TGF-beta 1 Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (11)
Supplemental Products

TGF-beta 1 Antibody Summary

Detects multiple species of TGF-beta 1 in direct ELISAs and Western blots. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) TGF‑ alpha, rhTGF‑ beta 2, rhTGF‑ beta 3, rhTGF‑ beta 5, rhLAP (TGF‑ beta 1), rhART, rhNeurturin, or recombinant mouse TRANCE.
Monoclonal Mouse IgG2B Clone # 141322
Protein A or G purified from hybridoma culture supernatant
Chinese hamster ovary cell line CHO-derived recombinant human TGF‑ beta 1
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
1 µg/mL
Recombinant Human TGF-beta 1 (Catalog # 240-B)
under non-reducing conditions only

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TGF-beta 1

Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.

TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.

Long Name
Transforming Growth Factor beta 1
Entrez Gene IDs
7040 (Human); 21803 (Mouse); 59086 (Rat); 397078 (Porcine); 100033900 (Equine)
Alternate Names
CEDLAP; DPD1; latency-associated peptide; TGF beta; TGF beta1; TGFB; TGFB1; TGF-beta 1 protein; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1; transforming growth factor beta-1; transforming growth factor, beta 1

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Citations for TGF-beta 1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

11 Citations: Showing 1 - 10
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  1. BMP4 inhibits PDGF-induced proliferation and collagen synthesis via PKA-mediated inhibition of calpain-2 in pulmonary artery smooth muscle cells.
    Authors: Cai P, Kovacs L, Dong S et al.
    Am. J. Physiol. Lung Cell Mol. Physiol.
  2. Suppression of AKT Phosphorylation Restores Rapamycin-Based Synthetic Lethality in SMAD4-Defective Pancreatic Cancer Cells
    Authors: Onica Le Le Gendre, Ayisha Sookdeo, Stephie-Anne Duliepre, Matthew Utter, Maria Frias, David A. Foster
    Molecular Cancer Research
  3. DCN released from ferroptotic cells ignites AGER-dependent immune responses
    Authors: J Liu, S Zhu, L Zeng, J Li, DJ Klionsky, G Kroemer, J Jiang, D Tang, R Kang
    Autophagy, 2021-12-29;0(0):1-14.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis.
    Authors: Zhu Y, Colak T, Shenoy M, Liu L, Mehta K, Pai R, Zou B, Xie X, Pasricha P
    Mol Pain, 2012-09-11;8(0):65.
    Species: Rat
    Sample Types: In Vivo
    Applications: Neutralization Control
  5. Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.
    Authors: Alexander S, Watt F, Sawaji Y, Hermansson M, Saklatvala J
    Arthritis Rheum., 2007-11-01;56(11):3715-25.
    Species: Human, Porcine
    Sample Types: Whole Cells
    Applications: Neutralization
  6. Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells.
    Authors: Bayry J, Triebel F, Kaveri SV, Tough DF
    J. Immunol., 2007-04-01;178(7):4184-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  7. Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C.
    Authors: Manigold T, Shin EC, Mizukoshi E, Mihalik K, Murthy KK, Rice CM, Piccirillo CA, Rehermann B
    Blood, 2006-02-14;107(11):4424-32.
    Species: Primate - Pan troglodytes (Chimpanzee)
    Sample Types: Whole Cells
    Applications: Neutralization
  8. Nonlymphoid peritoneal cells suppress the T cell response to Mls.
    Authors: Rosini L, Matlack R, Taylor J, Howell KF, Yeh K, Pennello A, Riggs JE
    Immunobiology, 2004-01-01;209(8):575-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  9. New methodologies to accurately assess circulating active transforming growth factor-beta 1 levels: implications for evaluating heart failure and the impact of left ventricular assist devices
    Authors: Donna Mancini, Juan Monteagudo, Mayte Suárez-Fariñas, Jeffrey Bander, Rohan Varshney, Juana Gonzalez et al.
    Translational Research
  10. HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-?1 and can be suppressed by exogenous carbon monoxide
    Authors: J Laurence, S Elhadad, T Robison, H Terry, R Varshney, S Woolington, S Ghafoory, ME Choi, J Ahamed
    PLoS ONE, 2017-10-31;12(10):e0187185.
  11. Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells
    Authors: Guang Liu, Courtney M. Shea, Juli E. Jones, Gavrielle M. Price, William Warren, Elisabeth Lonie et al.
    American Journal of Physiology-Renal Physiology


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