Recombinant Mouse IL-1 beta/IL-1F2 Protein 401-ML-005: R&D Systems

Recombinant Mouse IL-1 beta/IL-1F2 Protein

(107 citations)
(2 Reviews)
  
  • Purity
    >97%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Endotoxin Level
    <0.01 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272. The ED50 for this effect is 2-10 pg/mL.
  • Source
    E. coli-derived Val118-Ser269, with an N-terminal Met
  • Accession #
  • N-terminal Sequence
    Analysis
    Met
  • Predicted Molecular Mass
    17 kDa
Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
401-ML
 
401-ML/CF
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Formulation Supplied as a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after opening.
  • 3 months, -20 to -70 °C under sterile conditions after opening.
Data Images
Recombinant Mouse IL-1 beta /IL-1F2 (Catalog # 401-ML) stimulates cell proliferation of the D10.G4.1 mouse helper T cell line. The ED50 for this effect is 2‑10 pg/mL.
1 μg/lane of Recombinant Mouse IL1 beta /IL-1F2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 19 kDa.
Background: IL-1 beta/IL-1F2

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 17% amino acid (aa) identity in mouse. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI (1-4). The mouse IL-1 beta cDNA encodes a 269 aa precursor. A 117 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta -converting enzyme (Caspase-1/ICE) to generate the active cytokine (5, 6). The 17 kDa mature mouse IL-1 beta shares 90% aa sequence identity with cotton rat and rat and 65%-78% identity with canine, equine, feline, human, porcine, and rhesus IL-1 beta.

  • References:
    1. Allan, S.M. et al. (2005) Nat. Rev. Immunol. 5:629.
    2. Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229.
    3. Kornman, K.S. (2006) Am. J. Clin. Nutr. 83:475S.
    4. Isoda, K. and F. Ohsuzu (2006) J. Atheroscler. Thromb. 13:21.
    5. Gray, P.W. et al. (1986) J. Immunol. 137:3644.
    6. Martinon, F. and J. Tschopp (2007) Cell Death Differ. 14:10.
  • Long Name:
    Interleukin 1 beta
  • Entrez Gene IDs:
    3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)
  • Alternate Names:
    catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1b; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

