Mouse MMR/CD206 Antibody

Catalog # Availability Size / Price Qty
AF2535
AF2535-SP

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Detection of Mouse MMR/CD206 by Western Blot.
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Mouse MMR/CD206 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse MMR/CD206 in direct ELISAs and Western blots. In direct ELISAs, less than 45% cross-reactivity with recombinant human MMR is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse MMR/CD206
Leu19-Ala1388
Accession # Q2HZ94
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Flow Cytometry
0.25 µg/106 cells
J774 mouse monocyte/macrophage cell line
Immunohistochemistry
5-15 µg/mL
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Mouse MMR/CD206 antibody by Western Blot. View Larger

Detection of Mouse MMR/CD206 by Western Blot. Western blot shows lysates of mouse liver tissue. Gels were loaded with 12 µg, 6.5 µg, and 3 µg of tissue lysate. PVDF membrane was probed with 1 µg/mL of Goat Anti-Mouse MMR/CD206 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2535) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for MMR/CD206 at approximately 180 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunohistochemistry MMR/CD206 antibody in Mouse Testis by Immunohistochemistry (IHC-Fr). View Larger

MMR/CD206 in Mouse Testis. MMR/CD206 was detected in perfusion fixed frozen sections of mouse testis using Goat Anti-Mouse MMR/CD206 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2535) at 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to spermatocytes in testis. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Immunohistochemistry MMR/CD206 antibody in Mouse Lung by Immunohistochemistry (IHC-Fr). View Larger

MMR/CD206 in Mouse Lung. MMR/CD206 was detected in perfusion fixed frozen sections of mouse lung using Goat Anti-Mouse MMR/CD206 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2535) at 25 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 493-conjugated Anti-Goat IgG Secondary Antibody (green; Catalog # NL003) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm of macrophages. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.

Immunocytochemistry/ Immunofluorescence Detection of Human MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence Cells of human meninges co-express LLEC markers. a–c DAB-IHC with single antibodies detects VEGFR3 (a), LYVE1 (b), and MRC1 (c) in the meninges of human post mortem brain showing no signs of neuropathology. These images are taken from a 38 year old male (sample P17/07, Table 1), and confirmed in n = 2 additional samples. P parenchyma. Scale = 150 µm (a); 40 µm (b); and 20 µm (c). d–f DAB-IHC with single antibodies detects VEGFR3 (b), LYVE1 (c), and MRC1 (d) in elderly human meninges (age: 89–92) with evidence of neuropathology and confirmed in n = 3 brains (Table 1). P, parenchyma. Scale = 20 µm. g–p IHC with fluorescent antibodies detects human meningeal cells that co-express MRC1 (h, m, yellow), LYVE1 (i, n, white), and VEGFR3 (j, o, green). Nuclei/RNA are labelled with DAPI (g, l, blue) and images are merged in (k, p). Scale = 10 µm Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31696318), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence M1 and M2 phenotype in spinal cord after intraplantar IL-1 beta. Wild-type (WT) and LysM-G protein–coupled receptor kinase (GRK)2+/− mice received an intraplantar injection of 1 ng IL-1 beta. At 15 hours after injection, spinal cord was collected, and frozen sections of (A) lumbar spinal cord (L2 to L5) and as control (B) thoracic spinal cord (T6 to T10) were stained for M1 (CD16/32) and M2 (CD206 and arginase-I) phenotypic markers. A representative example of M1 and M2 staining in the dorsal horn of one of the four mice per group is displayed. Scale bar indicates 20 μm. (C) Quantification of microglia/macrophages expressing M1 and M2 phenotypic markers in spinal cord from WT and LysM-GRK2+/− mice. Expression was quantified in approximately 10 to 15 dorsal horns of spinal cords per group (4 mice per group). The level of expression in the lumbar or thoracic area from control WT mice was set at 100%. Data are expressed as means ± SEM. **P < 0.01, ***P < 0.001. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/22731384), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence Immunofluorescent staining for macrophage marker F4/80 in Acomys and Mus.(A–C) Bone-marrow-derived cells isolated from Acomys and stained for F4/80 (green). (A) unstimulated cells, (B) cells stimulated with IFN gamma and LPS, (C) cells stimulated with IL-4. (D–F) Bone-marrow-derived cells isolated from Mus and stained for F4/80 (green). (D) unstimulated cells, (E) cells stimulated with IFN gamma and LPS, and (F) cells stimulated with IL-4. Scale bar = 50 μm. (G) Acomys ear tissue at D15 after injury stained for F4/80 (green), CD206 (red) and DAPI (grey). (H) Mus ear tissue at D7 after injury stained for F4/80 (green), CD206 (red) and DAPI (grey). Scale bar = 50 μm.DOI:http://dx.doi.org/10.7554/eLife.24623.012 Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28508748), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse MMR/CD206/Mannose Receptor by Immunohistochemistry View Larger

