TACS Annexin V-FITC Apoptosis Detection Kit

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TACS Annexin V-FITC Apoptosis Detection Kit_4830-250-K
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Product Details
Citations (32)

TACS Annexin V-FITC Apoptosis Detection Kit Summary

Allows rapid, specific, and quantitative identification of apoptosis in individual cells when using flow cytometry.

Why Use the TACS Annexin V-FITC Apoptosis Detection Kit?

Annexin V is a calcium-dependent phospholipid binding protein that can be used to bind Phosphatidylserine(PS) during an early apoptosis event where the PS becomes exposed at the cell surface.

The TACS Annexin V-FITC Apoptosis Detection Kit is supplied with an optimized Binding Buffer and propidium iodide. Propidium iodide may be used on unfixed samples to determine the population of cells that have lost membrane integrity, allowing discrimination between apoptotic and necrotic (or late apoptotic) cells.

Kit Contents

• Annexin V FITC
• 10X Binding Buffer
• Propidium Iodide


Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended on the product label.
Store the unopened product at 2 - 8 °C. Do not use past expiration date.


For research use only. Not for diagnositic use.

Product Datasheets

Data Example

Flow Cytometry TACS Annexin V-FITC Apoptosis Detection Kit_4830-250-K View Larger

Detection of Apoptotic Dexamethasone-treated Thymocytes by Annexin V Staining. Thymocytes were left untrated (left) or treated with 100 nM Dexamethasone for 15.5 hours (right) and then stained using Annexin V-FITC and propidium iodide provided in the TACS Annexin V-FITC Apoptosis Detection Kit (Catalog # 4830-250-K). The combination of Annexin V-FITC and propidium iodide allows for the distinction between early apoptotic cells (Annexin V-FITC positive), late apoptotic and/or necrotic cells (Annexin V-FITC and propidium iodide positive), and viable cells (unstained). Analysis courtesy of Dr. C.M. Knudson, Howard Hughes Medical Institute, St. Louis, MO.

Citations for TACS Annexin V-FITC Apoptosis Detection Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

