Recombinant Mouse BMP-4 Protein, CF

Formulations:
Catalog # Availability Size / Price Qty
5020-BP-010/CF
Product Details
Citations (74)
FAQs
Reviews

Recombinant Mouse BMP-4 Protein, CF Summary

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250:351. The ED50 for this effect is 2-12 ng/mL.
Source
Chinese Hamster Ovary cell line, CHO-derived mouse BMP-4 protein
Ser293-Arg408
Accession #
N-terminal Sequence
Analysis
Ser293
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
13.1 kDa (monomer)
SDS-PAGE
18-26 kDa, reducing conditions

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

5020-BP/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute at 100 μg/mL in 4 mM HCl.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

5020-BP

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: BMP-4

BMP-4 is a TGF-beta superfamily ligand that is widely expressed from early embryogenesis through adulthood. It plays an important role in mesenchyme formation, epidermal determination, suppression of neural induction, the development of multiple organs, and tissue repair (1-5). The mouse BMP-4 precursor contains a 273 amino acid (aa) propeptide and a 116 aa mature protein (6). The propeptide is cleaved intracellularly by furin or proprotein convertase 6, enabling the 15 kDa mature BMP-4 monomer to form an active disulfide linked homodimer or heterodimer with BMP-7 (7-9). Mature mouse and human BMP-4 share 98% aa sequence identity. Mouse BMP-4 shares 85% aa sequence identity with mouse BMP-2 and 35%-54% with other mouse BMPs. Compared to BMP-4 homodimers, BMP-4/BMP-7 heterodimers exhibit a greater potency in inducing osteogenic differentiation (9). In Xenopus, the heterodimers can also induce the formation of mesoderm, whereas BMP-4 homodimers only provide ventralizing signals for existing mesoderm (10). BMP-4 signals through tetrameric complexes composed of type I (primarily Activin RIA or BMPR-IA) and type II (primarily Activin RIIA or BMPR-II) receptors (11, 12). The bioavailability of BMP-4 is regulated by its interaction with multiple proteins and glycosaminoglycans (13-15).

References
  1. Zhang, P. et al. (2008) Blood 111:1933.
  2. Gambaro, K. et al. (2006) Cell Death Differ. 13:1075.
  3. Simic, P. and S. Vukicevic (2005) Cytokine Growth Factor Rev. 16:299.
  4. Sadlon, T.J. et al. (2004) Stem Cells 22:457.
  5. Frank, D.B. et al. (2005) Circ. Res. 97:496.
  6. Oida, S. et al. (1995) DNA Seq. 5:273.
  7. Cui, Y. et al. (1998) EMBO J. 17:4735.
  8. Cui, Y. et al. (2001) Genes Dev. 15:2797.
  9. Aono, A. et al. (1995) Biochem. Biophys. Res. Commun. 210:670.
  10. Nishimatsu, S. and G.H. Thomsen (1998) Mech. Dev. 74:75.
  11. Chen, D. et al. (2004) Growth Factors 22:233.
  12. Lavery, K. et al. (2008) J. Biol. Chem. April 24 epub.
  13. Rosen, V. (2006) Ann. N.Y. Acad. Sci. 1068:19.
  14. Jones, C.M. and J.C. Smith (1998) Dev. Biol. 194:12.
  15. Takada, T. et al. (2003) J. Biol. Chem. 278:43229.
Long Name
Bone Morphogenetic Protein 4
Entrez Gene IDs
652 (Human); 12159 (Mouse); 25296 (Rat); 30612 (Zebrafish)
Alternate Names
BMP2B; BMP-2B; BMP2B1; BMP2BMCOPS6; BMP4; BMP-4; Bone morphogenetic protein 2B; bone morphogenetic protein 4; DVR4; MCOPS6; OFC11; ZYME

Citations for Recombinant Mouse BMP-4 Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

