga-Weis, MAR Vinolo
    Cell Rep, 2019;27(3):750-761.e7.
    Species: Mouse
    Sample Types: Tissue Homogenates
  7. Newly defined ABCB5+ dermal mesenchymal stem cells promote healing of chronic iron overload wounds via secretion of interleukin-1 receptor antagonist
    Authors: S Vander Bek, JC de Vries, B Meier-Schi, P Meyer, D Jiang, A Sindrilaru, FF Ferreira, A Hainzl, S Schatz, J Muschhamme, NJ Scheurmann, P Kampilafko, AM Seitz, L Dürselen, A Ignatius, MA Kluth, C Ganss, M Wlaschek, K Singh, P Maity, NY Frank, MH Frank, K Scharffett
    Stem Cells, 2019;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
  8. Human metapneumovirus activates NOD-like receptor protein 3 inflammasome via its small hydrophobic protein which plays a detrimental role during infection in mice
    Authors: VB Lê, J Dubois, C Couture, MH Cavanagh, O Uyar, A Pizzorno, M Rosa-Calat, MÈ Hamelin, G Boivin
    PLoS Pathog., 2019;15(4):e1007689.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  9. Elevated circulating TGF?1 during acute liver failure activates TGF?R2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice
    Authors: M McMillin, S Grant, G Frampton, AD Petrescu, E Williams, B Jefferson, A Thomas, A Brahmarout, S DeMorrow
    J Neuroinflammation, 2019;16(1):69.
  10. Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus
    Authors: L Whitesell, N Robbins, DS Huang, CA McLellan, T Shekhar-Gu, EV LeBlanc, CS Nation, R Hui, A Hutchinson, C Collins, S Chatterjee, R Trilles, JL Xie, DJ Krysan, S Lindquist, JA Porco, U Tatu, LE Brown, J Pizarro, LE Cowen
    Nat Commun, 2019;10(1):402.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  11. HSP70 is a negative regulator of NLRP3 inflammasome activation
    Authors: P Martine, A Chevriaux, V Derangère, L Apetoh, C Garrido, F Ghiringhel, C Rébé
    Cell Death Dis, 2019;10(4):256.
    Species: Mouse
    Sample Types: Lavage Fluid
  12. Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
    Authors: Z Gong, J Huang, B Xu, Z Ou, L Zhang, X Lin, X Ye, X Kong, D Long, X Sun, X He, L Xu, Q Li, A Xuan
    J Neuroinflammation, 2019;16(1):62.
    Species: Mouse
    Sample Types: Tissue Homogenates
  13. Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile
    Authors: P Mamareli, F Kruse, C Friedrich, N Smit, T Strowig, T Sparwasser, M Lochner
    Eur. J. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Serum
  14. The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1?-dependent manner in macrophages
    Authors: OM Finucane, J Sugrue, A Rubio-Arai, MV Guillot-Se, MA Lynch
    Sci Rep, 2019;9(1):4034.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  15. Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection
    Authors: I Santecchia, F Vernel-Pau, O Rasid, J Quintin, M Gomes-Sole, IG Boneca, C Werts
    PLoS Pathog., 2019;15(5):e1007811.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  16. Gum Arabic Ameliorates Impaired Coagulation and Cardiotoxicity Induced by Water-Pipe Smoke Exposure in Mice
    Authors: A Nemmar, S Al-Salam, S Beegam, P Yuvaraju, BH Ali
    Front Physiol, 2019;10(0):53.
    Species: Mouse
    Sample Types: Tissue Homogenates
  17. Exercise-induced AMPK activation and IL-6 muscle production are disturbed in adiponectin knockout mice
    Authors: TA Diniz, JCJ Aquino Jún, FC Mosele, C Cabral-San, EA Lima Junio, AAS Teixeira, FS Lira, JC Rosa Neto
    Cytokine, 2019;119(0):71-80.
    Species: Mouse
    Sample Types: Tissue Homogenates
  18. Interleukin-37 monomer is the active form for reducing innate immunity
    Authors: EZ Eisenmesse, A Gottschlic, JS Redzic, N Paukovich, JC Nix, T Azam, L Zhang, R Zhao, JS Kieft, E The, X Meng, CA Dinarello
    Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  19. Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome
    Authors: RVH de Carvalh, WA Andrade, DS Lima-Junio, M Dilucca, CV de Oliveir, K Wang, PM Nogueira, JN Rugani, RP Soares, SM Beverley, F Shao, DS Zamboni
    Cell Rep, 2019;26(2):429-437.e5.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  20. In�Vitro Macrophage Assay Predicts the In�Vivo Anti-inflammatory Potential of Exosomes from Human Mesenchymal Stromal Cells
    Authors: N Pacienza, RH Lee, EH Bae, DK Kim, Q Liu, DJ Prockop, G Yannarelli
    Mol Ther Methods Clin Dev, 2019;13(0):67-76.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  21. Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host
    Authors: M Ahn, DE Anderson, Q Zhang, CW Tan, BL Lim, K Luko, M Wen, WN Chia, S Mani, LC Wang, JHJ Ng, RM Sobota, CA Dutertre, F Ginhoux, ZL Shi, AT Irving, LF Wang
    Nat Microbiol, 2019;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  22. In-depth characterization of congenital Zika syndrome in immunocompetent mice: Antibody-dependent enhancement and an antiviral peptide therapy
    Authors: VN Camargos, G Foureaux, DC Medeiros, VT da Silveir, CM Queiroz-Ju, ALB Matosinhos, AFA Figueiredo, CDF Sousa, TP Moreira, VF Queiroz, ACF Dias, KTO Santana, I Passos, ALCV Real, LC Silva, FAG Mourão, NT Wnuk, MAP Oliveira, S Macari, T Silva, GP Garlet, JA Jackman, FM Soriani, MFD Moraes, EMAM Mendes, FM Ribeiro, GMJ Costa, AL Teixeira, NJ Cho, ACP Oliveira, MM Teixeira, VV Costa, DG Souza
    EBioMedicine, 2019;0(0):.
    Species: Mouse
    Sample Types: Plasma
  23. Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway
    Authors: SZA Shah, D Zhao, G Taglialate, T Hussain, H Dong, N Sabir, MH Mangi, W Wu, M Lai, X Zhang, Y Duan, L Wang, X Zhou, L Yang
    Int J Mol Sci, 2019;20(5):.
    Species: Hamster
    Sample Types: Tissue Homogenates
  24. Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation
    Authors: K Ishimaru, K Yoshioka, K Kano, M Kurano, D Saigusa, J Aoki, Y Yatomi, N Takuwa, Y Okamoto, RL Proia, Y Takuwa
    Sci Rep, 2019;9(1):18329.
    Species: Mouse
    Sample Types: Plasma
  25. PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils
    Authors: L Yue, M Yan, ML Tremblay, TJ Lin, H Li, T Yang, X Song, T Xie, Z Xie
    PLoS ONE, 2019;14(9):e0222753.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  26. Maternal Obesity in Mice Exacerbates the Allergic Inflammatory Response in the Airways of Male Offspring
    Authors: RR E-Lacerda, CJ Teixeira, S Bordin, E Antunes, GF Anhê
    Nutrients, 2019;11(12):.
    Species: Mouse
    Sample Types: BALF
  27. The effects of oxygen concentration on cell death, anti-oxidant transcription, acute inflammation, and cell proliferation in precision-cut lung slices
    Authors: MJR Ruigrok, J Tomar, HW Frijlink, BN Melgert, WLJ Hinrichs, P Olinga
    Sci Rep, 2019;9(1):16239.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  28. Adiponectin Reverses the Hypothalamic Microglial Inflammation during Short-Term Exposure to Fat-Rich Diet
    Authors: H Lee, TH Tu, BS Park, S Yang, JG Kim
    Int J Mol Sci, 2019;20(22):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  29. Caveolin-1 gene therapy inhibits inflammasome activation to protect from bleomycin-induced pulmonary fibrosis
    Authors: X Lin, M Barravecch, R Matthew Ko, P Sime, DA Dean
    Sci Rep, 2019;9(1):19643.
  30. A single systemic inflammatory insult causes acute motor deficits and accelerates disease progression in a mouse model of human tauopathy
    Authors: M Torvell, DW Hampton, P Connick, AMJ MacLullich, C Cunningham, S Chandran
    Alzheimers Dement (N Y), 2019;5(0):579-591.
    Species: Mouse
    Sample Types: Serum
  31. Role of adipose tissue inflammation in fat pad loss induced by fasting in lean and mildly obese mice
    Authors: DR Lacerda, KA Costa, ALM Silveira, DF Rodrigues, AN Silva, JL Sabino, V Pinho, GB Menezes, DD Soares, MM Teixeira, AVM Ferreira
    J. Nutr. Biochem., 2019;72(0):108208.
    Species: Mouse
    Sample Types: Tissue Homogenates
  32. Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to Streptococcus pneumoniae
    Authors: J Periselner, G Ercoli, T Pollard, S Chimalapat, E Camberlein, G Szylar, C Hyams, G Tomlinson, FC Petersen, RA Floto, M Noursadegh, JS Brown
    MBio, 2019;10(5):.
    Species: Mouse
    Sample Types: BALF
  33. Context-specific switch from anti- to pro-epileptogenic function of the P2Y1 receptor in experimental epilepsy
    Authors: M Alves, L De Diego G, G Conte, EM Jimenez-Ma, B D'Orsi, A Sanz-Rodri, JH Prehn, DC Henshall, T Engel
    J. Neurosci., 2019;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  34. Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy
    Authors: F Sato-Kanek, X Wang, S Yao, T Hosoya, FS Lao, K Messer, M Pu, NM Shukla, HB Cottam, M Chan, DA Carson, M Corr, T Hayashi
