Recombinant Human/Mouse/Rat BMP-2 Protein, CF

Newer Version Available: 355-BEC/CF
More economical E. coli option available
Formulations:
Catalog # Availability Size / Price Qty
355-BM-010/CF
355-BM-050/CF
355-BM-500/CF
355-BM-100/CF
355-BM-01M/CF
Graph showing dose-dependent bioactivity of Human BMP-2 protein
1 Image
Product Details
Citations (150)
FAQs
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Recombinant Human/Mouse/Rat BMP-2 Protein, CF Summary

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Binnerts, M.E. et al. (2004) Biochem. Biophys. Res. Commun. 315(2):272. The ED50 for this effect is 40-200 ng/mL.
The specific activity of Recombinant Human BMP-2 is approximately 781 U/μg, which is calibrated against human BMP-2 WHO International Standard (NIBSC code: 93/574).
Source
Chinese Hamster Ovary cell line, CHO-derived BMP-2 protein
Gln283-Arg396
Accession #
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
13 kDa (monomer)
SDS-PAGE
15-16 kDa, reducing conditions

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

355-BM/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Glycine, Sucrose, Tween® 80 and Glutamic Acid. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in Glycine, Sucrose, Tween® 80 and Glutamic Acid.
Reconstitution Reconstitute at 100-200 μg/mL in sterile 4 mM HCI.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

355-BM

Formulation Lyophilized from a 0.2 μm filtered solution in Glycine, Sucrose, Tween® 80 and Glutamic Acid with BSA as a carrier protein. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in Glycine, Sucrose, Tween® 80 and Glutamic Acid with BSA as a carrier protein.
Reconstitution Reconstitute at 100-200 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Image

Bioactivity Bioactivity of Human/Mouse/Rat BMP-2 Protein View Larger

Recombinant human/mouse/rat BMP-2 (355-BM/CF) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED50 for this effect is 40-200 ng/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: BMP-2

Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration (1, 2). Human BMP‑2 is synthesized as a 396 amino acid (aa) preproprotein that contains a 23 aa signal sequence, a 259 aa prosegment, and a 114 aa mature region (3). Proteolytic removal of the propeptide enables mature BMP-2 to form active disulfide linked homodimers and heterodimers with BMP-7 (2). Mature monomeric BMP-2 is an 18 kDa glycosylated peptide with seven conserved cysteines that form a cystine knot structure (4). Mature human BMP-2 shares 100% aa sequence identity with mouse and rat BMP-2. It shares 85% aa sequence identity with human BMP-4 and less than 51% with other BMPs. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMPR‑IA, or BMPR‑IB) and a type II receptor (BMP RII or Activin RIIB) (2, 5). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth, and bone and cartilage repair (6, 7). It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells, and vascular smooth muscle cells (2, 8‑10). BMP-2/BMP-7 heterodimers are significantly more potent than BMP-2 homodimers at inducing bone formation in vivo (11). BMP-2 also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells, and is required for cardiac contractility (12‑15).

References
  1. Kishigami, S. and Y. Mishina (2005) Cytokine Growth Factor Rev. 16:265.
  2. Chen, D. et al. (2004) Growth Factors 22:233.
  3. Wozney, J. et al. (1988) Science 242:1528.
  4. Sun, P.D. and D.R. Davies (1995) Annu. Rev. Biophys. Biomol. Struct. 24:269. 
  5. Sebald, W. et al. (2004) Biol. Chem. 385:697.
  6. De Luca, F. et al. (2001) Endocrinology 142:430.
  7. Davidson, E.N.B., et al. (2007) Arthritis Res. Ther. 9:R102.
  8. Ryoo, H.-M. et al. (2006) Gene 366:51.
  9. Kramer, J. et al. (2000) Mech. Dev. 92:193.
  10. Li, X. et al. (2008) Atherosclerosis January 5 epub.
  11. Zhu, W. et al. (2004) J. Bone Miner. Res. 19:2021.
  12. Peiris, D. et al. (2007) Am. J. Physiol. Gastrointest. Liver Physiol. 292:G753.
  13. Kano, Y. et al. (2005) Endocrinology 146:5332.
  14. Hallahan, A.R. et al. (2003) Nat. Med. 9:1033.
  15. Wang, Y.-X. et al. (2007) Cardiovasc. Res. 74:290.
Long Name
Bone Morphogenetic Protein 2
Entrez Gene IDs
650 (Human); 12156 (Mouse); 29373 (Rat)
Alternate Names
BDA2; BMP2; BMP-2; BMP-2A; BMP2ABone morphogenetic protein 2A; bone morphogenetic protein 2; SSFSC

Citations for Recombinant Human/Mouse/Rat BMP-2 Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