Detection of Mouse MMR/CD206/Mannose Receptor by Immunohistochemistry Characterization of M2 BV2 cells induced by IL-4 and identification of sEVs derived from M2 BV2 cells. (A, B) Representative images of BV2 cells immunostained for Iba-1 (green), CD206 (red), and arginase (red). Cultured systems were treated with 0 or 20 ng/µL IL-4. Cell nuclei were counterstained with DAPI. Scale bar = 50 µm. (C) Western blotting analysis of CD206 and arginase expression in BV2 cells after 0 or 20 ng/µL IL-4 treatment. (D) Representative electron microscopy images showing the phenotype of M2-sEVs. Left image scale bar = 100 nm, right image scale bar = 50 nm. (F) NTA of M2-sEVs isolated by ultracentrifugation from M2 BV2 cells. Data represent the average size distribution profile of three samples and each purification normalized to the total nanoparticle concentrations. Data for each sample was derived from three different videos and analyses. (G) Western blotting analysis of TSG101 and CD63 levels in M2 BV2 cells and M2-sEVs. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33391532), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence Cells of human meninges co-express LLEC markers. a–c DAB-IHC with single antibodies detects VEGFR3 (a), LYVE1 (b), and MRC1 (c) in the meninges of human post mortem brain showing no signs of neuropathology. These images are taken from a 38 year old male (sample P17/07, Table 1), and confirmed in n = 2 additional samples. P parenchyma. Scale = 150 µm (a); 40 µm (b); and 20 µm (c). d–f DAB-IHC with single antibodies detects VEGFR3 (b), LYVE1 (c), and MRC1 (d) in elderly human meninges (age: 89–92) with evidence of neuropathology and confirmed in n = 3 brains (Table 1). P, parenchyma. Scale = 20 µm. g–p IHC with fluorescent antibodies detects human meningeal cells that co-express MRC1 (h, m, yellow), LYVE1 (i, n, white), and VEGFR3 (j, o, green). Nuclei/RNA are labelled with DAPI (g, l, blue) and images are merged in (k, p). Scale = 10 µm Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31696318), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence Mouse LLECs take up A beta 1-40. a Schematic showing the site of dye and A beta 1-40 perfusion into the CSF via the cisterna magna (arrow) of a 2-month old mouse. The dotted line indicates the plane of section. A anterior, P posterior, D dorsal, V ventral. b Coronal brain section indicating the areas imaged. SF4 refers to area captured in Figure S4. c The percentage of each labelled cell type that internalized perfused A beta. Cells co-expressing VEGFR3 and LYVE1 take up A beta at a higher rate than MRC1, LYVE1 double-positive cells as well as MRC1-positive, LYVE1-negative cells (p ≤ 0.05, bootstrap). VEGFR3, LYVE1 counts, n = 2 brains (3 sections/brain). MRC1, LYVE1 counts, n = 3 brains (3 sections/brain). d–d′′′ Cells of the adult mouse meninges that co-express VEGFR3 (d, green) and LYVE1 (d′, white) internalize A beta 1-40 (d′′, cyan). Scale = 20 µm. e-e′′′) Cells of the adult mouse meninges that co-express VEGFR3 (e, green) and MRC1 (e′, white) internalize A beta 1-40 (e′′, cyan). Scale = 40 µm. f–f′′′) Cells of the adult mouse meninges that co-express MRC1 (f, magenta) and LYVE1 (f′, white) internalize A beta 1-40 (f′′, cyan). The walls of a blood vessel (white arrowhead, f′′) also accumulate A beta 1-40. Scale = 60 µm Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31696318), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence Cells of human meninges co-express LLEC markers. a–c DAB-IHC with single antibodies detects VEGFR3 (a), LYVE1 (b), and MRC1 (c) in the meninges of human post mortem brain showing no signs of neuropathology. These images are taken from a 38 year old male (sample P17/07, Table 1), and confirmed in n = 2 additional samples. P parenchyma. Scale = 150 µm (a); 40 µm (b); and 20 µm (c). d–f DAB-IHC with single antibodies detects VEGFR3 (b), LYVE1 (c), and MRC1 (d) in elderly human meninges (age: 89–92) with evidence of neuropathology and confirmed in n = 3 brains (Table 1). P, parenchyma. Scale = 20 µm. g–p IHC with fluorescent antibodies detects human meningeal cells that co-express MRC1 (h, m, yellow), LYVE1 (i, n, white), and VEGFR3 (j, o, green). Nuclei/RNA are labelled with DAPI (g, l, blue) and images are merged in (k, p). Scale = 10 µm Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31696318), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence Immunofluorescent staining for macrophage marker F4/80 in Acomys and Mus.(A–C) Bone-marrow-derived cells isolated from Acomys and stained for F4/80 (green). (A) unstimulated cells, (B) cells stimulated with IFN gamma and LPS, (C) cells stimulated with IL-4. (D–F) Bone-marrow-derived cells isolated from Mus and stained for F4/80 (green). (D) unstimulated cells, (E) cells stimulated with IFN gamma and LPS, and (F) cells stimulated with IL-4. Scale bar = 50 μm. (G) Acomys ear tissue at D15 after injury stained for F4/80 (green), CD206 (red) and DAPI (grey). (H) Mus ear tissue at D7 after injury stained for F4/80 (green), CD206 (red) and DAPI (grey). Scale bar = 50 μm.DOI:http://dx.doi.org/10.7554/eLife.24623.012 Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28508748), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence Mouse LLECs take up A beta 1-40. a Schematic showing the site of dye and A beta 1-40 perfusion into the CSF via the cisterna magna (arrow) of a 2-month old mouse. The dotted line indicates the plane of section. A anterior, P posterior, D dorsal, V ventral. b Coronal brain section indicating the areas imaged. SF4 refers to area captured in Figure S4. c The percentage of each labelled cell type that internalized perfused A beta. Cells co-expressing VEGFR3 and LYVE1 take up A beta at a higher rate than MRC1, LYVE1 double-positive cells as well as MRC1-positive, LYVE1-negative cells (p ≤ 0.05, bootstrap). VEGFR3, LYVE1 counts, n = 2 brains (3 sections/brain). MRC1, LYVE1 counts, n = 3 brains (3 sections/brain). d–d′′′ Cells of the adult mouse meninges that co-express VEGFR3 (d, green) and LYVE1 (d′, white) internalize A beta 1-40 (d′′, cyan). Scale = 20 µm. e-e′′′) Cells of the adult mouse meninges that co-express VEGFR3 (e, green) and MRC1 (e′, white) internalize A beta 1-40 (e′′, cyan). Scale = 40 µm. f–f′′′) Cells of the adult mouse meninges that co-express MRC1 (f, magenta) and LYVE1 (f′, white) internalize A beta 1-40 (f′′, cyan). The walls of a blood vessel (white arrowhead, f′′) also accumulate A beta 1-40. Scale = 60 µm Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31696318), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence In vitro activation assays shows Acomys macrophages can be polarized to express different markers.(A–I) Bone-marrow-derived macrophages isolated from Acomys femurs are cultured with no cytokines (unstimulated, A, D, G) with IFN gamma +LPS (M1, B, E, H) or with IL-4 (M2, C, F, I). Immunocytochemistry for the pan-macrophage marker CD11b (green) (A–C), for the M1 macrophage marker CD86 (green) and the M2 macrophage marker Arginase 1 (red) (D–F), or CD206 (red) (G–I). (J–R). Bone-marrow-derived macrophages were isolated from Mus femurs and cultured with no cytokines (J, M, P) with IFN gamma and LPS (K, N, Q) or with IL4 (L, O, R) as above. Immunocytochemistry was performed for CD11b (green) (J–K), for CD86 (green) and Arginase 1 (red) (M–O), and CD206 (red) (P–R). Nuclei were counterstained with DAPI (grey) in all panels. Scale bars = 50 μm. Images are representative of n = 3 technical replicates.DOI:http://dx.doi.org/10.7554/eLife.24623.011Immunofluorescent staining for macrophage marker F4/80 in Acomys and Mus.(A–C) Bone-marrow-derived cells isolated from Acomys and stained for F4/80 (green). (A) unstimulated cells, (B) cells stimulated with IFN gamma and LPS, (C) cells stimulated with IL-4. (D–F) Bone-marrow-derived cells isolated from Mus and stained for F4/80 (green). (D) unstimulated cells, (E) cells stimulated with IFN gamma and LPS, and (F) cells stimulated with IL-4. Scale bar = 50 μm. (G) Acomys ear tissue at D15 after injury stained for F4/80 (green), CD206 (red) and DAPI (grey). (H) Mus ear tissue at D7 after injury stained for F4/80 (green), CD206 (red) and DAPI (grey). Scale bar = 50 μm.DOI:http://dx.doi.org/10.7554/eLife.24623.012 Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28508748), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse MMR/CD206/Mannose Receptor by Immunohistochemistry View Larger

Detection of Mouse MMR/CD206/Mannose Receptor by Immunohistochemistry Microglial activation was attenuated by Hv1 deletion following LPC-induced demyelination. a Representative images of Iba-1 immunostaining in the CC of WT and Hv1−/− mice (scale bar, 200 μm). b Quantification of the number of microglia per high-power field (HPF) in the CC. Each point of WT and Hv1−/− mice, N = 5-7 mice. c Representative images of Iba-1 morphology and the corresponding 3D reconstructions (scale bars, magnified images, 20 μm; 3D reconstruction images, 5um) d Quantification analysis of the soma of microglia. Each point of WT and Hv1−/− mice, N = 4-6 mice, 6-15 cells per mouse. e Representative images of Iba-1 and CD16/32 co-localization in the CC of WT and Hv1−/− mice (scale bar, 50 μm; magnified images, 20 μm). f Quantification of the ratio of CD16/32+/Iba-1+. Each point of WT mice, N = 5-8 mice; Hv1−/− mice, N = 5-8 mice. g Representative images of Iba-1 and CD206 co-localization in the CC of WT and Hv1−/− mice (scale bar, 50 μm; magnified images, 20 μm). h Quantification of the ratio of CD206+/Iba-1+. Each point of WT mice, N = 6-7 mice; Hv1−/− mice, N = 5-6 mice. Data are shown as mean ± SD, *P < 0.05, ***P<0.001, two-way ANOVA with Dunnett’s post hoc test Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33158440), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence Cells with BLEC molecular markers are present within the mouse leptomeninges. a Coronal brain section of adult zebrafish brain indicating the imaging area in the dorsal optic tectum (TeO). b A 14 month old Tg(kdr-l:mCherry); Tg(flt4:mCitrine) double transgenic zebrafish has cells in the meninges (white bracket) that express flt4/vegfr3 ( alpha -GFP, green) near kdr-l positive ( alpha -RFP, red) blood vessels. DAPI (blue) labels the nuclei. Scale = 50 µm. c Coronal mouse brain section showing the imaging areas of the meninges. d As revealed by IHC, 17-week-old mouse brains express VEGFR3 (green) in the meninges (white bracket). Tie2-GFP;NG2-DsRed double reporter mice were used to distinguish arteries and veins. NG2 (red) labels pericytes and smooth muscle cells, Tie2 (magenta) labels vascular endothelial cells, and Hoechst (blue) stains nuclei. The image is rotated with the parenchyma at the bottom for ease of comparison with panel b. Scale = 50 µm. e-e′′′ As revealed by IHC, cells of the meninges co-express MRC1 (e, yellow), LYVE1 (e′, white), and VEGFR3 (e′′, green). Red arrows highlight cells expressing these three markers. The images are rotated with the parenchyma at the bottom. scale = 30 µm. f, g Quantification of the relative numbers of single and double-labelled cells in 2-month old mouse meninges. VEGFR3 and LYVE1 cell counts were from n = 2 brains, 3 coronal sections (10 area images)/brain. MRC1 and LYVE1 cell counts were from n = 3 brains, 3 coronal sections (4 area images)/brain. The mean values for each set are depicted Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31696318), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence M1 and M2 phenotype in spinal cord after intraplantar IL-1 beta. Wild-type (WT) and LysM-G protein–coupled receptor kinase (GRK)2+/− mice received an intraplantar injection of 1 ng IL-1 beta. At 15 hours after injection, spinal cord was collected, and frozen sections of (A) lumbar spinal cord (L2 to L5) and as control (B) thoracic spinal cord (T6 to T10) were stained for M1 (CD16/32) and M2 (CD206 and arginase-I) phenotypic markers. A representative example of M1 and M2 staining in the dorsal horn of one of the four mice per group is displayed. Scale bar indicates 20 μm. (C) Quantification of microglia/macrophages expressing M1 and M2 phenotypic markers in spinal cord from WT and LysM-GRK2+/− mice. Expression was quantified in approximately 10 to 15 dorsal horns of spinal cords per group (4 mice per group). The level of expression in the lumbar or thoracic area from control WT mice was set at 100%. Data are expressed as means ± SEM. **P < 0.01, ***P < 0.001. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/22731384), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human MMR/CD206/Mannose Receptor by Immunocytochemistry/Immunofluorescence Cells of human meninges co-express LLEC markers. a–c DAB-IHC with single antibodies detects VEGFR3 (a), LYVE1 (b), and MRC1 (c) in the meninges of human post mortem brain showing no signs of neuropathology. These images are taken from a 38 year old male (sample P17/07, Table 1), and confirmed in n = 2 additional samples. P parenchyma. Scale = 150 µm (a); 40 µm (b); and 20 µm (c). d–f DAB-IHC with single antibodies detects VEGFR3 (b), LYVE1 (c), and MRC1 (d) in elderly human meninges (age: 89–92) with evidence of neuropathology and confirmed in n = 3 brains (Table 1). P, parenchyma. Scale = 20 µm. g–p IHC with fluorescent antibodies detects human meningeal cells that co-express MRC1 (h, m, yellow), LYVE1 (i, n, white), and VEGFR3 (j, o, green). Nuclei/RNA are labelled with DAPI (g, l, blue) and images are merged in (k, p). Scale = 10 µm Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31696318), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse MMR/CD206/Mannose Receptor by Immunohistochemistry View Larger

