Recombinant Human TGF-beta 3 Protein, CF

Newer Version Available: 8420-B3/CF
A New and Improved rh TGF-beta 3 is Now Available! It is CHO-expressed and competitively priced
Formulations:
Catalog # Availability Size / Price Qty
243-B3-002/CF
243-B3-010/CF
243-B3-200/CF
Recombinant Human TGF-beta 3 Protein, CF Bioactivity
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Product Details
Citations (81)
FAQs
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Recombinant Human TGF-beta 3 Protein, CF Summary

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED50 for this effect is 0.01-0.04 ng/mL.
The specific activity of recombinant human TGF-beta 3 is approximately 2.2 x 104 IU/μg, which is calibrated against recombinant human TGF-beta 3 WHO International Standard (NIBSC code: 09/234).
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human TGF-beta 3 protein
Ala301-Ser412 (Tyr340Phe)
Accession #
N-terminal Sequence
Analysis
Ala301
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
12.7 kDa (monomer)
SDS-PAGE
12 kDa, reducing conditions
24 kDa, non-reducing conditions

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

243-B3/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute 2 µg vials at 20 µg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin. Reconstitute 10 µg or larger vials at 50 µg/mL in sterile 4 mM HCl.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

243-B3

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution Reconstitute at 20 μg/mL in sterile 4 mM HCl containing 1 mg/mL human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Images

Bioactivity Bioactivity View Larger

Recombinant Human TGF-beta 3 (Catalog # 243-B3/CF) inhibits Recombinant Mouse IL‑4 (Catalog # 404-ML) induced proliferation in the HT-2 mouse T cell line. The ED50 for this effect is 0.01-0.04 ng/mL.

SDS-PAGE SDS-PAGE View Larger

1 μg/lane of Recombinant Human TGF-beta 3 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing single bands at 12 kDa and 24 kDa, respectively.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: TGF-beta 3

TGF­ beta 3 (transforming growth factor-beta 3) is a member of a TGF­-beta superfamily subgroup that is defined by their structural and functional similarities (1-5). TGF-beta 3 and its closely related proteins, TGF-beta 1 and ­-beta 2, act as cellular switches to regulate immune function, cell proliferation, and epithelial­-mesenchymal transition (4, 6, 7). The non-redundant biological effects of TGF-­ beta 3 include involvement in palatogenesis, chondrogenesis, and pulmonary development (1, 2, 7-9). Human TGF-­ beta 3 cDNA encodes a 412 amino acid (aa) precursor that contains a 20 aa signal peptide and a 392 aa proprotein. The proprotein is processed by a furin­like convertase to generate a 220 aa latency­associated peptide (LAP) and a 112 aa mature TGF­-beta 3 (10, 11). Mature human TGF­-beta 3 shows 100%, 99%, and 98% aa identity with mouse/dog/horse, rat, and pig TGF-­ beta 3, respectively. TGF-beta 3 is secreted as a complex with LAP. This latent form of TGF-beta 3 becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin-1, and a subset of integrins (12). TGF-beta 3 binds with high affinity to TGF-beta RII, a type II serine/threonine kinase receptor. This receptor then phosphorylates and activates type I serine/threonine kinase receptors, TGF-­ beta RI or ALK-­1, to modulate transcription through Smad phosphorylation (13-15). The divergent biological effects exerted by individual TGF-beta isoforms is dependent upon the recruitment of co-receptors (TGF-­ beta RIII and endoglin) and the subsequent initiation of Smad-­dependent or -independent signaling pathways (14, 16, 17).