150 Citations: Showing 1 - 10
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  1. TGF-&beta-driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model
    Authors: DA Mázala, JS Novak, MW Hogarth, M Nearing, P Adusumalli, CB Tully, NF Habib, H Gordish-Dr, YW Chen, JK Jaiswal, TA Partridge
    JCI Insight, 2020;5(6):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  2. Fibrochondrogenic differentiation potential of tendon-derived stem/progenitor cells from human patellar tendon
    Authors: S Qin, W Wang, Z Liu, X Hua, S Fu, F Dong, A Li, Z Liu, P Wang, L Dai, P Liang, J Zhang, W Cao, X Xiong, H Chen, J Xu
    J Orthop Translat, 2020;22(0):101-108.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  3. Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo
    Authors: S Moghadasi, A Koontz, G Tseropoulo, L Kerosuo, P Mehrotra, VK Bajpai, SR Selvam, P Lei, ME Bronner, ST Andreadis
    Sci Rep, 2019;9(1):9750.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Potential for Drug Repositioning of Midazolam for Dentin Regeneration
    Authors: T Karakida, K Onuma, MM Saito, R Yamamoto, T Chiba, R Chiba, Y Hidaka, K Fujii-Abe, H Kawahara, Y Yamakoshi
    Int J Mol Sci, 2019;20(3):.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2
    Authors: S Hendrikx, S Coso, B Prat-Luri, L Wetterwald, A Sabine, CA Franco, S Nassiri, N Zangger, H Gerhardt, M Delorenzi, TV Petrova
    Cell Rep, 2019;26(5):1227-1241.e6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. BMP9 stimulates joint regeneration at digit amputation wounds in mice
    Authors: L Yu, LA Dawson, M Yan, K Zimmel, YL Lin, CP Dolan, M Han, K Muneoka
    Nat Commun, 2019;10(1):424.
    Species: Mouse
    Sample Types: Beads
    Applications: In Vivo
  7. Feather arrays are patterned by interacting signalling and cell density waves
    Authors: WKW Ho, L Freem, D Zhao, KJ Painter, TE Woolley, EA Gaffney, MJ McGrew, A Tzika, MC Milinkovit, P Schneider, A Drusko, F Matthäus, JD Glover, KL Wells, JA Johansson, MG Davey, HM Sang, M Clinton, DJ Headon
    PLoS Biol., 2019;17(2):e3000132.
    Species: Chicken
    Sample Types: Tissue Explants
    Applications: Bioassay
  8. Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis
    Authors: HJ Kim, HJ Kim, Y Choi, MK Bae, DS Hwang, SH Shin, JY Lee
    Int J Mol Sci, 2019;20(6):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Pericytes as a Source of Osteogenic Cells in Bone Fracture Healing
    Authors: S Supakul, K Yao, H Ochi, T Shimada, K Hashimoto, S Sunamura, Y Mabuchi, M Tanaka, C Akazawa, T Nakamura, A Okawa, S Takeda, S Sato
    Int J Mol Sci, 2019;20(5):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Osteogenic Enhancement Between Icariin and Bone Morphogenetic Protein 2: A Potential Osteogenic Compound for Bone Tissue Engineering
    Authors: X Zhang, X Lin, T Liu, L Deng, Y Huang, Y Liu
    Front Pharmacol, 2019;10(0):201.
    Species: Human
    Sample Types: Bone Substitute
    Applications: Bioassay
  11. Osteogenic differentiation of skeletal muscle progenitor cells is activated by the DNA damage response
    Authors: M Rosina, F Langone, G Giuliani, A Cerquone P, A Reggio, A Calderone, C Fuoco, L Castagnoli, C Gargioli, G Cesareni
    Sci Rep, 2019;9(1):5447.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation
    Authors: WN Addison, KC Hall, S Kokabu, T Matsubara, MM Fu, F Gori, R Baron
    Mol. Cell. Biol., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression
    Authors: J Ren, M Smid, J Iaria, DCF Salvatori, H van Dam, HJ Zhu, JWM Martens, P Ten Dijke
    Breast Cancer Res., 2019;21(1):109.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Muscle injury promotes heterotopic ossification by stimulating local bone morphogenetic protein-7 production
    Authors: Li, Y Jiang, H Lin, H Shen, J Sohn, PG Alexander, RS Tuan
    J Orthop Translat, 2019;18(0):142-153.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  15. Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair
    Authors: K Krüger, S Schmid, F Paulsen, A Ignatius, P Klinger, T Hotfiel, B Swoboda, K Gelse
    Int J Mol Sci, 2019;20(17):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD signaling pathway
    Authors: M Omi, V Kaartinen, Y Mishina
    J. Biol. Chem., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. No evidence of Gremlin1-mediated activation of VEGFR2 signalling in endothelial cells
    Authors: LR Dutton, CL O' Neill, RJ Medina, DP Brazil
    J. Biol. Chem., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  18. TGFbeta-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
    Authors: J Li, A Ayoub, Y Xiu, X Yin, JO Sanders, A Mesfin, L Xing, Z Yao, BF Boyce
    Nat Commun, 2019;10(1):2795.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Bone morphogenetic protein 2 induces the activation of WNT/beta-catenin signaling and human trophoblast invasion through up-regulating BAMBI
    Authors: HJ Zhao, HM Chang, C Klausen, H Zhu, Y Li, PCK Leung
    Cell. Signal., 2019;0(0):109489.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  20. The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway
    Authors: D Seo, SM Jung, JS Park, J Lee, J Ha, M Kim, SH Park
    EBioMedicine, 2019;49(0):55-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  21. Delivery of Allogeneic Adipose Stem Cells in Polyethylene Glycol-Fibrin Hydrogels as an Adjunct to Meshed Autografts After Sharp Debridement of Deep Partial Thickness Burns
    Authors: DM Burmeister, R Stone, N Wrice, A Laborde, SC Becerra, S Natesan, RJ Christy
    Stem Cells Transl Med, 2018;0(0):.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy
    Authors: M Desancé, R Contentin, L Bertoni, T Gomez-Ledu, T Branly, S Jacquet, JM Betsch, A Batho, F Legendre, F Audigié, P Galéra, M Demoor
    Int J Mol Sci, 2018;19(2):.
    Species: Equine
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Somatic activating mutations in MAP2K1 cause melorheostosis
    Authors: H Kang, S Jha, Z Deng, N Fratzl-Zel, WA Cabral, A Ivovic, F Meylan, EP Hanson, E Lange, J Katz, P Roschger, K Klaushofer, EW Cowen, RM Siegel, JC Marini, T Bhattachar
    Nat Commun, 2018;9(1):1390.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva
    Authors: JB Lees-Shepa, M Yamamoto, AA Biswas, SJ Stoessel, SE Nicholas, CA Cogswell, PM Devarakond, MJ Schneider, SM Cummins, NP Legendre, S Yamamoto, V Kaartinen, JW Hunter, DJ Goldhamer
    Nat Commun, 2018;9(1):471.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  25. BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-?1 signaling
    Authors: YH Chung, YH Huang, TH Chu, CL Chen, PR Lin, SC Huang, DC Wu, CC Huang, TH Hu, YH Kao, MH Tai
    Lab. Invest., 2018;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function
    Authors: P Jongwattan, M Terajima, PA Miguez, W Querido, H Nagaoka, N Sumida, EG Gurysh, KM Ainslie, N Pleshko, L Perera, M Yamauchi
    Sci Rep, 2018;8(1):7022.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling
    Authors: S Kokabu, V Rosen
    FEBS Open Bio, 2018;8(2):168-176.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development
    Authors: K Koefoed, J Skat-Rørda, P Andersen, CB Warzecha, M Pye, TA Andersen, KD Ajbro, E Bendsen, M Narimatsu, F Vilhardt, LB Pedersen, JL Wrana, RH Anderson, K Møllgård, ST Christense, LA Larsen
    Sci Rep, 2018;8(1):9542.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer
    Authors: LS Pane, FG Fulcoli, A Cirino, A Altomonte, R Ferrentino, M Bilio, A Baldini
    Dis Model Mech, 2018;11(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Nanoparticle-modified chitosan-agarose-gelatin scaffold for sustained release of SDF-1 and BMP-2
    Authors: B Wang, Y Guo, X Chen, C Zeng, Q Hu, W Yin, W Li, H Xie, B Zhang, X Huang, F Yu
    Int J Nanomedicine, 2018;13(0):7395-7408.
    Species: Human
    Sample Types: Nanoparticles
    Applications: Bioassay
  31. Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation
    Authors: M Subileau, G Merdzhanov, D Ciais, V Collin-Fau, JJ Feige, S Bailly, D Vittet
    Stem Cell Reports, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. The paracrine effects of human induced pluripotent stem cells promote bone-like structures via the upregulation of BMP expression in a mouse ectopic model
    Authors: K Oudina, J Paquet, A Moya, E Massouride, M Bensidhoum, N Larochette, M Deschepper, C Pinset, H Petite
    Sci Rep, 2018;8(1):17106.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. PAWS1 controls Wnt signalling through association with casein kinase 1?
    Authors: P Bozatzi, KS Dingwell, KZ Wu, F Cooper, TD Cummins, LD Hutchinson, J Vogt, NT Wood, TJ Macartney, J Varghese, R Gourlay, DG Campbell, JC Smith, GP Sapkota
    EMBO Rep., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
    Authors: SY Lee, ED Abel, F Long
    Nat Commun, 2018;9(1):4831.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation
    Authors: K Sasa, K Yoshimura, A Yamada, D Suzuki, Y Miyamoto, H Imai, K Nagayama, K Maki, M Yamamoto, R Kamijo
    Sci Rep, 2018;8(1):10579.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects
    Authors: DW Youngstrom, R Senos, RL Zondervan, JD Brodeur, AR Lints, DR Young, TL Mitchell, ME Moore, MH Myers, WJ Tseng, KM Loomes, KD Hankenson
    NPJ Regen Med, 2017;2(0):32.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  37. Explicit Modeling of siRNA-Dependent On- and Off-Target Repression Improves the Interpretation of Screening Results
    Authors: A Riba, M Emmenlauer, A Chen, F Sigoillot, F Cong, C Dehio, J Jenkins, M Zavolan
    Cell Syst, 2017;4(2):182-193.e4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver
    Authors: WS Fagg, N Liu, MJ Yang, K Cheng, E Chung, JS Kim, G Wu, J Fair
    Cell Transplant, 2017;26(12):1868-1877.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth
    Authors: SV Hegarty, AM Sullivan, GW O'Keeffe
    Neurosci. Lett, 2017;643(0):32-37.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling
    Authors: JO Múnera, N Sundaram, SA Rankin, D Hill, C Watson, M Mahe, JE Vallance, NF Shroyer, KL Sinagoga, A Zarzoso-La, JR Hudson, JC Howell, P Chatuvedi, JR Spence, JM Shannon, AM Zorn, MA Helmrath, JM Wells
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells
    Authors: O Veraitch, Y Mabuchi, Y Matsuzaki, T Sasaki, H Okuno, A Tsukashima, M Amagai, H Okano, M Ohyama
    Sci Rep, 2017;7(0):42777.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Potent osteogenic activity of a novel imidazobenzimidazole derivative, IBIP
    Authors: SJ Bae, YK Min, ES Hwang
    Biochem. Biophys. Res. Commun., 2017;487(2):409-414.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells
    Authors: T Jung, JH Lee, S Park, YJ Kim, J Seo, HE Shim, KS Kim, HS Jang, HM Chung, SG Oh, SH Moon, SW Kang
    Stem Cells Int, 2017;2017(0):7859184.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. BMP-9 interferes with liver regeneration and promotes liver fibrosis
    Authors: K Breitkopf-, C Meyer, C König, H Gaitantzi, A Addante, M Thomas, E Wiercinska, C Cai, Q Li, F Wan, C Hellerbran, NA Valous, M Hahnel, C Ehlting, JG Bode, S Müller-Boh, U Klingmülle, J Altenöder, I Ilkavets, MJ Goumans, LJ Hawinkels, SJ Lee, M Wieland, C Mogler, MP Ebert, B Herrera, H Augustin, A Sánchez, S Dooley, P Ten Dijke
    Gut, 2017;0(0):.
    Species: Mouse
    Sample Types:
  45. Genomic integration of Wnt/?-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional program
    Authors: ML Stevens, P Chaturvedi, SA Rankin, M Macdonald, S Jagannatha, M Yukawa, A Barski, AM Zorn
    Development, 2017;0(0):.
    Species: Xenopus
    Sample Types: Blastocele
    Applications: Organoid Culture
  46. Ascorbic acid promotes cardiomyogenesis through SMAD1 signaling in differentiating mouse embryonic stem cells
    Authors: MG Perino, S Yamanaka, DR Riordon, Y Tarasova, KR Boheler
    PLoS ONE, 2017;12(12):e0188569.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Critical attributes of human early mesenchymal stromal cell-laden microcarrier constructs for improved chondrogenic differentiation
    Authors: YM Lin, J Lee, JFY Lim, M Choolani, JKY Chan, S Reuveny, SKW Oh
    Stem Cell Res Ther, 2017;8(1):93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Bi-layered constructs of poly(glycerol-sebacate)-?-tricalcium phosphate for bone-soft tissue interface applications
    Authors: Atakan Tevlek
    Mater Sci Eng C Mater Biol Appl, 2017;72(0):316-324.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2