74 Citations: Showing 1 - 10
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  1. MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis
    Authors: M Pons-Espin, C Gasperini, MJ Marzi, C Braccia, A Armirotti, A Pötzsch, TL Walker, K Fabel, F Nicassio, G Kempermann, D De Pietri
    Stem Cell Reports, 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Cluh plays a pivotal role during adipogenesis by regulating the activity of mitochondria
    Authors: E Cho, W Jung, HY Joo, ER Park, MY Kim, SB Kim, KS Kim, YB Lim, KH Lee, HJ Shin
    Sci Rep, 2019;9(1):6820.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation
    Authors: W Zhang, C Chronis, X Chen, H Zhang, R Spalinskas, M Pardo, L Chen, G Wu, Z Zhu, Y Yu, L Yu, J Choudhary, J Nichols, MM Parast, B Greber, P Sahlén, K Plath
    Cell Stem Cell, 2019;24(1):138-152.e8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Mesenchymal Wnt/?-catenin signaling limits tooth number
    Authors: E Järvinen, J Shimomura-, A Balic, M Jussila, I Thesleff
    Development, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  5. BMP4 signaling in NPCs upregulates Bcl-xL to promote their survival in the presence of FGF-2
    Authors: H Yamamoto, M Kurachi, M Naruse, K Shibasaki, Y Ishizaki
    Biochem. Biophys. Res. Commun., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Precardiac organoids form two heart fields via Bmp/Wnt signaling
    Authors: P Andersen, E Tampakakis, DV Jimenez, S Kannan, M Miyamoto, HK Shin, A Saberi, S Murphy, E Sulistio, SP Chelko, C Kwon
    Nat Commun, 2018;9(1):3140.
    Species: Mouse
    Sample Types:
  7. Groucho related gene 5 (GRG5) is involved in embryonic and neural stem cell state decisions
    Authors: K Chanoumido, C Hadjimicha, P Athanasoul, H Ahlenius, A Klonizakis, C Nikolaou, E Drakos, A Kostouros, I Stratidaki, M Grigoriou, A Kretsovali
    Sci Rep, 2018;8(1):13790.
    Species: Mouse
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  8. Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells
    Authors: RL Wu, G Sedlmeier, L Kyjacova, A Schmaus, J Philipp, W Thiele, BK Garvalov, JP Sleeman
    Sci Rep, 2018;8(1):14913.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Biophysical subsets of embryonic stem cells display distinct phenotypic and morphological signatures
    Authors: T Bongiorno, J Gura, P Talwar, D Chambers, KM Young, D Arafat, G Wang, EL Jackson-Ho, P Qiu, TC McDevitt, T Sulchek
    PLoS ONE, 2018;13(3):e0192631.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Asymmetry between sister cells of pluripotent stem cells at the onset of differentiation
    Authors: S Nakamura, A Maruyama, Y Kondo, A Kano, OM De Sousa, M Iwahashi, B Hexig, T Akaike, J Li, Y Hayashi, K Ohnuma
    Stem Cells Dev., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. In vitro platform of allogeneic stem cell-derived cardiomyocyte transplantation for cardiac conduction defects
    Authors: A Yoshida, JK Lee, S Tomoyama, K Miwa, K Shirakawa, S Hamanaka, T Yamaguchi, H Nakauchi, S Miyagawa, Y Sawa, I Komuro, Y Sakata
    Europace, 2018;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis
    Authors: MA Deutsch, SA Doppler, X Li, H Lahm, G Santamaria, G Cuda, S Eichhorn, T Ratschille, E Dzilic, M Dre beta en, A Eckart, K Stark, S Massberg, A Bartels, C Rischpler, R Gilsbach, L Hein, BK Fleischman, SM Wu, R Lange, M Krane
    Cardiovasc. Res., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Derivation of hypermethylated pluripotent embryonic stem cells with high potency
    Authors: S Bao, WW Tang, B Wu, S Kim, J Li, L Li, T Kobayashi, C Lee, Y Chen, M Wei, S Li, S Dietmann, F Tang, X Li, MA Surani
    Cell Res., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. ATOH1 promotes leptomeningeal dissemination and metastasis of Sonic Hedgehog subgroup medulloblastomas
    Authors: KB Grausam, SD Dooyema, L Bihannic, H Premathila, AS Morrissy, A Forget, AM Schaefer, JH Gundelach, S Macura, DM Maher, X Wang, AH Heglin, X Ge, E Zeng, S Puget, I Chandrasek, K Surendran, RJ Bram, U Schüller, MD Taylor, O Ayrault, H Zhao
    Cancer Res., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs
    Authors: JM Brunger, A Zutshi, VP Willard, CA Gersbach, F Guilak
    Stem Cell Reports, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Transplantation of multipotent Isl1+ cardiac progenitor cells preserves infarcted heart function in mice
    Authors: Y Li, S Tian, I Lei, L Liu, P Ma, Z Wang