References
  1. Barrio, M.C. et al. (2014) Cells Tissues Organs. [Epub ahead of print; PMID 24861080].
  2. Doetschman, T. et al. (2012) Genesis 50:59.
  3. Mittl, P.R. et al. (1996) Protein Sci. 5:1261.
  4. Sporn, M.B. (2006) Cytokine Growth Factor Rev. 17:3.
  5. Wahl, S.M. et al. (2006) Immunol. Rev. 213:213.
  6. Chang, H. et al. (2002) Endocr. Rev. 23:787.
  7. Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. 267:6982.
  8. Jin, J.Z. et al. (2014) Dev. Dyn. [Epub ahead of print; PMID 25104574].
  9. Tang, Q.O. et al. (2009) Expert Opin. Biol Ther. 9:689.
  10. Derynck, R. et al. (1988) EMBO J. 7:3737.
  11. Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407.
  12. Oklu, R. and R. Hesketh (2000) Biochem. J. 352 Pt 3:601.
  13. Cui, X.M. and C.F. Shuler (2000) Int. J. Dev. Biol. 44:397.
  14. de Caestecker, M. (2004) Cytokine Growth Factor Rev. 15:1.
  15. Nakajima, A. et al. (2007) Dev. Dyn. 236:791.
  16. Iwata, J. et al. (2012) J. Clin. Invest. 122:873.
  17. Gatza, C.E. et al. (2010) Cell. Signal. 22:1163.
Long Name
Transforming Growth Factor beta 3
Entrez Gene IDs
7043 (Human); 21809 (Mouse); 25717 (Rat)
Alternate Names
ARVD; FLJ16571; TGFB3; TGFbeta 3; TGF-beta 3; TGF-beta3; TGF-beta-3; transforming growth factor beta-3; transforming growth factor, beta 3

Citations for Recombinant Human TGF-beta 3 Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

