Recombinant Mouse VEGF 164 Protein

Carrier Free

Catalog # Availability Size / Price Qty
493-MV-005/CF
493-MV-025/CF

With Carrier

Catalog # Availability Size / Price Qty
493-MV-005
493-MV-025
R&D Systems Recombinant Proteins and Enzymes
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Product Details
Citations (79)
FAQs
Reviews (7)

Recombinant Mouse VEGF 164 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. Conn, G. et al. (1990) Proc. Natl. Acad. Sci. USA 87:1323. The ED50 for this effect is 0.8-4 ng/mL.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived mouse VEGF protein
Ala27-Arg190
Accession #
N-terminal Sequence
Analysis
Ala27
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
19.4 kDa (monomer)
SDS-PAGE
42 kDa, non-reducing conditions

Product Datasheets

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493-MV (with carrier)

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493-MV/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

493-MV

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

493-MV/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 50 µg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: VEGF

Vascular endothelial growth factor (VEGF or VEGF‑A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult (1-3). It is a member of the PDGF family that is characterized by a cystine knot structure formed by eight conserved cysteine residues (4). Alternately spliced isoforms of 121, 145, 165, 183, 189, and 206 amino acids (aa) have been identified in humans, with 120, 164 and 188 aa isoforms found in mouse (2, 4). Isoforms other than VEGF120 and VEGF121 contain basic heparin-binding regions and are not freely diffusible (4). Mouse VEGF164 shares 97% aa sequence identity with corresponding regions of rat, 89% with human and porcine, 88% with bovine, and 90% with feline, equine and canine VEGF, respectively. VEGF binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt-1) and VEGF R2 (Flk-1/KDR) on endothelial cells (4). Although affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity (3, 4). Human VEGF165 binds the semaphorin receptor, Neuropilin-1 and promotes complex formation with VEGF R2 (5). VEGF is required during embryogenesis to regulate the proliferation, migration, and survival of endothelial cells (3, 4). In adults, VEGF functions mainly in wound healing and the female reproductive cycle (3). Pathologically, it is involved in tumor angiogenesis and vascular leakage (6, 7). Circulating VEGF levels correlate with disease activity in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (8). VEGF is induced by hypoxia and cytokines such as IL-1, IL-6, IL-8, oncostatin M and TNF-alpha (3, 4, 9).

References
  1. Breier, G. et al. (1992) Development 114:521.
  2. Shima, D.T. et al. (1996) J. Biol. Chem. 271:3877.
  3. Byrne, A.M. et al. (2005) J. Cell. Mol. Med. 9:777.
  4. Robinson, C.J. and S.E. Stringer (2001) J. Cell. Sci. 114:853.
  5. Pan, Q. et al. (2007) J. Biol. Chem. 282:24049.
  6. Weis, S.M. and D.A. Cheresh (2005) Nature 437:497.
  7. Thurston, G. (2002) J. Anat. 200:575.
  8. Carvalho, J.F. et al. (2007) J. Clin. Immunol. 27:246.
  9. Angelo, L.S. and R. Kurzrock (2007) Clin. Cancer Res. 13:2825.
Long Name
Vascular Endothelial Growth Factor
Entrez Gene IDs
7422 (Human); 22339 (Mouse); 83785 (Rat); 281572 (Bovine); 403802 (Canine); 493845 (Feline); 30682 (Zebrafish)
Alternate Names
MVCD1; VAS; vascular endothelial growth factor A; Vascular permeability factor; Vasculotropin; VEGF; VEGFA; VEGF-A; VEGFMGC70609; VPF; VPFvascular endothelial growth factor

Citations for Recombinant Mouse VEGF 164 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