    Biomed Res Int, 2018;2018(0):8091283.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  35. Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF-? Regulation and Myocardial Healing
    Authors: M Klier, S Gorressen, MA Urbahn, D Barbosa, M Ouwens, JW Fischer, M Elvers
    Front Physiol, 2018;9(0):1698.
    Species: Mouse
    Sample Types: Plasma
  36. The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1? Activation
    Authors: JE Vince, D De Nardo, W Gao, AJ Vince, C Hall, K McArthur, D Simpson, S Vijayaraj, LM Lindqvist, P Bouillet, MA Rizzacasa, SM Man, J Silke, SL Masters, G Lessene, DCS Huang, DHD Gray, BT Kile, F Shao, KE Lawlor
    Cell Rep, 2018;25(9):2339-2353.e4.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  37. Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop
    Authors: F Mouton-Lig, T Rosazza, J Sepulveda-, A Ieang, SM Hassoun, E Claire, G Mangone, A Brice, PP Michel, JC Corvol, O Corti
    Glia, 2018;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  38. FOXO3-dependent apoptosis limits alcohol-induced liver inflammation by promoting infiltrating macrophage differentiation
    Authors: Z Li, J Zhao, S Zhang, SA Weinman
    Cell Death Discov, 2018;4(0):16.
    Species: Mouse
    Sample Types: Serum
  39. Helminths-based bi-functional molecule, tuftsin-phosphorylcholine (TPC), ameliorates an established murine arthritis
    Authors: M Blank, T Bashi, J Lachnish, D Ben-Ami-Sh, O Shovman, M Fridkin, M Eisenstein, A Volkov, I Barshack, Y Shoenfeld
    PLoS ONE, 2018;13(8):e0200615.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  40. Genetically Engineered Resveratrol-Enriched Rice Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia Via Downregulating Mitogen-Activated Protein Kinase-Nuclear Factor Kappa B Signaling Pathway
    Authors: L Subedi, SH Baek, SY Kim
    Oxid Med Cell Longev, 2018;2018(0):8092713.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  41. NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of Toxoplasma gondii in Naive Macrophages
    Authors: SK Matta, K Patten, Q Wang, BH Kim, JD MacMicking, LD Sibley
    MBio, 2018;9(4):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  42. Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
    Authors: B Lagrange, S Benaoudia, P Wallet, F Magnotti, A Provost, F Michal, A Martin, F Di Lorenzo, BF Py, A Molinaro, T Henry
    Nat Commun, 2018;9(1):242.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  43. Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling
    Authors: C McWherter, YJ Choi, RL Serrano, SK Mahata, R Terkeltaub, R Liu-Bryan
    Arthritis Res. Ther., 2018;20(1):204.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  44. Choline transport links macrophage phospholipid metabolism and inflammation
    Authors: SA Snider, KD Margison, P Ghorbani, ND LeBlond, C O'Dwyer, JR Nunes, T Nguyen, H Xu, SA Bennett, MD Fullerton
    J. Biol. Chem., 2018;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  45. Activation of M1 macrophages play a critical role in the initiation of acute lung injury
    Authors: HL Lu, XY Huang, YF Luo, WP Tan, PF Chen, YB Guo
    Biosci. Rep., 2018;0(0):.
    Species: Mouse
    Sample Types: Serum
  46. Induction of endoplasmic reticulum stress under endotoxin tolerance increases inflammatory responses and decreases Pseudomonas aeruginosa pneumonia
    Authors: S Kim, Y Joe, SU Park, SO Jeong, JK Kim, SH Park, HO Pae, YJ Surh, J Shin, HT Chung
    J. Leukoc. Biol., 2018;0(0):.
    Species: Mouse
    Sample Types: BALF
  47. Disabled-2 (DAB2) Overexpression Inhibits Monocyte-Derived Dendritic Cells' Function in Vogt-Koyanagi-Harada Disease
    Authors: S Yi, R Chang, J Hu, Y Qiu, Q Wang, Q Cao, G Yuan, G Su, C Zhou, Y Wang, A Kijlstra, P Yang
    Invest. Ophthalmol. Vis. Sci., 2018;59(11):4662-4669.
    Species: Human
    Sample Types: Cell Culture Supernates
  48. Protective Effects of Anti-IL17 on Acute Lung Injury Induced by LPS in Mice
    Authors: RF Righetti, TM Dos Santos, LDN Camargo, LRCRB Aristótele, S Fukuzaki, FCR de Souza, FPR Santana, MVR de Agrela, MM Cruz, MIC Alonso-Val, IS Genaro, BM Saraiva-Ro, EA Leick, MA Martins, CM Prado, IFLC Tibério
    Front Pharmacol, 2018;9(0):1021.
    Species: Mouse
    Sample Types: Tissue Homogenates
  49. Extracellular ATP is a danger signal activating P2X7 receptor in a LPS mediated inflammation (ARDS/ALI)
    Authors: S Cicko, TC Köhler, CK Ayata, T Müller, N Ehrat, A Meyer, M Hossfeld, A Zech, F Di Virgili, M Idzko
    Oncotarget, 2018;9(55):30635-30648.
    Species: Mouse
    Sample Types: BALF
  50. Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation
    Authors: SB Kwak, S Koppula, EJ In, X Sun, YK Kim, MK Kim, KH Lee, TB Kang
    Mediators Inflamm., 2018;2018(0):6054069.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  51. Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria
    Authors: P Strangward, MJ Haley, MG Albornoz, J Barrington, T Shaw, R Dookie, L Zeef, SM Baker, E Winter, TC Tzeng, DT Golenbock, SM Cruickshan, SM Allan, A Craig, FY Liew, D Brough, KN Couper
    Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  52. Jugular arginine infusion relieves lipopolysaccharide-triggered inflammatory stress and improves immunity status of lactating dairy cows
    Authors: FF Zhao, TY Wu, HR Wang, LY Ding, G Ahmed, HW Li, W Tian, YZ Shen
    J. Dairy Sci., 2018;0(0):.
    Species: Bovine
    Sample Types: Serum
  53. A non-canonical autophagy-dependent role of the ATG16L1T300A variant in urothelial vesicular trafficking and uropathogenic Escherichia coli persistence
    Authors: C Wang, KA Bauckman, ASB Ross, JW Symington, MM Ligon, G Scholtes, A Kumar, HW Chang, J Twentyman, BE Fashemi, RJ Xavier, IU Mysorekar
    Autophagy, 2018;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  54. MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice
    Authors: AP Perera, R Fernando, T Shinde, R Gundamaraj, B Southam, SS Sohal, AAB Robertson, K Schroder, D Kunde, R Eri
    Sci Rep, 2018;8(1):8618.
    Species: Mouse
    Sample Types: Tissue Homogenates
  55. Human Defensin-5 Blocks Ethanol and Colitis-Induced Dysbiosis, Tight Junction Disruption and Inflammation in Mouse Intestine
    Authors: PK Shukla, AS Meena, V Rao, RG Rao, L Balazs, R Rao
    Sci Rep, 2018;8(1):16241.
  56. Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
    Authors: JC d'Avila, LD Siqueira, A Mazeraud, EP Azevedo, D Foguel, HC Castro-Far, T Sharshar, F Chrétien, FA Bozza
    J Neuroinflammation, 2018;15(1):28.
    Species: Mouse
    Sample Types: Tissue Homogenates
  57. Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses
    Authors: L Boutens, GJ Hooiveld, S Dhingra, RA Cramer, MG Netea, R Stienstra
    Diabetologia, 2018;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  58. Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects
    Authors: X Xiao, P Saha, BS Yeoh, JA Hipp, V Singh, M Vijay-Kuma
    J. Nutr. Biochem., 2018;62(0):28-34.
    Species: Mouse
    Sample Types: Tissue Homogenates
  59. Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice
    Authors: CW Hui, X Song, F Ma, X Shen, K Herrup
    J Neuroinflammation, 2018;15(1):308.
    Species: Mouse
    Sample Types: Tissue Homogenates
  60. Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages
    Authors: T Karasawa, A Kawashima, F Usui-Kawan, S Watanabe, H Kimura, R Kamata, K Shirasuna, Y Koyama, A Sato-Tomit, T Matsuzaka, H Tomoda, SY Park, N Shibayama, H Shimano, T Kasahara, M Takahashi
    Arterioscler. Thromb. Vasc. Biol., 2018;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  61. Analogous corticosteroids, 9A and EK100, derived from solid-state-cultured mycelium of Antrodia camphorata inhibit proinflammatory cytokine expression in macrophages
    Authors: ST Kao, YH Kuo, SD Wang, HJ Hong, LJ Lin
    Cytokine, 2018;108(0):136-144.
    Species: Mouse
    Sample Types: BALF
  62. Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury
    Authors: HJ Kim, Y Joe, SY Rah, SK Kim, SU Park, J Park, J Kim, J Ryu, GJ Cho, YJ Surh, SW Ryter, UH Kim, HT Chung
    Cell Death Dis, 2018;9(11):1060.
    Species: Mouse
    Sample Types: Serum
  63. Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection
    Authors: V Ciancarell, L Lembo-Fazi, I Paciello, AK Bruno, S Jaillon, S Berardi, M Barbagallo, S Meron-Suda, D Cohen, A Molinaro, G Rossi, C Garlanda, ML Bernardini
    PLoS Pathog., 2018;14(12):e1007469.
    Species: Mouse
    Sample Types: Tissue Homogenates
  64. A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling
    Authors: B Koch, AA Barugahare, TL Lo, C Huang, RB Schittenhe, DR Powell, TH Beilharz, A Traven
    Cell Rep, 2018;25(8):2244-2258.e7.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  65. Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis
    Authors: IM Medeiros-d, CF Gonçalves-, ARM Kurz, FMJ Oliveira, VHP de Abreu, RC Torres, VF Carvalho, V Estato, PT Bozza, M Sperandio, HC de Castro-, AR Silva
    Oxid Med Cell Longev, 2018;2018(0):6053492.
    Species: Mouse
    Sample Types: Peritoneal Lavage Fluid
  66. The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism
    Authors: N Eissa, P Jayaprakas, S Azimullah, SK Ojha, M Al-Houqani, FY Jalal, D ?a?ewska, K Kie?-Konon, B Sadek
    Sci Rep, 2018;8(1):13077.
    Species: Mouse
    Sample Types:
  67. Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis
    Authors: Y Fujita, A Khateb, Y Li, R Tinoco, T Zhang, H Bar-Yoseph, MA Tam, Y Chowers, E Sabo, S Gerassy-Va, E Starosvets, B James, K Brown, SS Shen-Orr, LM Bradley, PA Tessier, ZA Ronai
    Cell Rep, 2018;24(12):3296-3311.e6.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  68. Apigenin Retards Atherogenesis by Promoting ABCA1-Mediated Cholesterol Efflux and Suppressing Inflammation
    Authors: K Ren, T Jiang, HF Zhou, Y Liang, GJ Zhao
    Cell. Physiol. Biochem., 2018;47(5):2170-2184.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  69. HMGB1/IL-1? complexes in plasma microvesicles modulate immune responses to burn injury
    Authors: LG Coleman, R Maile, SW Jones, BA Cairns, FT Crews
    PLoS ONE, 2018;13(3):e0195335.
    Species: Mouse
    Sample Types: Plasma
  70. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
    Authors: SA Conos, KW Chen, D De Nardo, H Hara, L Whitehead, G N£¤ez, SL Masters, JM Murphy, K Schroder, DL Vaux, KE Lawlor, LM Lindqvist, JE Vince
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  71. MyD88-dependent pro-interleukin-1? induction in dendritic cells exposed to food-grade synthetic amorphous silica
    Authors: HC Winkler, J Kornprobst, P Wick, LM von Moos, I Trantakis, EM Schraner, B Bathke, H Hochrein, M Suter, H Naegeli
    Part Fibre Toxicol, 2017;14(1):21.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  72. Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection
    Authors: M Ivin, A Dumigan, FN de Vasconc, F Ebner, M Borroni, A Kavirayani, KN Przybyszew, RJ Ingram, S Lienenklau, U Kalinke, D Stoiber, JA Bengoechea, P Kovarik
    PLoS Pathog., 2017;13(11):e1006696.
    Species: Mouse
    Sample Types: Tissue Homogenates
  73. Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice
    Authors: A Nemmar, P Yuvaraju, S Beegam, MA Fahim, BH Ali
    Oxid Med Cell Longev, 2017;2017(0):9639035.
    Species: Mouse
    Sample Types: Tissue Homogenates
  74. Cathelicidins Inhibit Escherichia coli-Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner
    Authors: M Coorens, VAF Schneider, AM de Groot, A van Dijk, M Meijerink, JM Wells, MR Scheenstra, EJA Veldhuizen, HP Haagsman
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  75. Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance
    Authors: SY Lin, SY Hsieh, YT Fan, WC Wei, PW Hsiao, DH Tsai, TS Wu, NS Yang
    Autophagy, 2017;0(0):0.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  76. Nitric Oxide Modulates Macrophage Responses to Mycobacterium tuberculosis Infection through Activation of HIF-1? and Repression of NF-?B
    Authors: J Braverman, SA Stanley
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  77. Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome
    Authors: V Neudecker, M Haneklaus, O Jensen, L Khailova, JC Masterson, H Tye, K Biette, P Jedlicka, KS Brodsky, ME Gerich, M Mack, AAB Robertson, MA Cooper, GT Furuta, CA Dinarello, LA O'Neill, HK Eltzschig, SL Masters, EN McNamee
    J. Exp. Med., 2017;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  78. The anti-inflammatory and immunomodulatory potential of braylin: Pharmacological properties and mechanisms by in silico, in vitro and in vivo approaches
    Authors: RF Espírito-S, CS Meira, RDS Costa, OP Souza Filh, AF Evangelist, GHG Trossini, GM Ferreira, EDS Velozo, CF Villarreal, MB Pereira So
    PLoS ONE, 2017;12(6):e0179174.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  79. Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia
    Authors: S Paetau, T Rolova, L Ning, CG Gahmberg
    Front Mol Neurosci, 2017;10(0):431.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  80. The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression
    Authors: MS Gresnigt, M Jaeger, RK Subbarao M, O Rasid, G Jouvion, C Fitting, WJG Melchers, TD Kanneganti, A Carvalho, O Ibrahim-Gr, FL van de Vee
    Front Immunol, 2017;8(0):1777.
    Species: Mouse
    Sample Types: BALF
  81. Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice
    Authors: LN Masi, AR Martins, AR Crisma, CL do Amaral, MR Davanso, TDA Serdan, RDC da Cunha d, MM Cruz, MIC Alonso-Val, RP Torres, J Mancini-Fi, JNB Pereira, MM da Silva R, EA Liberti, SM Hirabara, R Curi
    Sci Rep, 2017;7(1):3937.
    Species: Mouse
    Sample Types: Tissue Homogenates
  82. Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection
    Authors: EE Hornick, B Banoth, AM Miller, ZR Zacharias, N Jain, ME Wilson, KN Gibson-Cor, KL Legge, GA Bishop, FS Sutterwala, SL Cassel
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  83. IL-24 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas
    Authors: BX Ross, N Gao, X Cui, TJ Standiford, J Xu, FX Yu
    J. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  84. Respiratory syncytial virus infection of newborn CX3CR1-deficent mice induces a pathogenic pulmonary innate immune response
    Authors: S Das, M Raundhal, J Chen, TB Oriss, R Huff, JV Williams, A Ray, P Ray
    JCI Insight, 2017;2(17):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  85. CRISPR/Cas9 mediated mutation of mouse IL-1? nuclear localisation sequence abolishes expression
    Authors: MJD Daniels, AD Adamson, N Humphreys, D Brough
    Sci Rep, 2017;7(1):17077.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  86. The dataset describes: HIF-1 ? expression and LPS mediated cytokine production in MKP-1 deficient bone marrow derived murine macrophages
    Authors: H Talwar, C Bauerfeld, Y Liu, L Samavati
    Data Brief, 2017;14(0):56-61.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  87. Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia mediated neurodegeneration
    Authors: L Shmuel-Gal, Y Klug, Z Porat, M Charni, B Zarmi, Y Shai
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  88. Elevated prostaglandin E2 post-bone marrow transplant mediates interleukin-1?-related lung injury
    Authors: GJ Martínez-C, QM Taylor, CA Wilke, AB Podsiad, BB Moore
    Mucosal Immunol, 2017;0(0):.
    Species: Mouse
    Sample Types: BALF
  89. P2X7 receptor-dependent tuning of gut epithelial responses to infection
    Authors: SW Huang, C Walker, J Pennock, K Else, W Muller, MJ Daniels, C Pellegrini, D Brough, G Lopez-Cast, SM Cruickshan
    Immunol. Cell Biol, 2017;95(2):178-188.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  90. CLEC5A is a critical receptor in innate immunity against Listeria infection
    Authors: ST Chen, FJ Li, TY Hsu, SM Liang, YC Yeh, WY Liao, TY Chou, NJ Chen, M Hsiao, WB Yang, SL Hsieh
    Nat Commun, 2017;8(1):299.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  91. Immunogenic Dendritic Cell Generation from Pluripotent Stem Cells by Ectopic Expression of Runx3
    Authors: Istvan Szatmari
    J. Immunol., 2016;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  92. Differential humoral and cellular immunity induced by vaccination using plasmid DNA and protein recombinant expressing the NS3 protein of dengue virus type 3
    J. Biomed. Sci, 2016;23(1):85.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  93. Sphingosine-1-Phosphate Receptor 2 Regulates Proinflammatory Cytokine Production and Osteoclastogenesis
    PLoS ONE, 2016;11(5):e0156303.
    Species: Mouse
    Sample Types: Cell Lysates
  94. Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype
    Sci Rep, 2016;6(0):29712.
    Species: Human
    Sample Types: Cell Culture Supernates
  95. The circadian clock regulates inflammatory arthritis
    FASEB J, 2016;0(0):.
    Species: Mouse
    Sample Types: Serum
  96. Klebsiella pneumoniae Siderophores Induce Inflammation, Bacterial Dissemination, and HIF-1? Stabilization during Pneumonia
    MBio, 2016;7(5):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  97. Carvacrol reduces irinotecan-induced intestinal mucositis through inhibition of inflammation and oxidative damage via TRPA1 receptor activation
    Authors: Jand Venes R Medeiros
    Chem. Biol. Interact., 2016;260(0):129-140.
    Species: Mouse