81 Citations: Showing 1 - 10
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  1. Cerebrospinal fluid from Alzheimer's disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer's disease
    Authors: J Lee, SJ Kwon, JH Kim, H Jang, NK Lee, JW Hwang, JH Kim, JW Chang, DL Na
    Sci Rep, 2019;9(1):564.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. ?2-HS Glycoprotein in Plasma Extracellular Vesicles Inhibits the Osteogenic Differentiation of Human Mesenchymal Stromal Cells In Vitro
    Authors: X Wu, M Ma, P Wang, Z Xie, S Wang, H Su, W Deng, P Feng, C Su, J Yang, J Li, S Tang, Y Wu, H Shen
    Stem Cells Int, 2019;2019(0):7246479.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Extracellular vesicles mediate improved functional outcomes in engineered cartilage produced from MSC/chondrocyte cocultures
    Authors: M Kim, DR Steinberg, JA Burdick, RL Mauck
    Proc. Natl. Acad. Sci. U.S.A., 2019;116(5):1569-1578.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Hypomorphic mutations of TRIP11 cause odontochondrodysplasia
    Authors: A Wehrle, TM Witkos, S Unger, J Schneider, JA Follit, J Hermann, T Welting, V Fano, M Hietala, N Vatanavich, K Schoner, J Spranger, M Schmidts, B Zabel, GJ Pazour, A Bloch-Zupa, G Nishimura, A Superti-Fu, M Lowe, E Lausch
    JCI Insight, 2019;4(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. A Novel Biodegradable and Thermosensitive Poly(Ester-Amide) Hydrogel for Cartilage Tissue Engineering
    Authors: TS Fu, YH Wei, PY Cheng, IM Chu, WC Chen
    Biomed Res Int, 2018;2018(0):2710892.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay
  6. A Reciprocal Role of the Smad4-Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells
    Authors: JS Park, M Kim, NJ Song, JH Kim, D Seo, JH Lee, SM Jung, JY Lee, J Lee, YS Lee, KW Park, SH Park
    Stem Cells, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. TGF?1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism
    Authors: KA de Lima, PB Donate, J Talbot, M Davoli-Fer, RS Peres, TM Cunha, JC Alves-Filh, FQ Cunha
    Cell Death Dis, 2018;9(11):1130.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Improvement of the Chondrocyte-Specific Phenotype upon Equine Bone Marrow Mesenchymal Stem Cell Differentiation: Influence of Culture Time, Transforming Growth Factors and Type I Collagen siRNAs on the Differentiation Index
    Authors: T Branly, R Contentin, M Desancé, T Jacquel, L Bertoni, S Jacquet, F Mallein-Ge, JM Denoix, F Audigié, M Demoor, P Galéra
    Int J Mol Sci, 2018;19(2):.
    Species: Equine
    Sample Types: Whole Cells
    Applications: Bioassay
  9. The functional role of chondrogenic stem/progenitor cells: novel evidence for immunomodulatory properties and regenerative potential after cartilage injury
    Authors: J Riegger, HG Palm, RE Brenner
    Eur Cell Mater, 2018;36(0):110-127.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons
    Authors: G Collo, L Cavalleri, M Zoli, U Maskos, E Ratti, E Merlo Pich
    Front Pharmacol, 2018;9(0):572.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. hPSC-derived Midbrain Dopaminergic Neurons Generated in a Scalable 3-D Biomaterial
    Authors: MM Adil, DV Schaffer
    Curr Protoc Stem Cell Biol, 2018;44(0):2D.21.1-2D.21.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing
    Authors: SS Adkar, CL Wu, VP Willard, A Dicks, A Ettyreddy, N Steward, N Bhutani, CA Gersbach, F Guilak
    Stem Cells, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGF?-dependent manner and limits osteoarthritis in mice
    Authors: H Lin, E Hay, A Latourte, T Funck-Bren, W Bouaziz, HK Ea, AM Khatib, P Richette, M Cohen-Sola
    Sci Rep, 2018;8(1):10488.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy
    Authors: M Desancé, R Contentin, L Bertoni, T Gomez-Ledu, T Branly, S Jacquet, JM Betsch, A Batho, F Legendre, F Audigié, P Galéra, M Demoor
    Int J Mol Sci, 2018;19(2):.
    Species: Equine
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF?1 antibody
    Authors: DM Lord, JJ Bird, DM Honey, A Best, A Park, RR Wei, H Qiu
    MAbs, 2018;0(0):0.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance (SPR
  16. Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-?-dependent and -independent mechanisms
    Authors: J Nishida, K Miyazono, S Ehata
    Oncogene, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. miR-29b regulates expression of collagens I and III in chondrogenically differentiating BMSC in an osteoarthritic environment
    Authors: U Mayer, A Benditz, S Grässel
    Sci Rep, 2017;7(1):13297.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Evaluation of Three Devices for the Isolation of the Stromal Vascular Fraction from Adipose Tissue and for ASC Culture: A Comparative Study
    Authors: J Rodriguez, AS Pratta, N Abbassi, H Fabre, F Rodriguez, C Debard, J Adobati, F Boucher, F Mallein-Ge, C Auxenfans, O Damour, A Mojallal
    Stem Cells Int, 2017;2017(0):9289213.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. TNF? promotes proliferation of human synovial MSCs while maintaining chondrogenic potential
