Recombinant Human IL-2 Protein 202-IL-010: R&D Systems

Recombinant Human IL-2 Protein

(197 citations)
(9 Reviews)
  
  • Purity
    >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Endotoxin Level
    <0.10 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. Gearing, A.J.H. and C.B. Bird (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 295. The ED50 for this effect is 0.05-0.25 ng/mL.
    The specific activity of Recombinant Human IL-2 is approximately 2.1 x 104 IU/μg, which is calibrated against recombinant human IL-2 WHO International Standard (NIBSC code: 86/500).
  • Source
    E. coli-derived Ala21-Thr153, with an N-terminal Met
  • Accession #
  • N-terminal Sequence
    Analysis
    Met
  • Predicted Molecular Mass
    15 kDa
  • SDS-PAGE
    13 kDa, reducing conditions
Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
202-IL
 
202-IL/CF
Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute at 100 μg/mL in sterile 100 mM Acetic Acid containing at least 0.1% human or bovine serum albumin.
Reconstitution Reconstitute at 100 μg/mL in sterile 100 mM Acetic Acid.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images
Recombinant Human IL-2 (Catalog # 202-IL) stimulates cell proliferation of the CTLL‑2 mouse cytotoxic T cell line. The ED50 for this effect is 0.05-0.25 ng/mL.
1 μg/lane of Recombinant Human IL-2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 13 kDa.
Background: IL-2

Interleukin-2 (IL-2) is a O-glycosylated, four alpha -helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4+ and CD8+ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils (1-3). Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit cross-species activity (4). The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes (5-7). The 55 kDa IL-2 R alpha is specific for IL-2 and binds with low affinity. The 75 kDa IL-2 R beta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. The 64 kDa common gamma chain gamma c/IL-2 R gamma, which is shared with the receptors for IL-4, -7, -9, -15, and -21, does not independently interact with IL-2. Upon ligand binding, signal transduction is performed by both IL-2 R beta and gamma c. IL-2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to proliferate and induces IL-2 and IL-2 R alpha synthesis (1, 2). It contributes to T cell homeostasis by promoting the Fas-induced death of naïve CD4+ T cells but not activated CD4+ memory lymphocytes (8). IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells (9-11). Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity (12, 13).

  • References:
    1. Ma, A. et al. (2006) Annu. Rev. Immunol. 24:657.
    2. Gaffen, S.L. and K.D. Liu (2004) Cytokine 28:109.
    3. Taniguchi, T. et al. (1983) Nature 302:305.
    4. Mosmann, T.R. et al. (1987) J. Immunol. 138:1813.
    5. Liparoto, S.F. et al. (2002) Biochemistry 41:2543.
    6. Wang, X. et al. (2005) Science 310:1159.
    7. Bodnar, A. et al. (2008) Immunol. Lett. 116:117.
    8. Jaleco, S. et al. (2003) J. Immunol. 171:61.
    9. Malek, T.R. (2003) J. Leukoc. Biol. 74:961.
    10. Laurence, A. et al. (2007) Immunity 26:371.
    11. Kryczek, I. et al. (2007) J. Immunol. 178:6730.
    12. Afzali, B. et al. (2007) Clin. Exp. Immunol. 148:32.
    13. Fehervari, Z. et al. (2006) Trends Immunol. 27:109.
  • Long Name:
    Interleukin 2
  • Entrez Gene IDs:
    3558 (Human); 16183 (Mouse); 116562 (Rat); 396868 (Porcine); 280822 (Bovine); 403989 (Canine); 100034204 (Equine); 751114 (Feline); 100302458 (Rabbit)
  • Alternate Names:
    aldesleukin; IL2; IL-2; IL-2lymphokine; interleukin 2; interleukin-2; involved in regulation of T-cell clonal expansion; T cell growth factor; T-cell growth factor; TCGF
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

