Vascular Smooth Muscle Products

R&D Systems supports vascular smooth muscle research with a full line of recombinant proteins and antibodies as well as Tocris Bioscience peptides and small molecules. Our immunoassay selection includes Quantikine^® and DuoSet^® ELISA kits, ELISpot kits, Luminex^® assays, and Proteome Profiler^™ antibody arrays. We also provide stem cell and cell culture products to support your research. Learn More.

Recombinant Proteins

FGF Family

Insulin Family

PDGF and Receptors

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Quantikine^® and DuoSet^® ELISA Kits

Insulin Family

Proteoglycans

VSMC Cytokines and Receptors

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Antibodies

Ephrin Ligands and Eph Receptors

Integrin Subunits and Heterodimers

TNF Superfamily Receptors on VSMC

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Multi-analyte Assays

Luminex^® High Performance Assays

Proteome Profiler^® Phospho-Kinase Antibody Arrays

Simple Plex Assays

 

Small Molecule Agonists and Antagonists

Adrenergic and Muscarinic Acetylcholine Receptors

Angiotensin and Endothelin Receptors

Prostanoid and Leukotriene Receptors

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Cardiovascular Diagnostics

BiosPacific^™ IVD Assay Development

Cliniqa^® Chemistry Controls

 

Vascular Smooth Muscle Literature and Resources

 

Brochures and Product Guides

Cardiovascular Research Product Guide

GPCR Product Listing

Kinases Product Listing

Mesenchymal Stem Cells

Peptide Hormone Receptors

Products for Angiogenesis Research

Products for Chemokine Research

Products for Glycobiology Research

Signal Transduction Antibody Reference Guide

 

Posters

Atherosclerosis Disease Progression

Exosomes: contents by Cell Type and Process Mini Poster

Periodic Table of Cytokine and Chemokine Families

 

References and Troubleshooting Guides

Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions

IHC/ICC Protocol Guide

Protocols/Troubleshooting Guides From Novus Biologicals^®

Protocols/Troubleshooting Guides From R&D Systems^®

Background

The vascular smooth muscle layer (tunica media) that surrounds arteries and arterioles provides physical support for these vessels. It also regulates blood pressure by contraction/relaxation induced by endocrine hormones and symathetic innervation. Vascular smooth muscle cells (VSMC) express a range of cytokine, growth factor, hormone, bioactive lipid, and neurotransmitter receptors. VSMC activation induces the upregulated secretion of inflammatory mediators and proteases. In some diseases, such as atherosclerosis, VSMC proliferate abnormally and acquire a partial osteoblastic phenotype, leading to tissue mineralization and a loss of arterial elasticity.