Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Bovine (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all RCAN2 Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 14 amino acid synthetic peptide near the center of human RCAN2. The immunogen is located within amino acids 70 - 120 of RCAN2. Amino Acid Squence: AQVQTPETDGDKLH

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RCAN2 Antibody - BSA Free

Western Blot: RCAN2 AntibodyBSA Free [NBP1-76995]

Western Blot: RCAN2 AntibodyBSA Free [NBP1-76995]

Western Blot: RCAN2 Antibody [NBP1-76995] - 3T3 cell lysate with RCAN2 antibody at (A) 1 and (B) 2 ug/mL.
RCAN2 Antibody - BSA Free

Immunohistochemistry: RCAN2 Antibody - BSA Free [NBP1-76995] -

Immunohistochemistry: RCAN2 Antibody - BSA Free [NBP1-76995] - Immunohistochemistry of RCAN2 in mouse brain tissue with RCAN2 antibody at 2.5 ug/mL.
RCAN2 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: RCAN2 Antibody - BSA Free [NBP1-76995] -

Immunocytochemistry/ Immunofluorescence: RCAN2 Antibody - BSA Free [NBP1-76995] - Immunofluorescence of RCAN2 in mouse brain tissue with RCAN2 antibody at 20 ug/mL.

Applications for RCAN2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RCAN2

Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.

Alternate Names

Calcipressin 2 (Thyroid hormone-responsive protein ZAKI-4) (Down syndromecandidate region 1-like 1) (Myocyte-enriched calcineurin interacting protein2) (MCIP2), calcipressin-2, Down syndrome candidate region 1-like 1, Down syndrome critical region gene 1-like 1, DSCR1L1MCIP2ZAKI4RCN2, hRCN2, Myocyte-enriched calcineurin-interacting protein 2, regulator of calcineurin 2CSP2, thyroid hormone-responsive (skin fibroblasts), Thyroid hormone-responsive protein ZAKI-4, ZAKI-4

Gene Symbol

RCAN2

UniProt

AAH62141 (Mouse)

Additional RCAN2 Products

Product Documents for RCAN2 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for RCAN2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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