    Am J Transl Res, 2017;9(3):1530-1542.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells
    Authors: Y Han, J Ren, E Lee, X Xu, W Yu, K Muegge
    Sci Rep, 2017;7(1):1136.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Native thymic extracellular matrix improves in�vivo thymic organoid T cell output, and drives in�vitro thymic epithelial cell differentiation
    Authors: Michael Hun
    Biomaterials, 2017;118(0):1-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors
    Authors: C Yoon, H Song, T Yin, D Bausch-Flu, AP Frei, S Kattman, N Dubois, AD Witty, JA Hewel, H Guo, A Emili, B Wollscheid, G Keller, PW Zandstra
    Stem Cell Reports, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. The BMP4-Smad Signaling Pathway Regulates Hyperandrogenism Development in a Female Mouse Model
    Authors: Y Liu, SY Du, M Ding, X Dou, FF Zhang, ZY Wu, SW Qian, W Zhang, QQ Tang, CJ Xu
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Phenolics and neolignans isolated from the fruits of Juglans mandshurica Maxim. and their effects on lipolysis in adipocytes
    Authors: S Park, N Kim, G Yoo, SN Kim, HJ Kwon, K Jung, DC Oh, YH Lee, SH Kim
    Phytochemistry, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue
    Authors: SN Kim, HJ Kwon, SW Im, YH Son, S Akindehin, YS Jung, SJ Lee, IJ Rhyu, IY Kim, JK Seong, J Lee, HC Yoo, JG Granneman, YH Lee
    Sci Rep, 2017;7(1):7159.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate
    Authors: H Ohta, K Kurimoto, I Okamoto, T Nakamura, Y Yabuta, H Miyauchi, T Yamamoto, Y Okuno, M Hagiwara, K Shirane, H Sasaki, M Saitou
    EMBO J., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
    Authors: N Cerdá-Este, H Naumann, S Ruzittu, N Mah, IM Pongrac, C Cozzitorto, A Hommel, MA Andrade-Na, E Bonifacio, FM Spagnoli
    Nat Commun, 2017;8(0):14127.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Conserved miR-10 family represses proliferation and induces apoptosis in ovarian granulosa cells
    Authors: T Jiajie, Y Yanzhou, AC Hoi-Hung, C Zi-Jiang, C Wai-Yee
    Sci Rep, 2017;7(0):41304.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Collagen-alginate microspheres as a 3D culture system for mouse embryonic stem cells differentiation to primordial germ cells
    Authors: V Mansouri, M Salehi, MD Omrani, Z Niknam, A Ardeshiryl
    Biologicals, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Generation of iPSC-derived limb progenitor-like cells for stimulating phalange regeneration in the adult mouse
    Authors: Y Chen, H Xu, G Lin
    Cell Discov, 2017;3(0):17046.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Hierarchical patterning modes orchestrate hair follicle morphogenesis
    Authors: JD Glover, KL Wells, F Matthäus, KJ Painter, W Ho, J Riddell, JA Johansson, MJ Ford, CAB Jahoda, V Klika, RL Mort, DJ Headon
    PLoS Biol., 2017;15(7):e2002117.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  29. BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice
    Authors: J Feng, J Jing, J Li, H Zhao, V Punj, T Zhang, J Xu, Y Chai
    Development, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. The Kielin/chordin-like Protein (KCP) Attenuates High Fat Diet Induced Obesity and Metabolic Syndrome in Mice
    Authors: A Soofi, KI Wolf, MP Emont, N Qi, G Martinez-S, E Grimley, W Ostwani, GR Dressler
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Transformation of jaw muscle satellite cells to cardiomyocytes
    Authors: Randall S Daughters
    Differentiation, 2016;93(0):58-65.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis
    Authors: J Lee, S Kang, KC Lilja, KJ Colletier, CJ Scheitz, YV Zhang, T Tumbar
    Nat Commun, 2016;7(0):11278.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Multifactorial Optimizations for Directing Endothelial Fate from Stem Cells
    PLoS ONE, 2016;11(12):e0166663.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Development-on-chip: in vitro neural tube patterning with a microfluidic device
    Authors: Christopher J Demers
    Development, 2016;143(11):1884-92.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. In�Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells
    Cell Rep, 2016;17(10):2789-2804.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Functional cardiomyocytes derived from Isl1 cardiac progenitors via Bmp4 stimulation.
    Authors: Cagavi E, Bartulos O, Suh C, Sun B, Yue Z, Jiang Z, Yue L, Qyang Y
    PLoS ONE, 2015;9(12):e110752.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesis.
