Catalog Number: 2305
Chemical Name: (1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester
Biological Activity
Selective inhibitor of protein phosphatase (PP)1 (IC50 values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells.
    Kim et al.
    Transplant Proc., 2005;37:1959
  2. Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1.
    Mitsuhashi et al.
    Biochem.Biophys.Res.Comm., 2001;287:328
  3. Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction.
    Shim et al.
    Proc.Natl.Acad.Sci.USA., 2002;99:10617

The citations listed below are publications that use Tocris products. Selected citations for Tautomycetin include:

7 Citations: Showing 1 - 7
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  1. DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons.
    Authors: Engmann Et al.
    Nat Commun 2015;6:10099
  2. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
    Authors: Mirante Et al.
    PLoS Genet 2014;7:62
  3. Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons.
    Authors: Isensee Et al.
    J Cell Sci 2014;127:216
  4. PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.
    Authors: Hégarat Et al.
    Anticancer Res 2014;10:e1004004
  5. TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
    Authors: Pribiag and Stellwagen
    Front Neurosci 2013;33:15879
  6. TGF-β regulation of focal adhesion proteins and motility of premalignant oral lesions via protein phosphatase 1.
    Authors: Walsh and Young
    Anticancer Res 2011;31:3159
  7. Interrelationship between protein phosphatase 1 and TGF-{β} in regulating motility and cytoskeletal architecture of endothelial cells.
    Authors: Walsh and Young
    J Neurosci 2010;30:4861

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