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Mouse IL-18 DuoSet ELISA

Name: Mouse IL-18 DuoSet ELISA
Brand: R&D Systems
SKU: DY7625-05
Price: 450 USD
Availability: InStock
Rating: 4.75 (8 reviews)

R&D Systems | Catalog # DY7625-05

(8)

Citations (63)

Product Documents

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Product Specifications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Assay Range

46.9-3000 pg/mL

Sample Type

Cell culture supernates, serum, and plasma
Note: Diluents for complex matrices, such as serum and plasma, should be evaluated prior to use in this DuoSet

Reactivity

Mouse

View all IL-18/IL-1F4 ELISA Kits »

Product Specifications

Detection Method

Colorimetric ELISA - 450nm (TMB)

Conjugate

Biotin

Specificity

Please see the product datasheet

Label

HRP

Preparation and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IL-18/IL-1F4

Interleukin 18 (IL-18), also known as interferon-gamma-inducing factor (IGIF) and IL-1 gamma, is a cytokine which shares biologic activities with IL-12 and structural similarities with the IL-1 family of proteins. IL-18 was originally cloned from liver cells and has since been shown to be expressed by monocyte/macrophages, osteoblasts and keratinocytes. Caspase-1 (IL-1 beta-converting enzyme) has been implicated in the physiological processing of pro-IL-18 to IL-18. Similarly to IL-12, human IL-18 has been shown to enhance NK cell activity in PBMC cultures. Human IL-18 has also been found to induce the production IFN-gamma and GM-CSF while inhibiting the production of IL-10 by PBMC. On enriched human T cells, human IL-18 can enhance Th1 cytokine production and stimulate cell proliferation via an IL-2-dependent pathway. In the mouse system, IL-18 has been shown to be a costimulatory factor for the activation of Th1, but not Th2, cells. IL-18 was found to selectively enhance the FasL-mediated cytotoxicity of Th1, but not Th0 or Th2, cells. IL-18 has also been shown to induce activated B cells to produce IFN-gamma that inhibits IgE production.

Long Name

Interleukin 18

Alternate Names

IGIF, IL-1F4, IL-1g, IL18

Entrez Gene IDs

3606 (Human); 16173 (Mouse); 29197 (Rat); 397057 (Porcine); 574151 (Primate)

Gene Symbol

IL18

Additional IL-18/IL-1F4 Products

Product Documents for Mouse IL-18 DuoSet ELISA

Download Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Mouse IL-18 DuoSet ELISA

For research use only

Related Research Areas

Cytokines and Receptors in Angiogenesis

Group 1 ILCs

IL-1 Family

Isolation, Culture, and Identification of Natural Killer Cells

Macrophage Activation Markers

Microglia Activation Markers

NOD-like Receptors and the Inflammasome

T Cell Cytokine Signaling

Citations for Mouse IL-18 DuoSet ELISA

Customer Reviews for Mouse IL-18 DuoSet ELISA (8)

4.8 out of 5

8 Customer Ratings

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Mouse IL-18 DuoSet ELISA

Name: Anonymous

Sample Tested: RAW 264.7 mouse monocyte/macrophage cell line

Verified Customer | Posted 05/29/2024

The kit works well
Mouse IL-18 DuoSet ELISA

Name: Anonymous

Sample Tested: mouse lung

Verified Customer | Posted 10/05/2023
Mouse IL-18 DuoSet ELISA

Name: Anonymous

Sample Tested: EDTA Plasma

Verified Customer | Posted 05/19/2023
Mouse IL-18 DuoSet ELISA

Name: Anonymous

Sample Tested: bronchoalviolar fluid

Verified Customer | Posted 04/17/2023
Mouse IL-18 DuoSet ELISA

Name: Do-Hyun Kim

Sample Tested: Plasma

Verified Customer | Posted 02/03/2023
Mouse IL-18 DuoSet ELISA

Name: Anonymous

Sample Tested: Serum

Verified Customer | Posted 01/31/2023
Mouse IL-18 DuoSet ELISA

Name: Anonymous

Sample Tested: Cell culture supernatant

Verified Customer | Posted 10/26/2022

Cell culture supernatant from transfected BHK-21 cells
Mouse IL-18 DuoSet ELISA

Name: Tauseef Ahmad

Sample Tested: Cell culture supernatant

Verified Customer | Posted 05/23/2022