NEDD8 Conjugation Reaction Buffer Kit
NEDD8 Conjugation Reaction Buffer Kit Summary
NEDD8 (Neural precursor cell-expressed developmentally down-regulated gene 8; also known as Rub1) is a 6-8 kDa member of the ubiquitin family of proteins. It is expressed in striated muscle, and via its C-terminal Gly, forms covalent bonds with cullin family proteins. This conjugation generates ubiquitin ligase activity that regulates cell cycle proteins. Human pro-NEDD8 is 81 amino acids (aa) in length. It contains one ubiquitin-like domain (aa 1-65), and a 4-5 aa C-terminal propeptide that is cleaved to expose a C-terminal Gly residue that is used to generate a Gly-Lys intermolecular bond. Mature human NEDD8 shows 100% aa identity to NEDD8 from both mouse and canine.
Citation for NEDD8 Conjugation Reaction Buffer Kit
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1 Citation: Showing 1 - 1
BLADE-ON-PETIOLE proteins act in an E3 ubiquitin ligase complex to regulate PHYTOCHROME INTERACTING FACTOR 4 abundance
Authors: B Zhang, M Holmlund, S Lorrain, M Norberg, L Bakó, C Fankhauser, O Nilsson
Elife, 2017;6(0):. 2017
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