    Authors: J Fan, J Pi-Anfruns, M Guo, DCS Im, ZK Cui, S Kim, BM Wu, TL Aghaloo, M Lee
    Sci Rep, 2017;7(1):7518.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-? superfamily as a regulator of XIST expression
    Authors: S Sripathy, V Leko, RL Adrianse, T Loe, EJ Foss, E Dalrymple, U Lao, T Gatbonton-, KT Carter, B Payer, PJ Paddison, WM Grady, JT Lee, MS Bartolomei, A Bedalov
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Synergistic effect of human Bone Morphogenic Protein-2 and Mesenchymal Stromal Cells on chronic wounds through hypoxia-inducible factor-1 ? induction
    Authors: S François, VV Eder, K Belmokhtar, MC Machet, L Douay, NC Gorin, M Benderitte, CA Alain
    Sci Rep, 2017;7(1):4272.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Supraphysiological levels of GDF11 induce striated muscle atrophy
    Authors: DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney
    EMBO Mol Med, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells
    Authors: L Bai, HM Chang, JC Cheng, C Klausen, G Chu, PCK Leung, G Yang
    Cell. Signal., 2017;37(0):52-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-? signaling
    Authors: Y Yu, S Gu, W Li, C Sun, F Chen, M Xiao, L Wang, D Xu, Y Li, C Ding, Z Xia, Y Li, S Ye, P Xu, B Zhao, J Qin, YG Chen, X Lin, XH Feng
    Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice
    Authors: J Feng, J Jing, J Li, H Zhao, V Punj, T Zhang, J Xu, Y Chai
    Development, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells
    Authors: C Sallon, I Callebaut, I Boulay, J Fontaine, D Logeart-Av, C Henriquet, M Pugnière, X Cayla, P Monget, G Harichaux, V Labas, S Canepa, C Taragnat
    J. Biol. Chem., 2017;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  57. Acceleration of osteoblast differentiation by a novel osteogenic compound, DMP-PYT, through activation of both the BMP and Wnt pathways
    Authors: SJ Bae, HJ Kim, HY Won, YK Min, ES Hwang
    Sci Rep, 2017;7(1):8455.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Regulation of hepcidin expression by inflammation-induced activin B
    Sci Rep, 2016;6(0):38702.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Bovine ovarian stem cells differentiate into germ cells and oocyte-like structures after culture in vitro
    Authors: G B de Souza
    Reprod. Domest. Anim, 2016;0(0):.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication
    PLoS ONE, 2016;11(12):e0168334.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Mesenchymal stem cells from cortical bone demonstrate increased clonal incidence, potency, and developmental capacity compared to their bone marrow-derived counterparts
    J Tissue Eng, 2016;7(0):2041731416661.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  62. Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
    Nat Commun, 2016;7(0):13247.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Cell type-specific control of protein synthesis and proliferation by FGF-dependent signaling to the translation repressor 4E-BP
    Authors: Rachel Ruoff
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Expression of nephronectin is enhanced by 1?,25-dihydroxyvitamin D3.
    Authors: Katsuhiro Hiranuma, Atsushi Yamada, Tamaki Kurosawa, Ryo Aizawa, Dai Suzuki, Yoshiro Saito, Ryo Nagahama, Mikiko Ikehata, Masayuki Tsukasaki, Naoko Morimura, Daichi Chikazu, Koutaro Maki, Tatsuo Shirota, Masamichi Takami, Matsuo Yamamoto, Takehiko Iijima, Ryutaro Kamijo
    FEBS Open Bio, 2016;0(0):2211-5463.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Wnt Protein Signaling Reduces Nuclear Acetyl-CoA Levels to Suppress Gene Expression during Osteoblast Differentiation
    Authors: CM Karner, E Esen, J Chen, FF Hsu, J Turk, F Long
    J. Biol. Chem., 2016;291(25):13028-39.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Bone morphogenetic protein 2 regulates cell-cell communication by down-regulating connexin43 expression in luteinized human granulosa cells
    Authors: Yan-Ting Wu
    Mol. Hum. Reprod, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension.
    Authors: Prewitt A, Ghose S, Frump A, Datta A, Austin E, Kenworthy A, de Caestecker M
    J Biol Chem, 2015;290(2):960-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis.
    Authors: Hill C, Jacobs B, Brown C, Barnett J, Goudy S
    Dev Dyn, 2015;244(2):122-33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency.
    Authors: Malhotra, Rajeev, Burke, Megan F, Martyn, Trejeeve, Shakartzi, Hannah R, Thayer, Timothy, O'Rourke, Caitlin, Li, Pingchen, Derwall, Matthias, Spagnolli, Ester, Kolodziej, Starsha, Hoeft, Konrad, Mayeur, Claire, Jiramongkolchai, Pawina, Kumar, Ravindra, Buys, Emmanuel, Yu, Paul B, Bloch, Kenneth, Bloch, Donald B
    PLoS ONE, 2015;10(1):e0117098.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Radiation-induced alterations of osteogenic and chondrogenic differentiation of human mesenchymal stem cells.
    Authors: Cruet-Hennequart S, Drougard C, Shaw G, Legendre F, Demoor M, Barry F, Lefaix J, Galera P
    PLoS ONE, 2015;10(3):e0119334.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Osteogenic differentiation of human mesenchymal stem cells in mineralized alginate matrices.
    Authors: Westhrin M, Xie M, Olderoy M, Sikorski P, Strand B, Standal T
    PLoS ONE, 2015;10(3):e0120374.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Osteogenic Surface Modification Based on Functionalized Poly-P-Xylylene Coating.
    Authors: Chang C, Yeh S, Lee B, Chen C, Su C, Lin Y, Liu C, Chen H
    PLoS ONE, 2015;10(9):e0137017.
    Species: Transgenic Mouse
    Sample Types: Recombinant Protein
    Applications: Bioassay
  73. Bone morphogenetic proteins are mediators of luteolysis in the human corpus luteum.
    Authors: Nio-Kobayashi J, Trendell J, Giakoumelou S, Boswell L, Nicol L, Kudo M, Sakuragi N, Iwanaga T, Duncan W
    Endocrinology, 2015;156(4):1494-503.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.
    Authors: Todaro M, Gaggianesi M, Catalano V, Benfante A, Iovino F, Biffoni M, Apuzzo T, Sperduti I, Volpe S, Cocorullo G, Gulotta G, Dieli F, De Maria R, Stassi G