    Authors: Sun C, Yu D, Ye W, Liu C, Gu S, Sinsheimer N, Song Z, Li X, Chen C, Song Y, Wang S, Schrader L, Chen Y
    J Biol Chem, 2015;290(4):2007-23.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes.
    Authors: Galvagni F, Lentucci C, Neri F, Dettori D, De Clemente C, Orlandini M, Anselmi F, Rapelli S, Grillo M, Borghi S, Oliviero S
    Stem Cells, 2015;33(3):742-50.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Generation of organized germ layers from a single mouse embryonic stem cell.
    Authors: Poh Y, Chen J, Hong Y, Yi H, Zhang S, Chen J, Wu D, Wang L, Jia Q, Singh R, Yao W, Tan Y, Tajik A, Tanaka T, Wang N
    Nat Commun, 2014;5(0):4000.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis.
    Authors: Li H, Yue R, Wei B, Gao G, Du J, Pei G
    EMBO J, 2014;33(12):1383-96.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. A novel, visible light-induced, rapidly cross-linkable gelatin scaffold for osteochondral tissue engineering.
    Authors: Mazaki T, Shiozaki Y, Yamane K, Yoshida A, Nakamura M, Yoshida Y, Zhou D, Kitajima T, Tanaka M, Ito Y, Ozaki T, Matsukawa A
    Sci Rep, 2014;4(0):4457.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay
  42. The formation of proximal and distal definitive endoderm populations in culture requires p38 MAPK activity.
    Authors: Yap C, Goh H, Familari M, Rathjen P, Rathjen J
    J Cell Sci, 2014;127(0):2204-16.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Endoderm generates endothelial cells during liver development
    Stem Cell Reports, 2014;3(4):556-65.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways.
    Authors: Zhu Q, Song L, Peng G, Sun N, Chen J, Zhang T, Sheng N, Tang W, Qian C, Qiao Y, Tang K, Han J, Li J, Jing N
    Elife, 2014;3(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Signaling mechanisms that suppress the cytostatic actions of rapamycin.
    Authors: Jahn S, Law M, Corsino P, Davis B, Harrison J, Law B
    PLoS ONE, 2014;9(6):e99927.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Local BMP-SMAD1 signaling increases LIF receptor-dependent STAT3 responsiveness and primed-to-naive mouse pluripotent stem cell conversion frequency.
    Authors: Onishi K, Tonge P, Nagy A, Zandstra P
    Stem Cell Reports, 2014;3(1):156-68.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway.
    Authors: Tanwar V, Bylund J, Hu J, Yan J, Walthall J, Mukherjee A, Heaton W, Wang W, Potet F, Rai M, Kupershmidt S, Knapik E, Hatzopoulos A
    Stem Cells, 2014;32(7):1774-88.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance.
    Authors: Xiao, Yanping, Yu, Sanhong, Zhu, Baogong, Bedoret, Denis, Bu, Xia, Francisco, Loise M, Hua, Ping, Duke-Cohan, Jonathan, Umetsu, Dale T, Sharpe, Arlene H, DeKruyff, Rosemari, Freeman, Gordon J
    J Exp Med, 2014;211(5):943-59.
    Species: Mouse
    Sample Types: Antibody
    Applications: ELISA (Capture)
  49. BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells.
    Authors: Yang J, Wang J, Pan L, Li H, Rao C, Zhang X, Niu G, Qu J, Hou L
    Exp Cell Res, 2014;320(1):54-61.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Determining cell division symmetry through the dissection of dividing cells using single-cell expression analysis.
    Authors: Jasnos, Lukasz, Sawado, Tomoyuki
    Nat Protoc, 2014;9(3):505-16.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Manipulating gene expression and signaling activity in cultured mouse limb bud cells.
    Authors: Lewandowski J, Pursell T, Rabinowitz A, Vokes S
    Dev Dyn, 2014;243(7):928-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2.
    Authors: Fujimoto M, Ohte S, Shin M, Yoneyama K, Osawa K, Miyamoto A, Tsukamoto S, Mizuta T, Kokabu S, Machiya A, Okuda A, Suda N, Katagiri T
    Biochem Biophys Res Commun, 2014;455(3):347-52.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors.
    Authors: Tsuchida, R, Osawa, T, Wang, F, Nishii, R, Das, B, Tsuchida, S, Muramatsu, M, Takahashi, T, Inoue, T, Wada, Y, Minami, T, Yuasa, Y, Shibuya, M
    Oncogene, 2014;33(29):3803-11.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.
    Authors: Chong J, Yang X, Don C, Minami E, Liu Y, Weyers J, Mahoney W, Van Biber B, Cook S, Palpant N, Gantz J, Fugate J, Muskheli V, Gough G, Vogel K, Astley C, Hotchkiss C, Baldessari A, Pabon L, Reinecke H, Gill E, Nelson V, Kiem H, Laflamme M, Murry C
    Nature, 2014;510(7504):273-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog.