197 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. ??TCR immunoglobulin constant region domain exchange in human ??TCRs improves TCR pairing without altering TCR gene-modified T cell function
    Authors: C Tao, H Shao, W Zhang, H Bo, F Wu, H Shen, S Huang
    Mol Med Rep, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  2. The IGH locus relocalizes to a recombination compartment in the perinucleolar region of differentiating B-lymphocytes
    Authors: A Pichugin, OV Iarovaia, A Gavrilov, I Sklyar, N Barinova, A Barinov, E Ivashkin, G Caron, S Aoufouchi, SV Razin, T Fest, M Lipinski, YS Vassetzky
    Oncotarget, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  3. IL-2 prevents deletion of developing T-regulatory cells in the thymus
    Authors: DY Hu, RC Wirasinha, CC Goodnow, SR Daley
    Cell Death Differ., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  4. Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates
    Authors: MM Shikhagaie, ÅK Björklund, J Mjösberg, JS Erjefält, AS Cornelisse, XR Ros, SM Bal, JJ Koning, RE Mebius, M Mori, M Bruchard, B Blom, H Spits
    Cell Rep, 2017;18(7):1761-1773.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  5. EBV induces persistent NF-?B activation and contributes to survival of EBV-positive neoplastic T- or NK-cells
    Authors: H Takada, KI Imadome, H Shibayama, M Yoshimori, L Wang, Y Saitoh, S Uota, S Yamaoka, T Koyama, N Shimizu, K Yamamoto, S Fujiwara, O Miura, A Arai
    PLoS ONE, 2017;12(3):e0174136.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  6. Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1
    Authors: JE Hammonds, N Beeman, L Ding, S Takushi, AC Francis, JJ Wang, GB Melikyan, P Spearman
    PLoS Pathog, 2017;13(1):e1006181.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  7. A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging
    Authors: A Lanna, DC Gomes, B Muller-Dur, T McDonnell, D Escors, DW Gilroy, JH Lee, M Karin, AN Akbar
    Nat. Immunol, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  8. PKC? links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton
    Authors: GJ Britton, R Ambler, DJ Clark, EV Hill, HM Tunbridge, KE McNally, BR Burton, P Butterweck, C Sabatos-Pe, LA Hampton-O', P Verkade, C Wlfing, DC Wraith
    Elife, 2017;6(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  9. Ref-1/APE1 as Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia
    Authors: J Ding, ML Fishel, AM Reed, E McAdams, M Czader, AA Cardoso, MR Kelley
    Mol. Cancer Ther., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  10. Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors
    Authors: A Van Hout, T D'huys, M Oeyen, D Schols, T Van Loy
    PLoS ONE, 2017;12(4):e0176057.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  11. CCR8(+)FOXp3(+) Treg cells as master drivers of immune regulation
    Authors: Y Barsheshet, G Wildbaum, E Levy, A Vitenshtei, C Akinseye, J Griggs, SA Lira, N Karin
    Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  12. The Intergenic Recombinant HLA-B?46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands
    Authors: HG Hilton, CP McMurtrey, AS Han, Z Djaoud, LA Guethlein, JH Blokhuis, JL Pugh, A Goyos, A Horowitz, R Buchli, KW Jackson, W Bardet, DA Bushnell, PJ Robinson, JL Mendoza, ME Birnbaum, M Nielsen, KC Garcia, WH Hildebrand, P Parham
    Cell Rep, 2017;19(7):1394-1405.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  13. Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells
    Authors: F Kawamura, M Inaki, A Katafuchi, Y Abe, N Tsuyama, Y Kurosu, A Yanagi, M Higuchi, S Muto, T Yamaura, H Suzuki, H Noji, S Suzuki, MA Yoshida, M Sasatani, K Kamiya, M Onodera, A Sakai
    Sci Rep, 2017;7(1):1659.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  14. C3d regulates immune checkpoint blockade and enhances antitumor immunity
    Authors: JL Platt, I Silva, SJ Balin, AR Lefferts, E Farkash, TM Ross, MC Carroll, M Cascalho
    JCI Insight, 2017;2(9):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  15. Neonatal myeloid derived suppressor cells show reduced apoptosis and immunosuppressive activity upon infection with Escherichia coli
    Authors: A Leiber, J Schwarz, N Köstlin, B Spring, B Fehrenbach, N Katava, CF Poets, C Gille
    Eur. J. Immunol., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  16. Therapeutic immune monitoring of CD4(+)CD25(+) T cells in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors
    Authors: Z Lu, N Xu, X Zhou, G Gao, L Li, J Huang, Y Li, Q Lu, B He, C Pan, X Liu
    Oncol Lett, 2017;14(2):1363-1372.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  17. Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses
    Authors: S Tousa, M Semitekolo, I Morianos, A Banos, AI Trochoutso, TM Brodie, N Poulos, K Samitas, M Kapasa, D Konstantop, G Paraskevop, M Gaga, CM Hawrylowic, F Sallusto, G Xanthou
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  18. Trastuzumab Increases HER2 Uptake and Cross-Presentation by Dendritic Cells
    Authors: VA Gall, AV Philips, N Qiao, K Clise-Dwye, AA Perakis, M Zhang, GT Clifton, P Sukhumalch, Q Ma, SM Reddy, D Yu, JJ Molldrem, GE Peoples, G Alatrash, EA Mittendorf
    Cancer Res., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  19. Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages
    Sci Rep, 2016;6(0):38597.
    Species: Pteropus alecto (bat)
    Sample Type: Whole Cells
    Application: Bioassay
  20. Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML
    Mol Ther Methods Clin Dev, 2016;3(0):16074.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  21. Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency
    Proc. Natl. Acad. Sci. U.S.A, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  22. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
    Circ Res, 2016;0(0):.
    Species: Human
    Sample Type: Plasma
    Application: Bioassay
  23. Development of engineered T cells expressing a chimeric CD16-CD3? receptor to improve the clinical efficacy of mogamulizumab therapy against adult T cell leukemia
    Authors: H Tanaka, H Fujiwara, F Ochi, K Tanimoto, N Casey, S Okamoto, J Mineno, K Kuzushima, H Shiku, T Sugiyama, J Barrett, M Yasukawa
    Clin Cancer Res, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  24. Native cellulose nanofibrills induce immune tolerance in vitro by acting on dendritic cells
    Sci Rep, 2016;6(0):31618.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  25. Granulocytic Myeloid-Derived Suppressor Cells Accumulate in Human Placenta and Polarize toward a Th2 Phenotype.
    Authors: Kostlin N, Hofstadter K, Ostermeir A, Spring B, Leiber A, Haen S, Abele H, Bauer P, Pollheimer J, Hartl D, Poets C, Gille C
    J Immunol, 2016;196(3):1132-45.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  26. Association of CD147 and Calcium Exporter PMCA4 Uncouples IL-2 Expression from Early TCR Signaling.
    Authors: Supper V, Schiller H, Paster W, Forster F, Boulegue C, Mitulovic G, Leksa V, Ohradanova-Repic A, Machacek C, Schatzlmaier P, Zlabinger G, Stockinger H
    J Immunol, 2016;196(3):1387-99.
    Species: Human
    Sample Type: Cell Culture Supernates
    Application: Luminex Development
  27. Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation
    Authors: Jun Li
    Nat Commun, 2016;7(0):11730.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  28. The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation
    Nat Commun, 2016;7(0):11473.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  29. Functional differences in hepatitis C virus nonstructural (NS) 3/4A- and 5A-specific T cell responses
    Sci Rep, 2016;6(0):24991.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  30. Effects of Cigarette Smoke Condensate on Oxidative Stress, Apoptotic Cell Death, and HIV Replication in Human Monocytic Cells
    PLoS ONE, 2016;11(5):e0155791.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  31. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes
    Authors: RB Jones, S Mueller, R O'Connor, K Rimpel, DD Sloan, D Karel, HC Wong, EK Jeng, AS Thomas, JB Whitney, SY Lim, C Kovacs, E Benko, S Karandish, SH Huang, MJ Buzon, M Lichterfel, A Irrinki, JP Murry, A Tsai, H Yu, R Geleziunas, A Trocha, MA Ostrowski, Irvi
    PLoS Pathog, 2016;12(4):e1005545.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  32. SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice
    Authors: M Ke, H Wang, Y Zhou, J Li, Y Liu, M Zhang, J Dou, T Xi, B Shen, C Zhou
    Oncotarget, 2016;7(31):49509-49526.
    Species: Human
    Sample Type: Whole Cell
    Application: Bioassay
  33. Enhanced Cytotoxic CD8 T Cell Priming Using Dendritic Cell-Expressing Human Papillomavirus-16 E6/E7-p16INK4 Fusion Protein with Sequenced Anti-Programmed Death-1
    Authors: TM Garcia-Bat, E Kim, F Concha-Ben, S Trivedi, RB Mailliard, A Gambotto, RL Ferris
    J. Immunol, 2016;196(6):2870-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  34. The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.
