Catalog # Availability Size / Price Qty
THAL SNS 032 | CAS No. 2139287-33-3 | Cyclin-dependent Kinase Inhibitors
1 Image
Description: Potent and selective Cdk9 degrading PROTAC

Chemical Name: N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxo-6,9,12-trioxa-3-azatetradecyl)piperidine-4-carboxamide

Purity: ≥98%

Product Details

Biological Activity

PROTAC comprising the cyclin-dependent kinase inhibitor SNS 032 (Cat. No. 4075) conjugated to the cereblon E3 ligase ligand, thalidomide (Cat. No. 0652). Potent, selective and cereblon-dependent degrader of Cdk9 (EC50 = 4 nM). Displays >15-fold selectivity for Cdk9 over other CDKs (EC50 values are 62, 171 and 398 nM for Cdk2, Cdk1 and Cdk7, respectively). Induces complete degradation of Cdlk9 at 250 nM in MOLT4 cells. Inhibits proliferation of leukemia cell lines.

Application of THAL SNS 032 in MOLT-4 cells

Application of THAL SNS 032 in MOLT-4 cells (Cat. No. 6532)

Wes data showing knockdown of both CDK9 isoforms after THAL SNS 032 (Cat. No. 6532) treatment of MOLT-4 cells (4 h incubation). Protein quantification (relative to DMSO-only control) is shown beneath the corresponding lane.

Data courtesy of Jeff Cooper, Bio-Techne.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

Background References

  1. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
    Olson et al.
    Nat.Chem.Biol., 2018;14:163

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for THAL SNS 032

There are currently no reviews for this product. Be the first to review THAL SNS 032 and earn rewards!

Have you used THAL SNS 032?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.