Recombinant Human/Mouse Wnt-5a Protein

Carrier Free

Catalog # Availability Size / Price Qty
645-WN-010/CF

With Carrier

Catalog # Availability Size / Price Qty
645-WN-010
Graph showing dose-dependent bioactivity of mouse Wnt-5a protein
1 Image
Product Details
Citations (162)
FAQs
Reviews (8)

Recombinant Human/Mouse Wnt-5a Protein Summary

Product Specifications

Purity
>80%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. The ED50 for this effect is 0.1-0.5 µg/mL, in the presence of 5 ng/mL rmWnt-3a.
Optimal concentrations should be determined by each laboratory for each application.
Source
Chinese Hamster Ovary cell line, CHO-derived Wnt-5a protein
Gln38-Lys380
Accession #
N-terminal Sequence
Analysis
Asn44 & No results obtained: Gln38 predicted
Predicted Molecular Mass
38 kDa
SDS-PAGE
45 kDa, reducing conditions

Product Datasheets

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645-WN (with carrier)

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645-WN/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

645-WN

Formulation Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

645-WN/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Graph showing dose-dependent bioactivity of mouse Wnt-5a protein View Larger

Recombinant mouse Wnt-5a (645-WN) inhibits Wnt-3a-induced alkaline phosphatase production in the MC3T3-E1 mouse preosteoblast cell line. The ED50 for this effect is 0.1-0.5 µg/mL in the presence of 5 ng/mL recombinant mouse Wnt-3a (1324-WN).

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Wnt-5a

Wnt-5a is a 44‑50 kDa member of the Wnt family of proteins (1‑6). Based on its activity towards C57Mg mammary epithelium, it is classified as a nontransforming Wnt. Human Wnt‑5a is synthesized as a 380 amino acid (aa) precursor that contains a 37 aa signal sequence, a 25 aa prosegment, and a 319 aa mature region (1, 2, 3). The mature region has 24 cysteine residues that form multiple intrachain disulfide bonds, plus four N‑linked glycosylation sites that are utilized for proper secretion (3, 5, 7). There is also a palmitate adduct at Cys104 that is essential for activity, and a potential palmitoleic acid modification at Ser244 that may also contribute to secretion (7‑9). One alternative start site is reported at Met16. Over aa 38‑380, human and mouse Wnt‑5a are identical in amino acid sequence (1, 10). Cells known to express Wnt‑5a include brainstem astrocytes (11), mammary epithelium (12), CD34+ primitive progenitor stem cells (13), chondrocytes (14), CD34- pericytes and vascular smooth muscle cells (15), plus mesenchymal cells at various sites (16, 17). There are multiple receptors for Wnt‑5a. These include Fzd-1, -2,
-3, -4, -5, and -7 (3, 18‑22), Ror2 (3), LRP6 (23), Ryk (24) and sFRP1 (25). All these molecules function within the context of a larger number of “co‑factors” that regulate signaling by the Wnts. Initially, it was suggested that there were three pathways for Wnt signaling; a beta -catenin-mediated canonical pathway, and two noncanonical pathways described as the Wnt/JNK (PCP) pathway and the Wnt/Ca++ pathway (26, 27). And it was assumed that various Wnts could be accommodated by these classifications. At present, it is now recognized that individual Wnts, through various combinations of receptor complex subunits, can have diverse effects, perhaps even within the same cell (3, 6, 27). Further complexity is introduced by the fact that Xenopus Wnt‑5a and Wnt‑11 are known to form bioactive heterodimers following Tyr sulfation (28). Thus, predicting the activity of Wnt‑5a, or any other Wnt, on any cell type will require substantial insight into the interaction between all the extracellular, cell surface and intracellular components of the Wnt signaling system.

References
  1. Clark, C.C. et al. (1993) Genomics 18:249.
  2. LeJeune, S. et al. (1995) Clin. Cancer Res. 1:215.
  3. Mikels, A.J. & R. Nusse (2006) PLoS Biol. 4:e115.
  4. Nishita, M. et al. (2010) Trends Cell Biol. 20:346.
  5. Mikels, A.J. & R. Nusse (2006) Oncogene 25:7461.
  6. van Amerongen, R. & R. Nusse (2009) Development 136:3205.
  7. Kurayoshi, M. et al. (2007) Biochem. J. 402:515.
  8. Takada, R. et al. (2006) Dev. Cell 11:791.
  9. Port, F. & K. Basler (2010) Traffic May 3. [Epub ahead of print].
  10. Gavin, B.J. et al. (1990) Genes Dev. 4:2319.
  11. Castelo-Branco, G. et al. (2006) Mol. Cell. Neurosci. 31:251.
  12. Jonsson, M. et al. (1998) Br. J. Cancer 78:430.
  13. van Den Berg, D.J. et al. (1998) Blood 92:3189.
  14. Kruger, C. & C. Kappen (2010) PLoS One 5:e8978.
  15. Lin, G. et al. (2008) Stem Cells Dev. 17:1053.
  16. Lickert, H. et al. (2001) Mech. Dev. 105:181.
  17. Danielson, K.G. et al. (1995) J. Biol. Chem. 270:31225.
  18. Gazit, A. et al. (1999) Oncogene 18:5959.
  19. Bazhin, A. V. et al. (2010) Cell. Mol. Life Sci. 67:817.
  20. Kawasaki, A. et al. (2007) Cell. Signal. 19:2498.
  21. Blumenthal, A. et al. (2006) Blood 108:965.
  22. Umbhauer, M. et al. (2000) EMBO J. 19:4944.
  23. Bryja, V. et al. (2009) Mol. Biol. Cell 20:924.
  24. Keeble, T.R. et al. (2006) J. Neurosci. 26:5840.
  25. Lin, K. et al. (1997) Proc. Natl. Acad. Sci. USA 94:11196.
  26. Rao, T.P. & M. Kuhl (2010) Circ. Res. 106:1798.
  27. McDonald, S.L. & A. Silver (2009) Br. J. Cancer 101:209.
  28. Cha, S-W. et al. (2009) Curr. Biol. 19:1573.
Long Name
Wingless-type MMTV Integration Site Family, Member 5a
Entrez Gene IDs
7474 (Human); 22418 (Mouse)
Alternate Names
hWNT5A; protein Wnt-5a; wingless-type MMTV integration site family, member 5A; WNT-5A protein; Wnt5a; Wnt-5a