    Cell Stem Cell, 2014;14(3):342-56.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. TGFbeta-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Authors: Suresh Babu S, Valdez Y, Xu A, O'Byrne A, Calvo F, Lei V, Conway E
    BMC Cancer, 2014;14(0):113.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5.
    Authors: Ratnayake M, Ploger F, Santibanez-Koref M, Loughlin J
    PLoS ONE, 2014;9(1):e86590.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression.
    Authors: Laperrousaz B, Jeanpierre S, Sagorny K, Voeltzel T, Ramas S, Kaniewski B, Ffrench M, Salesse S, Nicolini F, Maguer-Satta V
    Blood, 2014;122(23):3767-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHbeta gene expression.
    Authors: Garrel G, Simon V, Denoyelle C, Ishaq M, Rouch C, Dairou J, Magnan C, Migrenne S, Cruciani-Guglielmacci C, Cohen-Tannoudji J
    Endocrinology, 2014;155(2):592-604.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Matrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist.
    Authors: Yang X, Trehan S, Guan Y, Sun C, Moore D, Jayasuriya C, Chen Q
    J Biol Chem, 2014;289(50):34768-79.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Tissue engineering bone using autologous progenitor cells in the peritoneum.
    Authors: Shen, Jinhui, Nair, Ashwin, Saxena, Ramesh, Zhang, Cheng Ch, Borrelli, Joseph J, Tang, Liping
    PLoS ONE, 2014;9(3):e93514.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway.
    Authors: Tanwar V, Bylund J, Hu J, Yan J, Walthall J, Mukherjee A, Heaton W, Wang W, Potet F, Rai M, Kupershmidt S, Knapik E, Hatzopoulos A
    Stem Cells, 2014;32(7):1774-88.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis.
    Authors: Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, Hollander A
    Stem Cells Dev, 2014;23(5):541-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Changes of microRNA profile and microRNA-mRNA regulatory network in bones of ovariectomized mice.
    Authors: An J, Ohn J, Song J, Yang J, Park H, Choi H, Kim S, Kim S, Park W, Shin C
    J Bone Miner Res, 2014;29(3):644-56.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  84. The role of bone marrow derived-mesenchymal stem cells in attenuation of kidney function in rats with diabetic nephropathy.
    Authors: Abdel Aziz M, Wassef M, Ahmed H, Rashed L, Mahfouz S, Aly M, Hussein R, Abdelaziz M
    Diabetol Metab Syndr, 2014;6(1):34.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  85. An activin receptor IIA ligand trap corrects ineffective erythropoiesis in beta-thalassemia.
    Authors: Dussiot M, Maciel T, Fricot A, Chartier C, Negre O, Veiga J, Grapton D, Paubelle E, Payen E, Beuzard Y, Leboulch P, Ribeil J, Arlet J, Cote F, Courtois G, Ginzburg Y, Daniel T, Chopra R, Sung V, Hermine O, Moura I
    Nat Med, 2014;20(4):398-407.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Identification of BMP2 as an epigenetically silenced growth inhibitor in rhabdomyosarcoma.
    Authors: Wolf S, Hagl B, Kappler R
    Int J Oncol, 2014;44(5):1727-35.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Noncanonical Wnt5a enhances Wnt/beta-catenin signaling during osteoblastogenesis.
    Authors: Okamoto M, Udagawa N, Uehara S, Maeda K, Yamashita T, Nakamichi Y, Kato H, Saito N, Minami Y, Takahashi N, Kobayashi Y
    Sci Rep, 2014;4(0):4493.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis.
    Authors: Park J, Jang S, Park D, Lim N, Deng C, Kim D, Green J, Kim H
    Mol Cancer Res, 2014;12(8):1088-99.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  89. A growth-promoting signaling component cyclin D1 in neural stem cells has antiastrogliogenic function to execute self-renewal.
    Authors: Bizen N, Inoue T, Shimizu T, Tabu K, Kagawa T, Taga T
    Stem Cells, 2014;32(6):1602-15.
  90. A unique tool to selectively detect the chondrogenic IIB form of human type II procollagen protein.
    Authors: Aubert-Foucher E, Mayer N, Pasdeloup M, Pagnon A, Hartmann D, Mallein-Gerin F
    Matrix Biol, 2014;34(0):80-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis.
    Authors: Gao X, Cao Y, Staloch D, Gonzales M, Aronson J, Chao C, Hellmich M, Ko T
    PLoS ONE, 2014;9(2):e89114.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  92. TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.
    Authors: Gao L, Sheu T, Dong Y, Hoak D, Zuscik M, Schwarz E, Hilton M, O'Keefe R, Jonason J
    J Cell Sci, 2013;126(0):5704-13.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development.
    Authors: Wang, Yidong, Wu, Bingruo, Chamberlain, Alyssa A, Lui, Wendy, Koirala, Pratisth, Susztak, Katalin, Klein, Diana, Taylor, Verdon, Zhou, Bin
    PLoS ONE, 2013;8(4):e60244.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans.
    Authors: Clementi C, Tripurani S, Large M, Edson M, Creighton C, Hawkins S, Kovanci E, Kaartinen V, Lydon J, Pangas S, DeMayo F, Matzuk M
    PLoS Genet, 2013;9(11):e1003863.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts.
    Authors: Li S, Meyer N, Quarto N, Longaker M
    PLoS ONE, 2013;8(3):e58610.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  96. The transcription factor protein Sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors.
    Authors: Gadi, Jogeswar, Jung, Seung-Hy, Lee, Min-Jung, Jami, Ajita, Ruthala, Kalyani, Kim, Kyoung-M, Cho, Nam-Hoon, Jung, Han-Sung, Kim, Cheol-He, Lim, Sung-Kil
    J Biol Chem, 2013;288(35):25400-13.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  97. A novel adipokine C1q/TNF-related protein 1 (CTRP1) regulates chondrocyte proliferation and maturation through the ERK1/2 signaling pathway.
    Authors: Akiyama H, Otani M, Sato S, Toyosawa S, Furukawa S, Wakisaka S, Maeda T
    Mol Cell Endocrinol, 2013;369(1):63-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Protein phosphatase 2A isoforms utilizing Abeta scaffolds regulate differentiation through control of Akt protein.
    Authors: Hwang J, Jiang T, Kulkarni S, Faure N, Schaffhausen B
    J Biol Chem, 2013;288(44):32064-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses.
    Authors: Huegel J, Mundy C, Sgariglia F, Nygren P, Billings P, Yamaguchi Y, Koyama E, Pacifici M
    Dev Biol, 2013;377(1):100-12.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  100. Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation.