79 Citations: Showing 1 - 10
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  1. Protective role of VEGF/VEGFR2 signaling against high fatality associated with hepatic encephalopathy via sustaining mitochondrial bioenergetics functions
    Authors: CY Tsai, JCC Wu, CJ Wu, SHH Chan
    Oncogene, 2022;29(1):47.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Exposure to the Dioxin-like Pollutant PCB 126 Afflicts Coronary Endothelial Cells via Increasing 4-Hydroxy-2 Nonenal: A Role for Aldehyde Dehydrogenase 2
    Authors: B Roy, Z Yang, G Pan, K Roth, M Agarwal, R Sharma, MC Petriello, SS Palaniyand
    Oncogene, 2022;10(6):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis
    Authors: O Meçe, D Houbaert, ML Sassano, T Durré, H Maes, M Schaaf, S More, M Ganne, M García-Cab, M Borri, J Verhoeven, M Agrawal, K Jacobs, G Bergers, S Blacher, B Ghesquière, M Dewerchin, JV Swinnen, S Vinckier, MS Soengas, P Carmeliet, A Noël, P Agostinis
    Nature Communications, 2022;13(1):2760.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  4. Platycodon grandiflorum Triggers Antitumor Immunity by Restricting PD-1 Expression of CD8+ T Cells in Local Tumor Microenvironment
    Authors: R Yang, T Pei, R Huang, Y Xiao, J Yan, J Zhu, C Zheng, W Xiao, C Huang
    Frontiers in Pharmacology, 2022;13(0):774440.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Regenerating glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy
    Authors: J Fu, T Shinjo, Q Li, R St-Louis, K Park, MG Yu, H Yokomizo, F Simao, Q Huang, IH Wu, GL King
    JCI Insight, 2022;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Ultraefficient extracellular vesicle-guided direct reprogramming of fibroblasts into functional cardiomyocytes
    Authors: H Kim, BW Song, SJ Park, SW Choi, H Moon, KC Hwang, SW Kang, SH Moon, Y Yang, IC Kwon, SH Kim
    Science Advances, 2022;8(8):eabj6621.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage
    Authors: K Bubb, T Holzer, JL Nolte, M Krüger, R Wilson, U Schlötzer-, J Brinckmann, J Altmüller, A Aszodi, L Fleischhau, H Clausen-Sc, K Probst, B Brachvogel
    The Journal of Biological Chemistry, 2021;0(0):101224.
    Species: Mouse
    Sample Types: Recombinant Protein
    Applications: Western Blot Control
  8. Mucopolysaccharide polysulfate promotes microvascular stabilization and barrier integrity of dermal microvascular endothelial cells via activation of the angiopoietin-1/Tie2 pathway
    Authors: S Fujiwara-S, Y Ueda, M Fujikawa, M Osaki, N Yamanaka, T Matsumoto
    Journal of dermatological science, 2021;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  9. The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization
    Authors: W Li, Y Wang, L Zhu, S Du, J Mao, Y Wang, S Wang, Q Bo, Y Tu, Q Yi
    Journal of Cellular and Molecular Medicine, 2021;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  10. Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration
    Authors: A Yaguchi, M Oshikawa, G Watanabe, H Hiramatsu, N Uchida, C Hara, N Kaneko, K Sawamoto, T Muraoka, I Ajioka
    Nature Communications, 2021;12(1):6623.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Activated FGF2 signaling pathway in tumor vasculature is essential for acquired resistance to anti-VEGF therapy
    Authors: K Ichikawa, S Watanabe M, Y Minoshima, J Matsui, Y Funahashi
    Sci Rep, 2020;10(1):2939.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IP
  12. TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment
    Authors: P Zizza, R Dinami, M Porru, C Cingolani, E Salvati, A Rizzo, C D'Angelo, E Petti, CA Amoreo, M Mottolese, I Sperduti, A Chambery, R Russo, P Ostano, G Chiorino, G Blandino, A Sacconi, J Cherfils-V, C Leonetti, E Gilson, A Biroccio
    Nucleic Acids Res., 2019;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  13. A histone deacetylase 7-derived peptide promotes vascular regeneration via facilitating 14-3-3gamma phosphorylation
    Authors: J Yang, A Moraga, J Xu, Y Zhao, P Luo, KH Lao, A Margariti, Q Zhao, W Ding, G Wang, M Zhang, L Zheng, Z Zhang, Y Hu, W Wang, L Shen, A Smith, AM Shah, Q Wang, L Zeng
    Stem Cells, 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  14. EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development
    Authors: E Harde, L Nicholson, B Furones Cu, D Bissen, S Wigge, S Urban, M Segarra, C Ruiz de Al, A Acker-Palm