    Authors: Ranzani, Valeria, Rossetti, Grazisa, Panzeri, Ilaria, Arrigoni, Alberto, Bonnal, Raoul J, Curti, Serena, Gruarin, Paola, Provasi, Elena, Sugliano, Elisa, Marconi, Maurizio, De Francesco, Raffaele, Geginat, Jens, Bodega, Beatrice, Abrignani, Sergio, Pagani, Massimil
    Nat Immunol, 2015;16(3):318-25.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  35. The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects.
    Authors: Tian X, Zhang A, Qiu C, Wang W, Yang Y, Qiu C, Liu A, Zhu L, Yuan S, Hu H, Wang W, Wei Q, Zhang X, Xu J
    J Immunol, 2015;194(8):3873-82.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  36. Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells.
    Authors: Zingoni A, Cecere F, Vulpis E, Fionda C, Molfetta R, Soriani A, Petrucci M, Ricciardi M, Fuerst D, Amendola M, Mytilineos J, Cerboni C, Paolini R, Cippitelli M, Santoni A
    J Immunol, 2015;195(2):736-48.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  37. The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity.
    Authors: Hoffmann F, Kuhn P, Laurent S, Hauck S, Berer K, Wendlinger S, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister H, Alexander T, Hiepe F, Kumpfel T, Crawford H, Wekerle H, Hohlfeld R, Lichtenthaler S, Meinl E
    J Immunol, 2015;194(2):542-52.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  38. Hair regrowth in alopecia areata patients following Stem Cell Educator therapy.
    Authors: Li Y, Yan B, Wang H, Li H, Li Q, Zhao D, Chen Y, Zhang Y, Li W, Zhang J, Wang S, Shen J, Li Y, Guindi E, Zhao Y
    BMC Med, 2015;13(0):87.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  39. Antileukemia multifunctionality of CD4(+) T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer.
    Authors: Fujiwara H, Ochi T, Ochi F, Miyazaki Y, Asai H, Narita M, Okamoto S, Mineno J, Kuzushima K, Shiku H, Yasukawa M
    Leukemia, 2015;29(12):2393-401.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  40. Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein.
    Authors: Pery E, Sheehy A, Nebane N, Brazier A, Misra V, Rajendran K, Buhrlage S, Mankowski M, Rasmussen L, White E, Ptak R, Gabuzda D
    J Biol Chem, 2015;290(16):10504-17.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  41. Increased CD160 expression on circulating natural killer cells in atherogenesis.
    Authors: Zuo J, Shan Z, Zhou L, Yu J, Liu X, Gao Y
    J Transl Med, 2015;13(0):188.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  42. CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.
    Authors: Yan J, Hao C, DeLucia M, Swanson S, Florens L, Washburn M, Ahn J, Skowronski J
    J Biol Chem, 2015;290(21):13279-92.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  43. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis.
    Authors: Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, Ikinciogullari A, Dogu F, Belkadi A, Levy R, Migaud M, Boisson B, Bolze A, Itan Y, Goudin N, Cottineau J, Picard C, Abel L, Bustamante J, Casanova J, Puel A
    J Exp Med, 2015;212(5):619-31.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  44. Mature cytotoxic CD56(bright)/CD16(+) natural killer cells can infiltrate lymph nodes adjacent to metastatic melanoma.
    Cancer Res, 2015;74(0):81.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  45. Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines.
    Authors: Chien W, Le Beux C, Rachinel N, Julien M, Lacroix C, Allas S, Sahakian P, Cornut-Thibaut A, Lionnard L, Kucharczak J, Aouacheria A, Abribat T, Salles G
    Sci Rep, 2015;5(0):8068.
    Species: Human
    Sample Type: Whole Cell
    Application: Bioassay
  46. Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy.
    Authors: Lam, Sharon, Sung, Julia, Cruz, Conrad, Castillo-Caro, Paul, Ngo, Minhtran, Garrido, Carolina, Kuruc, Joann, Archin, Nancie, Rooney, Cliona, Margolis, David, Bollard, Catherin
    Mol Ther, 2015;23(2):387-95.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  47. MicroRNA-146a controls Th1-cell differentiation of human CD4+ T lymphocytes by targeting PRKCepsilon.
    Authors: Mohnle P, Schutz S, van der Heide V, Hubner M, Luchting B, Sedlbauer J, Limbeck E, Hinske L, Briegel J, Kreth S
    Eur J Immunol, 2015;45(1):260-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  48. A Human Monoclonal Antibody against Hepatitis B Surface Antigen with Potent Neutralizing Activity.
    Authors: Cerino A, Bremer C, Glebe D, Mondelli M
    PLoS ONE, 2015;10(4):e0125704.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  49. Impaired survival of regulatory T cells in pulmonary sarcoidosis.
    Authors: Broos C, van Nimwegen M, KleinJan A, ten Berge B, Muskens F, in 't Veen J, Annema J, Lambrecht B, Hoogsteden H, Hendriks R, Kool M, van den Blink B
    Respir Res, 2015;16(0):108.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  50. Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells.
    Authors: Odorizzi P, Pauken K, Paley M, Sharpe A, Wherry E
    J Exp Med, 2015;212(7):1125-37.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  51. Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter.
    Authors: Hill E, Ng T, Burton B, Oakley C, Malik K, Wraith D
    Eur J Immunol, 2015;45(4):1103-15.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  52. Alpha-Particle-Induced Complex Chromosome Exchanges Transmitted through Extra-Thymic Lymphopoiesis In Vitro Show Evidence of Emerging Genomic Instability.
    Authors: Sumption N, Goodhead D, Anderson R
    PLoS ONE, 2015;10(8):e0134046.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  53. In vivo maintenance of human regulatory T cells during CD25 blockade.
    Authors: Huss, David J, Mehta, Devangi, Sharma, Akanksha, You, Xiaojun, Riester, Katherin, Sheridan, James P, Amaravadi, Lakshmi, Elkins, Jacob S, Fontenot, Jason D
    J Immunol, 2015;194(1):84-92.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  54. Anti-CD20 Therapy Acts via FcgammaRIIIA to Diminish Responsiveness of Human Natural Killer Cells.
    Authors: Capuano C, Romanelli M, Pighi C, Cimino G, Rago A, Molfetta R, Paolini R, Santoni A, Galandrini R
    Cancer Res, 2015;75(19):4097-108.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  55. Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol.
    Authors: Goedken E, Argiriadi M, Banach D, Fiamengo B, Foley S, Frank K, George J, Harris C, Hobson A, Ihle D, Marcotte D, Merta P, Michalak M, Murdock S, Tomlinson M, Voss J
    J Biol Chem, 2015;290(8):4573-89.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  56. Role and species-specific expression of colon T cell homing receptor GPR15 in colitis.
    Authors: Nguyen L, Pan J, Dinh T, Hadeiba H, O'Hara E, Ebtikar A, Hertweck A, Gokmen M, Lord G, Jenner R, Butcher E, Habtezion A
    Nat Immunol, 2015;16(2):207-13.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  57. Identification of Four-Jointed Box 1 (FJX1)-Specific Peptides for Immunotherapy of Nasopharyngeal Carcinoma.
    Authors: Chai S, Yap Y, Foo Y, Yap L, Ponniah S, Teo S, Cheong S, Patel V, Lim K
    PLoS ONE, 2015;10(11):e0130464.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  58. Mapping the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy.
    Authors: Berlin C, Kowalewski D, Schuster H, Mirza N, Walz S, Handel M, Schmid-Horch B, Salih H, Kanz L, Rammensee H, Stevanovic S, Stickel J
    Leukemia, 2015;29(3):647-59.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  59. Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation.
    Authors: Ahn Y, Weeres M, Neulen M, Choi J, Kang S, Heo D, Bergerson R, Blazar B, Miller J, Verneris M
    Eur J Immunol, 2015;45(8):2335-42.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  60. Anti-beta(2)M monoclonal antibodies kill myeloma cells via cell- and complement-mediated cytotoxicity.
    Authors: Zhang M, Qian J, Lan Y, Lu Y, Li H, Hong B, Zheng Y, He J, Yang J, Yi Q
    Int J Cancer, 2014;135(5):1132-41.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  61. Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues.
    Authors: Honda T, Egen J, Lammermann T, Kastenmuller W, Torabi-Parizi P, Germain R
    Immunity, 2014;40(2):235-47.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  62. Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes.
    Authors: Kumari S, Walchli S, Fallang L, Yang W, Lund-Johansen F, Schumacher T, Olweus J
    Proc Natl Acad Sci U S A, 2014;111(1):403-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  63. E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-kappaB modulation.
    Authors: Ren Z, Kang W, Wang L, Sun B, Ma J, Zheng C, Sun J, Tian Z, Yang X, Xiao W
    Mol Cancer, 2014;13(0):84.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  64. Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8+ T cells.
    Authors: Rutigliano, John A, Sharma, Shalini, Morris, Melissa, Oguin, Thomas H, McClaren, Jennifer, Doherty, Peter C, Thomas, Paul G
    J Virol, 2014;88(3):1636-51.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  65. IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue.
    Authors: Leung J, Davenport M, Wolff M, Wiens K, Abidi W, Poles M, Cho I, Ullman T, Mayer L, Loke P
    Mucosal Immunol, 2014;7(1):124-33.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  66. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.
