Mouse IL-18 DuoSet ELISA

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Mouse IL-18 DuoSet ELISA Summary

Assay Range
46.9 - 3,000 pg/mL
Please see the product datasheet

* Provided that the recommended microplates, buffers, diluents, substrates and solutions are used, and the assay is run as summarized in the Assay Procedure provided.

Product Datasheets

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Preparation and Storage

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IL-18/IL-1F4

Interleukin 18 (IL-18), also known as interferon-gamma-inducing factor (IGIF) and IL-1 gamma, is a cytokine which shares biologic activities with IL-12 and structural similarities with the IL-1 family of proteins. IL-18 was originally cloned from liver cells and has since been shown to be expressed by monocyte/macrophages, osteoblasts and keratinocytes. Caspase-1 (IL-1 beta-converting enzyme) has been implicated in the physiological processing of pro-IL-18 to IL-18. Similarly to IL-12, human IL-18 has been shown to enhance NK cell activity in PBMC cultures. Human IL-18 has also been found to induce the production IFN-gamma and GM-CSF while inhibiting the production of IL-10 by PBMC. On enriched human T cells, human IL-18 can enhance Th1 cytokine production and stimulate cell proliferation via an IL-2-dependent pathway. In the mouse system, IL-18 has been shown to be a costimulatory factor for the activation of Th1, but not Th2, cells. IL-18 was found to selectively enhance the FasL-mediated cytotoxicity of Th1, but not Th0 or Th2, cells. IL-18 has also been shown to induce activated B cells to produce IFN-gamma that inhibits IgE production.

Long Name:
Interleukin 18
Entrez Gene IDs:
3606 (Human); 16173 (Mouse); 29197 (Rat); 397057 (Porcine); 574151 (Primate)
Alternate Names:
Iboctadekin; IFN-gamma-inducing factor; IGIF; IGIFIL-1 gamma; IL18; IL-18; IL-18MGC12320; IL-1F4; IL1F4iboctadekin; IL-1g; Interferon gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor); Interleukin-1 gamma; interleukin-18

