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proTAME

Catalog #: I-440
19 Citations Datasheet / COA / SDS
Cell-permeable APC/C inhibitor. The new catalog number will be 7734

Discontinued Product

I-440 has been discontinued.
View all Ubiquitin Ligase (E3) Inhibitors products.
Boston Biochem Supplemental Ubiquitin Reagents
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Citations (19)
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proTAME Summary

Specifications

Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species

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Apcin
Cat # 5747

Citations for proTAME

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

19 Citations: Showing 1 - 10
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  1. Self-assembly of pericentriolar material in interphase cells lacking centrioles
    Authors: F Chen, J Wu, MK Iwanski, D Jurriens, A Sandron, M Pasolli, G Puma, JZ Kromhout, C Yang, W Nijenhuis, LC Kapitein, F Berger, A Akhmanova
    Elife, 2022;11(0):.  2022
  2. A mitotic chromatin phase transition prevents perforation by microtubules
    Authors: MWG Schneider, BA Gibson, S Otsuka, MFD Spicer, M Petrovic, C Blaukopf, CCH Langer, P Batty, T Nagaraju, LK Doolittle, MK Rosen, DW Gerlich
    Nature, 2022;0(0):.  2022
  3. Epigenetic, genetic and maternal effects enable stable centromere inheritance
    Authors: A Das, A Iwata-Otsu, A Destouni, JM Dawicki-Mc, KG Boese, BE Black, MA Lampson
    Nature Cell Biology, 2022;24(5):748-756.  2022
  4. Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation
    Authors: S Carvalhal, I Bader, MA Rooimans, AB Oostra, JA Balk, RG Feichtinge, C Beichler, MR Speicher, JM van Hagen, Q Waisfisz, M van Haelst, M Bruijn, A Tavares, JA Mayr, RMF Wolthuis, RA Oliveira, J de Lange
    Science Advances, 2022;8(3):eabk0114.  2022
  5. A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
    Authors: C Thomas, B Wetherall, MD Levasseur, RJ Harris, ST Kerridge, JMG Higgins, OR Davies, S Madgwick
    Nature Communications, 2021;12(1):4322.  2021
  6. The APC/C targets the Cep152-Cep63 complex at the centrosome to regulate mitotic spindle assembly
    Authors: T Tischer, J Yang, D Barford
    Journal of Cell Science, 2021;0(0):.  2021
  7. The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance
    Authors: S Zhang, Y Shen, H Li, C Bi, Y Sun, X Xiong, W Wei, Y Sun
    Cell Rep, 2020;32(10):108102.  2020
  8. CRISPR-mediated gene targeting of CK1&delta/&epsilon leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1
    Authors: RX Guillen, JR Beckley, JS Chen, KL Gould
    Sci Rep, 2020;10(1):6797.  2020
  9. ProTAME Arrest in Mammalian Oocytes and Embryos Does Not Require Spindle Assembly Checkpoint Activity
    Authors: L Radonova, T Svobodova, M Skultety, O Mrkva, L Libichova, P Stein, M Anger
    Int J Mol Sci, 2019;20(18):.  2019
  10. Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability
    Authors: M Raab, M Sanhaji, S Zhou, F Rödel, A El-Balat, S Becker, K Strebhardt
    Neoplasia, 2019;21(4):363-375.  2019
  11. The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets and Cooperates with APC/C to Promote Quiescence
    Authors: AJ Bainor, S Saini, A Calderon, R Casado-Pol, B Giner-Rami, C Moncada, DJ Cantor, A Ernlund, L Litovchick, G David
    Cell Rep, 2018;25(10):2797-2807.e8.  2018
  12. EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle
    Authors: SD Cappell, KG Mark, D Garbett, LR Pack, M Rape, T Meyer
    Nature, 2018;0(0):.  2018
  13. ATP depletion during mitotic arrest induces mitotic slippage and APC/CCdh1-dependent cyclin B1 degradation
    Authors: YY Park, JH Ahn, MG Cho, JH Lee
    Exp. Mol. Med., 2018;50(4):46.  2018
  14. Reciprocal Regulation between 53BP1 and the Anaphase-Promoting Complex/Cyclosome Is Required for Genomic Stability during Mitotic Stress
    Authors: TJ Kucharski, PE Minshall, M Moustafa-K, AS Turnell, JG Teodoro
    Cell Rep, 2017;18(8):1982-1995.  2017
  15. APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry
    Cell Rep, 2016;16(12):3359-72.  2016
  16. AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest.
    Authors: Domenech E, Maestre C, Esteban-Martinez L, Partida D, Pascual R, Fernandez-Miranda G, Seco E, Campos-Olivas R, Perez M, Megias D, Allen K, Lopez M, Saha A, Velasco G, Rial E, Mendez R, Boya P, Salazar-Roa M, Malumbres M
    Nat Cell Biol, 2015;17(10):1304-16.  2015
  17. Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20.
    Authors: Boekhout M, Wolthuis R
    J Cell Sci, 2015;128(8):1639-53.  2015
  18. APC/C is an essential regulator of centrosome clustering.
    Authors: Drosopoulos, Konstant, Tang, Chan, Chao, William, Linardopoulos, Spiros
    Nat Commun, 2014;5(0):3686.  2014
  19. Microtubule-dependent regulation of mitotic protein degradation.
    Authors: Song L, Craney A, Rape M
    Mol Cell, 2014;53(2):179-92.  2014

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