    Sample Types: Tissue Homogenates
  98. Manipulation of Interleukin-1? and Interleukin-18 Production by Yersinia pestis Effectors YopJ and YopM and Redundant Impact on Virulence
    Authors: D Ratner, MP Orning, KK Starheim, R Marty-Roix, MK Proulx, JD Goguen, E Lien
    J. Biol. Chem., 2016;291(19):9894-905.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  99. Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4
    Authors: Kamlesh K Gupta
    Biochem Biophys Res Commun, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
  100. Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection
    Authors: Marieke Pingen
    Immunity, 2016;44(6):1455-69.
    Species: Mouse
    Sample Types: Tissue Homogenates
  101. Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts
    Authors: Arne Yndestad
    Biochim. Biophys. Acta, 2016;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  102. Indoor secondary organic aerosols formation from ozonolysis of monoterpene: An example of d-limonene with ammonia and potential impacts on pulmonary inflammations
    Authors: Rujin Huang
    Sci. Total Environ., 2016;0(0):.
    Species: Mouse
    Sample Types: BALF
  103. Infection-Mediated Priming of Phagocytes Protects against Lethal Secondary Aspergillus fumigatus Challenge
    Authors: A Savers, O Rasid, M Parlato, M Brock, G Jouvion, B Ryffel, JM Cavaillon, G Eberl, O Ibrahim-Gr
    PLoS ONE, 2016;11(4):e0153829.
    Species: Mouse
    Sample Types: Tissue Homogenates
  104. Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation
    J Clin Invest, 2016;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  105. Polarization of macrophages towards M2 phenotype is favored by reduction in iPLA2?
    J Biol Chem, 2016;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  106. LRP1 modulates the microglial immune response via regulation of JNK and NF-?B signaling pathways
    J Neuroinflammation, 2016;13(1):304.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  107. Chrysin promotes attenuation of depressive-like behavior and hippocampal dysfunction resulting from olfactory bulbectomy in mice
    Authors: Silvana Peterini Boeira
    Chem. Biol. Interact., 2016;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  108. The Carbohydrate Lectin Receptor, Dectin-1, Mediates Immune Response to Exserohilum rostratum
    Infect. Immun, 2016;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  109. Cell death is not essential for caspase-1-mediated interleukin-1? activation and secretion
    Cell Death Differ, 2016;0(0):.
  110. Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines
    EBioMedicine, 2016;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  111. A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet
    Authors: G Yang, HE Lee, JY Lee
    Sci Rep, 2016;6(0):24399.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  112. HIF-1? Is an Essential Mediator of IFN-?-Dependent Immunity to Mycobacterium tuberculosis
    J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  113. Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets.
    Authors: Ines Ambite, Manoj Puthia, Karoly Nagy, Caterina Cafaro, Aftab Nadeem, Daniel S C Butler, Gustav Rydström, Nina A Filenko, Björn Wullt, Thomas Miethke, Catharina Svanborg
    PloS Pathogens, 2016;0(0):1553-7374.
    Species: Mouse
    Sample Types: Urine
  114. Caspase-2 deficiency accelerates chemically induced liver cancer in mice
    Cell Death Differ, 2016;0(0):.
    Species: Mouse
    Sample Types: Serum
  115. A Simple Screening Approach To Prioritize Genes for Functional Analysis Identifies a Role for Interferon Regulatory Factor 7 in the Control of Respiratory Syncytial Virus Disease
    Authors: John S Tregoning
    mSystems, 2016;1(3):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  116. Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor
    Sci Rep, 2016;6(0):26490.
    Species: Mouse
    Sample Types: Tissue Homogenates
  117. C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF-?B Activation in Neutrophils
    J Immunol, 2016;196(5):2319-26.
    Species: Mouse
    Sample Types: BALF
  118. Hemocyanins Stimulate Innate Immunity by Inducing Different Temporal Patterns of Proinflammatory Cytokine Expression in Macrophages
    J Immunol, 2016;196(11):4650-62.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  119. Dental Calculus Stimulates Interleukin-1? Secretion by Activating NLRP3 Inflammasome in Human and Mouse Phagocytes
    Authors: JL Montenegro, A Yoshimura, Z Sm, T Kaneko, Y Ozaki, T Ukai, T Miyazaki, E Latz, Y Hara
    PLoS ONE, 2016;11(9):e0162865.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  120. NLRP12 negatively regulates proinflammatory cytokine production and host defense against Brucella abortus
    Eur. J. Immunol., 2016;0(0):.
    Species: Mouse
    Sample Types: Serum
  121. Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.
    Authors: Sester D, Sagulenko V, Thygesen S, Cridland J, Loi Y, Cridland S, Masters S, Genske U, Hornung V, Andoniou C, Sweet M, Degli-Esposti M, Schroder K, Stacey K
    J Immunol, 2015;195(3):1233-41.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  122. Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling.
    Authors: Wu Y, Wu Y, Mo S, Hsiao H, He Y, Lai M
    J Immunol, 2015;195(6):2612-23.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  123. The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling.
    Authors: Fleming B, Chandrasekaran P, Dillon L, Dalby E, Suresh R, Sarkar A, El-Sayed N, Mosser D
    J Leukoc Biol, 2015;98(3):395-407.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  124. Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.
    Authors: Brown A, Murphy A, Lalor S, Leech J, O'Keeffe K, Mac Aogain M, O'Halloran D, Lacey K, Tavakol M, Hearnden C, Fitzgerald-Hughes D, Humphreys H, Fennell J, van Wamel W, Foster T, Geoghegan J, Lavelle E, Rogers T, McLoughlin R
    PLoS Pathog, 2015;11(11):e1005226.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  125. Effects of High-Intensity Swimming on Lung Inflammation and Oxidative Stress in a Murine Model of DEP-Induced Injury.
    Authors: Avila L, Bruggemann T, Bobinski F, da Silva M, Oliveira R, Martins D, Mazzardo-Martins L, Duarte M, de Souza L, Dafre A, Vieira R, Santos A, Bonorino K, Hizume Kunzler D
    PLoS ONE, 2015;10(9):e0137273.
    Species: Mouse
    Sample Types: Tissue Homogenates
  126. Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy.
    Authors: Jabir M, Hopkins L, Ritchie N, Ullah I, Bayes H, Li D, Tourlomousis P, Lupton A, Puleston D, Simon A, Bryant C, Evans T
    Autophagy, 2015;11(1):166-82.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  127. Endoplasmic reticulum stress-induced IRE1alpha activation mediates cross-talk of GSK-3beta and XBP-1 to regulate inflammatory cytokine production.
    Authors: Kim S, Joe Y, Kim H, Kim Y, Jeong S, Pae H, Ryter S, Surh Y, Chung H
    J Immunol, 2015;194(9):4498-506.
    Species: Mouse
    Sample Types: Serum
  128. The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
    Authors: Douglas T, Champagne C, Morizot A, Lapointe J, Saleh M
    J Immunol, 2015;195(5):2365-73.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  129. Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production.
    Authors: Kearney C, Cullen S, Tynan G, Henry C, Clancy D, Lavelle E, Martin S
    Cell Death Differ, 2015;22(8):1313-27.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  130. A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis.
    Authors: Bernard N, Finlay C, Tannahill G, Cassidy J, O'Neill L, Mills K
    Mucosal Immunol, 2015;8(5):982-92.
    Species: Mouse
    Sample Types: Tissue Homogenates
  131. An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1.
    Authors: Shipkowski K, Taylor A, Thompson E, Glista-Baker E, Sayers B, Messenger Z, Bauer R, Jaspers I, Bonner J
    PLoS ONE, 2015;10(6):e0128888.
    Species: Mouse
    Sample Types: BALF
  132. Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2.
    Authors: Secor McVoy J, Oughli H, Oh U
    J Neuroinflammation, 2015;12(0):27.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  133. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
    Authors: Coll R, Robertson A, Chae J, Higgins S, Munoz-Planillo R, Inserra M, Vetter I, Dungan L, Monks B, Stutz A, Croker D, Butler M, Haneklaus M, Sutton C, Nunez G, Latz E, Kastner D, Mills K, Masters S, Schroder K, Cooper M, O'Neill L
    Nat Med, 2015;21(3):248-55.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  134. Toll-like receptor 9 deficiency protects mice against Pseudomonas aeruginosa lung infection.
    Authors: Benmohamed F, Medina M, Wu Y, Maschalidi S, Jouvion G, Guillemot L, Chignard M, Manoury B, Touqui L
    PLoS ONE, 2014;9(3):e90466.
    Species: Mouse
    Sample Types: BALF
  135. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
    Authors: Ataide M, Andrade W, Zamboni D, Wang D, Souza M, Franklin B, Elian S, Martins F, Pereira D, Reed G, Fitzgerald K, Golenbock D, Gazzinelli R
    PLoS Pathog, 2014;10(1):e1003885.
    Species: Mouse
    Sample Types: Whole Blood
  136. Role of IL-1β in experimental cystic fibrosis upon P. aeruginosa infection.
    PLoS ONE, 2014;9(12):e114884.
    Species: Mouse
    Sample Types: Tissue Homogenates
  137. Lack of platelet-activating factor receptor protects mice against diet-induced adipose inflammation and insulin-resistance despite fat pad expansion.
    Authors: Menezes-Garcia Z, Oliveira M, Lima R, Soriani F, Cisalpino D, Botion L, Teixeira M, Souza D, Ferreira A
    Obesity (Silver Spring), 2014;22(3):663-72.
    Species: Mouse
    Sample Types: Tissue Homogenates
  138. Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor.
    Authors: Goncalves-de-Albuquerque C, Burth P, Silva A, de Moraes I, Oliveira F, Santelli R, Freire A, de Lima G, da Silva E, da Silva C, Morandi V, Bozza P, Younes-Ibrahim M, de Castro Faria Neto H, de Castro Faria M
    Respir Res, 2014;15(0):93.
    Species: Mouse
    Sample Types: BALF
  139. Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections.
    Authors: Redlich S, Ribes S, Schutze S, Nau R
    J Neuroinflammation, 2014;11(0):108.
    Species: Mouse
    Sample Types: Tissue Homogenates
  140. IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.
    Authors: Hams, Emily, Armstrong, Michelle, Barlow, Jillian, Saunders, Sean P, Schwartz, Christia, Cooke, Gordon, Fahy, Ruairi J, Crotty, Thomas B, Hirani, Nikhil, Flynn, Robin J, Voehringer, David, McKenzie, Andrew N, Donnelly, Seamas C, Fallon, Padraic
    Proc Natl Acad Sci U S A, 2014;111(1):367-72.
    Species: Mouse
    Sample Types: Tissue Homogenates
  141. Lysosomes integrate metabolic-inflammatory cross-talk in primary macrophage inflammasome activation.
    Authors: Weber K, Schilling J
    J Biol Chem, 2014;289(13):9158-71.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  142. Dendritic cell IL-1alpha and IL-1beta are polyubiquitinated and degraded by the proteasome.
    Authors: Ainscough J, Frank Gerberick G, Zahedi-Nejad M, Lopez-Castejon G, Brough D, Kimber I, Dearman R
    J Biol Chem, 2014;289(51):35582-92.
    Species: Mouse
    Sample Types: Cell Lysates
  143. A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation.
    Authors: Csoka B, Koscso B, Toro G, Kokai E, Virag L, Nemeth Z, Pacher P, Bai P, Hasko G
    Diabetes, 2014;63(3):850-66.
    Species: Mouse
    Sample Types: Plasma
  144. Peripheral inflammation is associated with remote global gene expression changes in the brain.
    Authors: Thomson, Carolyn, McColl, Alison, Cavanagh, Jonathan, Graham, Gerard J
    J Neuroinflammation, 2014;11(0):73.
    Species: Mouse
    Sample Types: Plasma
  145. Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease.
    Authors: Noelker C, Morel L, Osterloh A, Alvarez-Fischer D, Lescot T, Breloer M, Gold M, Oertel W, Henze C, Michel P, Dodel R, Lu L, Hirsch E, Hunot S, Hartmann A
    J Neuroinflammation, 2014;11(0):86.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  146. Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.
    Authors: Dowling J, Becker C, Bourke N, Corr S, Connolly D, Quinn S, Pandolfi P, Mansell A, O'Neill L
    J Biol Chem, 2014;289(10):6429-37.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  147. Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer.
    Authors: Viennois E, Xiao B, Ayyadurai S, Wang L, Wang P, Zhang Q, Chen Y, Merlin D
    Lab Invest, 2014;94(9):950-65.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  148. The role of Nox2-derived ROS in the development of cognitive impairment after sepsis.
    Authors: Hernandes M, D'Avila J, Trevelin S, Reis P, Kinjo E, Lopes L, Castro-Faria-Neto H, Cunha F, Britto L, Bozza F
    J Neuroinflammation, 2014;11(0):36.
    Species: Mouse
    Sample Types: Peritoneal Fluid
  149. PPAR-gamma/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis.
    Authors: Ferreira A, Sisti F, Sonego F, Wang S, Filgueiras L, Brandt S, Serezani A, Du H, Cunha F, Alves-Filho J, Serezani C
    J Immunol, 2014;192(5):2357-65.
    Species: Mouse
    Sample Types: Serum
  150. MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection.
    Authors: Berod L, Stuve P, Swallow M, Arnold-Schrauf C, Kruse F, Gentilini M, Freitag J, Holzmann B, Sparwasser T
    Eur J Immunol, 2014;44(5):1399-409.
    Species: Mouse
    Sample Types: Serum
  151. Role of the aryl hydrocarbon receptor in the immune response profile and development of pathology during Plasmodium berghei Anka infection.
    Authors: Brant F, Miranda A, Esper L, Rodrigues D, Kangussu L, Bonaventura D, Soriani F, Pinho V, Souza D, Rachid M, Weiss L, Tanowitz H, Teixeira M, Teixeira A, Machado F
    Infect Immun, 2014;82(8):3127-40.
    Species: Mouse
    Sample Types: Tissue Homogenates
  152. The effect of size on Ag nanosphere toxicity in macrophage cell models and lung epithelial cell lines is dependent on particle dissolution.
    Authors: Hamilton, Raymond, Buckingham, Sarah, Holian, Andrij
    Int J Mol Sci, 2014;15(4):6815-30.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  153. Role of lysosomes in silica-induced inflammasome activation and inflammation in absence of MARCO.
    Authors: Biswas R, Hamilton R, Holian A
    J Immunol Res, 2014;2014(0):304180.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  154. Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw.
    Authors: Calil I, Zarpelon A, Guerrero A, Alves-Filho J, Ferreira S, Cunha F, Cunha T, Verri W
    PLoS ONE, 2014;9(3):e90013.
    Species: Mouse
    Sample Types: Tissue Homogenates
  155. ASC in renal collecting duct epithelial cells contributes to inflammation and injury after unilateral ureteral obstruction.
    Authors: Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S, Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M
    Am J Pathol, 2014;184(5):1287-98.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  156. Staphylococcus aureus infection of mice expands a population of memory gammadelta T cells that are protective against subsequent infection.
    Authors: Murphy A, O'Keeffe K, Lalor S, Maher B, Mills K, McLoughlin R
    J Immunol, 2014;192(8):3697-708.
    Species: Mouse
    Sample Types: Peritoneal Lavage Fluid
  157. No Impairment in host defense against Streptococcus pneumoniae in obese CPEfat/fat mice.
    Authors: Mancuso P, O Brien E, Prano J, Goel D, Aronoff D
    PLoS ONE, 2014;9(9):e106420.
    Species: Mouse
    Sample Types: Serum
  158. Protective or deleterious role of scavenger receptors SR-A and CD36 on host resistance to Staphylococcus aureus depends on the site of infection.
    Authors: Blanchet C, Jouvion G, Fitting C, Cavaillon J, Adib-Conquy M
    PLoS ONE, 2014;9(1):e87927.
    Species: Mouse
    Sample Types: Plasma
  159. Sustained Na+/H+ exchanger activation promotes gliotransmitter release from reactive hippocampal astrocytes following oxygen-glucose deprivation.
    Authors: Cengiz P, Kintner D, Chanana V, Yuan H, Akture E, Kendigelen P, Begum G, Fidan E, Uluc K, Ferrazzano P, Sun D
    PLoS ONE, 2014;9(1):e84294.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  160. Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization.
    Authors: Tatano Y, Shimizu T, Tomioka H
    Sci Rep, 2014;4(0):4146.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  161. Rift Valley fever virus infection induces activation of the NLRP3 inflammasome.
    Authors: Ermler M, Traylor Z, Patel K, Schattgen S, Vanaja S, Fitzgerald K, Hise A
    Virology, 2013;449(0):174-80.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  162. NLRP3 inflammasome activation by Paracoccidioides brasiliensis.
    Authors: Tavares A, Magalhaes K, Almeida R, Correa R, Burgel P, Bocca A
    PLoS Negl Trop Dis, 2013;7(12):e2595.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  163. The lung inflammation and skeletal muscle wasting induced by subchronic cigarette smoke exposure are not altered by a high-fat diet in mice.
    Authors: Hansen, Michelle, Chen, Hui, Jones, Jessica, Langenbach, Shenna Y, Vlahos, Ross, Gualano, Rosa C, Morris, Margaret, Anderson, Gary P
    PLoS ONE, 2013;8(11):e80471.
    Species: Mouse
    Sample Types: Tissue Homogenates
  164. Ghrelin inhibits LPS-induced release of IL-6 from mouse dopaminergic neurones.