    Elife, 2019;8(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Dietary compound glycyrrhetinic acid suppresses tumor angiogenesis and growth by modulating antiangiogenic and proapoptotic pathways in vitro and in vivo
    Authors: J Li, F Tang, R Li, Z Chen, SM Lee, C Fu, J Zhang, GP Leung
    J. Nutr. Biochem., 2019;77(0):108268.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  16. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing
    Authors: S Mahmoudi, E Mancini, L Xu, A Moore, F Jahanbani, K Hebestreit, R Srinivasan, X Li, K Devarajan, L Prélot, CE Ang, Y Shibuya, BA Benayoun, ALS Chang, M Wernig, J Wysocka, MT Longaker, MP Snyder, A Brunet
    Nature, 2019;574(7779):553-558.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  17. Age-related oxidative stress confines damage-responsive Bmi1+ cells to perivascular regions in the murine adult heart
    Authors: D Herrero, S Cañón, G Albericio, RM Carmona, S Aguilar, S Mañes, A Bernad
    Redox Biol, 2019;22(0):101156.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events
    Authors: N Honkura, M Richards, B Laviña, M Sáinz-Jasp, C Betsholtz, L Claesson-W
    Nat Commun, 2018;9(1):2746.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  19. Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling
    Authors: M Verma, Y Asakura, BSR Murakonda, T Pengo, C Latroche, B Chazaud, LK McLoon, A Asakura
    Cell Stem Cell, 2018;23(4):530-543.e9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  20. Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation
    Authors: G Del Monte-, M Ramialison, AAS Adam, B Wu, A Aharonov, G D'Uva, LM Bourke, ME Pitulescu, H Chen, JL de la Pomp, W Shou, RH Adams, SK Harten, E Tzahor, B Zhou, RP Harvey
    Nature, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  21. Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity
    Authors: T Ikeuchi, S de Vega, P Forcinito, AD Doyle, J Amaral, IR Rodriguez, E Arikawa-Hi, Y Yamada
    Sci Rep, 2018;8(1):17654.
  22. Glycosylation controls cooperative PECAM-VEGFR2-?3 integrin functions at the endothelial surface for tumor angiogenesis
    Authors: R Imamaki, K Ogawa, Y Kizuka, Y Komi, S Kojima, N Kotani, K Honke, T Honda, N Taniguchi, S Kitazume
    Oncogene, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Blockade of placental growth factor reduces vaso-occlusive complications in murine models of sickle cell disease
    Authors: JM Gu, S Yuan, D Sim, K Abe, P Liu, M Rosenbruch, P Bringmann, K Kauser
    Exp. Hematol., 2018;0(0):.
    Species: Mouse
    Sample Types: Recombinant Protein
    Applications: ELISA (Capture)
  24. Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis
    Authors: T Kobori, S Hamasaki, A Kitaura, Y Yamazaki, T Nishinaka, A Niwa, S Nakao, H Wake, S Mori, T Yoshino, M Nishibori, H Takahashi
    Front Immunol, 2018;9(0):334.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical Models
    Authors: Y Li, JA Hickson, DJ Ambrosi, DL Haasch, KD Foster-Duk, LJ Eaton, EL Digiammari, SC Panchal, F Jiang, SR Mudd, C Zhang, SS Akella, W Gao, SL Ralston, L Naumovski, J Gu, SE Morgan-Lap
    Mol. Cancer Ther., 2018;0(0):.
    Applications: ELISA (Standard)
  26. Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons
    Authors: S Schaller, D Buttigieg, A Alory, A Jacquier, M Barad, M Merchant, D Gentien, P de la Gran, G Haase
    Proc. Natl. Acad. Sci. U.S.A, 2017;114(12):E2486-E2493.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Intramyocardial Adipose-Derived Stem Cell Transplantation Increases Pericardial Fat with Recovery of Myocardial Function after Acute Myocardial Infarction
    Authors: Jong-Ho Kim
    PLoS ONE, 2016;11(6):e0158067.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone
    Nat Commun, 2016;7(0):13885.
    Species: Human
    Sample Types: Whole Cells
    Applications: Binding Assay
  29. A 3D Poly(ethylene glycol)-based Tumor Angiogenesis Model to Study the Influence of Vascular Cells on Lung Tumor Cell Behavior
    Sci Rep, 2016;6(0):32726.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes
    J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  31. Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways.
    Authors: Wang S, Amato K, Song W, Youngblood V, Lee K, Boothby M, Brantley-Sieders D, Chen J
    Mol Cell Biol, 2015;35(7):1299-313.
    Species: Mouse
    Sample Types: In Vivo
  32. Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8.