Detection of Mouse MMR/CD206/Mannose Receptor by Immunohistochemistry Representative images of HE, M3/84 (macrophages) and MR (CD206) immunohistochemistry. In control mice, no plaques with macrophages were observed, while fibrous/fibroatheromatous plaques were present in the aortas extracted from ApoE-KO mice. The lesions (fatty streaks and fibrous plaques) showed high amounts of MR+ macrophages (100 μm (bars), vascular lumen (L), intima (arrow), media (asterisk), adventitia (arrowhead)) Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28470406), licensed under a CC-BY license. Not internally tested by R&D Systems.

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Background: MMR/CD206

The mouse Macrophage Mannose Receptor (MMR), also known as CD206 and MRC1 (mannose receptor C, type 1), is a 175 kDa scavenger receptor that is expressed on tissue macrophages, myeloid dendritic cells, and liver and lymphatic endothelial cells (1). It belongs to a family of receptors sharing similar protein structure that also includes DEC205, phospholipase A2 receptor, and Endo180 (2, 3). The mouse MMR protein is synthesized as a 1456 amino acid (aa) precursor that contains a 19 aa signal sequence, a 1369 aa extracellular region, a 21 aa transmembrane segment and a 47 aa cytoplasmic domain (4). Its extracellular region is composed of an N-terminal cysteine-rich domain, followed by a single fibronectin type II repeat, and eight C-type lectin carbohydrate recognition domains (CRD) (3‑5). Mouse to human, the extracellular region is 82% aa identical. The cysteine-rich domain mediates recognition of sulfated N-acetylgalactosamine, which occurs on some extracellular matrix proteins and is the terminal sugar of the unusual oligosaccharides present on pituitary hormones such as lutropin and thyrotropin (6). Several of the CRDs participate in the Ca2+-dependent recognition of carbohydrates showing a preference for branched sugars with terminal mannose, fucose or N‑acetylglucosamine (7). The cytoplasmic domain of MMR includes a tyrosine-based motif for internalization in clathrin-coated vesicles. Once internalized, ligands are released following acidification of phagosomes or endosomes, and the receptor recycles to the cell surface (3, 8). MMR mediates phagocytosis upon binding to target structures that occur on a variety of pathogenic microorganisms including Gram-negative and Gram-positive bacteria, yeasts, parasites, and mycobacteria. MMR also functions to maintain homeostasis through the endocytosis of potentially harmful glycoproteins associated with inflammation (2, 3).

References
  1. East, L. and C. Isake (2002) Biochim. Biophys. Acta 1572:364. 
  2. Chieppa, M. et al. (2003) J. Immunol. 171:4552. 
  3. Figdor, C. et al. (2002) Nat. Rev. Immunol. 2:77. 
  4. Harris, N. et al. (1992) Blood 80:2363.
  5. Taylor, M. et al. (1990) J. Biol. Chem. 265:12156.
  6. Leteux, C. et al. (2000) J. Exp. Med. 191:1117.
  7. Martinez-Pomares, L. et al. (2001) Immunobiology 204:527.
  8. Feinberg, H. et al. (2000) J. Biol. Chem. 275:21539.
Long Name
Macrophage Mannose Receptor
Entrez Gene IDs
4360 (Human); 17533 (Mouse); 291327 (Rat)
Alternate Names
CD206; CLEC13D; CLEC13Dmacrophage mannose receptor 1; C-type lectin domain family 13 member D; mannose receptor, C type 1; MMR; MMRCD206 antigen; MRC1

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Citations for Mouse MMR/CD206 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

