Catalog Number: 1200
Chemical Name: N5-[Imino(propylamino)methyl]-L-ornithine hydrochloride
Biological Activity
Highly selective and potent inhibitor of nNOS (Ki = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.
Technical Data
  • M.Wt:
    252.74
  • Formula:
    C9H20N4O2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    137361-05-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney.
    Kakoki et al.
    Am.J.Physiol.Regul.Integr.Comp.Physiol., 2001;281:R91
  2. Potent and selective inhibition of neuronal nitric oxide synthase by Nω-propyl-L-arginine.
    Zhang et al.
    J.Med.Chem., 1997;40:3869
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Nω-Propyl-L-arginine hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Neuronal and Endothelial Nitric Oxide Synthases in the Paraventricular Nucleus Modulate Sympathetic Overdrive in Insulin-Resistant Rats.
    Authors: Lu Et al.
    Diabetes 2015;10:e0140762
  2. Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
    Authors: Mathison Et al.
    Br J Pharmacol 2004;142:1247
  3. Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels.
    Authors: Slesinger
    Biophys J 2001;80:707

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