107 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. TNF-? promotes extracellular vesicle release in mouse astrocytes through glutaminase
    Authors: K Wang, L Ye, H Lu, H Chen, Y Zhang, Y Huang, JC Zheng
    J Neuroinflammation, 2017;14(1):87.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  2. Intestinal fungi contribute to development of alcoholic liver disease
    Authors: AM Yang, T Inamine, K Hochrath, P Chen, L Wang, C Llorente, S Bluemel, P Hartmann, J Xu, Y Koyama, T Kisseleva, MG Torralba, K Moncera, K Beeri, CS Chen, K Freese, C Hellerbran, SM Lee, HM Hoffman, WZ Mehal, G Garcia-Tsa, EA Mutlu, A Keshavarzi, GD Brown, SB Ho, R Bataller, P Stärkel, DE Fouts, B Schnabl
    J. Clin. Invest., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  3. Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs
    Authors: MX Li, HL Zheng, Y Luo, JG He, W Wang, J Han, L Zhang, X Wang, L Ni, HY Zhou, ZL Hu, PF Wu, Y Jin, LH Long, H Zhang, G Hu, JG Chen, F Wang
    Mol. Psychiatry, 2017;0(0):.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  4. G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease
    Authors: MC Lee, JA McCubbin, AD Christense, DP Poole, P Rajasekhar, T Lieu, NW Bunnett, S Garcia-Car, A Erickson, SM Brierley, R Saleh, A Achuthan, AJ Fleetwood, RL Anderson, JA Hamilton, AD Cook
    J. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  5. The symbiotic bacterial surface factor polysaccharide A on Bacteroides fragilis inhibits IL-1?-induced inflammation in human fetal enterocytes via toll receptors 2 and 4
    Authors: F Jiang, D Meng, M Weng, W Zhu, W Wu, D Kasper, WA Walker
    PLoS ONE, 2017;12(3):e0172738.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  6. Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis
    Authors: L Franchi, I Monteleone, LY Hao, MA Spahr, W Zhao, X Liu, K Demock, A Kulkarni, CA Lesch, B Sanchez, L Carter, I Marafini, X Hu, O Mashadova, M Yuan, JM Asara, H Singh, CA Lyssiotis, G Monteleone, AW Opipari, GD Glick
    J. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  7. IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria
    Authors: F Reverchon, S Mortaud, M Sivoyon, I Maillet, A Laugeray, J Palomo, C Montécot, A Herzine, S Meme, W Meme, F Erard, B Ryffel, A Menuet, VFJ Quesniaux
    PLoS Pathog., 2017;13(4):e1006322.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  8. The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle
    Authors: K Kamizaki, R Doi, M Hayashi, T Saji, M Kanagawa, T Toda, SI Fukada, HH Ho, ME Greenberg, M Endo, Y Minami
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  9. Prolactin blocks the expression of receptor activator of nuclear factor ?B ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis
    Authors: MG Ledesma-Co, N Adán, G Ortiz, M Solís-Guti, F López-Barr, G Martínez d, C Clapp
    Arthritis Res. Ther., 2017;19(1):93.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  10. The Role of Inflammation in ?-cell Dedifferentiation
    Authors: TM Nordmann, E Dror, F Schulze, S Traub, E Berishvili, C Barbieux, M Böni-Schne, MY Donath
    Sci Rep, 2017;7(1):6285.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  11. Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells
    Authors: IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  12. Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells
    Authors: C Wang, CX Xu, Y Alippe, C Qu, J Xiao, E Schipani, R Civitelli, Y Abu-Amer, G Mbalaviele
    Sci Rep, 2017;7(1):4880.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  13. Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota
    Authors: Q Zhao, SN Harbour, R Kolde, IJ Latorre, HM Tun, TR Schoeb, H Turner, JJ Moon, E Khafipour, RJ Xavier, CT Weaver, CO Elson
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  14. TNF? drives mitochondrial stress in POMC neurons in obesity
    Authors: CX Yi, M Walter, Y Gao, S Pitra, B Legutko, S Kälin, C Layritz, C García-Các, M Bielohuby, M Bidlingmai, SC Woods, A Ghanem, KK Conzelmann, JE Stern, M Jastroch, MH Tschöp
    Nat Commun, 2017;8(0):15143.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  15. Platelets Guide Leukocytes to Their Sites of Extravasation
    PLoS Biol, 2016;14(5):e1002459.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  16. Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence
    Nature, 2016;535(7612):440-3.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  17. Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells
    J Immunol, 2016;196(11):4731-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  18. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response
    Authors: Shweta Pasi
    J Biol Chem, 2016;291(23):12358-69.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  19. SLAM-associated protein favours the development of iNKT2 over iNKT17 cells
    Authors: Marie-Laure Michel
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  20. A Critical Role for P2X7 Receptor-Induced VCAM-1 Shedding and Neutrophil Infiltration during Acute Lung Injury
    J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  21. HSP60 plays a regulatory role in IL-1beta-induced microglial inflammation via TLR4-p38 MAPK axis.
    Authors: Swaroop S, Sengupta N, Suryawanshi A, Adlakha Y, Basu A
    J Neuroinflammation, 2016;13(1):27.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  22. Epidermal RAF prevents allergic skin disease
    Elife, 2016;5(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  23. NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
