Catalog Number: 4620
Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-Imidazole-5-carboxylic acid-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
Biological Activity
Prodrug metabolised in vivo to Olmesartan (Cat. No. 4616), a selective non-peptide angiotensin II type I receptor (AT1) antagonist. Selectively inhibits angiotensin II binding to AT1 receptors in bovine adrenal cortical membranes (IC50 = 7.7 nM), with no effect on AT2 receptors.
Technical Data
  • M.Wt:
    558.59
  • Formula:
    C29H30N6O6
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    144689-63-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of angiotensin AT1 receptor antagonist on volume overload-induced cardiac gene expression in rats.
    Kim et al.
    Hypertens.Res., 1997;20:133
  2. Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist.
    Mizuno et al.
    Eur.J.Pharmacol., 1995;285:181
Tocris Small Molecules
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Olmesartan

4616  
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