    Authors: Talavera-Adame, Dodanim, Gupta, Ankur, Kurtovic, Silvia, Chaiboonma, Kira L, Arumugaswami, Vaithili, Dafoe, Donald C
    Stem Cells Dev, 2013;22(24):3252-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production.
    Authors: Glister C, Satchell L, Bathgate R, Wade J, Dai Y, Ivell R, Anand-Ivell R, Rodgers R, Knight P
    Proc Natl Acad Sci U S A, 2013;110(15):E1426-35.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  102. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs.
    Authors: Chen, Jiekai, Liu, He, Liu, Jing, Qi, Jing, Wei, Bei, Yang, Jiaqi, Liang, Hanquan, Chen, You, Chen, Jing, Wu, Yaran, Guo, Lin, Zhu, Jieying, Zhao, Xiangjie, Peng, Tianran, Zhang, Yixin, Chen, Shen, Li, Xuejia, Li, Dongwei, Wang, Tao, Pei, Duanqing
    Nat Genet, 2013;45(1):34-42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Human embryonic stem cells differentiate into functional renal proximal tubular-like cells.
    Authors: Narayanan, Karthike, Schumacher, Karl M, Tasnim, Farah, Kandasamy, Karthike, Schumacher, Annegret, Ni, Ming, Gao, Shujun, Gopalan, Began, Zink, Daniele, Ying, Jackie Y
    Kidney Int, 2013;83(4):593-603.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein alpha (SIRPalpha) signaling.
    Authors: Koskinen C, Persson E, Baldock P, Stenberg A, Bostrom I, Matozaki T, Oldenborg P, Lundberg P
    J Biol Chem, 2013;288(41):29333-44.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor.
    Authors: Yamamoto-Shiraishi Y, Kuroiwa A
    , 2013;0(0):.
    Species: Mouse
    Sample Types: Embryo
    Applications: In vivo
  106. Generation of robust vascular networks from cardiovascular blast populations derived from human induced pluripotent stem cells in vivo and ex vivo organ culture system.
    Authors: Kawamoto T, Kobayashi Y, Nakajima H, Yamagishi Y
    Biochem Biophys Res Commun, 2013;441(1):180-5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.
    Authors: Bruce D, Macartney T, Yong W, Shou W, Sapkota G
    Cell Signal, 2012;24(11):1999-2006.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs).
    Authors: Wu, Qifang, Sun, Chia Chi, Lin, Herbert, Babitt, Jodie L
    PLoS ONE, 2012;7(9):e46307.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance
  109. Gremlin-1 induces BMP-independent tumor cell proliferation, migration, and invasion.
    Authors: Kim M, Yoon S, Lee S
    PLoS ONE, 2012;7(4):e35100.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Binding Assay
  110. Osteoblast-like differentiation of cultured human coronary artery smooth muscle cells by bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER).
    Authors: Satomi-Kobayashi S, Kinugasa M, Kobayashi R, Hatakeyama K, Kurogane Y, Ishida T, Emoto N, Asada Y, Takai Y, Hirata K, Rikitake Y
    J Biol Chem, 2012;287(36):30336-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Sertoli cell-conditioned medium induces germ cell differentiation in human embryonic stem cells.
    Authors: Geens M, Sermon KD
    J. Assist. Reprod. Genet., 2011;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
    Authors: Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV
    J. Biol. Chem., 2011;286(34):30034-46.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance
  113. Age-related changes in rat bone-marrow mesenchymal stem cell plasticity.
    Authors: Asumda FZ, Chase PB
    BMC Cell Biol., 2011;12(0):44.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Bone morphogenetic protein-2 may represent the molecular link between oxidative stress and vascular stiffness in chronic kidney disease.
    Authors: Dalfino G, Simone S, Porreca S, Cosola C, Balestra C, Manno C, Schena FP, Grandaliano G, Pertosa G
    Atherosclerosis, 2010;211(2):418-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  115. The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis.
    Authors: Haupt LM, Murali S, Mun FK, Teplyuk N, Mei LF, Stein GS, van Wijnen AJ, Nurcombe V, Cool SM
    J. Cell. Physiol., 2009;220(3):780-91.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element.
    Authors: Shafer SL, Towler DA
    J. Mol. Cell. Cardiol., 2009;46(5):621-35.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells.
    Authors: Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, Lee YT, Goodnough JB, Harandi O, Ganz T, Paulson RF, Miller JL
    Blood, 2009;114(1):181-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis.
    Authors: Irie N, Takada Y, Watanabe Y, Matsuzaki Y, Naruse C, Asano M, Iwakura Y, Suda T, Matsuo K
    J. Biol. Chem., 2009;284(21):14637-44.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis.
    Authors: Little SC, Mullins MC
    Nat. Cell Biol., 2009;11(5):637-43.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: Bioassay
  120. Regulation of bone morphogenetic protein signalling in human pulmonary vascular development.
    Authors: Southwood M, Jeffery TK, Yang X, Upton PD, Hall SM, Atkinson C, Haworth SG, Stewart S, Reynolds PN, Long L, Trembath RC, Morrell NW
    J. Pathol., 2008;214(1):85-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  121. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.
    Authors: Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR
    Nature, 2008;454(7207):1000-4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  122. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.
    Authors: Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY
    J. Mol. Biol., 2008;381(4):1025-39.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA (Capture)
  123. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
    Authors: Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L
    Cell Stem Cell, 2008;2(6):602-12.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  124. BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling.
    Authors: Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V
    Blood, 2008;112(8):3154-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis.
    Authors: Kane R, Godson C, O'Brien C
    Mol. Vis., 2008;14(0):1138-48.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Targeting of bone morphogenetic protein growth factor complexes to fibrillin.
    Authors: Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bachinger HP, Sakai LY
