Catalog Number: 3856
Chemical Name: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-5-hydroxytryptamine ruthenium(2+) dihexafluorophosphate complex
Biological Activity
RuBi-caged version of serotonin (Cat. No. 3547). Excited by visible wavelengths (450 nm). Has no effect on firing of pyramidal neurons in mice; uncaging with blue light alters firing rate of COM and CPn neurons, which is blocked by MDL 100907 (Cat. No. 4173).
Technical Data
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under licence from Columbia University
Background References
  1. Ruthenium(II) bipyridyl complexes as photolabile caging groups for amines.
    Zayat et al.
    Inorg. Chem., 2006;45:1728
  2. A visible-light-sensitive caged serotonin.
    Cabrera et al.
    ACS Chem.Neurosci., 2017;8:1036

The citations listed below are publications that use Tocris products. Selected citations for RuBi-5-HT include:

1 Citations: Showing 1 - 1

  1. Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants.
    Authors: Baj Et al.
    Neuropsychopharmacology 2012;37:1600

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