NU 7441

  ( 29 citations )    
Product Datasheet
Catalog Number:3712
Alternate Names:KU 57788
Chemical Name:8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
Product Details
Citations (29)
Reviews
Biological Activity
Potent and selective DNA-PK inhibitor (IC50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin (Cat. No. 2252) and etoposide (Cat. No. 1226) in vitro and etoposide in vivo. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency 2 to 3-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%.
Technical Data
  • M.Wt:
    413.49
  • Formula:
    C25H19NO3S
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    503468-95-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for NU 7441 include:

29 Citations: Showing 1 - 10
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  1. DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination.
    Authors: Biehs Et al.
    Mol Cell  2017;65:671
  2. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.
    Authors: Cristini Et al.
    Nucleic Acids Res  2016;44:1161
  3. A novel cytoprotective function for the DNA repair protein Ku in regulating p53 mRNA translation and function.
    Authors: Lamaa Et al.
    EMBO Rep  2016;17:508
  4. Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.
    Authors: Hollingworth Et al.
    Nucleic Acids Res  2015;7:2908
  5. Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase.
    Authors: Mishra Et al.
    Mol Cancer Ther  2015;6:6224
  6. NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor.
    Authors: Yu Et al.
    Oncotarget  2015;6:3848
  7. Transcriptional elongation requires DNA break-induced signalling.
    Authors: Bunch Et al.
    Invest Ophthalmol Vis Sci  2015;6:10191
  8. Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins.
    Authors: Colin Et al.
    Viruses  2015;5:140156
  9. Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions.
    Authors: Thakran Et al.
    Open Biol  2015;56:177
  10. EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.
    Authors: Rein Et al.
    Nat Commun  2015;43:7371
  11. The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair.
    Authors: Henriksson Et al.
    Genes Dev  2014;28:2726
  12. Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.
    Authors: Zhou Et al.
    BMC Cancer  2014;14:944
  13. BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcitabine.
    Authors: Jones Et al.
    J Cell Biol  2014;13:2412
  14. Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins.
    Authors: Scanlon and Glazer
    Mol Cancer Res  2014;12:1016
  15. Human papillomavirus episome stability is reduced by aphidicolin and controlled by DNA damage response pathways.
    Authors: Edwards Et al.
    J Virol  2013;87:3979
  16. Targeting XRCC1 deficiency in breast cancer for personalized therapy.
    Authors: Sultana Et al.
    Cancer Res  2013;73:1621
  17. DNA-PK phosphorylation of IGFBP-3 is required to prevent apoptosis in retinal endothelial cells cultured in high glucose.
    Authors: Zhang and Steinle
    Neurobiol Dis  2013;54:3052
  18. Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
    Authors: Yüce and West
    Mol Cell Biol  2013;33:406
  19. Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.
    Authors: Lee Et al.
    PLoS One  2013;33:3568
  20. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells.
    Authors: Rass Et al.
    J Biol Chem  2013;288:7086
  21. DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).
    Authors: Zhou and Paull
    J Biol Chem  2013;288:37112
  22. A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair.
    Authors: Britton Et al.
    J Cell Biol  2013;202:579
  23. Targeting aberrant DNA double-strand break repair in triple-negative breast cancer with alpha-particle emitter radiolabeled anti-EGFR antibody.
    Authors: Song Et al.
    Mol Cancer Ther  2013;12:2043
  24. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.
    Authors: Oksenych Et al.
    Nat Commun  2013;110:2234
  25. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.
    Authors: Yamamoto Et al.
    J Virol  2012;198:305
  26. Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.
    Authors: Sultana Et al.
    Int J Cancer  2012;131:2433
  27. Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.
    Authors: Bohgaki Et al.
    PLoS Genet  2011;7:e1001381
  28. γ-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo.
    Authors: Sharma Et al.
    Invest Ophthalmol Vis Sci  2011;6:e28217
  29. Differential effects of DNA double-strand break repair pathways on single-strand and self-complementary adeno-associated virus vector genomes.
    Authors: Cataldi and McCarty
    Mol Cell Biol  2010;84:8673
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