Cell-permeable APC/C inhibitor. The new catalog number will be 7734

Discontinued Product

I-440 has been discontinued.
View all Ubiquitin Ligase (E3) Inhibitors products.
Boston Biochem Supplemental Ubiquitin Reagents
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Product Details
Citations (19)

proTAME Summary


Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Citations for proTAME

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

19 Citations: Showing 1 - 10
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  1. Self-assembly of pericentriolar material in interphase cells lacking centrioles
    Authors: F Chen, J Wu, MK Iwanski, D Jurriens, A Sandron, M Pasolli, G Puma, JZ Kromhout, C Yang, W Nijenhuis, LC Kapitein, F Berger, A Akhmanova
    Elife, 2022;11(0):.  2022
  2. A mitotic chromatin phase transition prevents perforation by microtubules
    Authors: MWG Schneider, BA Gibson, S Otsuka, MFD Spicer, M Petrovic, C Blaukopf, CCH Langer, P Batty, T Nagaraju, LK Doolittle, MK Rosen, DW Gerlich
    Nature, 2022;0(0):.  2022
  3. Epigenetic, genetic and maternal effects enable stable centromere inheritance
    Authors: A Das, A Iwata-Otsu, A Destouni, JM Dawicki-Mc, KG Boese, BE Black, MA Lampson
    Nature Cell Biology, 2022;24(5):748-756.  2022
  4. Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation
    Authors: S Carvalhal, I Bader, MA Rooimans, AB Oostra, JA Balk, RG Feichtinge, C Beichler, MR Speicher, JM van Hagen, Q Waisfisz, M van Haelst, M Bruijn, A Tavares, JA Mayr, RMF Wolthuis, RA Oliveira, J de Lange
    Science Advances, 2022;8(3):eabk0114.  2022
  5. A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
    Authors: C Thomas, B Wetherall, MD Levasseur, RJ Harris, ST Kerridge, JMG Higgins, OR Davies, S Madgwick
    Nature Communications, 2021;12(1):4322.  2021
  6. The APC/C targets the Cep152-Cep63 complex at the centrosome to regulate mitotic spindle assembly
    Authors: T Tischer, J Yang, D Barford
    Journal of Cell Science, 2021;0(0):.  2021
  7. The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance
    Authors: S Zhang, Y Shen, H Li, C Bi, Y Sun, X Xiong, W Wei, Y Sun
    Cell Rep, 2020;32(10):108102.  2020
  8. CRISPR-mediated gene targeting of CK1&delta/&epsilon leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1
    Authors: RX Guillen, JR Beckley, JS Chen, KL Gould
    Sci Rep, 2020;10(1):6797.  2020
  9. ProTAME Arrest in Mammalian Oocytes and Embryos Does Not Require Spindle Assembly Checkpoint Activity
    Authors: L Radonova, T Svobodova, M Skultety, O Mrkva, L Libichova, P Stein, M Anger
    Int J Mol Sci, 2019;20(18):.  2019
  10. Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability
    Authors: M Raab, M Sanhaji, S Zhou, F Rödel, A El-Balat, S Becker, K Strebhardt
    Neoplasia, 2019;21(4):363-375.  2019
  11. The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets and Cooperates with APC/C to Promote Quiescence
    Authors: AJ Bainor, S Saini, A Calderon, R Casado-Pol, B Giner-Rami, C Moncada, DJ Cantor, A Ernlund, L Litovchick, G David
    Cell Rep, 2018;25(10):2797-2807.e8.  2018
  12. EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle
    Authors: SD Cappell, KG Mark, D Garbett, LR Pack, M Rape, T Meyer
    Nature, 2018;0(0):.  2018
  13. ATP depletion during mitotic arrest induces mitotic slippage and APC/CCdh1-dependent cyclin B1 degradation
    Authors: YY Park, JH Ahn, MG Cho, JH Lee
    Exp. Mol. Med., 2018;50(4):46.  2018
  14. Reciprocal Regulation between 53BP1 and the Anaphase-Promoting Complex/Cyclosome Is Required for Genomic Stability during Mitotic Stress
    Authors: TJ Kucharski, PE Minshall, M Moustafa-K, AS Turnell, JG Teodoro
    Cell Rep, 2017;18(8):1982-1995.  2017
  15. APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry
    Cell Rep, 2016;16(12):3359-72.  2016
  16. AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest.
    Authors: Domenech E, Maestre C, Esteban-Martinez L, Partida D, Pascual R, Fernandez-Miranda G, Seco E, Campos-Olivas R, Perez M, Megias D, Allen K, Lopez M, Saha A, Velasco G, Rial E, Mendez R, Boya P, Salazar-Roa M, Malumbres M
    Nat Cell Biol, 2015;17(10):1304-16.  2015
  17. Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20.
    Authors: Boekhout M, Wolthuis R
    J Cell Sci, 2015;128(8):1639-53.  2015
  18. APC/C is an essential regulator of centrosome clustering.
    Authors: Drosopoulos, Konstant, Tang, Chan, Chao, William, Linardopoulos, Spiros
    Nat Commun, 2014;5(0):3686.  2014
  19. Microtubule-dependent regulation of mitotic protein degradation.
    Authors: Song L, Craney A, Rape M
    Mol Cell, 2014;53(2):179-92.  2014


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