    Authors: Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D
    J Clin Invest, 2014;124(6):2513-22.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  67. The regulation and role of c-FLIP in human Th cell differentiation.
    Authors: Kylaniemi M, Kaukonen R, Myllyviita J, Rasool O, Lahesmaa R
    PLoS ONE, 2014;9(7):e102022.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  68. Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction.
    Authors: Kurktschiev P, Raziorrouh B, Schraut W, Backmund M, Wachtler M, Wendtner C, Bengsch B, Thimme R, Denk G, Zachoval R, Dick A, Spannagl M, Haas J, Diepolder H, Jung M, Gruener N
    J Exp Med, 2014;211(10):2047-59.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  69. Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice.
    Authors: Tong Q, He S, Xie F, Mochizuki K, Liu Y, Mochizuki I, Meng L, Sun H, Zhang Y, Guo Y, Hexner E, Zhang Y
    J Immunol, 2014;192(11):5012-22.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  70. Multiplexed screening of natural humoral immunity identifies antibodies at fine specificity for complex and dynamic viral targets.
    Authors: McCutcheon, Krista M, Gray, Julia, Chen, Natalie, Liu, Keyi, Park, Minha, Ellsworth, Stote, Tripp, Ralph A, Tompkins, S Mark, Johnson, Scott K, Samet, Shelly, Pereira, Lenore, Kauvar, Lawrence
    MAbs, 2014;6(2):460-73.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  71. Signal tranducers and activators of transcription: expression and function in anti-neutrophil cytoplasmic antibody-associated vasculitis.
    Authors: Wilde B, Hoerning A, Kribben A, Witzke O, Dolff S
    Mol Med Rep, 2014;9(6):2316-20.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  72. Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses.
    Authors: Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine P, Gelfand E
    J Allergy Clin Immunol, 2014;133(4):1162-74.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  73. A spliced antigenic peptide comprising a single spliced amino acid is produced in the proteasome by reverse splicing of a longer peptide fragment followed by trimming.
    Authors: Michaux A, Larrieu P, Stroobant V, Fonteneau J, Jotereau F, Van den Eynde B, Moreau-Aubry A, Vigneron N
    J Immunol, 2014;192(4):1962-71.
    Species: Human
    Sample Type: Whole Tissue
    Application: Bioassay
  74. Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.
    Authors: Choudhuri K, Llodra J, Roth E, Tsai J, Gordo S, Wucherpfennig K, Kam L, Stokes D, Dustin M
    Nature, 2014;507(7490):118-23.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  75. c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells.
    Authors: Molfetta R, Quatrini L, Capuano C, Gasparrini F, Zitti B, Zingoni A, Galandrini R, Santoni A, Paolini R
    Eur J Immunol, 2014;44(9):2761-70.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  76. Tumor-activated TCRgammadelta(+) T cells from gastric cancer patients induce the antitumor immune response of TCRalphabeta(+) T cells via their antigen-presenting cell-like effects.
    Authors: Mao C, Mou X, Zhou Y, Yuan G, Xu C, Liu H, Zheng T, Tong J, Wang S, Chen D
    J Immunol Res, 2014;2014(0):593562.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  77. Ctla-4 modulates the differentiation of inducible Foxp3+ Treg cells but IL-10 mediates their function in experimental autoimmune encephalomyelitis.
    Authors: Verhagen J, Gabrysova L, Shepard E, Wraith D
    PLoS ONE, 2014;9(9):e108023.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  78. Tetherin can restrict cell-free and cell-cell transmission of HIV from primary macrophages to T cells.
    Authors: Giese, Sebastia, Marsh, Mark
    PLoS Pathog, 2014;10(7):e1004189.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  79. Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia.
    Authors: Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, Greil R, Geisberger R
    Eur J Immunol, 2014;44(7):2175-87.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  80. Granulocytic myeloid derived suppressor cells expand in human pregnancy and modulate T-cell responses.
    Authors: Kostlin N, Kugel H, Spring B, Leiber A, Marme A, Henes M, Rieber N, Hartl D, Poets C, Gille C
    Eur J Immunol, 2014;44(9):2582-91.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  81. Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.
    Authors: Forster F, Paster W, Supper V, Schatzlmaier P, Sunzenauer S, Ostler N, Saliba A, Eckerstorfer P, Britzen-Laurent N, Schutz G, Schmid J, Zlabinger G, Naschberger E, Sturzl M, Stockinger H
    J Immunol, 2014;192(2):771-81.
  82. Human AdV-specific T cells: persisting in vitro functionality despite lethal irradiation.
    Authors: Geyeregger R, Freimuller C, Stemberger J, Fischer G, Witt V, Fritsch G
    Bone Marrow Transplant, 2014;49(7):934-41.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  83. Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance.
    Authors: Martinelli R, Zeiger A, Whitfield M, Sciuto T, Dvorak A, Van Vliet K, Greenwood J, Carman C
    J Cell Sci, 2014;127(0):3720-34.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  84. Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection.
    Authors: Boswell K, Paris R, Boritz E, Ambrozak D, Yamamoto T, Darko S, Wloka K, Wheatley A, Narpala S, McDermott A, Roederer M, Haubrich R, Connors M, Ake J, Douek D, Kim J, Petrovas C, Koup R
    PLoS Pathog, 2014;10(1):e1003853.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  85. Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells.
    Authors: Shipony, Zohar, Mukamel, Zohar, Cohen, Netta Me, Landan, Gilad, Chomsky, Elad, Zeliger, Shlomit, Fried, Yael Cha, Ainbinder, Elena, Friedman, Nir, Tanay, Amos
    Nature, 2014;513(7516):115-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  86. Building and optimizing a virus-specific T cell receptor library for targeted immunotherapy in viral infections.
    Authors: Banu, Nasirah, Chia, Adeline, Ho, Zi Zong, Garcia, Alfonso, Paravasivam, Komathi, Grotenbreg, Gijsbert, Bertoletti, Antonio, Gehring, Adam J
    Sci Rep, 2014;4(0):4166.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  87. A p38 MAPK-mediated alteration of COX-2/PGE2 regulates immunomodulatory properties in human mesenchymal stem cell aging.
    Authors: Yu K, Lee J, Kim H, Hong I, Choi S, Seo Y, Kang I, Kim J, Lee B, Lee S, Kurtz A, Seo K, Kang K
    PLoS ONE, 2014;9(8):e102426.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  88. Differential IL-10 production by DCs determines the distinct adjuvant effects of LPS and PTX in EAE induction.
    Authors: Zhou H, Wang Y, Lian Q, Yang B, Ma Y, Wu X, Sun S, Liu Y, Sun B
    Eur J Immunol, 2014;44(5):1352-62.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  89. Epstein-Barr virus infection induces indoleamine 2,3-dioxygenase expression in human monocyte-derived macrophages through p38/mitogen-activated protein kinase and NF-kappaB pathways: impairment in T cell functions.
    Authors: Liu W, Lin Y, Xiao H, Xing S, Chen H, Chi P, Zhang G
    J Virol, 2014;88(12):6660-71.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  90. Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells.
    Authors: Kim, Dae Won, Zloza, Andrew, Broucek, Joseph, Schenkel, Jason M, Ruby, Carl, Samaha, Georges, Kaufman, Howard L
    J Transl Med, 2014;12(0):113.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  91. Absence of a role for interleukin-13 in inflammatory bowel disease.
    Authors: Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque S, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza G, MacDonald T
    Eur J Immunol, 2014;44(2):370-85.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  92. Extracorporeal photopheresis increases neutrophilic myeloid-derived suppressor cells in patients with GvHD.
    Authors: Rieber N, Wecker I, Neri D, Fuchs K, Schafer I, Brand A, Pfeiffer M, Lang P, Bethge W, Amon O, Handgretinger R, Hartl D
    Bone Marrow Transplant, 2014;49(4):545-52.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  93. The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells.
    Authors: Kurachi M, Barnitz R, Yosef N, Odorizzi P, DiIorio M, Lemieux M, Yates K, Godec J, Klatt M, Regev A, Wherry E, Haining W
    Nat Immunol, 2014;15(4):373-83.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  94. IL-2 phosphorylates STAT5 to drive IFN-gamma production and activation of human dendritic cells.
    Authors: Herr F, Lemoine R, Gouilleux F, Meley D, Kazma I, Heraud A, Velge-Roussel F, Baron C, Lebranchu Y
    J Immunol, 2014;192(12):5660-70.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  95. Gemcitabine sensitizes lung cancer cells to Fas/FasL system-mediated killing.
    Authors: Siena L, Pace E, Ferraro M, Di Sano C, Melis M, Profita M, Spatafora M, Gjomarkaj M
    Immunology, 2014;141(2):242-55.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  96. Linking the circadian rhythm gene Arntl2 to interleukin 21 expression in type 1 diabetes.
    Authors: Lebailly B, He C, Rogner U