    Authors: M Shioda, T Muneta, K Tsuji, M Mizuno, K Komori, H Koga, I Sekiya
    PLoS ONE, 2017;12(5):e0177771.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Dynamics of chromatin accessibility during TGF-?-induced EMT of Ras-transformed mammary gland epithelial cells
    Authors: M Arase, Y Tamura, N Kawasaki, K Isogaya, R Nakaki, A Mizutani, S Tsutsumi, H Aburatani, K Miyazono, D Koinuma
    Sci Rep, 2017;7(1):1166.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
    Authors: K Hino, K Horigome, M Nishio, S Komura, S Nagata, C Zhao, Y Jin, K Kawakami, Y Yamada, A Ohta, J Toguchida, M Ikeya
    J. Clin. Invest., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Granulocyte macrophage-colony stimulating factor (GM-CSF) significantly enhances articular cartilage repair potential by microfracture
    Authors: MD Truong, BH Choi, YJ Kim, MS Kim, BH Min
    Osteoarthr. Cartil, 2017;0(0):.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Exosomes from mesenchymal stem cells induce the conversion of hepatocytes into progenitor oval cells
    Authors: HH Wu, OK Lee
    Stem Cell Res Ther, 2017;8(1):117.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Enhancement of mesenchymal stem cell chondrogenesis with short-term low intensity pulsed electromagnetic fields
    Authors: D Parate, A Franco-Obr, J Fröhlich, C Beyer, AA Abbas, T Kamarul, JHP Hui, Z Yang
    Sci Rep, 2017;7(1):9421.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Characterization of single cell derived cultures of periosteal progenitor cells to ensure the cell quality for clinical application
    Authors: S Stich, A Loch, SJ Park, T Häupl, J Ringe, M Sittinger
    PLoS ONE, 2017;12(5):e0178560.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs
    Authors: JM Brunger, A Zutshi, VP Willard, CA Gersbach, F Guilak
    Stem Cell Reports, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Effect of microgravity on the mesenchymal stem cell characteristics of limbal fibroblasts
    Authors: SI Pao, KH Chien, HT Lin, MC Tai, JT Chen, CM Liang
    J Chin Med Assoc, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Neurotoxic reactive astrocytes are induced by activated microglia
    Authors: SA Liddelow, KA Guttenplan, LE Clarke, FC Bennett, CJ Bohlen, L Schirmer, ML Bennett, AE Mnch, WS Chung, TC Peterson, DK Wilton, A Frouin, BA Napier, N Panicker, M Kumar, MS Buckwalter, DH Rowitch, VL Dawson, TM Dawson, B Stevens, BA Barres
    Nature, 2017;541(7638):481-487.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Culture-expanded allogenic adipose tissue-derived stem cells attenuate cartilage degeneration in an experimental rat osteoarthritis model
    Authors: L Mei, B Shen, P Ling, S Liu, J Xue, F Liu, H Shao, J Chen, A Ma, X Liu
    PLoS ONE, 2017;12(4):e0176107.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Bromodomain and Extra-terminal Proteins (BET) Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth
    Authors: Weiguo Zou
    J. Biol. Chem., 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Mesenchymal stem cells from cortical bone demonstrate increased clonal incidence, potency, and developmental capacity compared to their bone marrow-derived counterparts
    J Tissue Eng, 2016;7(0):2041731416661.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Means of enhancing bone fracture healing: optimal cell source, isolation methods and acoustic stimulation
    BMC Biotechnol, 2016;16(1):89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Characterization and Immunomodulatory Effects of Canine Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stromal Cells
    PLoS ONE, 2016;11(12):e0167442.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Clinical-scale expansion of Adipose derived Stromal Cells starting from Stromal Vascular Fraction in a single-use bioreactor: Proof of concept for autologous applications
    Authors: Mélanie Gadelorge
    J Tissue Eng Regen Med, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Aberrant Transforming Growth Factor-? Activation Recruits Mesenchymal Stem Cells During Prostatic Hyperplasia
    Stem Cells Transl Med, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. EZH2 deletion in early mesenchyme compromises postnatal bone microarchitecture and structural integrity, and accelerates remodeling
    Authors: Sarah Hemming
    FASEB J, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Generation, Characterization, and Multilineage Potency of Mesenchymal-Like Progenitors Derived from Equine Induced Pluripotent Stem Cells.
    Authors: Lepage S, Nagy K, Sung H, Kandel R, Nagy A, Koch T
    Stem Cells Dev, 2016;25(1):80-9.
    Species: Equine
    Sample Types: Whole Cells
    Applications: Bioassay
  39. IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice
    J Immunol, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Canine Platelet Lysate Is Inferior to Fetal Bovine Serum for the Isolation and Propagation of Canine Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stromal Cells.
    Authors: Russell K, Gibson T, Chong A, Co C, Koch T