Citations for Recombinant Human/Mouse Wnt-5a Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

162 Citations: Showing 1 - 10
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  1. Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex.
    J. Cell. Sci., 2102;125(0):2017-29.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Hormone regulation of thrombospondin-1 mRNA in porcine granulosa cells in vitro
    Authors: LJ Spicer, JR Evans, NB Schreiber
    Oncogene, 2022;244(0):107048.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Non-canonical Wnt signaling participates in Jagged1-induced osteo/odontogenic differentiation in human dental pulp stem cells
    Authors: C Kornsuthis, A Chansaenro, J Manokawinc, KA Tompkins, N Pirarat, T Osathanon
    Scientific Reports, 2022;12(1):7583.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  4. Cadmium exposure reprograms energy metabolism of hematopoietic stem cells to promote myelopoiesis at the expense of lymphopoiesis in mice
    Authors: Y Zhao, J He, T Zhu, Y Zhang, Y Zhai, P Xue, Y Yao, Z Zhou, M He, W Qu, Y Zhang
    Oncogene, 2022;231(0):113208.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. FSH stimulated bovine granulosa cell steroidogenesis involves both canonical and noncanonical WNT signaling
    Authors: M Ashry, JK Folger, SK Rajput, J Baroni, GW Smith
    Domestic animal endocrinology, 2022;78(0):106678.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. High expression level of ROR1 and ROR1-signaling associates with venetoclax resistance in chronic lymphocytic leukemia
    Authors: EM Ghia, LZ Rassenti, MY Choi, M Quijada-Ál, E Chu, GF Widhopf, TJ Kipps
    Leukemia, 2022;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  7. Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
    Authors: CJ Brereton, L Yao, ER Davies, Y Zhou, M Vukmirovic, JA Bell, S Wang, RA Ridley, LSN Dean, OG Andriotis, F Conforti, L Brewitz, S Mohammed, T Wallis, A Tavassoli, RM Ewing, A Alzetani, BG Marshall, SV Fletcher, PJ Thurner, A Fabre, N Kaminski, L Richeldi, A Bhaskar, CJ Schofield, M Loxham, DE Davies, Y Wang, MG Jones
    Elife, 2022;11(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Wnt5A and TGFbeta1 Converges through YAP1 Activity and Integrin Alpha v Up-Regulation Promoting Epithelial to Mesenchymal Transition in Ovarian Cancer Cells and Mesothelial Cell Activation
    Authors: Z Dehghani-G, S Sheikh Has, E Arefian, G Hossein
    Cells, 2022;11(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice
    Authors: N Salerno, F Marino, M Scalise, L Salerno, C Molinaro, A Filardo, A Chiefalo, G Panuccio, A De Angelis, K Urbanek, D Torella, E Cianflone
    Mechanisms of Ageing and Development, 2022;208(0):111740.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Differentiation
  10. Transient and Prolonged Activation of Wnt Signaling Contribute Oppositely to the Pathogenesis of Asherman's Syndrome
    Authors: X Xue, X Li, J Yao, X Zhang, X Ren, S Xu
    International Journal of Molecular Sciences, 2022;23(15):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  11. Transcriptional Regulation of Drug Metabolizing CYP Enzymes by Proinflammatory Wnt5A Signaling in Human Coronary Artery Endothelial Cells
    Authors: T Skaria, E Bachli, G Schoedon
    Frontiers in Pharmacology, 2021;12(0):619588.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  12. FOSL2 promotes VEGF-independent angiogenesis by transcriptionnally activating Wnt5a in breast cancer-associated fibroblasts
    Authors: X Wan, S Guan, Y Hou, Y Qin, H Zeng, L Yang, Y Qiao, S Liu, Q Li, T Jin, Y Qiu, M Liu
    Theranostics, 2021;11(10):4975-4991.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates
    Authors: A Böttcher, M Büttner, S Tritschler, M Sterr, A Aliluev, L Oppenlände, I Burtscher, S Sass, M Irmler, J Beckers, C Ziegenhain, W Enard, AC Schamberge, FM Verhamme, O Eickelberg, FJ Theis, H Lickert
    Nature Cell Biology, 2021;23(1):23-31.
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  14. IgD promotes pannus formation by activating Wnt5A-Fzd5-CTHRC1-NF-kappaB signaling pathway in FLS of CIA rats and the regulation of IgD-Fc-Ig fusion protein
    Authors: Y Tai, Y Zhu, D Mei, H Wang, Q Yu, C Hong, X Cai, L Xu, J Ge, F Liang, C Jiang, Z Xue, L Hu, R Liu, T Zhang, P Wang, X Zhang, F Zhang, W Wei, L Zhang
    International immunopharmacology, 2021;101(0):108261.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Regulation of ABCG2 expression by Wnt5a through FZD7 in human pancreatic cancer cells
    Authors: Z Zhang, S Gao, Y Xu, C Zhao
    Mol Med Rep, 2021;23(1):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  16. RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy
    Authors: T Radaszkiew, M Nosková, K Gömöryová, O Vondálová, KA Radaszkiew, M Picková, R Víchová, T Gybe?, K Kaiser, L Demková, L Ku?erová, T Bárta, D Pot?šil, Z Zdráhal, K Sou?ek, V Bryja
    Elife, 2021;10(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation
    Authors: D Feng, J Wang, W Yang, J Li, X Lin, F Zha, X Wang, L Ma, NT Choi, Y Mii, S Takada, MSY Huen, Y Guo, L Zhang, B Gao
    Science Advances, 2021;7(20):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Phosphorylation-induced changes in the PDZ domain of Dishevelled 3
    Authors: M Jurásek, J Kumar, P Paclíková, A Kumari, K Tripsianes, V Bryja, R Vácha
    Scientific Reports, 2021;11(1):1484.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Immunocytochemical Analysis of Endogenous Frizzled-(Co-)Receptor Interactions and Rapid Wnt Pathway Activation in Mammalian Cells
    Authors: J Neuhaus, A Weimann, M Berndt-Pae
    International Journal of Molecular Sciences, 2021;22(21):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2&alpha HRI kinase
    Authors: E Ramos-Fern, MS Arrázola, CA Oliva, SB Arredondo, L Varela-Nal, NC Inestrosa
    Scientific Reports, 2021;11(1):7395.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain
    Authors: M Kowalski-J, H Schihada, A Turku, T Huber, TP Sakmar, G Schulte
    Science Advances, 2021;7(46):eabj7917.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy
    Authors: NC DeVito, M Sturdivant, B Thievanthi, C Xiao, MP Plebanek, AKS Salama, GM Beasley, A Holtzhause, V Novotny-Di, JH Strickler, BA Hanks
    Cell Reports, 2021;35(5):109071.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. H3K27me3-mediated PGC1&alpha gene silencing promotes melanoma invasion through WNT5A and YAP
    Authors: C Luo, E Balsa, EA Perry, J Liang, CD Tavares, F Vazquez, HR Widlund, P Puigserver
    J. Clin. Invest., 2020;130(2):853-862.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Wnt5a/CaMKII/ERK/CCL2 axis is required for tumor-associated macrophages to promote colorectal cancer progression
    Authors: Q Liu, J Song, Y Pan, D Shi, C Yang, S Wang, B Xiong