    Diabetes, 2014;63(6):2148-57.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  97. A novel self-lipid antigen targets human T cells against CD1c(+) leukemias.
    Authors: Lepore M, de Lalla C, Gundimeda S, Gsellinger H, Consonni M, Garavaglia C, Sansano S, Piccolo F, Scelfo A, Haussinger D, Montagna D, Locatelli F, Bonini C, Bondanza A, Forcina A, Li Z, Ni G, Ciceri F, Jeno P, Xia C, Mori L, Dellabona P, Casorati G, De Libero G
    J Exp Med, 2014;211(7):1363-77.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  98. Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection.
    Authors: Li H, Richert-Spuhler L, Evans T, Gillis J, Connole M, Estes J, Keele B, Klatt N, Reeves R
    PLoS Pathog, 2014;10(12):e1004551.
    Species: Rhesus Macaque
    Sample Type: Whole Cells
    Application: Bioassay
  99. The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.
    Authors: Lanna, Alessio, Henson, Sian M, Escors, David, Akbar, Arne N
    Nat Immunol, 2014;15(10):965-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  100. Reversal of tumor immune inhibition using a chimeric cytokine receptor.
    Authors: Leen A, Sukumaran S, Watanabe N, Mohammed S, Keirnan J, Yanagisawa R, Anurathapan U, Rendon D, Heslop H, Rooney C, Brenner M, Vera J
    Mol Ther, 2014;22(6):1211-20.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  101. Hepatitis C virus impairs natural killer cell-mediated augmentation of complement synthesis.
    Authors: Kim H, Bose S, Meyer K, Ray R
    J Virol, 2014;88(5):2564-71.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  102. Cytokine conditioning enhances systemic delivery and therapy of an oncolytic virus.
    Authors: Ilett E, Kottke T, Donnelly O, Thompson J, Willmon C, Diaz R, Zaidi S, Coffey M, Selby P, Harrington K, Pandha H, Melcher A, Vile R
    Mol Ther, 2014;22(10):1851-63.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  103. The secretion of IL-6 by CpG-ODN-treated cancer cells promotes T-cell immune responses partly through the TLR-9/AP-1 pathway in oral squamous cell carcinoma.
    Authors: Ruan M, Thorn K, Liu S, Li S, Yang W, Zhang C, Zhang C
    Int J Oncol, 2014;44(6):2103-10.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  104. The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling.
    Authors: Wu L, Wang C, Boisson B, Misra S, Rayman P, Finke J, Puel A, Casanova J, Li X
    J Immunol, 2014;193(4):1590-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  105. A Lectin-EGF antibody promotes regulatory T cells and attenuates nephrotoxic nephritis via DC-SIGN on dendritic cells.
    Authors: Cai, Minchao, Wu, Jing, Mao, Chaoming, Ren, Jianmin, Li, Pu, Li, Xiao, Zhong, Jiuchang, Xu, Chundi, Zhou, Tong
    J Transl Med, 2013;11(0):103.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  106. Neutrophil microparticles modulate cytokine production by natural killer cells.
    Authors: Pliyev B, Kalintseva M, Abdulaeva S, Yarygin K, Savchenko V
    Cytokine, 2013;65(2):126-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  107. Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.
    Authors: Knosp C, Schiering C, Spence S, Carroll H, Nel H, Osbourn M, Jackson R, Lyubomska O, Malissen B, Ingram R, Fitzgerald D, Powrie F, Fallon P, Johnston J, Kissenpfennig A
    J Immunol, 2013;190(7):3235-45.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  108. High mobility group nucleosomal binding domain 2 (HMGN2) SUMOylation by the SUMO E3 ligase PIAS1 decreases the binding affinity to nucleosome core particles.
    Authors: Wu J, Kim S, Kwak M, Jeong J, Min H, Yoon H, Ahn J, Shin J
    J Biol Chem, 2013;289(29):20000-11.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  109. Regulatory T cell phenotype and function 4 years after GAD-alum treatment in children with type 1 diabetes.
    Authors: Pihl M, Akerman L, Axelsson S, Cheramy M, Hjorth M, Mallone R, Ludvigsson J, Casas R
    Clin Exp Immunol, 2013;172(3):394-402.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  110. An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.
    Authors: Boisson B, Wang C, Pedergnana V, Wu L, Cypowyj S, Rybojad M, Belkadi A, Picard C, Abel L, Fieschi C, Puel A, Li X, Casanova J
    Immunity, 2013;39(4):676-86.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  111. Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization.
    Authors: Hawkins R, Larjo A, Tripathi S, Wagner U, Luu Y, Lonnberg T, Raghav S, Lee L, Lund R, Ren B, Lahdesmaki H, Lahesmaa R
    Immunity, 2013;38(6):1271-84.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  112. Detection of TCD4+ subsets in human carotid atheroma.
    Authors: Oliveira R, Silva R, Teo F, Mineiro M, Ferreira M, Altemani A, Mamoni R, Menezes F, Blotta M
    Cytokine, 2013;62(1):131-40.
    Species: Human
    Sample Type: Whole Tissue
    Application: Bioassay
  113. Study of the quantitative, functional, cytogenetic, and immunoregulatory properties of bone marrow mesenchymal stem cells in patients with B-cell chronic lymphocytic leukemia.
    Authors: Pontikoglou C, Kastrinaki M, Klaus M, Kalpadakis C, Katonis P, Alpantaki K, Pangalis G, Papadaki H
    Stem Cells Dev, 2013;22(9):1329-41.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  114. CD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia.
    Authors: Davila M, Kloss C, Gunset G, Sadelain M
    PLoS ONE, 2013;8(4):e61338.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  115. Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18.
    Authors: Li W, Okuda A, Yamamoto H, Yamanishi K, Terada N, Yamanishi H, Tanaka Y, Okamura H
    PLoS ONE, 2013;8(12):e82586.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  116. Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients.
    Authors: Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R
    Clin Cancer Res, 2013;19(7):1858-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  117. H-Y antigen-binding B cells develop in male recipients of female hematopoietic cells and associate with chronic graft vs. host disease.
    Authors: Sahaf B, Yang Y, Arai S, Herzenberg L, Herzenberg L, Miklos D
    Proc Natl Acad Sci U S A, 2013;110(8):3005-10.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  118. An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.
    Authors: Sharquie I, Al-Ghouleh A, Fitton P, Clark M, Armour K, Sewell H, Shakib F, Ghaemmaghami A
    BMC Immunol, 2013;14(0):54.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  119. Interferon gamma-induced intratumoral expression of CXCL9 alters the local distribution of T cells following immunotherapy with
    Authors: Guirnalda P, Wood L, Goenka R, Crespo J, Paterson Y
    Oncoimmunology, 2013;2(8):e25752.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  120. Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma.
    Authors: Huse K, Bakkebo M, Walchli S, Oksvold M, Hilden V, Forfang L, Bredahl M, Liestol K, Alizadeh A, Smeland E, Myklebust J
    PLoS ONE, 2012;7(10):e46117.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  121. Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients.
    Authors: Brusic, Ana, Hainz, Ursula, Wadleigh, Martha, Neuberg, Donna, Su, Mei, Canning, Christin, Deangelo, Daniel J, Stone, Richard, Lee, Jeng-Shi, Mulligan, Richard, Ritz, Jerome, Dranoff, Glenn, Sasada, Tetsuro, Wu, Catherin
    Oncoimmunology, 2012;1(7):1095-1103.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  122. Antigen-independent induction of Tim-3 expression on human T cells by the common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway.
    Authors: Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, Benko E, Kovacs C, Ostrowski MA
    J. Immunol., 2012;188(8):3745-56.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  123. Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.
    Authors: Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC
    Nature, 2012;484(7395):529-33.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  124. Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite.
    Authors: Emara M, Royer PJ, Mahdavi J
    J. Biol. Chem., 2012;287(8):5756-63.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  125. Identification of myeloid derived suppressor cells in dogs with naturally occurring cancer.
    Authors: Goulart MR, Pluhar GE, Ohlfest JR
    PLoS ONE, 2012;7(3):e33274.
    Species: Canine
    Sample Type: Whole Cells
    Application: Bioassay
  126. Tumor Microenvironment Macrophage Inhibitory Factor Directs the Accumulation of Interleukin-17-producing Tumor-infiltrating Lymphocytes and Predicts Favorable Survival in Nasopharyngeal Carcinoma Patients.
    Authors: Li J, Mo H, Xiong G, Zhang L, He J, Huang Z, Liu Z, Chen Q, Du Z, Zheng L, Qian C, Zeng Y
    J Biol Chem, 2012;287(42):35484-95.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  127. Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma.
    Authors: Bonanno G, Mariotti A, Procoli A, Folgiero V, Natale D, De Rosa L, Majolino I, Novarese L, Rocci A, Gambella M, Ciciarello M, Scambia G, Palumbo A, Locatelli F, De Cristofaro R, Rutella S
    J Transl Med, 2012;10(0):247.
    Species: Human
    Sample Type: whole cells
    Application: Bioassay
  128. Semen clusterin is a novel DC-SIGN ligand.