    Authors: Beynon A, Brown M, Wright R, Rees M, Sheldon I, Davies J
    J Neuroinflammation, 2013;10(0):40.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  165. Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model.
    Authors: Everitt, Aaron R, Clare, Simon, McDonald, Jacqueli, Kane, Leanne, Harcourt, Katherin, Ahras, Malika, Lall, Amar, Hale, Christin, Rodgers, Angela, Young, Douglas, Haque, Ashraful, Billker, Oliver, Tregoning, John S, Dougan, Gordon, Kellam, Paul
    PLoS ONE, 2013;8(11):e80723.
    Species: Mouse
    Sample Types: BALF
  166. TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis.
    Authors: Park Y, Yoon S, Suh H, Kim D, Park J, Jung H, Kim T, Yoon S, Min J, Na H, Lee S, Lee H, Lee Y, Lee H, Choi I
    PLoS Pathog, 2013;9(10):e1003646.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  167. Further evidence for an anti-inflammatory role of artesunate in experimental cerebral malaria.
    Authors: Miranda A, Brant F, Rocha N, Cisalpino D, Rodrigues D, Souza D, Machado F, Rachid M, Teixeira A, Campos A
    Malar J, 2013;12(0):388.
    Species: Mouse
    Sample Types: Tissue Homogenates
  168. A pseudopterane diterpene isolated from the octocoral Pseudopterogorgia acerosa inhibits the inflammatory response mediated by TLR-ligands and TNF-alpha in macrophages.
    Authors: Gonzalez Y, Doens D, Santamaria R, Ramos M, Restrepo C, Barros de Arruda L, Lleonart R, Gutierrez M, Fernandez P
    PLoS ONE, 2013;8(12):e84107.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  169. Milano summer particulate matter (PM10) triggers lung inflammation and extra pulmonary adverse events in mice.
    Authors: Farina F, Sancini G, Battaglia C, Tinaglia V, Mantecca P, Camatini M, Palestini P
    PLoS ONE, 2013;8(2):e56636.
    Species: Mouse
    Sample Types: BALF
  170. A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL-10 dependent derivatives of inflammatory monocytes.
    Authors: Fevre C, Almeida A, Taront S, Pedron T, Huerre M, Prevost M, Kieusseian A, Cumano A, Brisse S, Sansonetti P, Tournebize R
    EMBO Mol Med, 2013;5(4):516-30.
    Species: Mouse
    Sample Types: Tissue Homogenates
  171. Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation.
    Authors: Horton J, Hudak K, Chung E, White A, Scroggins B, Burkeen J, Citrin D
    Stem Cells, 2013;31(10):2231-41.
    Species: Mouse
    Sample Types: Tissue Homogenates
  172. Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model.
    Authors: Alvarez-Fischer D, Noelker C, Vulinovic F, Grunewald A, Chevarin C, Klein C, Oertel W, Hirsch E, Michel P, Hartmann A
    PLoS ONE, 2013;8(4):e61700.
    Species: Mouse
    Sample Types: Tissue Homogenates
  173. Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice.
    Authors: Waddell A, Ahrens R, Tsai Y, Sherrill J, Denson L, Steinbrecher K, Hogan S
    J Immunol, 2013;190(9):4773-85.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  174. Influence of hypoxia-inducible factor 1-alpha on dendritic cell differentiation and migration.
    Authors: Kohler T, Reizis B, Johnson RS, Weighardt H, Forster I
    Eur. J. Immunol., 2012;42(5):1226-36.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  175. TLR9 and MyD88 are crucial for the development of protective immunity to malaria.
    Authors: Gowda NM, Wu X, Gowda DC
    J. Immunol., 2012;188(10):5073-85.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  176. Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection.
    Authors: Veliz Rodriguez T, Moalli F, Polentarutti N, Paroni M, Bonavita E, Anselmo A, Nebuloni M, Mantero S, Jaillon S, Bragonzi A, Mantovani A, Riva F, Garlanda C
    Infect. Immun., 2012;80(1):100-9.
    Species: Mouse
    Sample Types: Serum
  177. Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response.
    Authors: Oh J, Lee R, Yu J, Ko J, Lee H, Ko A, Roddy G, Prockop D
    Mol Ther, 2012;20(11):2143-52.
    Species: Mouse
    Sample Types: Tissue Homogenates
  178. Dok2 mediates the CD200Fc attenuation of Abeta-induced changes in glia.
    Authors: Lyons A, Downer E, Costello D, Murphy N, Lynch M
    J Neuroinflammation, 2012;9(0):107.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  179. Macrophage Dectin-1 Expression Is Controlled by Leukotriene B4 via a GM-CSF/PU.1 Axis.
    Authors: Serezani CH, Kane S, Collins L
    J. Immunol., 2012;189(2):906-15.
    Species: Mouse
    Sample Types: BALF
  180. Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury.
    Authors: Sato A, Ohtaki H, Tsumuraya T, Song D, Ohara K, Asano M, Iwakura Y, Atsumi T, Shioda S
    J Neuroinflammation, 2012;9(0):65.
    Species: Mouse
    Sample Types: Tissue Homogenates
  181. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
    Authors: El-Behi M, Ciric B, Dai H
    Nat. Immunol., 2011;12(6):568-75.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  182. The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in Chronic Lung Infection Caused by Pseudomonas aeruginosa.
    Authors: Moalli F, Paroni M, Veliz Rodriguez T, Riva F, Polentarutti N, Bottazzi B, Valentino S, Mantero S, Nebuloni M, Mantovani A, Bragonzi A, Garlanda C
    J. Immunol., 2011;186(9):5425-34.
    Species: Mouse
    Sample Types: Tissue Homogenates
  183. CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition.
    Authors: Barber DL, Mayer-Barber KD, Feng CG
    J. Immunol., 2011;186(3):1598-607.
    Species: Mouse
    Sample Types: BALF
  184. Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens.
    Authors: Burton OT, Gibbs S, Miller N, Jones FM, Wen L, Dunne DW, Cooke A, Zaccone P
    Eur. J. Immunol., 2010;40(8):2221-9.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  185. Tyrosine kinase 2 controls IL-1beta production at the translational level.
    Authors: Radwan M, Stiefvater R, Grunert T, Sharif O, Miller I, Marchetti-Deschmann M, Allmaier G, Gemeiner M, Knapp S, Kovarik P, Muller M, Strobl B
    J. Immunol., 2010;185(6):3544-53.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  186. Distinct roles of hepatocyte- and myeloid cell-derived IL-1 receptor antagonist during endotoxemia and sterile inflammation in mice.
    Authors: Lamacchia C, Palmer G, Bischoff L, Rodriguez E, Talabot-Ayer D, Gabay C
    J. Immunol., 2010;185(0):2516-24.
    Species: Mouse
    Sample Types: Serum
  187. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5.
    Authors: Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S, Sitaraman SV, Knight R, Ley RE, Gewirtz AT
    Science, 2010;328(5975):228-31.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  188. Toll-like receptor 4 mediates the response of epithelial and stromal cells to lipopolysaccharide in the endometrium.
    Authors: Sheldon IM, Roberts MH,
    PLoS ONE, 2010;5(9):e12906.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  189. A critical role for C5L2 in the pathogenesis of experimental allergic asthma.
    Authors: Zhang X, Schmudde I, Laumonnier Y, Pandey MK, Clark JR, Konig P, Gerard NP, Gerard C, Wills-Karp M, Kohl J
    J. Immunol., 2010;185(11):6741-52.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  190. P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases.
    Authors: Lopez-Castejon G, Theaker J, Pelegrin P
    J. Immunol., 2010;185(4):2611-9.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  191. Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity.
    Authors: Sellge G, Magalhaes JG, Konradt C, Fritz JH, Salgado-Pabon W, Eberl G, Bandeira A, Di Santo JP, Sansonetti PJ, Phalipon A
    J. Immunol., 2010;184(4):2076-85.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  192. IL-27 mediates the response to IFN-beta therapy in multiple sclerosis patients by inhibiting Th17 cells.
    Authors: Sweeney CM, Lonergan R, Basdeo SA, Kinsella K, Dungan LS, Higgins SC, Kelly PJ, Costelloe L, Tubridy N, Mills KH, Fletcher JM
    Brain Behav. Immun., 2010;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  193. IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema.
    Authors: Couillin I, Vasseur V, Charron S, Gasse P, Tavernier M, Guillet J, Lagente V, Fick L, Jacobs M, Coelho FR, Moser R, Ryffel B
    J. Immunol., 2009;183(12):8195-202.
    Species: Mouse
    Sample Types: BALF
  194. A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARgamma-mediated suppression of toll-like receptor 4.
    Authors: Reynolds CM, Draper E, Keogh B, Rahman A, Moloney AP, Mills KH, Loscher CE, Roche HM
    J. Nutr., 2009;139(12):2351-7.
    Species: Mouse
    Sample Types: Serum
  195. The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages.
    Authors: Scatizzi JC, Mavers M, Hutcheson J, Young B, Shi B, Pope RM, Ruderman EM, Samways DS, Corbett JA, Egan TM, Perlman H