    Sci Rep, 2016;6(0):39075.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  24. NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
    Sci Rep, 2016;6(0):39075.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  25. Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses
    Authors: LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares
    J. Biol. Chem., 2016;291(30):15830-40.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  26. Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
    Sci Rep, 2016;6(0):37977.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  27. TLR4-Upregulated IL-1? and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism
    Sci Rep, 2016;6(0):31663.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  28. Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels
    PLoS ONE, 2016;11(9):e0163735.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  29. Direct conversion of fibroblasts into functional astrocytes by defined transcription factors.
    Authors: Caiazzo M, Giannelli S, Valente P, Lignani G, Carissimo A, Sessa A, Colasante G, Bartolomeo R, Massimino L, Ferroni S, Settembre C, Benfenati F, Broccoli V
    Stem Cell Reports, 2015;4(1):25-36.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  30. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
    Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
    Nat Immunol, 2015;16(3):286-95.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  31. Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.
    Authors: Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen M, Stozer A, Wnendt S, Piemonti L, Kohler M, Ferrer J, Thorens B, Schliess F, Rupnik M, Heise T, Berggren P, Klocker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E
    Nat Med, 2015;21(4):363-72.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  32. Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis.
    Authors: Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C
    J Immunol, 2015;194(6):2522-30.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  33. Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile.
    Authors: Cowardin C, Kuehne S, Buonomo E, Marie C, Minton N, Petri W
    MBio, 2015;6(1):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  34. IkappaBNS regulates murine Th17 differentiation during gut inflammation and infection.
    Authors: Annemann M, Wang Z, Plaza-Sirvent C, Glauben R, Schuster M, Ewald Sander F, Mamareli P, Kuhl A, Siegmund B, Lochner M, Schmitz I
    J Immunol, 2015;194(6):2888-98.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  35. TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms.
    Authors: Hu M, Xie X, Yang Q, Liao C, Ye W, Lin H, Shu H
    J Immunol, 2015;195(9):4415-25.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  36. A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.
    Authors: Dunne A, Mielke L, Allen A, Sutton C, Higgs R, Cunningham C, Higgins S, Mills K
    Mucosal Immunol, 2015;8(3):607-17.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  37. Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types.
    Authors: Liu X, Yamashita T, Chen Q, Belevych N, Mckim D, Tarr A, Coppola V, Nath N, Nemeth D, Syed Z, Sheridan J, Godbout J, Zuo J, Quan N
    J Neurosci, 2015;35(7):2860-70.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  38. A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion.
    Authors: Bakker P, Butter L, Claessen N, Teske G, Sutterwala F, Florquin S, Leemans J
    Am J Pathol, 2014;184(7):2013-22.
    Species: Mouse
    Sample Type: Tissue Homogenates
    Application: WB Standard
  39. IFN-gamma or IFN-alpha ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex.
    Authors: Tamiya H, Terao M, Takiuchi T, Nakahara M, Sasaki Y, Katayama I, Yoshikawa H, Iwai K
    J Immunol, 2014;192(8):3793-804.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  40. Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics.
    Authors: Hahn W, Kuzmicic J, Burrill J, Donoghue M, Foncea R, Jensen M, Lavandero S, Arriaga E, Bernlohr D
    Am J Physiol Endocrinol Metab, 2014;306(9):E1033-45.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  41. Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.
    Authors: Steelman A, Smith R, Welsh C, Li J
    J Biol Chem, 2014;288(33):23776-87.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  42. IL-18 regulates melanoma VLA-4 integrin activation through a Hierarchized sequence of inflammatory factors.
    Authors: Valcarcel M, Carrascal T, Crende O, Vidal-Vanaclocha F
    J Invest Dermatol, 2014;134(2):470-80.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  43. Reversal of beta cell de-differentiation by a small molecule inhibitor of the TGFbeta pathway.
    Authors: Blum B, Roose A, Barrandon O, Maehr R, Arvanites A, Davidow L, Davis J, Peterson Q, Rubin L, Melton D
    Elife, 2014;3(0):e02809.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  44. Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis.
    Authors: Jana M, Mondal S, Jana A, Pahan K
    Immunology, 2014;141(4):549-63.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  45. Role of Blimp-1 in programing Th effector cells into IL-10 producers.
    Authors: Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A
    J Exp Med, 2014;211(9):1807-19.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  46. Interleukin-1beta enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes.