    Authors: Ding X, Lucas T, Marcuzzi G, Pfister H, Eming S
    Cancer Res, 2015;75(2):330-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors.
    Authors: Hunter, K E, Palermo, C, Kester, J C, Simpson, K, Li, J-P, Tang, L H, Klimstra, D S, Vlodavsky, I, Joyce, J A
    Oncogene, 2014;33(14):1799-808.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. A Snail1/Notch1 signalling axis controls embryonic vascular development.
    Authors: Wu Z, Rowe R, Lim K, Lin Y, Willis A, Tang Y, Li X, Nor J, Maillard I, Weiss S
    Nat Commun, 2014;5(0):3998.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. RAS interaction with PI3K p110alpha is required for tumor-induced angiogenesis.
    Authors: Murillo M, Zelenay S, Nye E, Castellano E, Lassailly F, Stamp G, Downward J
    J Clin Invest, 2014;124(8):3601-11.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  36. The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling.
    Authors: Chen P, Qin L, Zhuang Z, Tellides G, Lax I, Schlessinger J, Simons M
    Proc Natl Acad Sci U S A, 2014;111(15):5514-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  37. Absence of CD9 reduces endometrial VEGF secretion and impairs uterine repair after parturition.
    Authors: Kawano, Natsuko, Miyado, Kenji, Yoshii, Noriko, Kanai, Seiya, Saito, Hidekazu, Miyado, Mami, Inagaki, Noboru, Odawara, Yasushi, Hamatani, Toshio, Umezawa, Akihiro
    Sci Rep, 2014;4(0):4701.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  38. Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm.
    Authors: Zhang H, Nieves J, Fraser S, Isern J, Douvaras P, Papatsenko D, D'Souza S, Lemischka I, Dyer M, Baron M
    Stem Cells, 2014;32(1):191-203.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity.
    Authors: Fleetwood F, Klint S, Hanze M, Gunneriusson E, Frejd F, Stahl S, Lofblom J
    Sci Rep, 2014;4(0):7518.
  40. Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo.
    Authors: Sundaram, J, Keshava, S, Gopalakrishnan, R, Esmon, C T, Pendurthi, U R, Rao, L V M
    J Thromb Haemost, 2014;12(5):690-700.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  41. Circulating mouse Flk1+/c-Kit+/CD45- cells function as endothelial progenitors cells (EPCs) and stimulate the growth of human tumor xenografts.
    Authors: Russell J, Brown J
    Mol Cancer, 2014;13(0):177.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro.
    Authors: Iwasaki T, Takeda Y, Maruyama K, Yokosaki Y, Tsujino K, Tetsumoto S, Kuhara H, Nakanishi K, Otani Y, Jin Y, Kohmo S, Hirata H, Takahashi R, Suzuki M, Inoue K, Nagatomo I, Goya S, Kijima T, Kumagai T, Tachibana I, Kawase I, Kumanogoh A
    J Biol Chem, 2013;288(4):2118-31.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  43. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
    Authors: Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, Mukhopadhyay S, Chen X, Leung T, Richardson R
    J Immunol, 2013;190(10):5329-36.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ELISA (Control)
  44. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis.
    Authors: Zhang G, Panigrahy D, Mahakian L, Yang J, Liu J, Stephen Lee K, Wettersten H, Ulu A, Hu X, Tam S, Hwang S, Ingham E, Kieran M, Weiss R, Ferrara K, Hammock B
    Proc Natl Acad Sci U S A, 2013;110(16):6530-5.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  45. VEGFA family isoforms regulate spermatogonial stem cell homeostasis in vivo.
    Authors: Caires KC, de Avila JM, Cupp AS
    Endocrinology, 2012;153(2):887-900.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  46. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment.
    Authors: Cook BD, Liu S, Evans T
    Blood, 2011;117(24):6489-97.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Flt-1 regulates vascular endothelial cell migration via a protein tyrosine kinase-7-dependent pathway.
    Authors: Lee HK, Chauhan SK, Kay E
    Blood, 2011;117(21):5762-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1.
    Authors: Ruiz de Almodovar C, Coulon C, Salin PA, Knevels E, Chounlamountri N, Poesen K, Hermans K, Lambrechts D, Van Geyte K, Dhondt J, Dresselaers T, Renaud J, Aragones J, Zacchigna S, Geudens I, Gall D, Stroobants S, Mutin M, Dassonville K, Storkebaum E, Jordan BF, Eriksson U, Moons L, D'Hooge R, Haigh JJ, Belin MF, Schiffmann S, Van Hecke P, Gallez B, Vinckier S, Chedotal A, Honnorat J, Thomasset N, Carmeliet P, Meissirel C