    PLoS ONE, 2015;10(9):e0136621.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs.
    Authors: Liu G, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang W, Ruiz S, Plongthongkum N, Zhang K, Masuda S, Nivet E, Tsunekawa Y, Soligalla R, Goebl A, Aizawa E, Kim N, Kim J, Dubova I, Li Y, Ren R, Benner C, del Sol A, Bueren J, Trujillo J, Surralles J, Cappelli E, Dufour C, Esteban C, Izpisua Belmonte J
    Nat Commun, 2014;5(0):4330.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. A role for topographic cues in the organization of collagenous matrix by corneal fibroblasts and stem cells.
    Authors: Karamichos D, Funderburgh M, Hutcheon A, Zieske J, Du Y, Wu J, Funderburgh J
    PLoS ONE, 2014;9(1):e86260.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells.
    Authors: Zhang H, Yin Y, Wang G, Liu Z, Liu L, Sun F
    Sci Rep, 2014;4(0):4260.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Sox9-regulated miRNA-574-3p inhibits chondrogenic differentiation of mesenchymal stem cells.
    Authors: Guerit D, Philipot D, Chuchana P, Toupet K, Brondello J, Mathieu M, Jorgensen C, Noel D
    PLoS ONE, 2014;8(4):e62582.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage.
    Authors: Brunger J, Huynh N, Guenther C, Perez-Pinera P, Moutos F, Sanchez-Adams J, Gersbach C, Guilak F
    Proc Natl Acad Sci U S A, 2014;111(9):E798-806.
    Species: N/A
    Sample Types: Complex Sample Type
    Applications: Bioassay
  46. Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA.
    Authors: Belzile, Jean-Phi, Stark, Thomas J, Yeo, Gene W, Spector, Deborah
    J Virol, 2014;88(8):4021-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis.
    Authors: Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, Hollander A
    Stem Cells Dev, 2014;23(5):541-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Semaphorin 3A induces mesenchymal-stem-like properties in human periodontal ligament cells.
    Authors: Wada, Naohisa, Maeda, Hidefumi, Hasegawa, Daigaku, Gronthos, Stan, Bartold, Peter Ma, Menicanin, Danijela, Fujii, Shinsuke, Yoshida, Shinichi, Tomokiyo, Atsushi, Monnouchi, Satoshi, Akamine, Akifumi
    Stem Cells Dev, 2014;23(18):2225-36.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Human bone marrow-derived mesenchymal stem cells display enhanced clonogenicity but impaired differentiation with hypoxic preconditioning.
    Authors: Boyette, Lisa B, Creasey, Olivia A, Guzik, Lynda, Lozito, Thomas, Tuan, Rocky S
    Stem Cells Transl Med, 2014;3(2):241-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. In vitro model suggests oxidative stress involved in keratoconus disease.
    Authors: Karamichos D, Hutcheon A, Rich C, Trinkaus-Randall V, Asara J, Zieske J
    Sci Rep, 2014;4(0):4608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Induction of immunomodulatory monocytes by human mesenchymal stem cell-derived hepatocyte growth factor through ERK1/2.
    Authors: Chen P, Liu K, Hsu P, Wei C, Bai C, Ho L, Sytwu H, Yen B
    J Leukoc Biol, 2014;96(2):295-303.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Protein-releasing polymeric scaffolds induce fibrochondrocytic differentiation of endogenous cells for knee meniscus regeneration in sheep.
    Authors: Lee C, Rodeo S, Fortier L, Lu C, Erisken C, Mao J
    Sci Transl Med, 2014;6(266):266ra171.
    Species: Ovine
    Sample Types: Whole Cells
    Applications: Bioassay
  53. microRNA-495 inhibits chondrogenic differentiation in human mesenchymal stem cells by targeting Sox9.
    Authors: Lee S, Yoon D, Paik S, Lee K, Jang Y, Lee J
    Stem Cells Dev, 2014;23(15):1798-808.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling.
    Authors: Jakobsen R, Ostrup E, Zhang X, Mikkelsen T, Brinchmann J
    PLoS ONE, 2014;9(5):e96615.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. CD146 expression on mesenchymal stem cells is associated with their vascular smooth muscle commitment.
    Authors: Espagnolle N, Guilloton F, Deschaseaux F, Gadelorge M, Sensebe L, Bourin P
    J Cell Mol Med, 2014;18(1):104-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Molecular characterization of prospectively isolated multipotent mesenchymal progenitors provides new insight into the cellular identity of mesenchymal stem cells in mouse bone marrow.
    Authors: Qian H, Badaloni A, Chiara F, Stjernberg J, Polisetti N, Nihlberg K, Consalez G, Sigvardsson M
    Mol Cell Biol, 2013;33(4):661-77.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. MicroRNA-based promotion of human neuronal differentiation and subtype specification.
    Authors: Stappert L, Borghese L, Roese-Koerner B, Weinhold S, Koch P, Terstegge S, Uhrberg M, Wernet P, Brustle O
    PLoS ONE, 2013;8(3):e59011.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Human embryonic stem cell-derived mesenchymal stroma cells (hES-MSCs) engraft in vivo and support hematopoiesis without suppressing immune function: implications for off-the shelf ES-MSC therapies.
    Authors: Li O, Tormin A, Sundberg B, Hyllner J, Le Blanc K, Scheding S