    Authors: Lutz A, Sanwald J, Thomas M, Feuer R, Sawodny O, Ederer M, Borner C, Humar M, Merfort I
    PLoS ONE, 2014;9(12):e115603.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  47. Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells.
    Authors: Jin, Shijie, Sonobe, Yoshifum, Kawanokuchi, Jun, Horiuchi, Hiroshi, Cheng, Yi, Wang, Yue, Mizuno, Tetsuya, Takeuchi, Hideyuki, Suzumura, Akio
    PLoS ONE, 2014;9(12):e115981.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  48. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis.
    Authors: Moon C, VanDussen K, Miyoshi H, Stappenbeck T
    Mucosal Immunol, 2014;7(4):818-28.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  49. Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-alpha and interleukin-1beta but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain.
    Authors: Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, Hoshino M, Imamura T, Akiyama C, Yasuhara R, Mishima K, Maruyama T, Kohda C, Tanaka K, Potempa J, Yasuda H, Baba K, Kamijo R
    J Biol Chem, 2014;289(22):15621-30.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  50. ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo.
    Authors: Halai, Krishma, Whiteford, James, Ma, Bin, Nourshargh, Sussan, Woodfin, Abigail
    J Cell Sci, 2014;127(0):620-9.
  51. Pseudomonas aeruginosa quorum-sensing molecule homoserine lactone modulates inflammatory signaling through PERK and eI-F2alpha.
    Authors: Grabiner M, Fu Z, Wu T, Barry K, Schwarzer C, Machen T
    J Immunol, 2014;193(3):1459-67.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  52. Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis.
    Authors: Glenn J, Smith M, Calabresi P, Whartenby K
    Stem Cells, 2014;32(10):2744-55.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  53. Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.
    Authors: Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone J, Takayanagi H
    Nat Med, 2014;20(1):62-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  54. Glimepiride reduces CD14 expression and cytokine secretion from macrophages.
    Authors: Ingham V, Williams A, Bate C
    J Neuroinflammation, 2014;11(0):115.
    Species: Mouse
    Sample Type: Cell Culture Supernates
    Application: ELISA Standard
  55. Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-kappaB pathway and attenuating ROS production.
    Authors: Lee S, Lee K, Yi S, Kook S, Lee J
    PLoS ONE, 2013;8(12):e80873.
    Species: Mouse
    Sample Type: Whole Cells
    Application: cell culture
  56. In vivo processing of CXCL5 (LIX) by matrix metalloproteinase (MMP)-2 and MMP-9 promotes early neutrophil recruitment in IL-1beta-induced peritonitis.
    Authors: Song J, Wu C, Zhang X, Sorokin L
    J Immunol, 2013;190(1):401-10.
    Species: Mouse
    Sample Type: In Vivo
    Application: InVivo
  57. PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth.
    Authors: Schmid M, Franco I, Kang S, Hirsch E, Quilliam L, Varner J
    PLoS ONE, 2013;8(4):e60226.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  58. IL-1beta promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation.
    Authors: Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson A, Kuchroo V, Remold H, Behar S
    J Immunol, 2013;190(8):4196-204.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  59. A novel in vitro model to study pericytes in the neurovascular unit of the developing cortex.
    Authors: Zehendner, Christop, Wedler, Hannah E, Luhmann, Heiko J
    PLoS ONE, 2013;8(11):e81637.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  60. Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS.
    Authors: Flanagan K, Fitzgerald K, Baker J
    PLoS ONE, 2012;7(7):e40443.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  61. Age-Dependent Neuroimmune Modulation of IGF-1R in the Traumatic Mice.
    Authors: Zhao H, Zhao X, Cao X, Wu G
    Immun Ageing, 2012;9(1):12.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  62. Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
    J. Exp. Med., 2012;209(8):1505-17.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  63. Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice.
    Authors: Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algul H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP
    J. Clin. Invest., 2012;122(5):1758-63.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  64. Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.
    Authors: Proebstl D, Voisin MB, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D, Nourshargh S
    J. Exp. Med., 2012;209(6):1219-34.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  65. Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1alpha regulation of FXR expression.
    Authors: Liu N, Meng Z, Lou G, Zhou W, Wang X, Zhang Y, Zhang L, Liu X, Yen Y, Lai L, Forman BM, Xu Z, Xu R, Huang W
    Mol. Endocrinol., 2012;26(5):775-85.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  66. Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
    Authors: Bruchard M, Mignot G, Derangere V, Chalmin F, Chevriaux A, Vegran F, Boireau W, Simon B, Ryffel B, Connat J, Kanellopoulos J, Martin F, Rebe C, Apetoh L, Ghiringhelli F
    Nat Med, 2012;19(1):57-64.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  67. Interleukin-23-mediated inflammation in Pseudomonas aeruginosa pulmonary infection.
    Authors: Dubin PJ, Martz A, Eisenstatt JR, Fox MD, Logar A, Kolls JK