162 Citations: Showing 1 - 10
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  1. M2a macrophages facilitate resolution of chemically-induced colitis in TLR4-SNP mice
    Authors: Vlk, AM;Prantner, D;Shirey, KA;Perkins, DJ;Buzza, MS;Thumbigere-Math, V;Keegan, AD;Vogel, SN;
    mBio
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  2. Differential Effects of Regulatory T Cells in the Meninges and Spinal Cord of Male and Female Mice with Neuropathic Pain
    Authors: Fiore, NT;Keating, BA;Chen, Y;Williams, SI;Moalem-Taylor, G;
    Cells
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  3. Manganese-Implanted Titanium Modulates the Crosstalk between Bone Marrow Mesenchymal Stem Cells and Macrophages to Improve Osteogenesis
    Authors: Ye, K;Zhang, X;Shangguan, L;Liu, X;Nie, X;Qiao, Y;
    Journal of functional biomaterials
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  4. Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons
    Authors: Halawani, D;Wang, Y;Ramakrishnan, A;Estill, M;He, X;Shen, L;Friedel, RH;Zou, H;
    Nature communications
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  5. The Single-Dose Application of Interleukin-4 Ameliorates Secondary Brain Damage in the Early Phase after Moderate Experimental Traumatic Brain Injury in Mice
    Authors: Walter, J;Mende, J;Hutagalung, S;Alhalabi, OT;Grutza, M;Zheng, G;Skutella, T;Unterberg, A;Zweckberger, K;Younsi, A;
    International journal of molecular sciences
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  6. Fetal Muse-based therapy prevents lethal radio-induced gastrointestinal syndrome by intestinal regeneration
    Authors: Honorine Dushime, Stéphanie G. Moreno, Christine Linard, Annie Adrait, Yohann Couté, Juliette Peltzer et al.
    Stem Cell Research & Therapy
  7. MicroRNA-124-3p Attenuated Retinal Neovascularization in Oxygen-Induced Retinopathy Mice by Inhibiting the Dysfunction of Retinal Neuroglial Cells through STAT3 Pathway
    Authors: Hong Y, Wang Y, Cui Y et al.
    International journal of molecular sciences
  8. Macrophage fusion event as one prerequisite for inorganic nanoparticle-induced antitumor response
    Authors: Chen S, Xing Z, Geng M et al.
    Science advances
  9. HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy
    Authors: Chen M, Menon MC, Wang W et al.
    Nature communications
  10. An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte-tumor cell crosstalk, local immunosuppression and tumor progression
    Authors: Wu, L;Yan, J;Bai, Y;Chen, F;Zou, X;Xu, J;Huang, A;Hou, L;Zhong, Y;Jing, Z;Yu, Q;Zhou, X;Jiang, Z;Wang, C;Cheng, M;Ji, Y;Hou, Y;Luo, R;Li, Q;Wu, L;Cheng, J;Wang, P;Guo, D;Huang, W;Lei, J;Liu, S;Yan, Y;Chen, Y;Liao, S;Li, Y;Sun, H;Yao, N;Zhang, X;Zhang, S;Chen, X;Yu, Y;Li, Y;Liu, F;Wang, Z;Zhou, S;Yang, H;Yang, S;Xu, X;Liu, L;Gao, Q;Tang, Z;Wang, X;Wang, J;Fan, J;Liu, S;Yang, X;Chen, A;Zhou, J;
    Cell research
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  11. Oleoylethanolamide Treatment Modulates Both Neuroinflammation and Microgliosis, and Prevents Massive Leukocyte Infiltration to the Cerebellum in a Mouse Model of Neuronal Degeneration
    Authors: Pérez-Martín, E;Pérez-Revuelta, L;Barahona-López, C;Pérez-Boyero, D;Alonso, JR;Díaz, D;Weruaga, E;
    International journal of molecular sciences
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  12. CD301b+ macrophage: the new booster for activating bone regeneration in periodontitis treatment
    Authors: Can Wang, Qin Zhao, Chen Chen, Jiaojiao Li, Jing Zhang, Shuyuan Qu et al.
    International Journal of Oral Science
  13. Age-related neuroimmune signatures in dorsal root ganglia of a Fabry disease mouse model
    Authors: Choconta JL, Labi V, Dumbraveanu C et al.
    Immunity & ageing : I & A
  14. Combining three independent pathological stressors induces a heart failure with preserved ejection fraction phenotype
    Authors: Li Y, Kubo H, Yu D et al.
    American journal of physiology. Heart and circulatory physiology
  15. iPSC-sEVs alleviate microglia senescence to protect against ischemic stroke in aged mice
    Authors: Xinyu Niu, Yuguo Xia, Lei Luo, Yu Chen, Ji Yuan, Juntao Zhang et al.
    Materials Today Bio
  16. Meningeal origins and dynamics of perivascular fibroblast development on the mouse cerebral vasculature
    Authors: HE Jones, V Coelho-San, SK Bonney, KA Abrams, AY Shih, JA Siegenthal
    bioRxiv : the preprint server for biology, 2023-03-23;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  17. Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma
    Authors: L Pang, M Dunterman, W Xuan, A Gonzalez, Y Lin, WH Hsu, F Khan, RS Hagan, WA Muller, AB Heimberger, P Chen
    Cell Reports, 2023-02-14;42(2):112127.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  18. Regulating macrophage-MSC interaction to optimize BMP-2-induced osteogenesis in the local microenvironment
    Authors: F Jiang, X Qi, X Wu, S Lin, J Shi, W Zhang, X Jiang
    Bioactive materials, 2023-02-11;25(0):307-318.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  19. Implantation and tracing of green fluorescent protein-expressing adipose-derived stem cells in peri-implant capsular fibrosis
    Authors: Bo-Yoon Park, Dirong Wu, Kyoo-Ri Kwon, Mi-Jin Kim, Tae-Gon Kim, Jun-Ho Lee et al.
    Stem Cell Research & Therapy
  20. CD206+ macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia
    Authors: Y Hattori, D Kato, F Murayama, S Koike, H Asai, A Yamasaki, Y Naito, A Kawaguchi, H Konishi, M Prinz, T Masuda, H Wake, T Miyata
    Cell Reports, 2023-02-07;42(2):112092.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  21. White-light crosslinkable milk protein bioadhesive with ultrafast gelation for first-aid wound treatment
    Authors: Q Zhu, X Zhou, Y Zhang, D Ye, K Yu, W Cao, L Zhang, H Zheng, Z Sun, C Guo, X Hong, Y Zhu, Y Zhang, Y Xiao, TG Valencak, T Ren, D Ren
    Biomaterials research, 2023-02-03;27(1):6.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  22. Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25-Nrf2 pathway
    Authors: T Tanaka, H Okuda, A Isonishi, Y Terada, M Kitabatake, T Shinjo, K Nishimura, S Takemura, H Furue, T Ito, K Tatsumi, A Wanaka
    Nature Immunology, 2023-01-26;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  23. Protective effects of blocking PD-1 pathway on retinal ganglion cells in a mouse model of chronic ocular hypertension
    Authors: Siqi Sheng, Yixian Ma, Yue Zou, Fangyuan Hu, Ling Chen
    Frontiers in Immunology
  24. Inhibiting phosphatase and actin regulator 1 expression is neuroprotective in the context of traumatic brain injury
    Authors: Heng-Li Tian, Zhi-Ming Zhang, Shi-Wen Ding, Yao Jing, Shi-Ming Zhang, Shi-Wen Chen et al.
    Neural Regeneration Research
  25. Selective brain hypothermia attenuates focal cerebral ischemic injury and improves long‐term neurological outcome in aged female mice
    Authors: Liqiang Liu, Jia Liu, Ming Li, Junxuan Lyu, Wei Su, Shejun Feng et al.
    CNS Neuroscience & Therapeutics
  26. Antibody-Mediated Delivery of VEGF-C Promotes Long-Lasting Lymphatic Expansion That Reduces Recurrent Inflammation
    Authors: N Cousin, S Bartel, J Scholl, C Tacconi, A Egger, G Thorhallsd, D Neri, LC Dieterich, M Detmar
    Cells, 2022-12-31;12(1):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  27. Infiltration of meningeal macrophages into the Virchow–Robin space after ischemic stroke in rats: Correlation with activated PDGFR-beta -positive adventitial fibroblasts
    Authors: Tae-Ryong Riew, Ji-Won Hwang, Xuyan Jin, Hong Lim Kim, Mun-Yong Lee
    Frontiers in Molecular Neuroscience
  28. An SPM-Enriched Marine Oil Supplement Shifted Microglia Polarization toward M2, Ameliorating Retinal Degeneration in rd10 Mice
    Authors: Lorena Olivares-González, Sheyla Velasco, Idoia Gallego, Marina Esteban-Medina, Gustavo Puras, Carlos Loucera et al.
    Antioxidants (Basel)
  29. Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel
    Authors: J Li, S Sudiwala, L Berthoin, S Mohabbat, EA Gaylord, H Sinada, N Cruz Pache, JC Chang, O Jeon, IMA Lombaert, AJ May, E Alsberg, CS Bahney, SM Knox
    Science Advances, 2022-12-21;8(51):eadc8753.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC/IF
  30. Tumor necrosis factor-alpha -primed mesenchymal stem cell-derived exosomes promote M2 macrophage polarization via Galectin-1 and modify intrauterine adhesion on a novel murine model
    Authors: Jingman Li, Yuchen Pan, Jingjing Yang, Jiali Wang, Qi Jiang, Huan Dou et al.
    Frontiers in Immunology
  31. Interleukin-4 promotes microglial polarization toward a neuroprotective phenotype after retinal ischemia/reperfusion injury
    Authors: D Chen, C Peng, XM Ding, Y Wu, CJ Zeng, L Xu, WY Guo
    Oncogene, 2022-12-01;17(12):2755-2760.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  32. Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer
    Authors: Cappellesso F, Orban MP, Shirgaonkar N et al.
    Nature cancer
  33. IL-33/ST2 axis promotes remodeling of the extracellular matrix and drives protective microglial responses in the mouse model of perioperative neurocognitive disorders
