Newer Version Available: 1336

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Tautomycetin | CAS No. 119757-73-2 | Protein Ser/Thr Phosphatase Inhibitors
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Description: Selective PP1 inhibitor

Chemical Name: (1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester

Purity: ≥95%

Product Details
Citations (17)

Biological Activity

Tautomycetin is a selective inhibitor of protein phosphatase (PP)1 (IC50 values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.

Technical Data

Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Tautomycetin

The citations listed below are publications that use Tocris products. Selected citations for Tautomycetin include:

17 Citations: Showing 1 - 10

  1. Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
    Authors: Messal Et al.
    Nature  2019;566:126
  2. Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling.
    Authors: Garzón Et al.
    Cell Rep  2019;27:2558
  3. In vivo brain GPCR signaling elucidated by phosphoproteomics.
    Authors: Liu
    Science  2018;360(6395):eaao4927
  4. PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.
    Authors: Georgilis Et al.
    Cancer Cell  2018;34:85
  5. ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation.
    Authors: Pyo Et al.
    Cell Rep  2018;25:2878
  6. M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation.
    Authors: Wan Et al.
    Front Mol Neurosci  2018;11:287
  7. Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation.
    Authors: Hiraga Et al.
    EMBO Rep  2017;18:403
  8. Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1.
    Authors: Alver Et al.
    Cell Rep  2017;18:2508
  9. DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons.
    Authors: Engmann Et al.
    Nat Commun  2015;6:10099
  10. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
    Authors: Mirante Et al.
    PLoS Genet  2014;7:62


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