    PLoS ONE, 2013;8(1):e55319.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  59. Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression.
    Authors: Lund, Troy C, Kobs, Amanda J, Kramer, Ashley, Nyquist, Mick, Kuroki, Marcos T, Osborn, John, Lidke, Diane S, Low-Nam, Shalini, Blazar, Bruce R, Tolar, Jakub
    PLoS ONE, 2013;8(3):e58945.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. TGF-beta-induced apoptosis of B-cell lymphoma Ramos cells through reduction of MS4A1/CD20.
    Authors: Kawabata K, Ehata S, Komuro A, Takeuchi K, Miyazono K
    Oncogene, 2013;32(16):2096-106.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Transforming growth factor Beta 3 is required for excisional wound repair in vivo.
    Authors: Le M, Naridze R, Morrison J, Biggs L, Rhea L, Schutte B, Kaartinen V, Dunnwald M
    PLoS ONE, 2012;7(10):e48040.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  62. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Primary Mesenchymal Stem and Progenitor Cells from Bone Marrow Lack Expression of CD44 Protein.
    Authors: Qian H, Le Blanc K, Sigvardsson M
    J. Biol. Chem., 2012;287(31):25795-807.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
    Authors: Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV
    J. Biol. Chem., 2011;286(34):30034-46.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance
  65. Age-related changes in rat bone-marrow mesenchymal stem cell plasticity.
    Authors: Asumda FZ, Chase PB
    BMC Cell Biol., 2011;12(0):44.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  66. An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.
    Authors: Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, Lindeman GJ, Shannon MF, Drew PA, Khew-Goodall Y, Goodall GJ
    Mol. Biol. Cell, 2011;22(10):1686-98.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos.
    Authors: Kawaguchi J, Nichols J, Gierl MS, Faial T, Smith A
    Development, 2010;137(5):693-704.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis.
    Authors: Moransard M, Sawitzky M, Fontana A, Suter T
    Glia, 2010;58(5):559-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells.
    Authors: English K, Ryan JM, Tobin L, Murphy MJ, Barry FP, Mahon BP
    Clin. Exp. Immunol., 2009;156(1):149-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation
  70. Autologous stem cell regeneration in craniosynostosis.
    Authors: Moioli EK, Clark PA, Sumner DR, Mao JJ
    Bone, 2007;42(2):332-40.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  71. Transforming growth factor-beta in the brain enhances fat oxidation via noradrenergic neurons in the ventromedial and paraventricular hypothalamic nucleus.
    Authors: Fujikawa T, Matsumura S, Yamada H, Inoue K, Fushiki T
    Brain Res., 2007;1173(0):92-101.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  72. Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.
    Authors: Neurohr C, Nishimura SL, Sheppard D
    Am. J. Respir. Cell Mol. Biol., 2006;35(2):252-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
    Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
    J. Cell. Physiol., 2005;203(1):35-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads.
    Authors: Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI
    Am. J. Respir. Cell Mol. Biol., 2004;30(6):816-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Derivation of midbrain dopamine neurons from human embryonic stem cells.
    Authors: Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, Topf N, Harrison NL, Studer L
    Proc. Natl. Acad. Sci. U.S.A., 2004;101(34):12543-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein.
    Authors: Mogi K, Goto M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi R
    Int. J. Dev. Biol., 2003;47(1):15-29.
    Species: Xenopus
    Sample Types: In Vivo
    Applications: In Vivo
  77. Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.
    Authors: Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI
    Am. J. Physiol. Lung Cell Mol. Physiol., 2002;282(5):L1049-56.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  78. Induction of a hypertrophic growth status of coronary smooth muscle cells is associated with an overexpression of TGF-beta.
    Authors: Schmidt A, 2019, Gopfert C, Vlodavsky I, Volker W, Buddecke E
    101211, 2002;81(3):138-44.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Transforming growth factor beta expression in human placenta and placental bed during early pregnancy.
    Authors: Simpson H, 2019, Robson SC, Bulmer JN, Barber A, Lyall F
    6897, 2002;23(1):44-58.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  80. Isoform specificity of commercially-available anti-TGF-beta antibodies.
    Authors: Mozes MM, Hodics T, Kopp JB
    J. Immunol. Methods, 1999;225(1):87-93.
    Species: N/A
    Sample Types: N/A
    Applications: Western Blot
  81. TGF-beta Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner.
    Authors: Elias S, Schmidt A, Kannan V, Andersson J, Tegner J
    Front Immunol, 0;7(0):603.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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