    Authors: S Li, H Liu, Y Qian, L Jiang, S Liu, Y Liu, C Liu, X Gu
    International immunopharmacology, 2022-11-26;114(0):109479.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  34. Constitutively active microglial populations limit anorexia induced by the food contaminant deoxynivalenol
    Authors: S Gaige, R Barbouche, M Barbot, S Boularand, M Dallaporta, A Abysique, JD Troadec
    Journal of Neuroinflammation, 2022-11-19;19(1):280.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  35. Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution
    Authors: NM Sodir, L Pellegrine, RM Kortlever, T Campos, YW Kwon, S Kim, D Garcia, A Perfetto, P Anastasiou, LB Swigart, MJ Arends, TD Littlewood, GI Evan
    Nature Communications, 2022-11-09;13(1):6782.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  36. Multiplex immunohistochemistry reveals cochlear macrophage heterogeneity and local auditory nerve inflammation in cisplatin-induced hearing loss
    Authors: Mai Mohamed Bedeir, Yuzuru Ninoyu, Takashi Nakamura, Takahiro Tsujikawa, Shigeru Hirano
    Frontiers in Neurology
  37. HRas and Myc synergistically induce cell cycle progression and apoptosis of murine cardiomyocytes
    Authors: Aleksandra Boikova, Megan J. Bywater, Gregory A. Quaife-Ryan, Jasmin Straube, Lucy Thompson, Camilla Ascanelli et al.
    Frontiers in Cardiovascular Medicine
  38. Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system
    Authors: A Weigert, X Zheng, A Nenzel, K Turkowski, S Günther, E Strack, E Sirait-Fis, E Elwakeel, IM Kur, VS Nikam, C Valasaraja, H Winter, A Wissgott, R Voswinkel, F Grimminger, B Brüne, W Seeger, SS Pullamsett, R Savai
    Nature Communications, 2022-10-14;13(1):6078.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  39. Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity
    Authors: Agnieszka Chryplewicz, Julie Scotton, Mélanie Tichet, Anoek Zomer, Ksenya Shchors, Johanna A. Joyce et al.
    Cancer Cell
  40. Ginsenoside Rg3-enriched Korean red ginseng extract attenuates Non-Alcoholic Fatty Liver Disease by way of suppressed VCAM-1 expression in liver sinusoidal endothelium
    Authors: Lee S, Baek S, Lee Y et al.
    Journal of Ginseng Research
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  41. Chuanzhitongluo regulates microglia polarization and inflammatory response in acute ischemic stroke
    Authors: Q Wang, B Han, X Man, H Gu, J Sun
    Brain research bulletin, 2022-09-21;190(0):97-104.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  42. Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity
    Authors: T Ye, Z Chen, J Zhang, L Luo, R Gao, L Gong, Y Du, Z Xie, B Zhao, Q Li, Y Wang
    Oncogene, 2022-08-26;21(0):194-208.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  43. Transforming growth factor-beta1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-kappaB/ERK1/2 pathways
    Authors: Y Xie, X Chen, Y Li, S Chen, S Liu, Z Yu, W Wang
    Journal of Neuroinflammation, 2022-07-28;19(1):194.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  44. Rationally designed bioactive milk-derived protein scaffolds enhanced new bone formation
    Authors: MS Lee, J Jeon, S Park, J Lim, HS Yang
    Oncogene, 2022-06-16;20(0):368-380.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  45. FGF-2 signaling in nasopharyngeal carcinoma modulates pericyte-macrophage crosstalk and metastasis
    Authors: Y Wang, Q Sun, Y Ye, X Sun, S Xie, Y Zhan, J Song, X Fan, B Zhang, M Yang, L Lv, K Hosaka, Y Yang, G Nie
    JCI Insight, 2022-05-23;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  46. Interleukin 13 promotes long-term recovery after ischemic stroke by inhibiting the activation of STAT3
    Authors: D Chen, J Li, Y Huang, P Wei, W Miao, Y Yang, Y Gao
    Journal of Neuroinflammation, 2022-05-16;19(1):112.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  47. Repetitive transcranial magnetic stimulation exerts anti-inflammatory effects via modulating glial activation in mice with chronic unpredictable mild stress-induced depression
    Authors: C Zuo, H Cao, F Feng, G Li, Y Huang, L Zhu, Z Gu, Y Yang, J Chen, Y Jiang, F Wang
    International immunopharmacology, 2022-04-30;109(0):108788.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IF, Western Blot
  48. Specification of CNS macrophage subsets occurs postnatally in defined niches
    Authors: T Masuda, L Amann, G Monaco, R Sankowski, O Staszewski, M Krueger, F Del Gaudio, L He, N Paterson, E Nent, F Fernández-, A Yamasaki, M Frosch, M Fliegauf, LFP Bosch, H Ulupinar, N Hagemeyer, D Schreiner, C Dorrier, M Tsuda, C Grothe, A Joutel, R Daneman, C Betsholtz, U Lendahl, KP Knobeloch, T Lämmermann, J Priller, K Kierdorf, M Prinz
    Nature, 2022-04-20;604(7907):740-748.
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  49. Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T�cell lymphoma
    Authors: JR Cortes, I Filip, R Albero, JA Patiño-Gal, SA Quinn, WW Lin, AP Laurent, BB Shih, JA Brown, AJ Cooke, A Mackey, J Einson, S Zairis, A Rivas-Delg, MA Laginestra, S Pileri, E Campo, G Bhagat, AA Ferrando, R Rabadan, T Palomero
    Cell Reports, 2022-04-19;39(3):110695.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC
  50. Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction
    Authors: Jesus Maria Gómez-Salinero, Franco Izzo, Yang Lin, Sean Houghton, Tomer Itkin, Fuqiang Geng et al.
    Cell Stem Cell
  51. Targeted Accumulation of Macrophages Induced by Microbeam Irradiation in a Tissue-Dependent Manner
    Authors: V Trappetti, J Fazzari, C Fernandez-, L Smyth, M Potez, N Shintani, B de Breuyn, OA Martin, V Djonov
    Biomedicines, 2022-03-22;10(4):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  52. A Novel Staining Method for Detection of Brain Perivascular Injuries Induced by Nanoparticle: Periodic Acid-Schiff and Immunohistochemical Double-Staining
    Authors: Atsuto Onoda, Shin Hagiwara, Natsuko Kubota, Shinya Yanagita, Ken Takeda, Masakazu Umezawa
    Frontiers in Toxicology
  53. A bioactive gypenoside (GP-14) alleviates neuroinflammation and blood brain barrier (BBB) disruption by inhibiting the NF-kappaB signaling pathway in a mouse high-altitude cerebral edema (HACE) model
    Authors: Y Geng, J Yang, X Cheng, Y Han, F Yan, C Wang, X Jiang, X Meng, M Fan, M Zhao, L Zhu
    International immunopharmacology, 2022-03-14;107(0):108675.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  54. MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma
    Authors: Ravikanth Maddipati, Robert J. Norgard, Timour Baslan, Komal S. Rathi, Amy Zhang, Asal Saeid et al.
    Cancer Discovery
  55. A muscle cell‐macrophage axis involving matrix metalloproteinase 14 facilitates extracellular matrix remodeling with mechanical loading
    Authors: Bailey D. Peck, Kevin A. Murach, R. Grace Walton, Alexander J. Simmons, Douglas E. Long, Kate Kosmac et al.
    The FASEB Journal
  56. miR-204-containing exosomes ameliorate GVHD-associated dry eye disease
    Authors: T Zhou, C He, P Lai, Z Yang, Y Liu, H Xu, X Lin, B Ni, R Ju, W Yi, L Liang, D Pei, CE Egwuagu, X Liu
    Science Advances, 2022-01-12;8(2):eabj9617.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  57. An HDAC6 inhibitor reverses chemotherapy-induced mechanical hypersensitivity via an IL-10 and macrophage dependent pathway
    Authors: J Zhang, J Ma, RT Trinh, CJ Heijnen, A Kavelaars
    Brain, Behavior, and Immunity, 2021-12-13;100(0):287-296.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  58. Characterization of macrophage infiltration and polarization by double fluorescence immunostaining in mouse colonic mucosa
    Authors: María López Chiloeches, Anna Bergonzini, Teresa Frisan, Océane C.B. Martin
    STAR Protocols
  59. Mad2 Induced Aneuploidy Contributes to Eml4-Alk Driven Lung Cancer by Generating an Immunosuppressive Environment
    Authors: Kristina Alikhanyan, Yuanyuan Chen, Kalman Somogyi, Simone Kraut, Rocio Sotillo
    Cancers (Basel)
  60. Hypothermia modulates myeloid cell polarization in neonatal hypoxic-ischemic brain injury
    Authors: M Seitz, C Köster, M Dzietko, H Sabir, M Serdar, U Felderhoff, I Bendix, J Herz
    Journal of Neuroinflammation, 2021-11-13;18(1):266.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  61. Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving
    Authors: HH Yu, XT Ma, X Ma, M Chen, YH Chu, LJ Wu, W Wang, C Qin, DS Tian
    Journal of the American Heart Association, 2021-11-02;10(22):e023077.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  62. Raloxifene Modulates Microglia and Rescues Visual Deficits and Pathology After Impact Traumatic Brain Injury
    Authors: Marcia G. Honig, Nobel A. Del Mar, Desmond L. Henderson, Dylan O’Neal, John B. Doty, Rachel Cox et al.
    Frontiers in Neuroscience
  63. Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury
    Authors: H Iwai, K Ataka, H Suzuki, A Dhar, E Kuramoto, A Yamanaka, T Goto
    Journal of Neuroinflammation, 2021-10-13;18(1):227.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IF