    Infect. Immun., 2012;80(1):398-409.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  68. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  69. Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo.
    Authors: Petri B, Kaur J, Long EM, Li H, Parsons SA, Butz S, Phillipson M, Vestweber D, Patel KD, Robbins SM, Kubes P
    Blood, 2011;117(3):942-52.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  70. Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors.
    Authors: Sanchez-Alavez M, Osborn O, Tabarean IV
    J. Biol. Chem., 2011;286(17):14983-90.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  71. XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1beta-mediated diseases.
    Authors: Owyang AM, Issafras H, Corbin J, Ahluwalia K, Larsen P, Pongo E, Handa M, Horwitz AH, Roell MK, Haak-Frendscho M, Masat L
    MAbs, 2011;3(1):49-60.
    Species: Mouse
    Sample Type: Buffer
    Application: Binding Assay
  72. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
    Authors: El-Behi M, Ciric B, Dai H
    Nat. Immunol., 2011;12(6):568-75.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  73. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
    Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L
    J. Exp. Med., 2011;208(3):491-503.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  74. Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130.
    Authors: Grossberg AJ, Scarlett JM, Zhu X, Bowe DD, Batra AK, Braun TP, Marks DL
    Endocrinology, 2010;151(2):606-16.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  75. Systemic inflammation sensitizes the neonatal brain to excitotoxicity through a pro-/anti-inflammatory imbalance: key role of TNFalpha pathway and protection by etanercept.
    Authors: Aden U, Favrais G, Plaisant F, Winerdal M, Felderhoff-Mueser U, Lampa J, Lelievre V, Gressens P
    Brain Behav. Immun., 2010;24(5):747-58.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  76. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice.
    Authors: Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung AL, Cheng G, Modlin RL, Miller LS
    J. Clin. Invest., 2010;120(5):1762-73.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  77. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
    J. Virol., 2010;84(24):12703-12.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  78. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis.
    Authors: Chou RC, Kim ND, Sadik CD
    Immunity, 2010;33(2):266-78.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  79. Tim3 binding to galectin-9 stimulates antimicrobial immunity.
    Authors: Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM
    J. Exp. Med., 2010;207(11):2343-54.
    Species: Mouse
    Sample Type: Cell Culture Supernates
    Application: Bioassay
  80. Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice.
    Authors: Mizutani N, Nabe T, Yoshino S
    J. Immunol., 2009;183(6):4039-46.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  81. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
    Authors: Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L
    Nat. Med., 2009;15(10):1170-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  82. Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages.
    Authors: Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA
    J. Immunol., 2009;183(6):4021-30.
    Species: N/A
    Sample Type: N/A
    Application: WB Ctrl
  83. The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation.
    Authors: Koziczak-Holbro M, Littlewood-Evans A, Pollinger B, Kovarik J, Dawson J, Zenke G, Burkhart C, Muller M, Gram H
    Arthritis Rheum., 2009;60(6):1661-71.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  84. The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2.
    Authors: Nilsberth C, Elander L, Hamzic N, Norell M, Lonn J, Engstrom L, Blomqvist A
    Endocrinology, 2009;150(4):1850-60.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  85. Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway.
    Authors: Chen X, Fang L, Song S, Guo TB, Liu A, Zhang JZ
    J. Immunol., 2009;183(10):6135-44.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  86. Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.
    Authors: Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S
    J. Immunol., 2009;183(12):7890-7.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  87. IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8.
    Authors: Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME, Garlanda C, Mantovani A, O'Neill LA, Mills KH, Lynch MA
    J. Neurochem., 2008;105(5):1960-9.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  88. Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient mice.
    Authors: Olivadoti MD, Opp MR
    Neuroscience, 2008;153(1):338-48.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  89. In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model.
    Authors: Wu CC, Sabet M, Hayashi T, Tawatao R, Fierer J, Carson DA, Guiney DG, Corr M
    Cell. Immunol., 2008;251(2):78-85.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  90. Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling.
    Authors: Bujak M, Dobaczewski M, Chatila K, Mendoza LH, Li N, Reddy A, Frangogiannis NG
    Am. J. Pathol., 2008;173(1):57-67.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  91. A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs.
    Authors: Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A