    J. Biol. Chem., 2008;283(20):13874-88.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Binding Assay
  127. New cell lines from mouse epiblast share defining features with human embryonic stem cells.
    Authors: Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD
    Nature, 2007;448(7150):196-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  128. BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin.
    Authors: Wen Z, Han L, Bamburg JR, Shim S, Ming GL, Zheng JQ
    J. Cell Biol., 2007;178(1):107-19.
    Species: Xenopus
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction.
    Authors: Niki Y, Takaishi H, Takito J, Miyamoto T, Kosaki N, Matsumoto H, Toyama Y, Tada N
    J. Immunol., 2007;179(1):639-46.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  130. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.
    Authors: Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T
    Blood, 2007;110(6):2182-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Dickkopf-1 is a master regulator of joint remodeling.
    Authors: Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, van der Heide D, Landewe R, Lacey D, Richards WG, Schett G
    Nat. Med., 2007;13(2):156-63.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  132. Activin-like kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells.
    Authors: Yao Y, Zebboudj AF, Torres A, Shao E, Bostrom K
    Cardiovasc. Res., 2007;74(2):279-89.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  133. Antitumor activity of ALK1 in pancreatic carcinoma cells.
    Authors: Ungefroren H, Schniewind B, Groth S, Chen WB, Muerkoster SS, Kalthoff H, Fandrich F
    Int. J. Cancer, 2007;120(8):1641-51.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Bone morphogenetic protein-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells.
    Authors: Gossrau G, Thiele J, Konang R, Schmandt T, Brustle O
    Stem Cells, 2007;25(4):939-49.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  135. Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors.
    Authors: Pi X, Ren R, Kelley R, Zhang C, Moser M, Bohil AB, Divito M, Cheney RE, Patterson C
    J. Cell Biol., 2007;179(7):1569-82.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
    Authors: Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG
    Blood, 2007;109(9):3706-12.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  137. TGFbeta ligands promote the initiation of retinal ganglion cell dendrites in vitro and in vivo.
    Authors: Hocking JC, Hehr CL, Chang RY, Johnston J, McFarlane S
    Mol. Cell. Neurosci., 2007;37(2):247-60.
    Species: Xenopus
    Sample Types: Whole Cells
    Applications: Bioassay
  138. BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression.
    Authors: Bonafede A, Kohler T, Rodriguez-Niedenfuhr M, Brand-Saberi B
    Dev. Biol., 2006;299(2):330-44.
    Species: Chicken
    Sample Types: In Ovo
    Applications: In Ovo
  139. Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium.
    Authors: Bartunek J, Croissant JD, Wijns W, Gofflot S, de Lavareille A, Vanderheyden M, Kaluzhny Y, Mazouz N, Willemsen P, Penicka M, Mathieu M, Homsy C, De Bruyne B, McEntee K, Lee IW, Heyndrickx GR
    Am. J. Physiol. Heart Circ. Physiol., 2006;292(2):H1095-104.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  140. Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm.
    Authors: Lindsley RC, Gill JG, Kyba M, Murphy TL, Murphy KM
    Development, 2006;133(19):3787-96.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  141. TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells.
    Authors: Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H, Nakao A
    Arthritis Res. Ther., 2006;8(5):R146.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  142. Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2-mediated carrier-protein conjugation.
    Authors: Liu HW, Chen CH, Tsai CL, Hsiue GH
    Bone, 2006;39(4):825-36.
    Species: Rabbit
    Sample Types: In Vivo
    Applications: In Vivo
  143. BMP is an important regulator of proepicardial identity in the chick embryo.
    Authors: Schlueter J, Manner J, Brand T
    Dev. Biol., 2006;295(2):546-58.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  144. The effect of a fibrin-fibronectin/beta-tricalcium phosphate/recombinant human bone morphogenetic protein-2 system on bone formation in rat calvarial defects.
    Authors: Hong SJ, Kim CS, Han DK, Cho IH, Jung UW, Choi SH, Kim CK, Cho KS
    Biomaterials, 2006;27(20):3810-6.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  145. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct.
    Authors: Maeshima A, Vaughn DA, Choi Y, Nigam SK
    Dev. Biol., 2006;295(2):473-85.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: Bioassay
  146. Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins.
    Authors: Binnerts ME, Wen X, Cante-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F
    Biochem. Biophys. Res. Commun., 2004;315(2):272-80.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  147. HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis.
    Authors: Knosp WM, Scott V, Bachinger HP, Stadler HS
    Development, 2004;131(18):4581-92.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  148. Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis.
    Authors: Blair DG, Plisov S, Vasiliev G, Perantoni AO, Athanasiou M, Wu JY, Oppenheim JJ
    J. Immunol., 2004;173(10):5914-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  149. BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation.
    Authors: Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, Bautch VL, Conlon FL, Patterson C
    Mol. Cell. Biol., 2003;23(16):5664-79.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  150. Enhanced bone augmentation by controlled release of recombinant human bone morphogenetic protein-2 from bioabsorbable membranes.
    Authors: Lee YM, Nam SH, Seol YJ, Kim TI, Lee SJ, Ku Y, Rhyu IC, Chung CP, Han SB, Choi SM
    J. Periodontol., 2003;74(6):865-72.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. The vial is supposed to contain lyophilized protein but it appears to be empty. Is there anything in it?

    • Pellets can be dislodged during shipping and become disbursed on the vial wall and in the cap. Centrifuge or tap the vial on the benchtop to return this material to the vial bottom. If this does not reveal a pellet, closely inspect the cone of the vial. Some pellets appear as only a tiny amount of material or as a transparent film due to the original buffer formulation. This is a normal appearance for many proteins. For example, if the product is originally lyophilized from a solvent such as acetonitrile or ethanol, and supplied carrier-free, you may not be able to detect the pellet with the naked eye. This does not mean the vial is empty. Reconstitute the vial as directed. After reconstitution, protein concentration can be tested with a spectrophotometer.

  2. What is the recommended method for reconstitution of a lyophilized protein or antibody?

    • Unless more specific directions are on the Certificate of Analysis provided with the product, we suggest the following procedure to ensure optimal recovery: 1. Allow the vial and reconstitution buffer to equilibrate to room temperature. 2. Briefly centrifuge the vial to ensure that all lyophiliate is collected at the bottom of the vial. 3. Add the amount of buffer required to achieve the concentration recommended on the product insert. 4. Allow the vial to reconstitute for 15-30 minutes at room temperature with gentle agitation, like on a rocker platform or rotating by hand.  Avoid vigorous shaking that can cause foaming and protein denaturation. 5. Aliquot into volumes greater than 20 μL and store as indicated on the product insert. If the vial exhibits flakes or particulates, mix the product for a couple of hours at room temperature and then at 4oC overnight. Contact Technical Service if product does not go into solution.  

       

  3. Are R&D Systems recombinant proteins and antibodies sterile?

    • Although the vials are bottled using aseptic techniques, heat-treated vials, and sterile stock solutions, they are not considered or guaranteed to be sterile. If sterile material is needed for an experiment, the material can be filtered through a 0.2 micron filter designed for use with biological fluids.

  4. What is the difference between the two Recombinant Human/Mouse/Rat BMP-2 Proteins (Catalog # 355-BM and 355-BEC)?

    • Catalog # 355-BM is produced in a mammalian system using CHO cells and exhibits better activity in our routine QC bioassay, while Catalog # 355-BEC is produced in an E. coli expression system and is less expensive. Bioactivity of both Human/Mouse/Rat BMP-2 Proteins is measured in an alkaline phosphatase assay using by ATDC5 mouse chondrogenic cells. For 355-BM, the ED50 for this effect is 40-200 ng/mL, while for 355-BEC, the ED50 range is 80-480 ng/mL. We recommend reviewing our list of publications under the Citations tab for both 355-BM and 355-BEC to determine which of the two proteins is most suitable for your experiment.

  5. What is the sequence homology between human, mouse and rat BMP-2

    • Mature human BMP-2 shares 100% aa sequence identity with mouse and rat BMP-2.

  6. Does Recombinant Human/Mouse/Rat BMP-2 Protein (Catalog # 355-BM) have a histidine tag?

    • Recombinant Human/Mouse/Rat BMP-2 Protein (Catalog # 355-BM) does not contain a histidine tag. The sequence of this protein contains Gln283-Arg396 aa based on Accession # P12643.

View all Proteins and Enzyme FAQs

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