    Int. J. Biol. Sci., 2020;16(6):1023-1034.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities
    Authors: S Ikezu, H Yeh, JC Delpech, ME Woodbury, AA Van Enoo, Z Ruan, S Sivakumara, Y You, C Holland, T Guillamon-, A Yoshii-Kit, MB Botros, C Madore, PH Chao, A Desani, S Manimaran, SV Kalavai, WE Johnson, O Butovsky, M Medalla, JI Luebke, T Ikezu
    Mol. Psychiatry, 2020;0(0):.
    Species: Mouse
    Sample Types: Reference Standard
    Applications: ELISA Standard
  26. A tumor-intrinsic PD-L1-NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy
    Authors: B Theivanthi, KS Evans, NC DeVito, MP Plebanek, M Sturdivant, LP Wachsmuth, AK Salama, Y Kang, D Hsu, JM Balko, DB Johnson, M Starr, AB Nixon, A Holtzhause, BA Hanks
    J. Clin. Invest., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Wnt5a regulates Ameloblastoma Cell Migration by modulating Mitochondrial and Cytoskeletal Dynamics
    Authors: X Qiao, X Niu, J Shi, L Chen, X Wang, J Liu, L Zhu, M Zhong
    J Cancer, 2020;11(18):5490-5502.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability
    Authors: M Díaz-Corán, CM Lin, S Liebner, DA Antonetti
    J. Biol. Chem., 2020;0(0):.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis
    Authors: M Mecha, N Yanguas-Ca, A Feliú, L Mestre, FJ Carrillo-S, K Riecken, D Gomez-Nico, C Guaza
    J Neuroinflammation, 2020;17(1):88.
    Species: Rat
    Sample Types:
    Applications: Cell Culture
  30. Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression
    Authors: Q Chen, J Jiao, Y Wang, Z Mai, J Ren, S He, X Li, Z Chen
    BMC Mol Cell Biol, 2020;21(1):80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Control
  31. Structural insight into small molecule action on Frizzleds
    Authors: P Kozielewic, A Turku, CF Bowin, J Petersen, J Valnohova, MCA Cañizal, Y Ono, A Inoue, C Hoffmann, G Schulte
    Nat Commun, 2020;11(1):414.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  32. Glucocorticoids induce differentiation and chemoresistance in ovarian cancer by promoting ROR1-mediated stemness
    Authors: H Karvonen, M Arjama, L Kaleva, W Niininen, H Barker, R Koivisto-K, J Tapper, P Pakarinen, H Lassus, M Loukovaara, R Bützow, O Kallioniem, A Murumägi, D Ungureanu
    Cell Death Dis, 2020;11(9):790.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Wnt5a regulates Ameloblastoma Cell Migration by modulating Mitochondrial and Cytoskeletal Dynamics
    Authors: X Qiao, X Niu, J Shi, L Chen, X Wang, J Liu, L Zhu, M Zhong
    J Cancer, 2020;11(18):5490-5502.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  34. Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency
    Authors: W Kawarazaki, R Mizuno, M Nishimoto, N Ayuzawa, D Hirohama, K Ueda, F Kawakami-M, S Oba, T Marumo, T Fujita
    J. Clin. Invest., 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  35. Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/beta-catenin axis
    Authors: A Reggio, M Rosina, A Palma, A Cerquone P, LL Petrilli, C Gargioli, C Fuoco, E Micarelli, G Giuliani, M Cerretani, A Bresciani, F Sacco, L Castagnoli, G Cesareni
    Cell Death Differ., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling
    Authors: SY Jeong, J Lyu, JA Kim, IH Oh
    Exp. Mol. Med., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  37. Notch signalling drives synovial fibroblast identity and arthritis pathology
    Authors: K Wei, I Korsunsky, JL Marshall, A Gao, GFM Watts, T Major, AP Croft, J Watts, PE Blazar, JK Lange, TS Thornhill, A Filer, K Raza, LT Donlin,, CW Siebel, CD Buckley, S Raychaudhu, MB Brenner
    Nature, 2020;582(7811):259-264.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Canonical and non-canonical Wnt signaling are simultaneously activated by Wnts in colon cancer cells
    Authors: E Flores-Her, DM Velázquez, MC Castañeda-, G Fuentes-Ga, G Fonseca-Ca, JK Yamamoto-F, MT Romero-Avi, JA García-Sái, M Robles-Flo
    Cell. Signal., 2020;72(0):109636.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. A Zic2-regulated switch in a noncanonical Wnt/&betacatenin pathway is essential for the formation of bilateral circuits
    Authors: C Morenilla-, MT López-Casc, JP López-Atal, D Baeza, L Calvo-Díaz, A Barco, E Herrera
    Sci Adv, 2020;6(46):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Tissue Culture
  40. Rlip Depletion Suppresses Growth of Breast Cancer
    Authors: C Bose, S Yadav, SS Singhal, J Singhal, A Hindle, J Lee, NKS Cheedella, S Rehman, RL Rahman, C Jones, M Darden, PT Palade, D Berz, SP Singh, S Awasthi
    Cancers (Basel), 2020;12(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody
    Authors: S Zhang, H Zhang, EM Ghia, J Huang, L Wu, J Zhang, S Lam, Y Lei, J He, B Cui, GF Widhopf, J Yu, R Schwab, K Messer, W Jiang, BA Parker, DA Carson, TJ Kipps
    Proc. Natl. Acad. Sci. U.S.A., 2019;116(4):1370-1377.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Non-canonical WNT-signaling controls differentiation of lymphatics and extension lymphangiogenesis via RAC and JNK signaling
    Authors: G Lutze, A Haarmann, JA Demanou To, K Buttler, J Wilting, J Becker
    Sci Rep, 2019;9(1):4739.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting
    Authors: H Karvonen, R Perttilä, W Niininen, V Hautanen, H Barker, A Murumägi, CA Heckman, D Ungureanu
    Oncogene, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Divergent effects of Wnt5b on IL-3- and GM-CSF-induced myeloid differentiation
    Authors: MM de Rezende, JP Ng-Blichfe, GZ Justo, EJ Paredes-Ga, R Gosens
    Cell. Signal., 2019;67(0):109507.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
    Authors: K Kaiser, D Gyllborg, J Procházka, A Salašová, P Kompaníkov, FL Molina, R Laguna-Goy, T Radaszkiew, J Harnoš, M Procházkov, D Pot?šil, RA Barker, ÁG Casado, Z Zdráhal, R Sedlá?ek, E Arenas, JC Villaescus, V Bryja
    Nat Commun, 2019;10(1):1498.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors
    Authors: X Wu, EM van Dijk, JP Ng-Blichfe, IST Bos, C Ciminieri, M Königshoff, LEM Kistemaker, R Gosens
    Cells, 2019;8(10):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Systematically understanding the immunity leading to CRPC progression
    Authors: Z Ji, W Zhao, HK Lin, X Zhou
    PLoS Comput. Biol., 2019;15(9):e1007344.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Construction of a vascularized bladder with autologous adipose-derived stromal vascular fraction cells combined with bladder acellular matrix via tissue engineering
    Authors: F Zhao, L Zhou, J Liu, Z Xu, W Ping, H Li, L Xu, Z Xu, C Zhou, M Wang, R Jia
    J Tissue Eng, 2019;10(0):2041731419891.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  49. An Autocrine Wnt5a Loop Promotes NF-kappaB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma
    Authors: G Barbero, MV Castro, MB Villanueva, MJ Quezada, NB Fernández, S DeMorrow, P Lopez-Berg
    Cells, 2019;8(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. A20 regulates canonical wnt-signaling through an interaction with RIPK4
    Authors: BN Nakamura, A Glazier, MG Kattah, B Duong, Y Jia, D Campo, L Shao
    PLoS ONE, 2018;13(5):e0195893.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Caveolin-1 down-regulation is required for Wnt5a-Frizzled 2 signalling in Ha-RasV12-induced cell transformation
    Authors: HK Lin, HH Lin, YW Chiou, CL Wu, WT Chiu, MJ Tang
    J. Cell. Mol. Med., 2018;0(0):.
    Applications: Bioassay
  52. Intracellular Calcium Determines the Adipogenic Differentiation Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells via the Wnt5a/?-Catenin Signaling Pathway
    Authors: YK Bae, JH Kwon, M Kim, GH Kim, SJ Choi, W Oh, YS Yang, HJ Jin, HB Jeon
    Stem Cells Int, 2018;2018(0):6545071.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Population snapshots predict early haematopoietic and erythroid hierarchies
    Authors: BK Tusi, SL Wolock, C Weinreb, Y Hwang, D Hidalgo, R Zilionis, A Waisman, JR Huh, AM Klein, M Socolovsky
    Nature, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Spaceflight Activates Protein Kinase C Alpha Signaling and Modifies the Developmental Stage of Human Neonatal Cardiovascular Progenitor Cells
    Authors: J Baio, AF Martinez, LL Bailey, N Hasaniya, M Pecaut, M Kearns-Jon
    Stem Cells Dev., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. The Coordinated Activities of nAChR and Wnt Signaling Regulate Intestinal Stem Cell Function in Mice
    Authors: T Takahashi, A Shiraishi, J Murata
    Int J Mol Sci, 2018;19(3):.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: Bioassay
  56. Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia
    Authors: MK Hasan, J Yu, GF Widhopf, LZ Rassenti, L Chen, Z Shen, SP Briggs, DS Neuberg, TJ Kipps
    Blood, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target
    Authors: J Heliste, A Jokilammi, I Paatero, D Chakrobort, C Stark, T Savunen, M Laaksonen, K Elenius
    BMC Cardiovasc Disord, 2018;18(1):196.
  58. Identification of genes which regulate stroma-dependent in vitro hematopoiesis
    Authors: P Periasamy, V Tran, HC O'Neill
    PLoS ONE, 2018;13(10):e0205583.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Effect of SFRP5 (Secreted Frizzled-Related Protein 5) on the WNT5A (Wingless-Type Family Member 5A)-Induced Endothelial Dysfunction and Its Relevance With Arterial Stiffness in Human Subjects
    Authors: YK Cho, YM Kang, SE Lee, Y Lee, SM Seol, WJ Lee, JY Park, CH Jung
    Arterioscler. Thromb. Vasc. Biol., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  60. miR-613 inhibits cell migration and invasion by downregulating Daam1 in triple-negative breast cancer
    Authors: H Xiong, T Yan, W Zhang, F Shi, X Jiang, X Wang, S Li, Y Chen, C Chen, Y Zhu
    Cell. Signal., 2018;44(0):33-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Wnt5a suppresses inflammation-driven intervertebral disc degeneration via a TNF-α/NF-κB -Wnt5a negative-feedback loop
    Authors: Z Li, K Zhang, X Li, H Pan, S Li, F Chen, J Zhang, Z Zheng, J Wang, H Liu
    Osteoarthr. Cartil., 2018;0(0):.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  62. Reduced Cdc42 Activity Compromises Hematopoiesis-Supportive Function Of Fanconi Anemia Mesenchymal Stromal Cells
    Authors: J Xu, X Li, A Cole, Z Sherman, W Du
    Stem Cells, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms
    Authors: T Rosengren, LJ Larsen, LB Pedersen, ST Christense, LB Møller
    Cell. Mol. Life Sci., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Blocking Wnt5a signaling decreases CD36 expression and foam cell formation in atherosclerosis
    Authors: I Ackers, C Szymanski, KJ Duckett, LA Consitt, MJ Silver, R Malgor
    Cardiovasc. Pathol., 2018;34(0):1-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Precardiac organoids form two heart fields via Bmp/Wnt signaling
    Authors: P Andersen, E Tampakakis, DV Jimenez, S Kannan, M Miyamoto, HK Shin, A Saberi, S Murphy, E Sulistio, SP Chelko, C Kwon
    Nat Commun, 2018;9(1):3140.
    Species: Mouse
    Sample Types:
  66. Wnt inhibition promotes vascular specification of embryonic cardiac progenitors
    Authors: DE Reichman, L Park, L Man, D Redmond, K Chao, RP Harvey, MM Taketo, Z Rosenwaks, D James
    Development, 2018;145(1):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation
  67. Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes
    Authors: SH Lee, SM Shin, P Zhong, HT Kim, DI Kim, JM Kim, W Do Heo, DW Kim, CY Yeo, CH Kim, QS Liu
    Nat Commun, 2018;9(1):3434.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells
    Authors: BA Brown, GM Connolly, CEJ Mill, H Williams, GD Angelini, JL Johnson, SJ George
    Aging Cell, 2018;0(0):e12844.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma
    Authors: A Ogorodniko, M Levin, S Tattikota, S Tokalov, M Hoque, D Scherzinge, F Marini, A Poetsch, H Binder, S Macher-Göp, HC Probst, B Tian, M Schaefer, KJ Lackner, F Westermann, S Danckwardt
    Nat Commun, 2018;9(1):5331.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis
    Authors: P Qian, B De Kumar, XC He, C Nolte, M Gogol, Y Ahn, S Chen, Z Li, H Xu, JM Perry, D Hu, F Tao, M Zhao, Y Han, K Hall, A Peak, A Paulson, C Zhao, A Venkatrama, A Box, A Perera, JS Haug, T Parmely, H Li, R Krumlauf, L Li
    Cell Stem Cell, 2018;22(5):740-754.e7.
  71. BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling
    Authors: S Kokabu, V Rosen
    FEBS Open Bio, 2018;8(2):168-176.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Role of Wnt11 during Osteogenic Differentiation of Human Mesenchymal Stem Cells on Microstructured Titanium Surfaces
    Authors: BD Boyan, R Olivares-N, MB Berger, SL Hyzy, Z Schwartz
    Sci Rep, 2018;8(1):8588.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates
    Authors: MW Susman, EP Karuna, RC Kunz, TS Gujral, AV Cantú, SS Choi, BY Jong, K Okada, MK Scales, J Hum, LS Hu, MW Kirschner, R Nishinakam, S Yamada, DJ Laird, LE Jao, SP Gygi, ME Greenberg, HH Ho
    Elife, 2017;6(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Wnt5A/Ryk signaling critically affects barrier function in human vascular endothelial cells
    Authors: T Skaria, E Bachli, G Schoedon
    Cell Adh Migr, 2017;11(1):24-38.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling
    Authors: J Petersen, SC Wright, D Rodríguez, P Matricon, N Lahav, A Vromen, A Friedler, J Strömqvist, S Wennmalm, J Carlsson, G Schulte
    Nat Commun, 2017;8(1):226.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. N-terminal part of Dishevelled DEP domain is required for Wnt/?-catenin signaling in mammalian cells