    Arthritis Rheum., 2008;58(11):3510-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  92. Induction of IL-33 expression and activity in central nervous system glia.
    Authors: Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT
    J. Leukoc. Biol., 2008;84(3):631-43.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  93. Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation.
    Authors: Scarlett JM, Zhu X, Enriori PJ, Bowe DD, Batra AK, Levasseur PR, Grant WF, Meguid MM, Cowley MA, Marks DL
    Endocrinology, 2008;149(10):4837-45.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  94. Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages.
    Authors: Kang YJ, Kim SO, Shimada S, Otsuka M, Seit-Nebi A, Kwon BS, Watts TH, Han J
    Nat. Immunol., 2007;8(6):601-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  95. IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis.
    Authors: Antonopoulos C, Cumberbatch M, Mee JB, Dearman RJ, Wei XQ, Liew FY, Kimber I, Groves RW
    J. Leukoc. Biol., 2007;83(2):361-7.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  96. Protection of CD8+ T cells from activation-induced cell death by IL-18.
    Authors: Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H
    J. Leukoc. Biol., 2007;82(1):142-51.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  97. Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice.
    Authors: Penido C, Conte FP, Chagas MS, Rodrigues CA, Pereira JF, Henriques MG
    Inflamm. Res., 2006;55(11):457-64.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  98. Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury.
    Authors: Mendez MP, Morris SB, Wilcoxen S, Greeson E, Moore B, Paine R
    Am. J. Physiol. Lung Cell Mol. Physiol., 2006;290(5):L962-70.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  99. Modification of MyD88 mRNA splicing and inhibition of IL-1beta signaling in cell culture and in mice with a 2'-O-methoxyethyl-modified oligonucleotide.
    Authors: Vickers TA, Zhang H, Graham MJ, Lemonidis KM, Zhao C, Dean NM
    J. Immunol., 2006;176(6):3652-61.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  100. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.
    Authors: Osuchowski MF, Welch K, Siddiqui J, Remick DG
    J. Immunol., 2006;177(3):1967-74.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  101. A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model.
    Authors: Haraguchi G, Suzuki J, Kosuge H, Ogawa M, Koga N, Muto S, Itai A, Kagechika H, Shudo K, Isobe M
    J. Mol. Cell. Cardiol., 2006;41(5):885-92.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  102. The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.
    Authors: Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI
    Genes Dev., 2006;20(18):2527-38.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  103. Sequential ELISA to profile multiple cytokines from small volumes.
    Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
    J. Immunol. Methods, 2005;302(1):172-81.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  104. TLR-2 is upregulated and mobilized to the hepatocyte plasma membrane in the space of Disse and to the Kupffer cells TLR-4 dependently during acute endotoxemia in mice.
    Authors: Ojaniemi M, Liljeroos M, Harju K, Sormunen R, Vuolteenaho R, Hallman M
    Immunol. Lett., 2005;102(2):158-68.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  105. Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration.
    Authors: Perrin FE, Lacroix S, Aviles-Trigueros M, David S
    Brain, 2005;128(0):854-66.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  106. IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system.
    Authors: Ching S, He L, Lai W, Quan N
    Brain Behav. Immun., 2005;19(2):127-37.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  107. Selective macrophage suppression during sepsis.
    Authors: Ellaban E, Bolgos G, Remick D
    Cell. Immunol., 2004;231(1):103-11.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
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Animal-Free Recombinant Proteins
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Recombinant Mouse IL-1 beta/IL-1F2, Animal-Free Protein

BA AFL401
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Average Rating: 4.5 (Based on 2 reviews)

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We have 2 reviews tested in 2 applications: In vitro bioactivity in cell culture, Apoptosis assay.
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In vitro bioactivity in cell culture Recombinant Mouse IL-1 beta/IL-1F2 Protein 401-ML
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 In vitro bioactivity in cell culture Anonymous 08/02/2017
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In vitro bioactivity in cell culture Recombinant Mouse IL-1 beta/IL-1F2 Protein 401-ML
In vitro bioactivity in cell culture: Recombinant Mouse IL-1 beta/IL-1F2 Protein [401-ML]

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ApplicationIn vitro bioactivity in cell culture
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 Apoptosis assay Anonymous 01/13/2016
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ApplicationApoptosis assay
Reason for RatingI have a good apoptosis results

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Other Experimental DetailsI treat the IL-1 beta with IFN-gamma in beta-Tc3 cells.Cell death rate is almost 30% for 48 hrs.

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