  64. Activating a collaborative innate-adaptive immune response to control metastasis
    Authors: Lijuan Sun, Tim Kees, Ana Santos Almeida, Bodu Liu, Xue-Yan He, David Ng et al.
    Cancer Cell
  65. Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder
    Authors: X Ma, C Qin, M Chen, HH Yu, YH Chu, TJ Chen, DB Bosco, LJ Wu, BT Bu, W Wang, DS Tian
    Journal of Neuroinflammation, 2021-09-15;18(1):201.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  66. InVision: An optimized tissue clearing approach for three-dimensional imaging and analysis of intact rodent eyes
    Authors: Akshay Gurdita, Philip E.B. Nickerson, Neno T. Pokrajac, Arturo Ortín-Martínez, En Leh Samuel Tsai, Lacrimioara Comanita et al.
    iScience
  67. Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke
    Authors: X Zhou, YN Zhang, FF Li, Z Zhang, LY Cui, HY He, X Yan, WB He, HS Sun, ZP Feng, SF Chu, NH Chen
    Acta pharmacologica Sinica, 2021-08-12;0(0):.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  68. A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state
    Authors: M Fremder, SW Kim, A Khamaysi, L Shimshilas, H Eini-Rider, IS Park, U Hadad, JH Cheon, E Ohana
    Cell Reports, 2021-08-10;36(6):109521.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  69. Axonal Injuries Cast Long Shadows: Long Term Glial Activation in Injured and Contralateral Retinas after Unilateral Axotomy
    Authors: María José González-Riquelme, Caridad Galindo-Romero, Fernando Lucas-Ruiz, Marina Martínez-Carmona, Kristy T. Rodríguez-Ramírez, José María Cabrera-Maqueda et al.
    International Journal of Molecular Sciences
  70. Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system
    Authors: Sílvia Gras, Alba Blasco, Guillem Mòdol-Caballero, Olga Tarabal, Anna Casanovas, Lídia Piedrafita et al.
    Aging (Albany NY)
  71. Resveratrol Ameliorates Cardiac Remodeling in a Murine Model of Heart Failure With Preserved Ejection Fraction
    Authors: L Zhang, J Chen, L Yan, Q He, H Xie, M Chen
    Frontiers in Pharmacology, 2021-06-10;12(0):646240.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  72. Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway
    Authors: X Xu, W Gao, L Li, J Hao, B Yang, T Wang, L Li, X Bai, F Li, H Ren, M Zhang, L Zhang, J Wang, D Wang, J Zhang, L Jiao
    Journal of Neuroinflammation, 2021-05-22;18(1):119.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  73. Quercetin Attenuates Trauma-Induced Heterotopic Ossification by Tuning Immune Cell Infiltration and Related Inflammatory Insult
    Authors: Juehong Li, Ziyang Sun, Gang Luo, Shuo Wang, Haomin Cui, Zhixiao Yao et al.
    Frontiers in Immunology
  74. Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia
    Authors: Z Germana, G Simona, L Marialucia, M Biagina, V Christine, F Paola, C Matteo, C Pasquale, M Davide, T Mario, M Massimilia, G Carlo, S Gaia, M Fabio
    Cell Death & Disease, 2021-05-01;12(5):435.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  75. Tanshinone IIA Protects Against Cerebral Ischemia Reperfusion Injury by Regulating Microglial Activation and Polarization via NF-kappa B Pathway
    Authors: Zhibing Song, Jingjing Feng, Qian Zhang, Shanshan Deng, Dahai Yu, Yuefan Zhang et al.
    Frontiers in Pharmacology
  76. High-salt diet downregulates TREM2 expression and blunts efferocytosis of macrophages after acute ischemic stroke
    Authors: M Hu, Y Lin, X Men, S Wang, X Sun, Q Zhu, D Lu, S Liu, B Zhang, W Cai, Z Lu
    Journal of Neuroinflammation, 2021-04-12;18(1):90.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  77. Imaging of Inflammation in Spinal Cord Injury: Novel Insights on the Usage of PFC-Based Contrast Agents
    Authors: F Garello, M Boido, M Miglietti, V Bitonto, M Zenzola, M Filippi, F Arena, L Consolino, M Ghibaudi, E Terreno
    Biomedicines, 2021-04-03;9(4):.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  78. Mutant p53 suppresses innate immune signaling to promote tumorigenesis
    Authors: Monisankar Ghosh, Suchandrima Saha, Julie Bettke, Rachana Nagar, Alejandro Parrales, Tomoo Iwakuma et al.
    Cancer Cell
  79. Minocycline promotes functional recovery in ischemic stroke by modulating microglia polarization through STAT1/STAT6 pathways
    Authors: Yunnan Lu, Mingming Zhou, Yun Li, Yan Li, Ye Hua, Yi Fan
    Biochemical Pharmacology
  80. Epithelial membrane protein 2 (Emp2) modulates innate immune cell population recruitment at the maternal-fetal interface
    Authors: A Chu, SY Kok, J Tsui, MC Lin, B Aguirre, M Wadehra
    Journal of reproductive immunology, 2021-03-09;145(0):103309.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  81. Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration
    Authors: A Uneda, K Kurozumi, A Fujimura, K Fujii, J Ishida, Y Shimazu, Y Otani, Y Tomita, Y Hattori, Y Matsumoto, N Tsuboi, K Makino, S Hirano, A Kamiya, I Date
    Acta neuropathologica communications, 2021-02-22;9(1):29.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  82. Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a promotes M2 macrophage polarization in spinal cord injury by downregulating IRF5
    Authors: Q Chang, Y Hao, Y Wang, Y Zhou, H Zhuo, G Zhao
    Brain research bulletin, 2021-02-17;170(0):199-210.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  83. GSK2593074A blocks progression of existing abdominal aortic dilation
    Authors: Mitri K. Khoury, Ting Zhou, Huan Yang, Samantha R. Prince, Kartik Gupta, Amelia R. Stranz et al.
    JVS-Vascular Science
  84. Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPAR&gamma pathway after cerebral ischemia/reperfusion injury in rats
    Authors: L Li, H Gan, H Jin, Y Fang, Y Yang, J Zhang, X Hu, L Chu
    International immunopharmacology, 2021-01-08;92(0):107335.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  85. M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice
    Authors: Z Li, Y Song, T He, R Wen, Y Li, T Chen, S Huang, Y Wang, Y Tang, F Shen, HL Tian, GY Yang, Z Zhang
    Theranostics, 2021-01-01;11(3):1232-1248.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  86. Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension
    Authors: Amira Zawia, Nadine D. Arnold, Laura West, Josephine A. Pickworth, Helena Turton, James Iremonger et al.
    Arteriosclerosis, Thrombosis, and Vascular Biology
  87. The novel Nrf2 activator CDDO‐EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice
    Authors: Xia Lei, Hanxia Li, Min Li, Qiwei Dong, Huayang Zhao, Zongyong Zhang et al.
    CNS Neuroscience & Therapeutics
  88. Motoneuron deafferentation and gliosis occur in association with neuromuscular regressive changes during ageing in mice
    Authors: Alba Blasco, Sílvia Gras, Guillem Mòdol‐Caballero, Olga Tarabal, Anna Casanovas, Lídia Piedrafita et al.
    Journal of Cachexia, Sarcopenia and Muscle
  89. CNS macrophages differentially rely on an intronic Csf1r enhancer for their development
    Authors: David A. D. Munro, Barry M. Bradford, Samanta A. Mariani, David W. Hampton, Chris S. Vink, Siddharthan Chandran et al.
    Development
  90. Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction
    Authors: Hiroyuki Konishi, Takayuki Okamoto, Yuichiro Hara, Okiru Komine, Hiromi Tamada, Mitsuyo Maeda et al.
    The EMBO Journal
  91. Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation
    Authors: Y Nam, D Yoon, J Hong, MS Kim, TY Lee, KS Kim, HW Lee, K Suk, SR Kim
    J Clin Med, 2020-11-13;9(11):.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  92. Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model
    Authors: M Chen, LL Yang, ZW Hu, C Qin, LQ Zhou, YL Duan, DB Bosco, LJ Wu, KB Zhan, SB Xu, DS Tian
    J Neuroinflammation, 2020-11-06;17(1):333.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  93. TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice
    Authors: Y Wang, Y Lin, L Wang, H Zhan, X Luo, Y Zeng, W Wu, X Zhang, F Wang
    Aging (Albany NY), 2020-10-16;12(0):.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  94. Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia
    Authors: Jialei Yang, Shipo Wu, Lihua Hou, Danni Zhu, Shimin Yin, Guodong Yang et al.
    Molecular Therapy - Nucleic Acids
  95. Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages
    Authors: A Menga, M Serra, S Todisco, C Riera-Domi, U Ammarah, M Ehling, EM Palmieri, MA Di Noia, R Gissi, M Favia, CL Pierri, PE Porporato, A Castegna, M Mazzone
    EMBO Mol Med, 2020-09-04;0(0):e11210.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  96. The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination
    Authors: Monique Marylin Alves de Almeida, Francesca Pieropan, Larissa de Mattos Oliveira, Manoelito Coelho dos Santos Junior, Jorge Mauricio David, Juceni Pereira David et al.
    Pharmacological Research
  97. FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages
    Authors: D Wang, F Liu, L Zhu, P Lin, F Han, X Wang, X Tan, L Lin, Y Xiong
    J Neuroinflammation, 2020-08-31;17(1):257.
    Species: Mouse
    Sample Types: Whole Tissue, Whole Tissues
