Tautomycetin
Chemical Name: (1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester
Purity: ≥95%
Biological Activity
Tautomycetin is a selective inhibitor of protein phosphatase (PP)1 (IC50 values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells.
Kim et al.
Transplant Proc., 2005;37:1959 -
Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1.
Mitsuhashi et al.
Biochem.Biophys.Res.Comm., 2001;287:328 -
Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction.
Shim et al.
Proc.Natl.Acad.Sci.USA., 2002;99:10617
Product Datasheets
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Citations for Tautomycetin
The citations listed below are publications that use Tocris products. Selected citations for Tautomycetin include:
17 Citations: Showing 1 - 10
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Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
Authors: Messal Et al.
Nature 2019;566:126
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Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling.
Authors: Garzón Et al.
Cell Rep 2019;27:2558
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In vivo brain GPCR signaling elucidated by phosphoproteomics.
Authors: Liu
Science 2018;360(6395):eaao4927
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PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.
Authors: Georgilis Et al.
Cancer Cell 2018;34:85
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ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation.
Authors: Pyo Et al.
Cell Rep 2018;25:2878
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M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation.
Authors: Wan Et al.
Front Mol Neurosci 2018;11:287
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Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation.
Authors: Hiraga Et al.
EMBO Rep 2017;18:403
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Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1.
Authors: Alver Et al.
Cell Rep 2017;18:2508
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DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons.
Authors: Engmann Et al.
Nat Commun 2015;6:10099
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Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
Authors: Mirante Et al.
PLoS Genet 2014;7:62
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PP1γ functionally augments the alternative splicing of CaMKIIδ through interaction with ASF.
Authors: Huang Et al.
Am J Physiol Cell Physiol 2014;306:C167
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Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons.
Authors: Isensee Et al.
J Cell Sci 2014;127:216
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PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.
Authors: Hégarat Et al.
Anticancer Res 2014;10:e1004004
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A novel effect of MARCKS phosphorylation by activated PKC: the dephosphorylation of its serine 25 in chick neuroblasts.
Authors: Toledo Et al.
PLoS One 2013;8:e62863
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TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
Authors: Pribiag and Stellwagen
Front Neurosci 2013;33:15879
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TGF-β regulation of focal adhesion proteins and motility of premalignant oral lesions via protein phosphatase 1.
Authors: Walsh and Young
Anticancer Res 2011;31:3159
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Interrelationship between protein phosphatase 1 and TGF-{β} in regulating motility and cytoskeletal architecture of endothelial cells.
Authors: Walsh and Young
J Neurosci 2010;30:4861
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