    Authors: P Paclíková, O Bernatík, TW Radaszkiew, V Bryja
    Mol. Cell. Biol., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
  77. Rear-polarized Wnt5a-receptor-actin-myosin-polarity (WRAMP) structures promote the speed and persistence of directional cell migration
    Authors: MK Connacher, JW Tay, NG Ahn
    Mol. Biol. Cell, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. WNT/?-catenin pathway modulates the TNF-?-induced inflammatory response in bronchial epithelial cells
    Authors: J Jang, Y Jung, S Chae, SI Chung, SM Kim, Y Yoon
    Biochem. Biophys. Res. Commun, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling
    Authors: M Vesel, J Rapp, D Feller, E Kiss, L Jaromi, M Meggyes, G Miskei, B Duga, G Smuk, T Laszlo, I Karner, JE Pongracz
    Respir. Res, 2017;18(1):52.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974
    Authors: J Jang, Y Jung, Y Kim, EH Jho, Y Yoon
    Sci Rep, 2017;7(0):41612.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation
    Authors: O Bernatik, T Radaszkiew, M Behal, Z Dave, F Witte, A Mahl, NH Cernohorsk, P Krejci, S Stricker, V Bryja
    Front Cell Dev Biol, 2017;5(0):47.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Generation of iPSC-derived limb progenitor-like cells for stimulating phalange regeneration in the adult mouse
    Authors: Y Chen, H Xu, G Lin
    Cell Discov, 2017;3(0):17046.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Inhibition of age-related therapy resistance in melanoma by rosiglitazone-mediated induction of Klotho
    Authors: R Behera, A Kaur, MR Webster, S Kim, A Ndoye, CH Kugel, GM Alicea, JX Wang, K Ghosh, PF Cheng, S Lisanti, K Marchbank, V Dang, MP Levesque, R Dummer, X Xu, M Heryn, AE Aplin, A Roesch, MC Caino, DC Altieri, AT Weeraratna
    Clin. Cancer Res, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Heterozygous Vangl2(Looptail) mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair
    Authors: T Poobalasin, LL Yates, SA Walker, M Pereira, NY Gross, A Ali, M Kolatsi-Jo, MR Jarvelin, J Pekkanen, E Papakrivop, DA Long, M Griffiths, D Wagner, M Königshoff, M Hind, C Minelli, CM Lloyd, CH Dean
    Dis Model Mech, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells
    Authors: T Skaria, E Bachli, G Schoedon
    J Inflamm (Lond), 2017;14(0):10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking
    Authors: K Minegishi, M Hashimoto, R Ajima, K Takaoka, K Shinohara, Y Ikawa, H Nishimura, AP McMahon, K Willert, Y Okada, H Sasaki, D Shi, T Fujimori, T Ohtsuka, Y Igarashi, TP Yamaguchi, A Shimono, H Shiratori, H Hamada
    Dev. Cell, 2017;40(5):439-452.e4.
    Species: Mouse
    Sample Types: Whole Embryo
    Applications: Bioassay
  87. Ring finger protein 43 associates with gastric cancer progression and attenuates the stemness of gastric cancer stem-like cells via the Wnt-?/catenin signaling pathway
    Authors: Y Gao, A Cai, H Xi, J Li, W Xu, Y Zhang, K Zhang, J Cui, X Wu, B Wei, L Chen
    Stem Cell Res Ther, 2017;8(1):98.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. The tyrosine Y250(2.39) in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled
    Authors: K Strakova, P Matricon, C Yokota, E Arthofer, O Bernatik, D Rodriguez, E Arenas, J Carlsson, V Bryja, G Schulte
    Cell. Signal., 2017;38(0):85-96.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation
    Authors: MMF Steinbusch, MMJ Caron, DAM Surtel, F Friedrich, E Lausch, GJM Pruijn, W Verhesen, BLM Schroen, LW van Rhijn, B Zabel, TJM Welting
    Sci Rep, 2017;7(1):6440.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling
    Authors: K Kessenbroc, P Smith, SC Steenbeek, N Pervolarak, R Kumar, Y Minami, A Goga, L Hinck, Z Werb
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Higher expression of WNT5A protein in oral squamous cell carcinoma compared with dysplasia and oral mucosa with a normal appearance
    Authors: Z Prgomet, T Andersson, P Lindberg
    Eur. J. Oral Sci., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Beta-catenin inhibitor BC2059 is efficacious as monotherapy or in combination with proteasome inhibitor bortezomib in multiple myeloma
    Authors: I Savvidou, T Khong, A Cuddihy, C McLean, S Horrigan, A Spencer
    Mol. Cancer Ther., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. ATG5 mediates a positive feedback loop between Wnt signaling and autophagy in melanoma
    Authors: A Ndoye, A Budina-Kol, CH Kugel, MR Webster, A Kaur, R Behera, VW Rebecca, L Li, PA Brafford, Q Liu, YN Vashisht G, MA Davies, GB Mills, X Xu, H Wu, M Herlyn, MC Nicastri, JD Winkler, MS Soengas, RK Amaravadi, ME Murphy, AT Weeraratna
    Cancer Res., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling
    Authors: KB Schou, JB Mogensen, SK Morthorst, BS Nielsen, A Aleliunait, A Serra-Marq, N Frstenber, S Saunier, AA Bizet, IR Veland, A Akhmanova, ST Christense, LB Pedersen
    Nat Commun, 2017;8(0):14177.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD
    Authors: Hoeke A Baarsma
    J. Exp. Med, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Wnt-5a/Frizzled9 receptor signaling through the G?o/G?? complex regulates dendritic spine formation
    J Biol Chem, 2016;0(0):.
    Species: N/A
    Sample Types:
    Applications: Bioassay
  97. IL-4 Causes Hyperpermeability of Vascular Endothelial Cells through Wnt5A Signaling
    PLoS ONE, 2016;11(5):e0156002.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  98. KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification
    Sci Rep, 2016;6(0):26130.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth
    Authors: Ronald A DePinho
    Cell, 2016;167(5):1281-1295.e18.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  100. Regeneration of Articular Cartilage by Human ESC-Derived Mesenchymal Progenitors Treated Sequentially With BMP-2 and Wnt5a
    Stem Cells Transl Med, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Dysregulation of WNT5A/ROR2 Signaling Characterizes the Progression of Barrett's-associated Esophageal Adenocarcinoma
    Authors: O Lyros, L Nie, T Moore, R Medda, M Otterson, B Behmaram, A Mackinnon, I Gockel, R Shaker, P Rafiee
    Mol Cancer Res, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice.
    Authors: Tu Z, Wang Q, Cui T, Wang J, Ran H, Bao H, Lu J, Wang B, Lydon J, DeMayo F, Zhang S, Kong S, Wu X, Wang H
    Cell Death Differ, 2016;23(1):169-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Porcupine-dependent Wnt signaling controls stromal proliferation and endometrial gland maintenance through the action of distinct WNTs
    Authors: Omar Farah
    Dev. Biol, 2016;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  104. WNT5A signaling impairs breast cancer cell migration and invasion via mechanisms independent of the epithelial-mesenchymal transition