    J. Neurosci., 2010;30(45):15052-66.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  50. Production of scFv antibody fragments from a hybridoma with functional activity against human vascular endothelial growth factor.
    Authors: Irani Y, Brereton HM, Tilton RG
    Hybridoma (Larchmt), 2009;28(3):205-9.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Binding Assay
  51. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment.
    Authors: Crawford Y, Kasman I, Yu L, Zhong C, Wu X, Modrusan Z, Kaminker J, Ferrara N
    Cancer Cell, 2009;15(1):21-34.
    Species: N/A
    Sample Types: N/A
    Applications: Western Blot
  52. The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice.
    Authors: Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid PC, Hamakubo T, Ryeom S, Aird WC, Kodama T
    J. Clin. Invest., 2009;119(8):2257-70.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  53. Dysfunctional microvasculature as a consequence of shb gene inactivation causes impaired tumor growth.
    Authors: Funa NS, Kriz V, Zang G, Calounova G, Akerblom B, Mares J, Larsson E, Sun Y, Betsholtz C, Welsh M
    Cancer Res., 2009;69(5):2141-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  54. Inhibition of endothelial progenitor cell differentiation by VEGI.
    Authors: Tian F, Liang PH, Li LY
    Blood, 2009;113(21):5352-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivation.
    Authors: Noman AS, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T
    Biochem. Biophys. Res. Commun., 2008;374(4):683-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Interaction between bevacizumab and murine VEGF-A: a reassessment.
    Authors: Yu L, Wu X, Cheng Z, Lee CV, LeCouter J, Campa C, Fuh G, Lowman H, Ferrara N
    Invest. Ophthalmol. Vis. Sci., 2008;49(2):522-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1.
    Authors: Ponticelli S, Marasco D, Tarallo V, Albuquerque RJ, Mitola S, Takeda A, Stassen JM, Presta M, Ambati J, Ruvo M, De Falco S
    J. Biol. Chem., 2008;283(49):34250-9.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  58. Adenoviral expression of vascular endothelial growth factor splice variants differentially regulate bone marrow-derived mesenchymal stem cells.
    Authors: Lin H, Shabbir A, Molnar M, Yang J, Marion S, Canty JM, Lee T
    J. Cell. Physiol., 2008;216(2):458-68.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Regulation of scar formation by vascular endothelial growth factor.
    Authors: Wilgus TA, Ferreira AM, Oberyszyn TM, Bergdall VK, DiPietro LA
    Lab. Invest., 2008;88(6):579-90.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  60. Characterization of the anti-angiogenic properties of arresten, an alpha1beta1 integrin-dependent collagen-derived tumor suppressor.
    Authors: Nyberg P, Xie L, Sugimoto H, Colorado P, Sund M, Holthaus K, Sudhakar A, Salo T, Kalluri R
    Exp. Cell Res., 2008;314(18):3292-305.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  61. Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function.
    Authors: Rossiter H, Barresi C, Ghannadan M, Gruber F, Mildner M, Fodinger D, Tschachler E
    FASEB J., 2007;21(14):3994-4004.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  62. alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner.
    Authors: Zhang Z, Ramirez NE, Yankeelov TE, Li Z, Ford LE, Qi Y, Pozzi A, Zutter MM
    Blood, 2007;111(4):1980-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  63. Bv8 regulates myeloid-cell-dependent tumour angiogenesis.
    Authors: Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N
    Nature, 2007;450(7171):825-31.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. VEGF reduces astrogliosis and preserves neuromuscular junctions in ALS transgenic mice.
    Authors: Zheng C, Skold MK, Li J, Nennesmo I, Fadeel B, Henter JI
    Biochem. Biophys. Res. Commun., 2007;363(4):989-93.
  65. Corneal avascularity is due to soluble VEGF receptor-1.
    Authors: Ambati BK, Nozaki M, Singh N, Takeda A, Jani PD, Suthar T, Albuquerque RJ, Richter E, Sakurai E, Newcomb MT, Kleinman ME, Caldwell RB, Lin Q, Ogura Y, Orecchia A, Samuelson DA, Agnew DW, St Leger J, Green WR, Mahasreshti PJ, Curiel DT, Kwan D, Marsh H, Ikeda S, Leiper LJ, Collinson JM, Bogdanovich S, Khurana TS, Shibuya M, Baldwin ME, Ferrara N, Gerber HP, De Falco S, Witta J, Baffi JZ, Raisler BJ, Ambati J