    Authors: Sabatte J, Faigle W, Ceballos A, Morelle W, Rodrígues CR, Lenicov FR, Thepaut M, Fieschi F, Malchiodi E, Fernandez M, Arenzana-Seisdedos F, Lortat-Jacob H, Michalski JC, Geffner J, Amigorena S
    J. Immunol., 2011;187(10):5299-309.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  129. The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans.
    Authors: Di Meglio P, Di Cesare A, Laggner U
    PLoS ONE, 2011;6(2):e17160.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  130. Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis.
    Authors: Hogan AE, Tobin AM, Ahern T, Corrigan MA, Gaoatswe G, Jackson R, O'Reilly V, Lynch L, Doherty DG, Moynagh PN, Kirby B, O'Connell J, O'Shea D
    Diabetologia, 2011;54(11):2745-54.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  131. Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis.
    Authors: Bowness P, Ridley A, Shaw J
    J. Immunol., 2011;186(0):2672.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  132. Protein kinase C and NF-kappaB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.
    Authors: Raposo RA, Trudgian DC, Thomas B, van Wilgenburg B, Cowley SA, James W
    J. Immunol., 2011;187(2):748-59.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  133. HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma.
    Authors: Buglio D, Khaskhely NM, Voo KS, Martinez-Valdez H, Liu YJ, Younes A
    Blood, 2011;117(10):2910-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  134. Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells.
    Authors: Maarof G, Bouchet-Delbos L, Gary-Gouy H, Durand-Gasselin I, Krzysiek R, Dalloul A
    Blood, 2010;115(9):1718-26.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  135. ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma.
    Authors: Ungerer C, Doberstein K, Burger C, Hardt K, Boehncke WH, Bohm B, Pfeilschifter J, Dummer R, Mihic-Probst D, Gutwein P
    Biochem. Biophys. Res. Commun., 2010;401(3):363-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  136. Mouse natural killer (NK) cells express the nerve growth factor receptor TrkA, which is dynamically regulated.
    Authors: Ralainirina N, Brons NH, Ammerlaan W, Hoffmann C, Hentges F, Zimmer J
    PLoS ONE, 2010;5(12):e15053.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  137. IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients.
    Authors: Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK
    Immunol. Lett., 2010;127(2):150-6.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  138. Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge.
    Authors: Kwant-Mitchell A, Pek EA, Rosenthal KL
    PLoS ONE, 2009;4(12):e8379.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  139. Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients.
    Authors: Pfistershammer K, Lawitschka A, Klauser C, Leitner J, Weigl R, Heemskerk MH, Pickl WF, Majdic O, Bohmig GA, Fischer GF, Greinix HT, Steinberger P
    Blood, 2009;114(11):2323-32.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  140. Autologous melanoma vaccine induces antitumor and self-reactive immune responses that affect patient survival and depend on MHC class II expression on vaccine cells.
    Authors: Lotem M, Machlenkin A, Hamburger T, Nissan A, Kadouri L, Frankenburg S, Gimmon Z, Elias O, David IB, Kuznetz A, Shiloni E, Peretz T
    Clin. Cancer Res., 2009;15(15):4968-77.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  141. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines.
    Authors: Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R, Wolk K
    Genes Immun., 2009;10(8):702-14.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  142. TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses.
    Authors: Duraisingham SS, Hornig J, Gotch F, Patterson S
    J. Immunol., 2009;183(4):2242-51.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  143. Bortezomib treatment and regulatory T-cell depletion enhance the antitumor effects of adoptively infused NK cells.
    Authors: Lundqvist A, Yokoyama H, Smith A, Berg M, Childs R
    Blood, 2009;113(24):6120-7.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  144. Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1.
    Authors: Christophi GP, Panos M, Hudson CA, Tsikkou C, Mihai C, Mejico LJ, Jubelt B, Massa PT
    Clin. Immunol., 2009;133(1):27-44.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  145. Local IL-21 promotes the therapeutic activity of effector T cells by decreasing regulatory T cells within the tumor microenvironment.
    Authors: Kim-Schulze S, Kim HS, Fan Q, Kim DW, Kaufman HL
    Mol. Ther., 2009;17(2):380-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  146. Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma.
    Authors: Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, Carbone A, Colombatti A, Pinto A, Aldinucci D
    Int. J. Cancer, 2009;125(5):1092-101.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  147. Human bronchial intraepithelial T cells produce interferon-gamma and stimulate epithelial cells.
    Authors: Hirosako S, Goto E, Fujii K, Tsumori K, Hirata N, Tsumura S, Kamohara H, Kohrogi H
    Clin. Exp. Immunol., 2009;155(2):266-74.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  148. Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms.
    Authors: Correale J, Farez M
    J. Immunol., 2009;183(9):5999-6012.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  149. Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients.
    Authors: Zheng CF, Jones GJ, Shi M, Wiseman JC, Marr KJ, Berenger BM, Huston SM, Gill MJ, Krensky AM, Kubes P, Mody CH
    J. Immunol., 2008;180(11):7221-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  150. Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
    Authors: Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB
    AIDS Res. Hum. Retroviruses, 2008;24(3):453-62.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  151. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities.
    Authors: Rickel EA, Siegel LA, Yoon BR, Rottman JB, Kugler DG, Swart DA, Anders PM, Tocker JE, Comeau MR, Budelsky AL
    J. Immunol., 2008;181(6):4299-310.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  152. IL-15 does not affect IEL development in the thymus but regulates homeostasis of putative precursors and mature CD8 alpha alpha+ IELs in the intestine.
    Authors: Lai YG, Hou MS, Hsu YW, Chang CL, Liou YH, Tsai MH, Lee F, Liao NS
    J. Immunol., 2008;180(6):3757-65.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  153. CD27 defines phenotypically and functionally different human NK cell subsets.
    Authors: Vossen MT, Matmati M, Hertoghs KM, Baars PA, Gent MR, Leclercq G, Hamann J, Kuijpers TW, van Lier RA
    J. Immunol., 2008;180(6):3739-45.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  154. Helminth infections associated with multiple sclerosis induce regulatory B cells.
    Authors: Correale J, Farez M, Razzitte G
    Ann. Neurol., 2008;64(2):187-99.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  155. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes.
    Authors: Pene J, Chevalier S, Preisser L, Venereau E, Guilleux MH, Ghannam S, Moles JP, Danger Y, Ravon E, Lesaux S, Yssel H, Gascan H
    J. Immunol., 2008;180(0):7423.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  156. Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay.
    Authors: Miller R, Sadhukhan R, Wu C
    J. Immunol. Methods, 2008;334(1):134-41.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  157. SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.
    Authors: Christophi GP, Hudson CA, Gruber RC, Christophi CP, Mihai C, Mejico LJ, Jubelt B, Massa PT
    Lab. Invest., 2008;88(3):243-55.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  158. Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis.
    Authors: Correale J, Villa A
    J. Neuroimmunol., 2008;195(1):121-34.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  159. A synergistic antitumor effect of interleukin-2 addition with CD80 immunogene therapy for peritoneal metastasis of gastric carcinoma.
    Authors: Kosaka K, Yashiro M, Sakate Y, Hirakawa K
    Dig. Dis. Sci., 2007;52(8):1946-53.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  160. Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15.
    Authors: Bulanova E, Budagian V, Duitman E, Orinska Z, Krause H, Ruckert R, Reiling N, Bulfone-Paus S
    J. Biol. Chem., 2007;282(18):13167-79.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  161. IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells.
    Authors: Gleissner CA, Zastrow A, Klingenberg R, Kluger MS, Konstandin M, Celik S, Haemmerling S, Shankar V, Giese T, Katus HA, Dengler TJ
    Eur. J. Immunol., 2007;37(1):177-92.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  162. Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells.
    Authors: Bayry J, Triebel F, Kaveri SV, Tough DF
    J. Immunol., 2007;178(7):4184-93.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  163. WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).