    Authors: Karwacki-Neisius V, Goke J, Osorno R, Halbritter F, Ng J, Weisse A, Wong F, Gagliardi A, Mullin N, Festuccia N, Colby D, Tomlinson S, Ng H, Chambers I
    Cell Stem Cell, 2013;12(5):531-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties.
    Authors: Nishino, Jinsuke, Kim, Sunjung, Zhu, Yuan, Zhu, Hao, Morrison, Sean J
    Elife, 2013;2(0):e00924.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  57. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs.
    Authors: Chen, Jiekai, Liu, He, Liu, Jing, Qi, Jing, Wei, Bei, Yang, Jiaqi, Liang, Hanquan, Chen, You, Chen, Jing, Wu, Yaran, Guo, Lin, Zhu, Jieying, Zhao, Xiangjie, Peng, Tianran, Zhang, Yixin, Chen, Shen, Li, Xuejia, Li, Dongwei, Wang, Tao, Pei, Duanqing
    Nat Genet, 2013;45(1):34-42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.
    Authors: Najm, Fadi J, Lager, Angela M, Zaremba, Anita, Wyatt, Krysta, Caprariello, Andrew V, Factor, Daniel C, Karl, Robert T, Maeda, Tadao, Miller, Robert H, Tesar, Paul J
    Nat Biotechnol, 2013;31(5):426-33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth.
    Authors: Sakaguchi, Masaji, Sharmin, Sazia, Taguchi, Atsuhiro, Ohmori, Tomoko, Fujimura, Sayoko, Abe, Takaya, Kiyonari, Hiroshi, Komatsu, Yoshihir, Mishina, Yuji, Asashima, Makoto, Araki, Eiichi, Nishinakamura, Ryuichi
    Nat Commun, 2013;4(0):1398.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Identifying division symmetry of mouse embryonic stem cells: negative impact of DNA methyltransferases on symmetric self-renewal.
    Authors: Jasnos L, Aksoy F, Hersi H, Wantuch S, Sawado T
    Stem Cell Reports, 2013;1(4):360-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Activation of the PTHRP/adenylate cyclase pathway promotes differentiation of rat XEN cells into parietal endoderm, whereas Wnt/beta-catenin signaling promotes differentiation into visceral endoderm.
    Authors: Chuykin I, Schulz H, Guan K, Bader M
    J Cell Sci, 2013;126(0):128-38.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Defined extracellular matrix components are necessary for definitive endoderm induction.
    Authors: Taylor-Weiner H, Schwarzbauer J, Engler A
    Stem Cells, 2013;31(10):2084-94.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis.
    Authors: Qian S, Tang Y, Li X, Liu Y, Zhang Y, Huang H, Xue R, Yu H, Guo L, Gao H, Liu Y, Sun X, Li Y, Jia W, Tang Q
    Proc Natl Acad Sci U S A, 2013;110(9):E798-807.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Specialized tip/stalk-like and phalanx-like endothelial cells from embryonic stem cells.
    Authors: Blancas A, Wong L, Glaser D, McCloskey K
    Stem Cells Dev, 2013;22(9):1398-407.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Epigenetic regulation of sensory axon regeneration after spinal cord injury.
    Authors: Finelli M, Wong J, Zou H
    J Neurosci, 2013;33(50):19664-76.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo.
    Authors: Ueki Y, Reh TA,
    PLoS ONE, 2012;7(6):e38690.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  67. Opposing Nodal and BMP Signals Regulate Left-Right Asymmetry in the Sea Urchin Larva.
    Authors: Luo, Yi-Jyun, Su, Yi-Hsien
    PLoS Biol, 2012;10(10):e1001402.
    Species: Sea Urchin
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
    Authors: Sneddon, Julie B, Borowiak, Malgorza, Melton, Douglas
    Nature, 2012;491(7426):765-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  69. Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells.
    Authors: Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M
    Stem Cells, 2011;29(6):964-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos.
    Authors: Kawaguchi J, Nichols J, Gierl MS, Faial T, Smith A
    Development, 2010;137(5):693-704.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade.
    Authors: Du Y, Xiao Q, Yip HK
    Invest. Ophthalmol. Vis. Sci., 2010;51(7):3764-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro.
    Authors: Hayashi K, Surani MA
    Development, 2009;136(21):3549-56.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling.
    Authors: Kelley R, Ren R, Pi X, Wu Y, Moreno I, Willis M, Moser M, Ross M, Podkowa M, Attisano L, Patterson C
    J. Cell Biol., 2009;184(4):597-609.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells.
    Authors: Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, Klein T, Maddox-Hyttel P, Serup P
    Dev. Biol., 2009;330(2):286-304.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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