    Nature, 2006;443(7114):993-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  66. Antagonists to human and mouse vascular endothelial growth factor receptor 2 generated by directed protein evolution in vitro.
    Authors: Getmanova EV, Chen Y, Bloom L, Gokemeijer J, Shamah S, Warikoo V, Wang J, Ling V, Sun L
    Chem. Biol., 2006;13(5):549-56.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Cytokine-containing gelfoam implants at a postsurgical tumor excision site to stimulate local immune reactivity.
    Authors: Young MR
    Int. J. Cancer, 2006;119(1):133-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  68. The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.
    Authors: Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI
    Genes Dev., 2006;20(18):2527-38.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  69. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
    Authors: Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Breant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL
    Nat. Neurosci., 2006;9(3):340-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action.
    Authors: Cao R, Bjorndahl MA, Gallego MI, Chen S, Religa P, Hansen AJ, Cao Y
    Blood, 2006;107(9):3531-6.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  71. Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx.
    Authors: Hutson MR, Zhang P, Stadt HA, Sato AK, Li YX, Burch J, Creazzo TL, Kirby ML
    Dev. Biol., 2006;295(2):486-97.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  72. VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis.
    Authors: Del Moral PM, Sala FG, Tefft D, Shi W, Keshet E, Bellusci S, Warburton D
    Dev. Biol., 2005;290(1):177-88.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2.
    Authors: Usui T, Ishida S, Yamashiro K, Kaji Y, Poulaki V, Moore J, Moore T, Amano S, Horikawa Y, Dartt D, Golding M, Shima DT, Adamis AP
    Invest. Ophthalmol. Vis. Sci., 2004;45(2):368-74.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  74. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia.
    Authors: Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Jeltsch M, Mitchell C, Alitalo K, Shima D, Betsholtz C
    J. Cell Biol., 2003;161(6):1163-77.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  75. Quantitative assessment of angiogenic responses by the directed in vivo angiogenesis assay.
    Authors: Guedez L, Rivera AM, Salloum R, Miller ML, Diegmueller JJ, Bungay PM, Stetler-Stevenson WG
    Am. J. Pathol., 2003;162(5):1431-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  76. Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity.
    Authors: Yi M, Sakai T, Fassler R, Ruoslahti E
    Proc. Natl. Acad. Sci. U.S.A., 2003;100(20):11435-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  77. Inhibition of programmed cell death impairs in vitro vascular-like structure formation and reduces in vivo angiogenesis.
    Authors: Segura I, 2019, Serrano A, De Buitrago GG, Gonzalez MA, Abad JL, Claveria C, Gomez L, Bernad A, Martinez-A C, Riese HH
    7096, 2002;16(8):833-41.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  78. Tumor-targeting properties of antibody-vascular endothelial growth factor fusion proteins.
    Authors: Halin C, Niesner U, Villani ME, Zardi L, Neri D
    Int. J. Cancer, 2002;102(2):109-16.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  79. VEGF increases engraftment of bone marrow-derived endothelial progenitor cells (EPCs) into vasculature of newborn murine recipients.
    Authors: Young PP, 107327, Hofling AA, Sands MS
    Proc. Natl. Acad. Sci. U.S.A., 2002;99(18):11951-6.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo

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Recombinant Mouse VEGF 164 Protein
By Anonymous on 04/06/2021
Application: Cell migration/motility
Reason for Rating: PMID: 32382040

Recombinant Mouse VEGF 164 Protein
By Jenna Nguyen on 10/17/2019
Application: Cell Adhesion

Recombinant Mouse VEGF 164 Protein
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Application: CellProlif

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Application: SDS-PAGE Control

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By Anonymous on 04/22/2018
Application: CellProlif

Recombinant Mouse VEGF 164 Protein
By Anonymous on 04/17/2018

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By Anonymous on 06/13/2017
Application: VEGFA effect on p38MAPK activation in mouse retinal epithelial cells