    Eur. J. Immunol., 2009;39(3):820-5.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  196. Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy.
    Authors: Jaffre F, Bonnin P, Callebert J, Debbabi H, Setola V, Doly S, Monassier L, Mettauer B, Blaxall BC, Launay JM, Maroteaux L
    Circ. Res., 2009;104(1):113-23.
    Species: Mouse
    Sample Types: Plasma
  197. TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia.
    Authors: Lagler H, Sharif O, Haslinger I, Matt U, Stich K, Furtner T, Doninger B, Schmid K, Gattringer R, de Vos AF, Knapp S
    J. Immunol., 2009;183(3):2027-36.
    Species: Mouse
    Sample Types: Tissue Homogenates
  198. E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection.
    Authors: Aronoff DM, Lewis C, Serezani CH, Eaton KA, Goel D, Phipps JC, Peters-Golden M, Mancuso P
    J. Immunol., 2009;183(4):2642-9.
    Species: Mouse
    Sample Types: BALF
  199. Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent.
    Authors: Doz E, Noulin N, Boichot E, Guenon I, Fick L, Le Bert M, Lagente V, Ryffel B, Schnyder B, Quesniaux VF, Couillin I
    J. Immunol., 2008;180(2):1169-78.
    Species: Mouse
    Sample Types: Tissue Homogenates
  200. Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection.
    Authors: Bozza S, Zelante T, Moretti S, Bonifazi P, DeLuca A, D'Angelo C, Giovannini G, Garlanda C, Boon L, Bistoni F, Puccetti P, Mantovani A, Romani L
    J. Immunol., 2008;180(6):4022-31.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  201. Induction of IL-33 expression and activity in central nervous system glia.
    Authors: Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT
    J. Leukoc. Biol., 2008;84(3):631-43.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  202. Divergent effects of hypoxia on dendritic cell functions.
    Authors: Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen IH, Sozzani S, Austyn JM, Mantovani A, Sica A
    Blood, 2008;112(9):3723-34.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  203. Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis.
    Authors: Kaya Z, Goser S, Buss SJ, Leuschner F, Ottl R, Li J, Volkers M, Zittrich S, Pfitzer G, Rose NR, Katus HA
    Circulation, 2008;118(20):2063-72.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  204. Mutual modulation between interleukin-10 and interleukin-6 induced by Rhodococcus aurantiacus infection in mice.
    Authors: Yimin, Kohanawa M, Ozaki M, Haga S, Fujikawa K, Zhao S, Kuge Y, Tamaki N
    Microbes Infect., 2008;10(14):1450-8.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  205. Differential ex vivo nitric oxide production by acutely isolated neonatal and adult microglia.
    Authors: Schell JB, Crane CA, Smith MF, Roberts MR
    J. Neuroimmunol., 2007;189(1):75-87.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  206. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.
    Authors: Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I
    J. Clin. Invest., 2007;117(12):3786-99.
    Species: Mouse
    Sample Types: BALF
  207. CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.
    Authors: Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J
    Neurobiol. Dis., 2007;29(2):336-53.
    Species: Mouse
    Sample Types: Plasma
  208. Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.
    Authors: Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ
    Immunity, 2007;26(4):445-59.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  209. Glucose-6-phosphate dehydrogenase deficiency and the inflammatory response to endotoxin and polymicrobial sepsis.
    Authors: Wilmanski J, Villanueva E, Deitch EA, Spolarics Z
    Crit. Care Med., 2007;35(2):510-8.
    Species: Mouse
    Sample Types: Plasma
  210. Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis.
    Authors: Hegde A, Zhang H, Moochhala SM, Bhatia M
    J. Leukoc. Biol., 2007;82(3):678-85.
    Species: Mouse
    Sample Types: Plasma
  211. Lactoferrin enhanced efficacy of the BCG vaccine to generate host protective responses against challenge with virulent Mycobacterium tuberculosis.
    Authors: Hwang SA, Wilk KM, Budnicka M, Olsen M, Bangale YA, Hunter RL, Kruzel ML, Actor JK
    Vaccine, 2007;25(37):6730-43.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  212. ABCC transporter inhibition reduces zymosan-induced peritonitis.
    Authors: Leite DF, Echevarria-Lima J, Ferreira SC, Calixto JB, Rumjanek VM
    J. Leukoc. Biol., 2007;82(3):630-7.
    Species: Mouse
    Sample Types: Tissue Secretion
  213. Deletion of TLR5 results in spontaneous colitis in mice.
    Authors: Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT
    J. Clin. Invest., 2007;117(12):3909-21.
    Species: Mouse
    Sample Types: Serum
  214. Involvement of vitronectin in lipopolysaccaride-induced acute lung injury.
    Authors: Tsuruta Y, Park YJ, Siegal GP, Liu G, Abraham E
    J. Immunol., 2007;179(10):7079-86.
    Species: Mouse
    Sample Types: Tissue Homogenates
  215. Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes.
    Authors: Tjwa M, Bellido-Martin L, Lin Y, Lutgens E, Plaisance S, Bono F, Delesque-Touchard N, Herve C, Moura R, Billiau AD, Aparicio C, Levi M, Daemen M, Dewerchin M, Lupu F, Arnout J, Herbert JM, Waer M, Garcia de Frutos P, Dahlback B, Carmeliet P, Hoylaerts MF, Moons L
    Blood, 2007;111(8):4096-105.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  216. TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells.
    Authors: Higgins SC, Jarnicki AG, Lavelle EC, Mills KH
    J. Immunol., 2006;177(11):7980-9.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  217. The effects of dehydroepiandrosterone (DHEA) on in vitro spleen cell proliferation and cytokine production.
    Authors: Powell JM, Sonnenfeld G
    J. Interferon Cytokine Res., 2006;26(1):34-9.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  218. Anti-tumor necrosis factor alpha F(ab')2 antibody fragments protect in murine polymicrobial sepsis: concentration and early intervention are fundamental to the outcome.
    Authors: Marquez-Velasco R, Bojalil R, Buelna A, Flores-Guzman F, Estevez-Ramirez J, Laguna J, Hernandez AM, Diaz-Quinonez A, Paniagua-Solis JF
    Inflamm. Res., 2006;55(9):378-84.
    Species: Mouse
    Sample Types: Serum
  219. Choosing the frequency of deep inflation in mice: balancing recruitment against ventilator-induced lung injury.
    Authors: Allen GB, Suratt BT, Rinaldi L, Petty JM, Bates JH
    Am. J. Physiol. Lung Cell Mol. Physiol., 2006;291(4):L710-7.
    Species: Mouse
    Sample Types: BALF
  220. Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals.
    Authors: Scott P, Ma H, Viriyakosol S, Terkeltaub R, Liu-Bryan R
    J. Immunol., 2006;177(9):6370-8.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  221. Attenuation of primary nonfunction for syngeneic islet graft using sodium 4-phenylbutyrate.
    Authors: Fu SH, Chen ST, Hsu BR
    Transplant. Proc., 2005;37(4):1830-1.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  222. Anti-inflammatory activity in the aqueous crude extract of the leaves of Nidularium procerum: A bromeliaceae from the Brazilian coastal rain forest.
    Authors: Amendoeira FC, Frutuoso VS, Zanon C, Chedier LM, Figueiredo MR, Kaplan MA, Bandeira-Melo C, Bozza PT, Castro-Faria-Neto HC
    Biol. Pharm. Bull., 2005;28(6):1010-5.
    Species: Mouse
    Sample Types: Pleural Fluid
  223. An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia.
    Authors: Hajjar AM, Harowicz H, Liggitt HD, Fink PJ, Wilson CB, Skerrett SJ
    Am. J. Respir. Cell Mol. Biol., 2005;33(5):470-5.
    Species: Mouse
    Sample Types: Tissue Homogenates
  224. Toll-like receptor 2 (TLR2) mediates astrocyte activation in response to the Gram-positive bacterium Staphylococcus aureus.
    Authors: Esen N, Tanga FY, DeLeo JA, Kielian T
    J. Neurochem., 2004;88(3):746-58.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  225. Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions.
    Authors: Aviles H, Belay T, Vance M, Sun B, Sonnenfeld G
    J. Appl. Physiol., 2004;97(4):1437-44.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  226. ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer's disease.
    Authors: Evans C, Miners J, Piva G, Willis C, Heard D, Kidd E, Good M, Kehoe P
    Acta Neuropathol, 0;139(3):485-502.
    Species: Mouse
    Sample Types: Tissue Homogenates
  227. TLR2 deletion promotes arthritis through reduction of IL-10.
    Authors: Huang Q, Koessler R, Birkett R, Perlman H, Xing L, Pope R
    J Leukoc Biol, 0;93(5):751-9.
    Species: Mouse
    Sample Types: Tissue Homogenates

