Selective inhibitor of protein phosphatase (PP)1 (IC50
values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo
. Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.
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All Tocris products are intended for laboratory research use only.
Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells.
Kim et al.
Transplant Proc., 2005;37:1959
Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1.
Mitsuhashi et al.
Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction.
Shim et al.
The citations listed below are publications that use Tocris products. Selected citations for Tautomycetin include:
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