    Applications: IF, IHC
  98. An ErbB2 splice variant lacking exon 16 drives lung carcinoma
    Authors: Harvey W. Smith, Lei Yang, Chen Ling, Arlan Walsh, Victor D. Martinez, Jonathan Boucher et al.
    Proceedings of the National Academy of Sciences
  99. The Distribution and Role of M1 and M2 Macrophages in Aneurysm Healing after Platinum Coil Embolization
    Authors: Z. Khashim, D. Daying, D.Y. Hong, J.A. Ringler, S. Herting, D. Jakaitis et al.
    American Journal of Neuroradiology
  100. The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination
    Authors: A Pu, MK Mishra, Y Dong, S Ghorbaniga, EL Stephenson, KS Rawji, C Silva, H Kitagawa, S Sawcer, VW Yong
    J Neuroinflammation, 2020-07-23;17(1):220.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  101. Endochondral Bone Regeneration by Non-autologous Mesenchymal Stem Cells
    Authors: Alessia Longoni, I. Pennings, Marta Cuenca Lopera, M. H. P. van Rijen, Victor Peperzak, A. J. W. P. Rosenberg et al.
    Frontiers in Bioengineering and Biotechnology
  102. Carbon nanoparticles induce endoplasmic reticulum stress around blood vessels with accumulation of misfolded proteins in the developing brain of offspring
    Authors: A Onoda, T Kawasaki, K Tsukiyama, K Takeda, M Umezawa
    Sci Rep, 2020-06-22;10(1):10028.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IF
  103. Human amniotic mesenchymal stromal cells promote bone regeneration via activating endogenous regeneration
    Authors: F Jiang, W Zhang, M Zhou, Z Zhou, M Shen, N Chen, X Jiang
    Theranostics, 2020-05-15;10(14):6216-6230.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC, Neutralization
  104. High‐fat diet‐induced GAIT element‐mediated translational silencing of mRNAs encoding inflammatory proteins in macrophage protects against atherosclerosis
    Authors: Abhijit Basu, Nina Dvorina, William M. Baldwin, Barsanjit Mazumder
    The FASEB Journal
  105. A Membrane-Bound Transcription Factor is Proteolytically Regulated by the AAA+ Protease FtsH in Staphylococcus aureus
    Authors: Won-Sik Yeo, Chiamara Anokwute, Philip Marcadis, Marcus Levitan, Mahmoud Ahmed, Yeun Bae et al.
    Journal of Bacteriology
  106. Transient microglial absence assists postmigratory cortical neurons in proper differentiation
    Authors: Y Hattori, Y Naito, Y Tsugawa, S Nonaka, H Wake, T Nagasawa, A Kawaguchi, T Miyata
    Nat Commun, 2020-04-02;11(1):1631.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  107. Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release
    Authors: Ge Gao, Congcong Li, Jie Zhu, Yi Wang, Yunlong Huang, Shu Zhao et al.
    Frontiers in Immunology
  108. IL-13 Ameliorates Neuroinflammation and Promotes Functional Recovery after Traumatic Brain Injury
    Authors: W Miao, Y Zhao, Y Huang, D Chen, C Luo, W Su, Y Gao
    J. Immunol., 2020-02-07;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  109. Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome‐autophagosome‐lysosome pathway dysfunction and microglia‐mediated neuroinflammation
    Authors: Yi Xie, Li Ba, Min Wang, Sai‐Yue Deng, Si‐Miao Chen, Li‐Fang Huang et al.
    CNS Neuroscience & Therapeutics
  110. Modeling pulmonary fibrosis through bleomycin delivered by osmotic minipump: a new histomorphometric method of evaluation
    Authors: Francesca Ravanetti, Luisa Ragionieri, Roberta Ciccimarra, Francesca Ruscitti, Daniela Pompilio, Ferdinando Gazza et al.
    American Journal of Physiology-Lung Cellular and Molecular Physiology
  111. Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke
    Authors: D Song, X Zhang, J Chen, X Liu, J Xue, L Zhang, X Lan
    J Neuroinflammation, 2019-12-06;16(1):256.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  112. Iron nanoparticle-labeled murine mesenchymal stromal cells in an osteoarthritic model persists and suggests anti-inflammatory mechanism of action
    Authors: AM Hamilton, WY Cheung, A Gómez-Aris, A Sharma, S Nakamura, A Chaboureau, S Bhatt, R Rabani, M Kapoor, PJ Foster, S Viswanatha
    PLoS ONE, 2019-12-03;14(12):e0214107.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  113. Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex
    Authors: SY Ye, JE Apple, X Ren, FL Tang, LL Yao, YG Wang, L Mei, YG Zhou, WC Xiong
    J Neuroinflammation, 2019-11-26;16(1):235.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  114. p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization
    Authors: Jinjin Peng, Jiacheng Li, Jing Huang, Pan Xu, Heming Huang, Yanjun Liu et al.
    Theranostics
  115. STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice
    Authors: W Cai, X Dai, J Chen, J Zhao, M Xu, L Zhang, B Yang, W Zhang, M Rocha, T Nakao, J Kofler, Y Shi, RA Stetler, X Hu, J Chen
    JCI Insight, 2019-10-17;4(20):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  116. Skewed macrophage polarization in aging skeletal muscle
    Authors: CY Cui, RK Driscoll, Y Piao, CW Chia, M Gorospe, L Ferrucci
    Aging Cell, 2019-09-02;0(0):e13032.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  117. Dualism of FGF and TGF-beta Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant
    Authors: Pino Bordignon, Giulia Bottoni, Xiaoying Xu, Alma S. Popescu, Zinnia Truan, Emmanuella Guenova et al.
    Cell Reports
  118. Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease
    Authors: Ge Gao, Shu Zhao, Xiaohuan Xia, Chunhong Li, Congcong Li, Chenhui Ji et al.
    Frontiers in Cellular Neuroscience
  119. Amelioration of visual deficits and visual system pathology after mild TBI with the cannabinoid type-2 receptor inverse agonist SMM-189
    Authors: Natalie M. Guley, Nobel A. Del Mar, Tyler Ragsdale, Chunyan Li, Aaron M. Perry, Bob M. Moore et al.
    Experimental Eye Research
  120. Transiently proliferating perivascular microglia harbor M1 type and precede cerebrovascular changes in a chronic hypertension model
    Authors: T Koizumi, K Taguchi, I Mizuta, H Toba, M Ohigashi, O Onishi, K Ikoma, S Miyata, T Nakata, M Tanaka, S Foulquier, HWM Steinbusch, T Mizuno
    J Neuroinflammation, 2019-04-10;16(1):79.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  121. Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance
    Authors: S Morita-Tak, K Nakahara, S Hasegawa-I, A Isonishi, K Tatsumi, H Okuda, T Tanaka, M Kitabatake, T Ito, A Wanaka
    J Neuroinflammation, 2019-02-14;16(1):39.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  122. Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems
    Authors: Imke Rudnik-Jansen, Nina Woike, Suzanne de Jong, Sabine Versteeg, Marja Kik, Pieter Emans et al.
    Pharmaceutics
  123. Induction of M2 Macrophages Prevents Bone Loss in Murine Periodontitis Models
    Authors: Z. Zhuang, S. Yoshizawa-Smith, A. Glowacki, K. Maltos, C. Pacheco, M. Shehabeldin et al.
    Journal of Dental Research
  124. Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
    Authors: V Bellver-La, F Bretheau, B Mailhot, N Vallières, M Lessard, ME Janelle, N Vernoux, MÈ Tremblay, T Fuehrmann, MS Shoichet, S Lacroix
    Nat Commun, 2019-01-31;10(1):518.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  125. Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway
    Authors: C Qin, Q Liu, ZW Hu, LQ Zhou, K Shang, DB Bosco, LJ Wu, DS Tian, W Wang
    Theranostics, 2018-10-29;8(19):5434-5451.
    Species: Mouse
    Sample Types: Cell Lysates, Tissue Homogenates, Whole Tissue
    Applications: ICC, IHC-Fr, Western Blot
  126. Interleukin-12p35 Knock Out Aggravates Doxorubicin-Induced Cardiac Injury and Dysfunction by Aggravating the Inflammatory Response, Oxidative Stress, Apoptosis and Autophagy in Mice
    Authors: J Ye, Y Huang, B Que, C Chang, W Liu, H Hu, L Liu, Y Shi, Y Wang, M Wang, T Zeng, W Zhen, Y Xu, L Shi, J Liu, H Jiang, D Ye, Y Lin, J Wan, Q Ji
    EBioMedicine, 2018-09-15;35(0):29-39.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  127. 2-carba cyclic phosphatidic acid suppresses inflammation via regulation of microglial polarisation in the stab-wounded mouse cerebral cortex
    Authors: K Hashimoto, M Nakashima, A Hamano, M Gotoh, H Ikeshima-K, K Murakami-M, Y Miyamoto
    Sci Rep, 2018-06-26;8(1):9715.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  128. Molecular and cellular identification of the immune response in peripheral ganglia following nerve injury
    Authors: JA Lindborg, JP Niemi, MA Howarth, KW Liu, CZ Moore, D Mahajan, RE Zigmond
    J Neuroinflammation, 2018-06-26;15(1):192.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  129. Alpha-1 Antitrypsin Attenuates M1 Microglia-Mediated Neuroinflammation in Retinal Degeneration
    Authors: Tian Zhou, Zijing Huang, Xiaowei Zhu, Xiaowei Sun, Yan Liu, Bing Cheng et al.
    Frontiers in Immunology
  130. Serelaxin Induces Notch1 Signaling and Alleviates Hepatocellular Damage in Orthotopic Liver Transplantation
    Authors: S Kageyama, K Nakamura, B Ke, RW Busuttil, JW Kupiec-Weg
    Am. J. Transplant., 2018-03-23;0(0):.
    Species: Mouse
    Sample Types: Protein
    Applications: Western Blot
  131. B-cell leukemia/lymphoma 10 promotes angiogenesis in an experimental corneal neovascularization model