    J Exp Clin Cancer Res, 2016;35(1):144.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. FRIZZLED7 Is Required for Tumor Inititation and Metastatic Growth of Melanoma Cells.
    Authors: Tiwary S, Xu L
    PLoS ONE, 2016;11(1):e0147638.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms
    Nat. Med, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIalpha pathway during neuronal polarization.
    Authors: Horigane S, Ageta-Ishihara N, Kamijo S, Fujii H, Okamura M, Kinoshita M, Takemoto-Kimura S, Bito H
    Mol Brain, 2016;9(1):8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Increased Wnt5a in squamous cell lung carcinoma inhibits endothelial cell motility
    BMC Cancer, 2016;16(1):915.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway
    Nat Commun, 2016;7(0):13636.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Identification of proliferative and mature ?-cells in the islets of Langerhans
    Nature, 2016;535(7612):430-4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Endogenously produced Indian Hedgehog regulates TGFbeta-driven chondrogenesis of human bone marrow stromal/stem cells.
    Authors: Handorf A, Chamberlain C, Li W
    Stem Cells Dev, 2015;24(8):995-1007.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. WNT5A transforms intestinal CD8alphaalpha(+) IELs into an unconventional phenotype with pro-inflammatory features.
    Authors: Zhao D, Xu A, Dai Z, Peng J, Zhu M, Shen J, Zheng Q, Ran Z
    BMC Gastroenterol, 2015;15(0):173.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Partial maintenance and long-term expansion of murine skin epithelial stem cells by Wnt-3a in vitro.
    Authors: Ouji Y, Ishizaka S, Nakamura-Uchiyama F, Okuzaki D, Yoshikawa M
    J Invest Dermatol, 2015;135(6):1598-608.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.
    Authors: Suryawanshi A, Manoharan I, Hong Y, Swafford D, Majumdar T, Taketo M, Manicassamy B, Koni P, Thangaraju M, Sun Z, Mellor A, Munn D, Manicassamy S
    J Immunol, 2015;194(7):3295-304.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  115. IL-1beta mediates MCP-1 induction by Wnt5a in gastric cancer cells.
    Authors: Li S, Wang W, Zhang N, Ma T, Zhao C
    BMC Cancer, 2014;14(0):480.
  116. Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres.
    Authors: Many A, Brown A
    PLoS ONE, 2014;9(7):e101800.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains.
    Authors: Bainbridge T, DeAlmeida V, Izrael-Tomasevic A, Chalouni C, Pan B, Goldsmith J, Schoen A, Quinones G, Kelly R, Lill J, Sandoval W, Costa M, Polakis P, Arnott D, Rubinfeld B, Ernst J
    PLoS ONE, 2014;9(7):e102695.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Wnt-5a ligand modulates mitochondrial fission-fusion in rat hippocampal neurons.
    Authors: Godoy J, Arrazola M, Ordenes D, Silva-Alvarez C, Braidy N, Inestrosa N
    J Biol Chem, 2014;289(52):36179-93.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity.
    Authors: Kilander M, Dahlstrom J, Schulte G
    Cell Signal, 2014;26(9):1943-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Wnt5a promotes migration of human osteosarcoma cells by triggering a phosphatidylinositol-3 kinase/Akt signals.
    Authors: Zhang A, He S, Sun X, Ding L, Bao X, Wang N
    Cancer Cell Int, 2014;14(1):15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.
    Authors: Povinelli B, Nemeth M
    Stem Cells, 2014;32(1):105-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis.
    Authors: Keats E, Dominguez J, Grant M, Khan Z
    Stem Cells, 2014;32(6):1649-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism.
    Authors: Dawes L, Sugiyama Y, Lovicu F, Harris C, Shelley E, McAvoy J
    Dev Biol, 2014;385(2):291-303.
    Species: Rat
    Sample Types: Tissue Homogenates
    Applications: Bioassay
  124. WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells.
    Authors: Ekstrom E, Bergenfelz C, von Bulow V, Serifler F, Carlemalm E, Jonsson G, Andersson T, Leandersson K
    Mol Cancer, 2014;13(0):88.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4.
    Authors: Yu C, Nguyen T, Irvine K, Sweet M, Frazer I, Blumenthal A
    Eur J Immunol, 2014;44(5):1480-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Wnt5a through noncanonical Wnt/JNK or Wnt/PKC signaling contributes to the differentiation of mesenchymal stem cells into type II alveolar epithelial cells in vitro.
    Authors: Liu, Airan, Chen, Song, Cai, Shixia, Dong, Liang, Liu, Le, Yang, Yi, Guo, Fengmei, Lu, Xiaomin, He, Hongli, Chen, Qihong, Hu, Shuling, Qiu, Haibo
    PLoS ONE, 2014;9(3):e90229.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways.
    Authors: Tsai H, Deng W, Lai W, Chiu W, Yang C, Tsai Y, Hwang S, Renshaw P
    PLoS ONE, 2014;9(8):e104937.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart.
    Authors: Smith A, Lewis F, Aquila I, Waring C, Nocera A, Agosti V, Nadal-Ginard B, Torella D, Ellison G
    Nat Protoc, 2014;9(7):1662-81.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Interleukin-1beta-induced Wnt5a enhances human corneal endothelial cell migration through regulation of Cdc42 and RhoA.
    Authors: Lee J, Heur M
    Mol Cell Biol, 2014;34(18):3535-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  130. GEC-derived SFRP5 inhibits Wnt5a-induced macrophage chemotaxis and activation.
    Authors: Zhao C, Bu X, Wang W, Ma T, Ma H
    PLoS ONE, 2014;9(1):e85058.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Thyroid hormone-regulated Wnt5a/Ror2 signaling is essential for dedifferentiation of larval epithelial cells into adult stem cells in the Xenopus laevis intestine.
    Authors: Ishizuya-Oka, Atsuko, Kajita, Mitsuko, Hasebe, Takashi
    PLoS ONE, 2014;9(9):e107611.
    Species: N/A
    Sample Types: N/A
    Applications: Western Blot
  132. Prostate cancer bone metastases acquire resistance to androgen deprivation via WNT5A-mediated BMP-6 induction.
    Authors: Lee G, Kang D, Ha Y, Jung Y, Chung J, Min K, Kim T, Moon K, Chung J, Lee D, Kim W, Kim I
    Br J Cancer, 2014;110(6):1634-44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  133. Interleukin-6 drives melanoma cell motility through p38alpha-MAPK-dependent up-regulation of WNT5A expression.
    Authors: Linnskog R, Jonsson G, Axelsson L, Prasad C, Andersson T
    Mol Oncol, 2014;8(8):1365-78.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength.
    Authors: Bentzinger C, von Maltzahn J, Dumont N, Stark D, Wang Y, Nhan K, Frenette J, Cornelison D, Rudnicki M
    J Cell Biol, 2014;205(1):97-111.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  135. Noncanonical Wnt5a enhances Wnt/beta-catenin signaling during osteoblastogenesis.
    Authors: Okamoto M, Udagawa N, Uehara S, Maeda K, Yamashita T, Nakamichi Y, Kato H, Saito N, Minami Y, Takahashi N, Kobayashi Y