Citations for Mouse IL-18 DuoSet ELISA

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

15 Citations: Showing 1 - 10
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  1. Discovery of anti-neuroinflammatory agents from 1,4,5,6-tetrahydrobenzo[2,3]oxepino[4,5-d]pyrimidin-2-amine derivatives by regulating microglia polarization
    Authors: Yang, Y;Gao, ZF;Hou, GG;Meng, QG;Hou, Y;
    European journal of medicinal chemistry
    Species: Mouse
    Sample Types: Cell Culture Supernates
  2. Inflammasome activation occurs in CD4+ and CD8+ T cells during graft-versus-host disease
    Authors: Talley, S;Rademacher, DJ;Campbell, EM;
    Cell death & disease
    Species: Mouse
    Sample Types: Cell Culture Supernates
  3. Salmonella Enteritidis T1SS protein SiiD inhibits NLRP3 inflammasome activation via repressing the mtROS-ASC dependent pathway
    Authors: Guo, Y;Gu, D;Huang, T;Li, A;Zhou, Y;Kang, X;Meng, C;Xiong, D;Song, L;Jiao, X;Pan, Z;
    PLoS pathogens
    Species: Transgenic Mouse, Mouse
    Sample Types: Cell Culture Supernates, Serum
  4. Kamuvudine-9 Protects Retinal Structure and Function in a Novel Model of Experimental Rhegmatogenous Retinal Detachment
    Authors: Huang, P;Thomas, CC;Ambati, K;Dholkawala, R;Nagasaka, A;Yerramothu, P;Narendran, S;Pereira, F;Nagasaka, Y;Apicella, I;Cai, X;Makin, RD;Magagnoli, J;Stains, CI;Yin, R;Wang, SB;Gelfand, BD;Ambati, J;
    Investigative ophthalmology & visual science
    Species: Mouse
    Sample Types: Tissue Homogenates
  5. IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii
    Authors: JT Clark, OE Weizman, DL Aldridge, LA Shallberg, J Eberhard, Z Lanzar, D Wasche, JD Huck, T Zhou, AM Ring, CA Hunter
    Cell Reports, 2023-02-23;42(3):112147.
    Species: Mouse
    Sample Types: Serum
  6. Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization
    Authors: KK Jang, T Heaney, M London, Y Ding, F Yeung, D Ercelen, YH Chen, J Axelrad, S Gurunathan, A Marijke Ke, ME Griffin, HC Hang, K Cadwell
    bioRxiv : the preprint server for biology, 2023-02-01;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  7. Blockage of KHSRP-NLRP3 by MCC950 Can Reverse the Effect of Manganese-Induced Neuroinflammation in N2a Cells and Rat Brain
    Authors: S Singh, IA Shaikh, SS More, MH Mahnashi, HM Almohaimee, M El-Sherbin, MM Ghoneim, A Umar, HK Soni, H Agrawal, BA Mannasaheb, AA Khan, UM Muddapur, SMS Iqubal
    International Journal of Molecular Sciences, 2022-10-30;23(21):.
    Species: Mouse, Rat
    Sample Types: Cell Culture Supernates, Tissue Homogenates
  8. Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation
    Authors: Y Ni, GH Wu, JJ Cai, R Zhang, Y Zheng, JQ Liu, XH Yang, X Yang, Y Shen, JM Lai, XM Ye, SJ Mo
    International journal of biological sciences, 2022-08-08;18(13):5168-5184.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  9. Neuroprotective Effect of Dexmedetomidine against Postoperative Cognitive Decline via NLRP3 Inflammasome Signaling Pathway
    Authors: I Cho, BN Koo, SY Kim, S Park, EJ Kim, EH Kam, J Kim
    International Journal of Molecular Sciences, 2022-08-08;23(15):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  10. MicroRNA-299a-5p Protects against Spinal Cord Injury through Activating AMPK Pathway
    Authors: ZZ Zhang, SY Xian, C Bao, F Chen
    Oxidative Medicine and Cellular Longevity, 2022-05-13;2022(0):8659587.
    Species: Mouse
    Sample Types: Tissue Homogenates
  11. Tetracycline ameliorates silica-induced pulmonary inflammation and fibrosis via inhibition of caspase-1
    Authors: K Peukert, F Steinhagen, M Fox, C Feuerborn, S Schulz, B Seeliger, P Schuss, M Schneider, S Frede, A Sauer, C Putensen, E Latz, C Wilhelm, C Bode
    Respiratory Research, 2022-02-07;23(1):21.
    Species: Mouse
    Sample Types: BALF
  12. The Role of Cytokines Produced via the NLRP3 Inflammasome in Mouse Macrophages Stimulated with Dental Calculus in Osteoclastogenesis
    Authors: M Mae, MI Alam, Y Yamashita, Y Ozaki, K Higuchi, SM Ziauddin, JL Montenegro, E Sakai, T Tsukuba, A Yoshimura
    International Journal of Molecular Sciences, 2021-11-18;22(22):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  13. Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
    Authors: S Rastogi, S Ellinwood, J Augenstrei, KD Mayer-Barb, V Briken
    PloS Pathogens, 2021-07-29;17(7):e1009712.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  14. DHX15 is required to control RNA virus-induced intestinal inflammation
    Authors: J Xing, X Zhou, M Fang, E Zhang, LJ Minze, Z Zhang
    Cell Reports, 2021-06-22;35(12):109205.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  15. NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes
    Authors: FRC Costa, JA Leite, DM Rassi, JF da Silva, J Elias-Oliv, JB Guimarães, MC Foss-Freit, NOS Câmara, A Pontillo, RC Tostes, JS Silva, D Carlos
    Cell Reports, 2021-05-25;35(8):109176.
    Species: Mouse
    Sample Types: Tissue Homogenates


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Reviews for Mouse IL-18 DuoSet ELISA

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Mouse IL-18 DuoSet ELISA
By Anonymous on 10/05/2023
Sample Tested: mouse lung

Mouse IL-18 DuoSet ELISA
By Anonymous on 05/19/2023
Sample Tested: EDTA Plasma

Mouse IL-18 DuoSet ELISA
By Anonymous on 04/17/2023
Sample Tested: bronchoalviolar fluid

Mouse IL-18 DuoSet ELISA
By Do-Hyun Kim on 02/03/2023
Sample Tested: Plasma

Mouse IL-18 DuoSet ELISA
By Anonymous on 01/31/2023
Sample Tested: Serum

Mouse IL-18 DuoSet ELISA
By Anonymous on 10/26/2022
Sample Tested: Cell culture supernatant

Cell culture supernatant from transfected BHK-21 cells

Mouse IL-18 DuoSet ELISA
By Tauseef Ahmad on 05/23/2022
Sample Tested: Cell culture supernatant