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Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 10/20/2020
Application: Sample Tested: THP-1 human acute monocytic leukemia cell line

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 09/11/2019
Application: Sample Tested: mouse macrophages

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 08/06/2019
Application: Sample Tested: Bone marrow-derived dendritic cells

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 05/20/2019
Application: Sample Tested: Adult lung

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 12/11/2018
Application: Sample Tested: Serum and Plasma

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 07/27/2018
Application: Sample Tested: Brain (glial cell in hippocampus)

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 07/17/2018
Application: Sample Tested: J774A.1 mouse reticulum cell sarcoma macrophage cell line

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 07/13/2018
Application: Sample Tested: Cell culture supernatant

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 11/22/2017
Application: Sample Tested: mouse primary microglia cells

We needed to calibrate the dilutions of our samples.


Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 09/27/2017
Application: Sample Tested: Peritoneal resident macrophages

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 07/21/2017
Application: Sample Tested: Brain tissue

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 05/24/2017
Application: Sample Tested: Plasma

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 05/22/2017
Application: Sample Tested: Whole blood

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 04/19/2017
Application: Sample Tested: Lung tissue

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 07/05/2016
Application: Sample Tested: Mouse plasma samples

Mouse IL-1 beta/IL-1F2 DuoSet ELISA
By Anonymous on 05/24/2016
Application: Sample Tested: BMDC cells stimulated with LPS for 4 hrs,Bone marrow-derived dendritic cells

Mouse IL-1 beta/IL-1F2 DuoSet ELISA, 15 Plate
By Anonymous on 04/05/2016
Application: Sample Tested: murine lung homogenate supernatant

lungs were homogenized in PBS-T, and sup was filtered through 0.22um filter before use. Homogenate was diluted 1:3 for analysis by ELISA.


Mouse IL-1 beta/IL-1F2 DuoSet ELISA, 15 Plate
By Anonymous on 10/26/2015
Application: Sample Tested: Purified mouse IL-1beta protein

50ul of murine IL-1beta Capture antibody (4ug/mL) was coated per well of a 96 well plate at 4 degrees overnight. Purified IL-1beta standard was diluted (7 fold) and assayed to ensure the quality of the ELISA. Mouse IL-1beta Detector antibody was added (2h @ RT) followed by a 20 min incubation with Streptavidin-HRP. Substrate solution was added to measure IL-1beta concentration according to the manufactures protocol. The standard curve looked great as can be seen by calculation of the R- squared value. Highly recommend doing ELISA's using kits from R&D.
Buffer: 7-point standard curve