    Authors: G Liu, P Lu, L Chen, W Zhang, M Wang, D Li, X Zhang
    Eye (Lond), 2018-03-08;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  132. Salidroside provides neuroprotection by modulating microglial polarization after cerebral ischemia
    Authors: X Liu, S Wen, F Yan, K Liu, L Liu, L Wang, S Zhao, X Ji
    J Neuroinflammation, 2018-02-09;15(1):39.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  133. Intranasal stem cell treatment as a novel therapy for subarachnoid hemorrhage
    Authors: CH Nijboer, E Kooijman, CT van Veltho, E Van Tilbor, IA Tiebosch, N Eijkelkamp, RM Dijkhuizen, J Kesecioglu, C Heijnen
    Stem Cells Dev., 2018-01-08;0(0):.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC-P
  134. Development and plasticity of meningeal lymphatic vessels
    Authors: Salli Antila, Sinem Karaman, Harri Nurmi, Mikko Airavaara, Merja H. Voutilainen, Thomas Mathivet et al.
    Journal of Experimental Medicine
  135. Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes
    Authors: Hiroyuki Konishi, Masaaki Kobayashi, Taikan Kunisawa, Kenta Imai, Akira Sayo, Bernard Malissen et al.
    Glia
  136. Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-kappa B Signaling in Alzheimer’s Disease Mice and Wild-Type Littermates
    Authors: Feng Zhang, Rujia Zhong, Song Li, Zhenfa Fu, Cheng Cheng, Huaibin Cai et al.
    Frontiers in Aging Neuroscience
  137. HDAC3 inhibition ameliorates spinal cord injury by immunomodulation
    Authors: T Kuboyama, S Wahane, Y Huang, X Zhou, JK Wong, A Koemeter-C, M Martini, RH Friedel, H Zou
    Sci Rep, 2017-08-17;7(1):8641.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  138. IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury
    Authors: Weiwei Gao, Fei Li, Ziwei Zhou, Xin Xu, Yingang Wu, Shuai Zhou et al.
    Frontiers in Neurology
  139. Macrophages are necessary for epimorphic regeneration in African spiny mice
    Authors: Jennifer Simkin, Thomas R Gawriluk, John C Gensel, Ashley W Seifert
    eLife
  140. Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using (111)In-tilmanocept
    Authors: Z Varasteh, F Hyafil, N Anizan, D Diallo, R Aid-Launai, S Mohanta, Y Li, M Braeuer, K Steiger, J Vigne, Z Qin, SG Nekolla, JE Fabre, Y Döring, D Le Guludec, A Habenicht, DR Vera, M Schwaiger
    EJNMMI Res, 2017-05-03;7(1):40.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  141. ST2/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury
    Authors: Y Yang, H Liu, H Zhang, Q Ye, J Wang, B Yang, L Mao, W Zhu, RK Leak, B Xiao, B Lu, J Chen, X Hu
    J. Neurosci., 2017-04-07;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  142. Perivascular Accumulation of beta -Sheet-Rich Proteins in Offspring Brain following Maternal Exposure to Carbon Black Nanoparticles
    Authors: Atsuto Onoda, Takayasu Kawasaki, Koichi Tsukiyama, Ken Takeda, Masakazu Umezawa
    Frontiers in Cellular Neuroscience
  143. Dependence of Glomerulonephritis Induction on Novel Intraglomerular Alternatively Activated Bone Marrow-Derived Macrophages and Mac-1 and PD-L1 in Lupus-Prone NZM2328 Mice
    Authors: SJ Sung, Y Ge, C Dai, H Wang, SM Fu, R Sharma, YS Hahn, J Yu, TH Le, MD Okusa, WK Bolton, JR Lawler
    J. Immunol, 2017-02-20;0(0):.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC
  144. Predictive screening of M1 and M2 macrophages reveals the immunomodulatory effectiveness of post spinal cord injury azithromycin treatment
    Authors: JC Gensel, TJ Kopper, B Zhang, MB Orr, WM Bailey
    Sci Rep, 2017-01-06;7(0):40144.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  145. Temporal Characterization of Microglia/Macrophage Phenotypes in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury
    Front Cell Neurosci, 2016-12-15;10(0):286.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  146. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain
    Authors: Raffaella Moretti, Pierre-Louis Leger, Valérie C. Besson, Zsolt Csaba, Julien Pansiot, Lorena Di Criscio et al.
    Journal of Neuroinflammation
  147. Dynamic Modulation of Microglia/Macrophage Polarization by miR-124 after Focal Cerebral Ischemia
    Authors: Somayyeh Hamzei Taj, Widuri Kho, Markus Aswendt, Franziska M. Collmann, Claudia Green, Joanna Adamczak et al.
    Journal of Neuroimmune Pharmacology
  148. In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response
    Authors: Juan Carlos Pena-Philippides, Ernesto Caballero-Garrido, Tamar Lordkipanidze, Tamara Roitbak
    Journal of Neuroinflammation
  149. Rescue therapy with Tanshinone IIA hinders transition of acute kidney injury to chronic kidney disease via targeting GSK3?
    Sci Rep, 2016-11-18;6(0):36698.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  150. Regulatory T cell transfer ameliorates lymphedema and promotes lymphatic vessel function
    Authors: Epameinondas Gousopoulos, Steven T. Proulx, Samia B. Bachmann, Jeannette Scholl, Dimitris Dionyssiou, Efterpi Demiri et al.
    JCI Insight
  151. miR-155 Deletion in Mice Overcomes Neuron-Intrinsic and Neuron-Extrinsic Barriers to Spinal Cord Repair
    J Neurosci, 2016-08-10;36(32):8516-32.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  152. The importance of nerve microenvironment for schwannoma development
    Authors: Alexander Schulz, Robert Büttner, Christian Hagel, Stephan L. Baader, Lan Kluwe, Johannes Salamon et al.
    Acta Neuropathologica
  153. IFN alpha gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment
    Authors: Mario Catarinella, Andrea Monestiroli, Giulia Escobar, Amleto Fiocchi, Ngoc Lan Tran, Roberto Aiolfi et al.
    EMBO Molecular Medicine
  154. Administration of DHA Reduces Endoplasmic Reticulum Stress-Associated Inflammation and Alters Microglial or Macrophage Activation in Traumatic Brain Injury
    Authors: Lloyd D. Harvey, Yan Yin, Insiya Y. Attarwala, Gulnaz Begum, Julia Deng, Hong Q. Yan et al.
    ASN Neuro
  155. Progression of Alport Kidney Disease in Col4a3 Knock Out Mice Is Independent of Sex or Macrophage Depletion by Clodronate Treatment
    Authors: Munkyung Kim, Alessandro Piaia, Neeta Shenoy, David Kagan, Berangere Gapp, Benjamin Kueng et al.
    PLOS ONE
  156. Positively Charged Oligo[Poly(Ethylene Glycol) Fumarate] Scaffold Implantation Results in a Permissive Lesion Environment after Spinal Cord Injury in Rat
    Authors: Jeffrey S. Hakim, Melika Esmaeili Rad, Peter J. Grahn, Bingkun K. Chen, Andrew M. Knight, Ann M. Schmeichel et al.
    Tissue Engineering Part A
  157. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.
    Authors: Kan M, Lee J, Wilson J, Everhart A, Brown C, Hoofnagle A, Jansen M, Vitek M, Gunn M, Colton C
    J Neurosci, 2015-04-15;35(15):5969-82.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  158. Galectin-1-secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury.
    Authors: Wang J, Xia J, Zhang F, Shi Y, Wu Y, Pu H, Liou A, Leak R, Yu X, Chen L, Chen J
    Sci Rep, 2015-04-10;5(0):9621.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  159. Heterogeneous induction of microglia M2a phenotype by central administration of interleukin-4.
    Authors: Pepe, Giovanna, Calderazzi, Giorgia, De Maglie, Marcella, Villa, Alessand, Vegeto, Elisabet
    J Neuroinflammation, 2014-12-31;11(1):211.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  160. Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype.
    Authors: Ko S, Ladanyi A, Lengyel E, Naora H
    Am J Pathol, 2014-01-01;184(1):271-81.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  161. MicroRNA-124 as a novel treatment for persistent hyperalgesia.
    J Neuroinflammation, 2012-06-25;9(0):143.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  162. p47phox deficiency induces macrophage dysfunction resulting in progressive crystalline macrophage pneumonia.
    Authors: Liu Q, Cheng LI, Yi L, Zhu N, Wood A, Changpriroa CM, Ward JM, Jackson SH
    Am. J. Pathol., 2008-12-18;174(1):153-63.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P

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Mouse MMR/CD206 Antibody
By Anonymous on 04/04/2023
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Brain (vasculature) Species: Mouse

Mouse MMR/CD206 Antibody
By Anonymous on 06/27/2021
Application: IHC Sample Tested: Connective tissue Species: Mouse

Mouse MMR/CD206 Antibody
By Tina Yuan on 11/23/2020
Application: IHC Sample Tested: mouse oral tissue Species: Mouse

Mouse MMR/CD206 Antibody
By Anonymous on 07/16/2019
Application: IHC Sample Tested: Adult brain,Brain tissue Species: Mouse

Dilution 1:200


Mouse MMR/CD206 Antibody
By Anonymous on 04/05/2019
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Spinal cord Species: Mouse

Mouse MMR/CD206 Antibody
By Anonymous on 12/18/2018
Application: Flow Sample Tested: Pancreas tissue Species: Mouse

Mouse MMR/CD206 Antibody
By Anonymous on 03/12/2018
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Kidney tissue Species: Mouse

Mouse MMR/CD206 Antibody
By Anonymous on 09/26/2016
Application: WB Sample Tested: Liver tissue Species: Mouse