    Sci Rep, 2014;4(0):4493.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Wnt5a promotes inflammatory responses via nuclear factor kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK) pathways in human dental pulp cells.
    Authors: Zhao Y, Wang C, Li R, Hui T, Su Y, Yuan Q, Zhou X, Ye L
    J Biol Chem, 2014;289(30):21028-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  137. Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons.
    Authors: Cajanek L, Ganji R, Henriques-Oliveira C, Theofilopoulos S, Konik P, Bryja V, Arenas E
    Mol Cell Biol, 2013;33(1):59-70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  138. Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension.
    Authors: Ye Z, Zhang C, Tu T, Sun M, Liu D, Lu D, Feng J, Yang D, Liu F, Yan X
    Nat Commun, 2013;4(0):2803.
  139. A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.
    Authors: Florian M, Nattamai K, Dorr K, Marka G, Uberle B, Vas V, Eckl C, Andra I, Schiemann M, Oostendorp R, Scharffetter-Kochanek K, Kestler H, Zheng Y, Geiger H
    Nature, 2013;503(7476):392-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  140. Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120)-induced expression of pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and c-Jun N-terminal kinase (JNK) signaling pathways.
    Authors: Li B, Shi Y, Shu J, Gao J, Wu P, Tang S
    J Biol Chem, 2013;288(19):13610-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  141. Activation of intracellular calcium by multiple Wnt ligands and translocation of beta-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/beta-catenin pathways.
    Authors: Thrasivoulou C, Millar M, Ahmed A
    J Biol Chem, 2013;288(50):35651-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  142. Wnt5a and Wnt11 are essential for second heart field progenitor development.
    Authors: Cohen E, Miller M, Wang Z, Moon R, Morrisey E
    Development, 2012;139(11):1931-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  143. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  144. Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.
    Authors: Goel S, Chin EN, Fakhraldeen SA
    J. Biol. Chem., 2012;287(20):16454-66.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  145. Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the beta-catenin destruction complex.
    Authors: Tran H, Polakis P
    J Biol Chem, 2012;287(34):28552-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  146. Wnt5a regulates midbrain dopaminergic axon growth and guidance.
    Authors: Blakely BD, Bye CR, Fernando CV
    PLoS ONE, 2011;6(3):e18373.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  147. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast.
    Authors: Scheel C, Eaton E, Li S, Chaffer C, Reinhardt F, Kah K, Bell G, Guo W, Rubin J, Richardson A, Weinberg R
    Cell, 2011;145(6):926-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  148. WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.
    Authors: Kilander MB, Dijksterhuis JP, Ganji RS, Bryja V, Schulte G
    Cell. Signal., 2011;23(3):550-4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  149. WNT5A Signaling Contributes to Abeta-Induced Neuroinflammation and Neurotoxicity.
    Authors: Li B, Zhong L, Yang X, Andersson T, Huang M, Tang SJ
    PLoS ONE, 2011;6(8):e22920.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  150. Evidence for altered Wnt signaling in psoriatic skin.
    Authors: Gudjonsson JE, Johnston A, Stoll SW
    J. Invest. Dermatol., 2010;130(7):1849-59.
    Species: Human
    Sample Types: Whole Cells
  151. Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.
    Authors: Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN
    J. Biol. Chem., 2010;285(12):9172-9.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Binding Assay
  152. The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma.
    Authors: O'Connell MP, Fiori JL, Xu M
    Oncogene, 2010;29(1):34-44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  153. Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus.
    Authors: Gogolla N, Galimberti I, Deguchi Y, Caroni P
    Neuron, 2009;62(4):510-25.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  154. Canonical Wnt signaling negatively regulates platelet function.
    Authors: Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB
    Proc. Natl. Acad. Sci. U.S.A., 2009;106(47):19836-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  155. Wnt5A activates the calpain-mediated cleavage of filamin A.
    Authors: O'Connell MP, Fiori JL, Baugher KM, Indig FE, French AD, Camilli TC, Frank BP, Earley R, Hoek KS, Hasskamp JH, Elias EG, Taub DD, Bernier M, Weeraratna AT
    J. Invest. Dermatol., 2009;129(7):1782-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  156. Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells.
    Authors: Verkaar F, van Rosmalen JW, Smits JF, Blankesteijn WM, Zaman GJ
    Cell. Signal., 2009;21(1):22-33.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  157. Establishment of a transitory dorsal-biased window of localized Ca2+ signaling in the superficial epithelium following the mid-blastula transition in zebrafish embryos.
    Authors: Ma LH, Webb SE, Chan CM, Zhang J, Miller AL
    Dev. Biol., 2009;327(1):143-57.
    Species: Zebrafish
    Sample Types: Whole Cells
    Applications: Bioassay
  158. The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility.
    Authors: Safholm A, Tuomela J, Rosenkvist J, Dejmek J, Harkonen P, Andersson T
    Clin. Cancer Res., 2008;14(20):6556-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  159. Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism.
    Authors: Endo Y, Beauchamp E, Woods D, Taylor WG, Toretsky JA, Uren A, Rubin JS
    Mol. Cell. Biol., 2008;28(7):2368-79.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  160. Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway.
    Authors: Matushansky I, Hernando E, Socci ND, Mills JE, Matos TA, Edgar MA, Singer S, Maki RG, Cordon-Cardo C
    J. Clin. Invest., 2007;117(11):3248-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  161. Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2.
    Authors: Masckauchan TN, Agalliu D, Vorontchikhina M, Ahn A, Parmalee NL, Li CM, Khoo A, Tycko B, Brown AM, Kitajewski J
    Mol. Biol. Cell, 2006;17(12):5163-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  162. Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion.
    Authors: Henry C, Llamosas E, Knipprath-Meszaros A, Schoetzau A, Obermann E, Fuenfschilling M, Caduff R, Fink D, Hacker N, Ward R, Heinzelmann-Schwarz V, Ford C
    Oncotarget, 0;6(37):40310-26.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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Reviews for Recombinant Human/Mouse Wnt-5a Protein