    Authors: de la Fuente MA, Sasahara Y, Calamito M, Anton IM, Elkhal A, Gallego MD, Suresh K, Siminovitch K, Ochs HD, Anderson KC, Rosen FS, Geha RS, Ramesh N
    Proc. Natl. Acad. Sci. U.S.A., 2007;104(3):926-31.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  164. Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis.
    Authors: Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, Gurrieri C, Trentin L, Zambello R, Calabrese F, Cassatella MA, Semenzato G, Agostini C
    J. Leukoc. Biol., 2007;82(4):946-55.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  165. Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation.
    Authors: Schade AE, Schieven GL, Townsend R, Jankowska AM, Susulic V, Zhang R, Szpurka H, Maciejewski JP
    Blood, 2007;111(3):1366-77.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  166. Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo.
    Authors: Ruzek MC, Waire JS, Hopkins D, Lacorcia G, Sullivan J, Roberts BL, Richards SM, Nahill SR, Williams JM, Scaria A, Dzuris J, Shankara S, Garman RD
    Blood, 2007;111(3):1726-34.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  167. In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.
    Authors: Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F
    J. Clin. Invest., 2007;117(12):3868-3878.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  168. Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.
    Authors: Conrad C, Boyman O, Tonel G, Tun-Kyi A, Laggner U, de Fougerolles A, Kotelianski V, Gardner H, Nestle FO
    Nat. Med., 2007;13(7):836-42.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  169. Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.
    Authors: Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA
    Nat. Immunol., 2007;8(8):825-34.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  170. GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells.
    Authors: De Fanis U, Mori F, Kurnat RJ, Lee WK, Bova M, Adkinson NF, Casolaro V
    Blood, 2007;109(10):4343-50.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  171. HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.
    Authors: Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P
    AIDS, 2007;21(10):1263-72.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  172. Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription.
    Authors: Ebert EC, Mehta V
    Cell. Immunol., 2006;241(1):7-13.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  173. CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands.
    Authors: Ancuta P, Autissier P, Wurcel A, Zaman T, Stone D, Gabuzda D
    J. Immunol., 2006;176(10):5760-71.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  174. Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL).
    Authors: Hanabuchi S, Watanabe N, Wang YH, Ito T, Shaw J, Cao W, Qin FX, Liu YJ
    Blood, 2006;107(9):3617-23.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  175. A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo.
    Authors: von Strandmann EP, Hansen HP, Reiners KS, Schnell R, Borchmann P, Merkert S, Simhadri VR, Draube A, Reiser M, Purr I, Hallek M, Engert A
    Blood, 2006;107(5):1955-62.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  176. Dendritic cells can turn CD4+ T lymphocytes into vascular endothelial growth factor-carrying cells by intercellular neuropilin-1 transfer.
    Authors: Bourbie-Vaudaine S, Blanchard N, Hivroz C, Romeo PH
    J. Immunol., 2006;177(3):1460-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  177. The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors.
    Authors: Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS
    J. Immunol., 2006;177(7):4488-94.
    Species: Human
    Sample Type: Whole Tissue
    Application: Bioassay
  178. Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function.
    Authors: Roda-Navarro P, Vales-Gomez M, Chisholm SE, Reyburn HT
    Proc. Natl. Acad. Sci. U.S.A., 2006;103(30):11258-63.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  179. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium.
    Authors: Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG
    J. Exp. Med., 2006;203(12):2763-77.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  180. Th2 cytokine response in Major Depressive Disorder patients before treatment.
    Authors: Pavon L, Kiryushko D, Novitskaya V, Sandoval-Lopez G, Eugenia Hernandez M, Soroka V, Klingelhofer J, Loria F, Estrada I, Lukanidin E, Berezin V, Perez M, Moreno J, Bock E, Avila U, Leff P, Anton B, Heinze G
    J. Neuroimmunol., 2006;172(1):156-65.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  181. Resistance to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis by death receptor 6-deficient mice.
    Authors: Schmidt CS, Zhao J, Chain J, Hepburn D, Gitter B, Sandusky G, Chintalacharuvu S, Glasebrook A, Na S
    J. Immunol., 2005;175(4):2286-92.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  182. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.
    Authors: Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM
    Arthritis Rheum., 2005;52(3):770-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  183. Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism.
    Authors: Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, Kufe D
    J. Immunol., 2005;174(4):2376-86.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  184. Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10.
    Authors: Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA
    J. Immunol., 2004;172(9):5213-21.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  185. Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells.
    Authors: Megjugorac NJ, Young HA, Amrute SB, Olshalsky SL, Fitzgerald-Bocarsly P
    J. Leukoc. Biol., 2004;75(3):504-14.
    Species: Human
    Sample Type:
    Application: Bioassay
  186. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
    Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
    J. Immunol., 2004;173(5):3482-91.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  187. Involvement of Fc gamma RI (CD64) in the mechanism of HIV-1 inhibition by polyclonal IgG purified from infected patients in cultured monocyte-derived macrophages.
    Authors: Holl V, Hemmerter S, Burrer R, Schmidt S, Bohbot A, Aubertin AM, Moog C
    J. Immunol., 2004;173(10):6274-83.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  188. BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone.
    Authors: Moreaux J, Legouffe E, Jourdan E, Quittet P, Reme T, Lugagne C, Moine P, Rossi JF, Klein B, Tarte K
    Blood, 2004;103(8):3148-57.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  189. Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor.
    Authors: Wang P, Zhang J, Bian H, Wu P, Kuvelkar R, Kung TT, Crawley Y, Egan RW, Billah MM
    Biochem. J., 2004;380(0):425-33.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  190. Cutting edge: immune cells as sources and targets of the IL-10 family members?
    Authors: Wolk K, Kunz S, Asadullah K, Sabat R
    J. Immunol., 2002;168(11):5397-402.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  191. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
    Authors: Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F, To W, Wagner J, O&amp;amp;apos;Farrell AM, McClanahan T, Zurawski S, Hannum C, Gorman D, Rennick DM, Kastelein RA, de Waal Malefyt R, Moore KW
    J. Immunol., 2002;168(11):5699-708.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  192. Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4.
    Authors: Farah IO, Mola PW, Kariuki TM, Nyindo M, Blanton RE, King CL
    J. Immunol., 2000;164(10):5337-43.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  193. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
    Authors: Oppmann, B, Lesley, R, Blom, B, Timans, J C, Xu, Y, Hunte, B, Vega, F, Yu, N, Wang, J, Singh, K, Zonin, F, Vaisberg, E, Churakova, T, Liu, M, Gorman, D, Wagner, J, Zurawski, S, Liu, Y, Abrams, J S, Moore, K W, Rennick, D, de Waal-Malefyt, R, Hannum, C, Bazan, J F, Kastelein, R A
    Immunity, 2000;13(5):715-25.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  194. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells.
    Authors: Nestle, F O, Alijagic, S, Gilliet, M, Sun, Y, Grabbe, S, Dummer, R, Burg, G, Schadendorf, D
    Nat Med, 1998;4(3):328-32.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  195. TGF-beta Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner.
    Authors: Elias S, Schmidt A, Kannan V, Andersson J, Tegner J
    Front Immunol, 0;7(0):603.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  196. Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate.
    Authors: Schmidt A, Eriksson M, Shang M, Weyd H, Tegner J
    PLoS ONE, 0;11(2):e0148474.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  197. Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta.
    Authors: Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J
    Immunol Cell Biol, 0;94(8):747-62.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
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Recombinant Human IL-2, Animal-Free Protein

