Mouse Laminin alpha 4 Antibody
Mouse Laminin alpha 4 Antibody Summary
Accession # P97927
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Laminin alpha 4 in Mouse Stomach. Laminin a4 was detected in perfusion fixed frozen sections of mouse stomach using Rat Anti-Mouse Laminin a4 Monoclonal Antibody (Catalog # MAB3837) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS017) and counterstained with hematoxylin (blue). Specific staining was localized to endothelial cells in gastric pits. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Laminin alpha 4
Laminins are heterotrimeric glycoproteins and are major components of the basement membrane. Each laminin is comprised of a single alpha, beta, and gamma chain that heterotrimerize via their coiled-coil domains to form a large cruciform-shaped molecule. Mature Laminin alpha 4 is a subunit of Laminin 411, Laminin 421, and Laminin 423. Mature Laminin alpha 4 is a 1792 amino acid (aa) residue protein that has a Laminin N-terminal domain, four Laminin EGF-like domains, the coiled-coil domain, and five C‑terminal tandem Laminin G-like domains. The G-like domains contain binding sites for integrin, heparin, and dystroglycan. Within the region used as immunogen, mouse Laminin alpha 4 shows 91% and 97% aa sequence identity with human and rat Laminin alpha 4, respectively.
Citations for Mouse Laminin alpha 4 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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Synthesis of human amyloid restricted to liver results in an Alzheimer disease-like neurodegenerative phenotype
Authors: V Lam, R Takechi, MJ Hackett, R Francis, M Bynevelt, LM Celliers, M Nesbit, S Mamsa, F Arfuso, S Das, F Koentgen, M Hagan, L Codd, K Richardson, B O'Mara, RK Scharli, L Morandeau, J Gauntlett, C Leatherday, J Boucek, JCL Mamo
PloS Biology, 2021-09-14;19(9):e3001358.
Species: Mouse, Transgenic Mouse
Sample Types: Whole Tissue
The lymph node stromal laminin alpha 5 shapes alloimmunity
Authors: L Li, MW Shirkey, T Zhang, Y Xiong, W Piao, V Saxena, C Paluskievi, YS Lee, N Toney, BM Cerel, Q Li, T Simon, KD Smith, KL Hippen, BR Blazar, R Abdi, JS Bromberg
J. Clin. Invest., 2020-05-01;0(0):.
Sample Types: Whole Tissue
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