32 Citations: Showing 1 - 10
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  1. Hemistepsin A protects human keratinocytes against hydrogen peroxide-induced oxidative stress through activation of the Nrf2/HO-1 signaling pathway
    Authors: C Park, H Lee, JS Noh, CY Jin, GY Kim, JW Hyun, SH Leem, YH Choi
    Arch. Biochem. Biophys., 2020;691(0):108512.  2020
  2. Apatinib ameliorates doxorubicin-induced migration and cancer stemness of osteosarcoma cells by inhibiting Sox2 via STAT3 signalling
    Authors: ZC Tian, JQ Wang, H Ge
    J Orthop Translat, 2020;22(0):132-141.  2020
  3. Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts
    Authors: CA Nadalutti, DF Stefanick, ML Zhao, JK Horton, R Prasad, AM Brooks, JD Griffith, SH Wilson
    Sci Rep, 2020;10(1):5575.  2020
  4. IGF2 autocrine-mediated IGF1R activation is a clinically relevant mechanism of osimertinib resistance in lung cancer
    Authors: T Manabe, H Yasuda, H Terai, H Kagiwada, J Hamamoto, T Ebisudani, K Kobayashi, K Masuzawa, S Ikemura, I Kawada, Y Hayashi, K Fukui, K Horimoto, K Fukunaga, K Soejima
    Mol. Cancer Res., 2020;0(0):.  2020
  5. Inhibition of Heparanase Expression Results in Suppression of Invasion, Migration and Adhesion Abilities of Bladder Cancer Cells
    Authors: Y Tatsumi, M Miyake, K Shimada, T Fujii, S Hori, Y Morizawa, Y Nakai, S Anai, N Tanaka, N Konishi, K Fujimoto
    Int J Mol Sci, 2020;21(11):.  2020
  6. Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response
    Authors: H Schwenzer, F Jühling, A Chu, LJ Pallett, TF Baumert, M Maini, A Fassati
    Cell Rep, 2019;26(12):3416-3428.e5.  2019
  7. Efferocytosis of apoptotic alveolar epithelial cells is sufficient to initiate lung fibrosis
    Authors: KK Kim, MR Dotson, M Agarwal, J Yang, PB Bradley, N Subbotina, JJ Osterholze, TH Sisson
    Cell Death Dis, 2018;9(11):1056.  2018
  8. Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
    Authors: MJ Mitchell, J Webster, A Chung, PP Guimarães, OF Khan, R Langer
    Nat Commun, 2017;8(0):14179.  2017
  9. EBV induces persistent NF-?B activation and contributes to survival of EBV-positive neoplastic T- or NK-cells
    Authors: H Takada, KI Imadome, H Shibayama, M Yoshimori, L Wang, Y Saitoh, S Uota, S Yamaoka, T Koyama, N Shimizu, K Yamamoto, S Fujiwara, O Miura, A Arai
    PLoS ONE, 2017;12(3):e0174136.  2017
  10. FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis.
    Authors: Coe, Lindsay, Madathil, Sangeeth, Casu, Carla, Lanske, Beate, Rivella, Stefano, Sitara, Despina
    J Biol Chem, 2014;289(14):9795-810.  2014
  11. Plasma membrane Pdia3 and VDR interact to elicit rapid responses to 1alpha,25(OH)(2)D(3).
    Authors: Chen J, Doroudi M, Cheung J, Grozier A, Schwartz Z, Boyan B
    Cell Signal, 2013;25(12):2362-73.  2013
  12. Endothelial Cells Inhibit the Angiotensin II Induced Phenotypic Modulation of Rat Vascular Adventitial Fibroblasts.
    Authors: Xu J, Chang N, Li T, Jiang R, Sun X, He Y, Jiang J
    J Cell Biochem, 0;118(7):1921-1927.  0
  13. Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK).
    Authors: Shajahan A, Dobbin Z, Hickman F, Dakshanamurthy S, Clarke R
    J Biol Chem, 0;287(21):17682-92.  0
  14. Naphthol AS-E Phosphate Inhibits the Activity of the Transcription Factor Myb by Blocking the Interaction with the KIX Domain of the Coactivator p300.
    Authors: Uttarkar S, Dukare S, Bopp B, Goblirsch M, Jose J, Klempnauer K
    Mol Cancer Ther, 0;14(6):1276-85.  0
  15. A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase.
    Authors: Kim I, Stegeman R, Brosey C, Ellenberger T
    J Biol Chem, 0;290(6):3775-83.  0
  16. Staphylococcus aureus Inhibits Neutrophil-derived IL-8 to Promote Cell Death.
    Authors: Zurek O, Pallister K, Voyich J
    J Infect Dis, 0;212(6):934-8.  0
  17. Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction.
    Authors: Uttarkar S, Dasse E, Coulibaly A, Steinmann S, Jakobs A, Schomburg C, Trentmann A, Jose J, Schlenke P, Berdel W, Schmidt T, Muller-Tidow C, Frampton J, Klempnauer K
    Blood, 0;127(9):1173-82.  0
  18. PCK3145 inhibits proliferation and induces apoptosis in breast and colon cancer cells.
    Authors: Kostopoulos A, Papageorgiou E, Koutsilieris M, Sivolapenko G
    Anticancer Res, 0;35(3):1377-84.  0
  19. An LRP16-containing preassembly complex contributes to NF-kappaB activation induced by DNA double-strand breaks.
    Authors: Wu Z, Wang C, Bai M, Li X, Mei Q, Li X, Wang Y, Fu X, Luo G, Han W
    Nucleic Acids Res, 0;43(6):3167-79.  0
  20. Mitochondrial DNA-depleted A549 cells are resistant to bleomycin.
    Authors: Brar S, Meyer J, Bortner C, Van Houten B, Martin W
    Am J Physiol Lung Cell Mol Physiol, 0;303(5):L413-24.  0
  21. Kruppel-like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling.
    Authors: Brown A, Simmen R, Raj V, Van T, MacLeod S, Simmen F
    Carcinogenesis, 0;36(9):946-55.  0
  22. Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity.
    Authors: Balasubramanian K, Maeda A, Lee J, Mohammadyani D, Dar H, Jiang J, St Croix C, Watkins S, Tyurin V, Tyurina Y, Kloditz K, Polimova A, Kapralova V, Xiong Z, Ray P, Klein-Seetharaman J, Mallampalli R, Bayir H, Fadeel B, Kagan V
    Sci Signal, 0;8(395):ra95.  0
  23. Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes.
    Authors: McGrath J, Williamson K, Balasubramanian S, Odate S, Arora S, Hatton C, Edwards T, O'Brien T, Magnuson S, Stokoe D, Daniels D, Bryant B, Trojer P
    Cancer Res, 0;76(7):1975-88.  0
  24. The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2.
    Authors: Sen R, Natarajan K, Bhullar J, Shukla S, Fang H, Cai L, Chen Z, Ambudkar S, Baer M
    Mol Cancer Ther, 0;11(9):2033-44.  0
  25. A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications.
    Authors: Chen Q, Wang W, Zeng S, Urayama S, Yu A
    Nucleic Acids Res, 0;43(7):3857-69.  0
  26. CBS9106-induced CRM1 degradation is mediated by cullin ring ligase activity and the neddylation pathway.
    Authors: Saito N, Sakakibara K, Sato T, Friedman J, Kufe D, VonHoff D, Kawabe T
    Mol Cancer Ther, 0;13(12):3013-23.  0
  27. IFN-gamma-independent intraocular tumor rejection is mediated by a macrophage-dependent process that leaves the eye intact.
    Authors: Coursey T, Chen P, Niederkorn J
    J Leukoc Biol, 0;92(5):939-50.  0
  28. CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure.
    Authors: Kuse Y, Tsuruma K, Kanno Y, Shimazawa M, Hara H
    Front Pharmacol, 0;8(0):207.  0
  29. Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system.
    Authors: Keshwani M, Kanter J, Ma Y, Wilderman A, Darshi M, Insel P, Taylor S
    Proc Natl Acad Sci U S A, 0;112(41):12681-6.  0
  30. Reovirus uses multiple endocytic pathways for cell entry.
    Authors: Schulz W, Haj A, Schiff L
    J Virol, 0;86(23):12665-75.  0
  31. MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC.
    Authors: Joshi P, Jeon Y, Lagana A, Middleton J, Secchiero P, Garofalo M, Croce C
    Proc Natl Acad Sci U S A, 0;112(28):8650-5.  0
  32. Poly(ADP-ribose) polymerase-1 inhibition by arsenite promotes the survival of cells with unrepaired DNA lesions induced by UV exposure.
    Authors: Qin X, Liu W, Li Y, Sun X, Hai C, Hudson L, Liu K
    Toxicol Sci, 0;127(1):120-9.  0


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