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(3)
In vitro bioactivity in cell culture
(2)
Cell Adhesion
(1)
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Images Ratings Applications Species Reviewed By Date Details
Stem/Immune cell maintenance or differentiation  Recombinant Human IL-2 Protein 202-IL
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Excellent
 Stem/Immune cell maintenance or differentiation Anonymous 09/08/2017
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Image Details
Stem/Immune cell maintenance or differentiation  Recombinant Human IL-2 Protein 202-IL
Stem/Immune cell maintenance or differentiation : Recombinant Human IL-2 Protein [202-IL]

Summary

ApplicationStem/Immune cell maintenance or differentiation
Reason for RatingThis product was used to help maintain PBMCs in culture overnight.

Other Experimental Details

Other Experimental DetailsImage key: Left: PBMCs prior to IL2Right: PBMCs after overnight culture with IL2
  Excellent
 Cell proliferation Anonymous 07/04/2017
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Summary

ApplicationCell proliferation

Other Experimental Details

Other Experimental DetailsUSED IN T CELL EXPANSION ASSAYS
  Excellent
 Cell proliferation Anonymous 05/19/2017
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Summary

ApplicationCell proliferation
Reason for RatingR&D IL-2 has allowed me to successfully propagate human PBMCs in cultured for up to 3 months. This product is reliable and gives good results every time I order it. It works well for culturing both human and rhesus macaque PBMCs.
  Excellent
  Anonymous 04/26/2017
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Other Experimental Details

Other Experimental DetailsExcellent, order processing extremely helpful, order received next day! Will do business again with you.
  Excellent
 Cell proliferation Anonymous 07/21/2016
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Summary

ApplicationCell proliferation
Reason for RatingTrying to maintain a finicky cell line. Other sources of IL-2 have performed poorly in the past, but with R&D systems IL-2, the cells are very happy.
In vitro bioactivity in cell culture Recombinant Human IL-2 Protein 202-IL
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Very Good
 In vitro bioactivity in cell culture Anonymous 01/21/2016
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Image Details
In vitro bioactivity in cell culture Recombinant Human IL-2 Protein 202-IL
In vitro bioactivity in cell culture: Recombinant Human IL-2 Protein [202-IL]

Summary

ApplicationIn vitro bioactivity in cell culture
  Excellent
 In vitro bioactivity in cell culture Anonymous 01/14/2016
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Summary

ApplicationIn vitro bioactivity in cell culture
  Very Good
 Stem/Immune cell maintenance or differentiation Anonymous 01/13/2016
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Summary

ApplicationStem/Immune cell maintenance or differentiation
  Very Good
 Cell Adhesion Anonymous 01/13/2016
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Summary

ApplicationCell Adhesion

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The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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