Catalog Number: 2305
Chemical Name: (1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester
Biological Activity
Selective inhibitor of protein phosphatase (PP)1 (IC50 values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells.
    Kim et al.
    Transplant Proc., 2005;37:1959
  2. Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1.
    Mitsuhashi et al.
    Biochem.Biophys.Res.Comm., 2001;287:328
  3. Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction.
    Shim et al.
    Proc.Natl.Acad.Sci.USA., 2002;99:10617
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