Tautomycetin

  ( 9 citations )    
Product Datasheet
Catalog Number:2305
Chemical Name:(1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester
Product Details
Citations (9)
Reviews
Biological Activity
Selective inhibitor of protein phosphatase (PP)1 (IC50 values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.
Technical Data
  • M.Wt:
    606.75
  • Formula:
    C33H50O10
  • Solubility:
    Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
  • Purity:
    >95
  • Storage:
    Desiccate at -20°C
  • CAS No:
    119757-73-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tautomycetin include:

9 Citations: Showing 1 - 9
Filter your results:

  1. Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1.
    Authors: Alver Et al.
    Cell Rep  2017;18:2508
  2. DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons.
    Authors: Engmann Et al.
    Nat Commun  2015;6:10099
  3. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
    Authors: Mirante Et al.
    PLoS Genet  2014;7:62
  4. PP1γ functionally augments the alternative splicing of CaMKIIδ through interaction with ASF.
    Authors: Huang Et al.
    Am J Physiol Cell Physiol  2014;306:C167
  5. Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons.
    Authors: Isensee Et al.
    J Cell Sci  2014;127:216
  6. PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.
    Authors: Hégarat Et al.
    Anticancer Res  2014;10:e1004004
  7. TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
    Authors: Pribiag and Stellwagen
    Front Neurosci  2013;33:15879
  8. TGF-β regulation of focal adhesion proteins and motility of premalignant oral lesions via protein phosphatase 1.
    Authors: Walsh and Young
    Anticancer Res  2011;31:3159
  9. Interrelationship between protein phosphatase 1 and TGF-{β} in regulating motility and cytoskeletal architecture of endothelial cells.
    Authors: Walsh and Young
    J Neurosci  2010;30:4861

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used Tautomycetin?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee