Chemical Name: 6,6'-Dithiodi-2-naphthtol
Biological ActivityNegative control of IPA 3, a direct, non-competitive inhibitor of group I p21-activated kinase (Pak1).
Active Analog also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.
Deacon et al.
Citations for PIR 3.5
The citations listed below are publications that use Tocris products. Selected citations for PIR 3.5 include:
3 Citations: Showing 1 - 3
Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala.
Authors: Das Et al.
Sci Rep 2017;7:13930
Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.
Authors: Imle Et al.
Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase.
Authors: Molosh Et al.
J Biol Chem 2014;17:1583
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