Average Rating: 5 (Based on 8 Reviews)

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Recombinant Human/Mouse Wnt-5a Protein
By Anonymous on 06/18/2022
Application: CellProlif
Reason for Rating: wnt5a was used to test if it an promote stem cell proliferation.

put it in -80 freezer


Recombinant Human/Mouse Wnt-5a Protein
By Anonymous on 03/01/2022
Application: In vitro bioactivity in cell culture

Kept in -80 freezer


Recombinant Human/Mouse Wnt-5a Protein
By Anonymous on 11/29/2021
Application: Enzymatic activity in vitro

avoid freezing and refreezing, and kept in -80


Recombinant Human/Mouse Wnt-5a Protein
By Anonymous on 08/06/2021
Application: Luciferase activity.
Reason for Rating: very good product

Try to avoid thaw and freeze many times.


Recombinant Human/Mouse Wnt-5a Protein
By Anonymous on 08/06/2021
Application: Enzymatic activity in vitro
Reason for Rating: it worked very good.

preserve it under -20 after reconstitution


Recombinant Human/Mouse Wnt-5a Protein
By Gerre Lafond on 02/19/2021
Application: Binding assay/Protein-protein interaction

Recombinant Human/Mouse Wnt-5a Protein
By Anonymous on 10/07/2020
Application: Binding assay/Protein-protein interaction

Recombinant Human/Mouse Wnt-5a Protein
By Jignesh Patel on 03/22/2018
Application: In vitro bioactivity in cell culture
Reason for Rating: Works great with invitro studies