Mouse IL-15R alpha APC-conjugated Antibody Summary
Accession # Q60819
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of IL‑15 R alpha in C57BL/6 Mouse Bone Marrow Cells by Flow Cytometry. C57BL/6 mouse bone marrow cells treated with 20 ng/mL Recombinant Mouse GM-CSF (Catalog # 415-ML) for 5 days, 1 µg/mL LPS on day 6, and harvested on day 7 were stained with Rat Anti-Mouse IL-15 Ra APC-conjugated Monoclonal Antibody (Catalog # FAB5511A, filled histogram) or isotype control antibody (Catalog # IC013A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: IL-15R alpha
Interleukin 15 Receptor alpha (IL-15 R alpha ) is a high affinity receptor that specifically binds IL-15 with high affinity and associates as a heterotrimer with the IL-2 receptors beta and gamma subunits to initiate signal transduction. IL-15 R alpha is expressed on a wide variety of T cells and B cells as well as non-lymphoid cells. IL‑15 R alpha is a 58-60 kDa protein that shares structural similarities to the IL-2 R alpha protein. IL-15 R alpha and IL-2 R alpha genes also share similar intron-exon organization and are closely linked on human chromosome 10p14-p15. Human IL-15 R alpha shares 45% amino acid (aa) homology with the mouse form of the receptor. Signaling of IL-15 can occur in one of three ways; through the heterotrimeric complex of IL-15 R alpha, IL-2 R beta and IL-2 R gamma c, through the heterodimeric complex of IL-2 receptors beta and gamma common, and through a novel 60-65 kDa IL-15 RX subunit found on mast cells. The binding of IL-15 to IL-15 R alpha has been reported to antagonize the TNF‑ alpha ‑mediated apoptosis in fibroblasts by competing with TNFRI for TRAF2 binding.
Citation for Mouse IL-15R alpha APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Reprogramming the lung microenvironment by inhaled immunotherapy fosters immune destruction of tumor
Authors: Valentino Le Noci
Sample Types: Whole Cells
Applications: Flow Cytometry
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