RuBi-5-HT
Discontinued Product
Chemical Name: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-5-hydroxytryptamine ruthenium(2+) dihexafluorophosphate complex
Biological Activity
RuBi-caged version of serotonin (Cat. No. 3547). Excited by visible wavelengths (450 nm). Has no effect on firing of pyramidal neurons in mice; uncaging with blue light alters firing rate of COM and CPn neurons, which is blocked by MDL 100907 (Cat. No. 4173).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Ruthenium(II) bipyridyl complexes as photolabile caging groups for amines.
Zayat et al.
Inorg. Chem., 2006;45:1728 -
A visible-light-sensitive caged serotonin.
Cabrera et al.
ACS Chem.Neurosci., 2017;8:1036
Product Datasheets
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Citation for RuBi-5-HT
The citations listed below are publications that use Tocris products. Selected citations for RuBi-5-HT include:
1 Citation: Showing 1 - 1
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Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants.
Authors: Baj Et al.
Neuropsychopharmacology 2012;37:1600
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